Ethyl pyruvate ameliorates endotoxin-induced corneal inflammation.

Investigative ophthalmology & visual science 20120901

Protective effect of ethyl pyruvate on liver injury in streptozotocin-induced diabetic rats.

Acta gastro-enterologica Belgica 20120901

Role of high mobility group box 1 (HMGB1) in wound healing.

The Journal of surgical research 20120701

Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms.

Neurochemistry international 20120701

HMGB1 was a pivotal