Flupirtine maleate
| Title | Journal |
|---|---|
| Efficacy and safety of flupirtine modified release for the management of moderate to severe chronic low back pain: results of SUPREME, a prospective randomized, double-blind, placebo- and active-controlled parallel-group phase IV study. | Current medical research and opinion 20121001 |
| M-type potassium channels modulate Schaffer collateral-CA1 glutamatergic synaptic transmission. | The Journal of physiology 20120815 |
| Concomitant facilitation of GABAA receptors and KV7 channels by the non-opioid analgesic flupirtine. | British journal of pharmacology 20120701 |
| Unexpected frequent hepatotoxicity of a prescription drug, flupirtine, marketed for about 30 years. | British journal of clinical pharmacology 20120501 |
| Efficacy and safety of flupirtine maleate and tramadol hydrochloride in postoperative pain management--a prospective randomised double blinded study. | Journal of the Indian Medical Association 20120301 |
| [Chronic backache. Rational therapy of muscle-induced pain]. | MMW Fortschritte der Medizin 20120223 |
| M channel enhancers and physiological M channel block. | The Journal of physiology 20120215 |
| The evolving understanding of the analgesic mechanism of action of flupirtine. | Journal of clinical pharmacy and therapeutics 20120201 |
| Retigabine, a K(V)7 (KCNQ) potassium channel opener, attenuates L-DOPA-induced dyskinesias in 6-OHDA-lesioned rats. | Neuropharmacology 20120201 |
| Flupirtine inhibits calcitonin-gene related peptide release from rat brainstem in vitro. | Neuroscience letters 20120111 |
| Kv7 potassium channels in airway smooth muscle cells: signal transduction intermediates and pharmacological targets for bronchodilator therapy. | American journal of physiology. Lung cellular and molecular physiology 20120101 |
| Protective effect of the KCNQ activator flupirtine on a model of repetitive febrile seizures. | Epilepsy research 20111101 |
| Efficacy and tolerability of flupirtine in subacute/ chronic musculoskeletal pain - results of a patient level, pooled re-analysis of randomized, double-blind, controlled trials. | International journal of clinical pharmacology and therapeutics 20111101 |
| Parent-reported benefits of flupirtine in juvenile neuronal ceroid lipofuscinosis (Batten disease; CLN3) are not supported by quantitative data. | Journal of inherited metabolic disease 20111001 |
| Flupirtine is a safe alternative drug in patients with hypersensitivity to NSAIDs. | European journal of clinical pharmacology 20110901 |
| Flupirtine-induced hepatic failure requiring orthotopic liver transplant. | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation 20110801 |
| Pathology of flupirtine-induced liver injury: a histological and clinical study of six cases. | Virchows Archiv : an international journal of pathology 20110601 |
| Transcriptional repression of the M channel subunit Kv7.2 in chronic nerve injury. | Pain 20110401 |
| The contribution of Kv7 channels to pregnant mouse and human myometrial contractility. | Journal of cellular and molecular medicine 20110301 |
| Flupirtine antinociception in the rat orofacial formalin test: an analysis of combination therapies with morphine and tramadol. | Pharmacology, biochemistry, and behavior 20110101 |
| [Effect of maladaptive sets on the clinical picture and prediction of chronic headache of tension]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| [Flupirtin (katadolon): a nonstandard action on pain transmission]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20110101 |
| Correlation versus causation? Pharmacovigilance of the analgesic flupirtine exemplifies the need for refined spontaneous ADR reporting. | PloS one 20110101 |
| Bioanalytical method development, validation and quantification of flupirtine maleate in rat plasma by liquid chromatography-tandem mass spectrometry. | Arzneimittel-Forschung 20110101 |
| [2010 German Pain Congress. Backache - new data, specific muscle etiology and targeted therapy]. | MMW Fortschritte der Medizin 20101216 |
| [Musculoskeletal pain. Pain relief with muscle relaxant]. | MMW Fortschritte der Medizin 20101202 |
| Flupirtine may stop the progressive course of subacute sclerosing panencephalitis. | Medical hypotheses 20101201 |
| Green urine following exposure to flupirtine. | American journal of kidney diseases : the official journal of the National Kidney Foundation 20101101 |
| Flupirtine in pain management: pharmacological properties and clinical use. | CNS drugs 20101001 |
| M-type potassium channels modulate the intrinsic excitability of infralimbic neurons and regulate fear expression and extinction. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100915 |
| Positive reinforcing effects of flupirtine--two case reports. | Progress in neuro-psychopharmacology & biological psychiatry 20100816 |
| [IGOST guideline for pharmacotherapy of low back pain]. | MMW Fortschritte der Medizin 20100812 |
| The Kv7 potassium channel activator flupirtine affects clinical excitability parameters of myelinated axons in isolated rat sural nerve. | Journal of the peripheral nervous system : JPNS 20100301 |
| CNSB004 (Leconotide) causes antihyperalgesia without side effects when given intravenously: a comparison with ziconotide in a rat model of diabetic neuropathic pain. | Pain medicine (Malden, Mass.) 20100201 |
| [New approaches to the treatment of chronic daily headache]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20100101 |
| [Efficient treatment of chronic backache]. | MMW Fortschritte der Medizin 20091210 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Treatment with the Kv7 potassium channel activator flupirtine is beneficial in two independent mouse models of pulmonary hypertension. | British journal of pharmacology 20090801 |
| [Systematic review of the therapeutics for prion diseases]. | Brain and nerve = Shinkei kenkyu no shinpo 20090801 |
| A girl with headache, confusion and green urine. | Journal of neurology 20090701 |
| Flupirtine: pharmacology and clinical applications of a nonopioid analgesic and potentially neuroprotective compound. | Expert opinion on pharmacotherapy 20090601 |
| Clinical trials for prion disease: difficult challenges, but hope for the future. | The Lancet. Neurology 20090401 |
| Investigation of the in vitro metabolism of the analgesic flupirtine. | Drug metabolism and disposition: the biological fate of chemicals 20090301 |
| A KCNQ channel opener for experimental neonatal seizures and status epilepticus. | Annals of neurology 20090301 |
| Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial*. | Current medical research and opinion 20081201 |
| Flupirtine as neuroprotective add-on therapy in autoimmune optic neuritis. | The American journal of pathology 20081101 |
| Combination therapy with flupirtine and opioid: studies in rat pain models. | Pain medicine (Malden, Mass.) 20081001 |
| Combination therapy with flupirtine and opioid: open-label case series in the treatment of neuropathic pain associated with cancer. | Pain medicine (Malden, Mass.) 20081001 |
| Bimodal effects of the Kv7 channel activator retigabine on vascular K+ currents. | British journal of pharmacology 20080901 |
| Vascular KCNQ potassium channels as novel targets for the control of mesenteric artery constriction by vasopressin, based on studies in single cells, pressurized arteries, and in vivo measurements of mesenteric vascular resistance. | The Journal of pharmacology and experimental therapeutics 20080501 |
| Systematic review of therapeutic interventions in human prion disease. | Neurology 20080408 |
| Molecular pharmacology and therapeutic potential of neuronal Kv7-modulating drugs. | Current opinion in pharmacology 20080201 |
| [Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain. Results of a standardized therapeutic evaluation applying objective methods for measuring pain pressure threshold, pain pressure tolerance and muscle tension]. | MMW Fortschritte der Medizin 20080117 |
| Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia. | European journal of pain (London, England) 20080101 |
| [Efficacy of katadolon and cranial-spine electromagnetic neuromodulation in patients with discogenic radiculopathy]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101 |
| [Analgesic and muscle tonus normalizing effect of flupirtine retard in chronic back pain]. | MMW Fortschritte der Medizin 20071025 |
| Flupirtine attenuates sodium nitroprusside-induced damage to retinal photoreceptors, in situ. | Brain research bulletin 20070712 |
| Molecular expression and pharmacological identification of a role for K(v)7 channels in murine vascular reactivity. | British journal of pharmacology 20070701 |
| [Many faces--one disease: fibromyalgia]. | Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege 20070701 |
| Activators of potassium M currents have anticonvulsant actions in two rat models of encephalitis. | European journal of pharmacology 20070119 |
| The use of flupirtine in treatment of tinnitus. | Acta oto-laryngologica. Supplementum 20061201 |
| KCNQ/M-currents contribute to the resting membrane potential in rat visceral sensory neurons. | The Journal of physiology 20060815 |
| Retigabine and flupirtine exert neuroprotective actions in organotypic hippocampal cultures. | Neuropharmacology 20060801 |
| [Backache is often caused by strained muscles]. | MMW Fortschritte der Medizin 20060525 |
| [The use of katadolon (flupirtine) in the treatment of lower back pain]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101 |
| [Use of katadolon in the treatment of abuse headache]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101 |
| [The use of katadolon in patients with spondylogenic dorsalgia]. | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20060101 |
| Tumor-necrosis-factor-related apoptosis-inducing-ligand (TRAIL)-mediated death of neurons in living human brain tissue is inhibited by flupirtine-maleate. | Journal of neuroimmunology 20051001 |
| Recent developments on KCNQ potassium channel openers. | Current medicinal chemistry 20050101 |
| The potassium channel modulator flupirtine shifts the frequency-response function of hippocampal synapses to favour LTD in mice. | Neuroscience letters 20041111 |
| [Parental administration of flupirtine in musculoskeletal pain. Results of a postmarket surveillance study]. | MMW Fortschritte der Medizin 20040524 |
| Efficacy of flupirtine on cognitive function in patients with CJD: A double-blind study. | Neurology 20040309 |
| M channels containing KCNQ2 subunits modulate norepinephrine, aspartate, and GABA release from hippocampal nerve terminals. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040121 |
| Paradoxical cerebral cortical hyperexcitability following flupirtine overdose. | Journal of toxicology. Clinical toxicology 20040101 |
| [Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study]. | MMW Fortschritte der Medizin 20030310 |
| Attenuation of methamphetamine induced dopaminergic neurotoxicity by flupirtine: microdialysis study on dopamine release and free radical generation. | Journal of neural transmission (Vienna, Austria : 1996) 20030201 |
| Analgesic efficacy of flupirtine in primary care of patients with osteoporosis related pain. A multivariate analysis. | Arzneimittel-Forschung 20030101 |
| [Flupirtine in acute and chronic pain associated with muscle tenseness. Results of a postmarket surveillance study]. | Fortschritte der Medizin. Originalien 20030101 |
| Effect of functional NMDA-antagonist flupirtine on automatic postural responses in Parkinson's disease. | Journal of neurology 20020701 |
| Treatment of spasticity. | Spinal cord 20020601 |
| [Centrally acting analgesic against fibromyalgia. The body's own pain control is activated]. | MMW Fortschritte der Medizin 20020506 |
| Flupirtine blocks apoptosis in batten patient lymphoblasts and in human postmitotic CLN3- and CLN2-deficient neurons. | Annals of neurology 20020401 |
| Neuroprotective effect of flupirtine in prion disease. | Drugs of today (Barcelona, Spain : 1998) 20020101 |
| Simultaneous determination of flupirtine and its major active metabolite in human plasma by liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Biomedical sciences and applications 20010505 |
| [Asymptomatic diclofenac-induced acute hepatitis]. | Deutsche medizinische Wochenschrift (1946) 20000623 |
| Melatonin counteracts ischemia-induced apoptosis in human retinal pigment epithelial cells. | Investigative ophthalmology & visual science 19981101 |
| Antiparkinsonian and other motor effects of flupirtine alone and in combination with dopaminergic drugs. | European journal of pharmacology 19970526 |
| Pharmacological mechanisms of action of flupirtine: a novel, centrally acting, nonopioid analgesic evaluated by its discriminative effects in the rat. | The Journal of pharmacology and experimental therapeutics 19880901 |
| Pharmacokinetics of flupirtine in elderly volunteers and in patients with moderate renal impairment. | Postgraduate medical journal 19880501 |
| [General pharmacologic studies on the analgesic flupirtine]. | Arzneimittel-Forschung 19850101 |
| Quantitation of flupirtine and its active acetylated metabolite by reversed-phase high-performance liquid chromatography using fluorometric detection. | Journal of chromatography 19840113 |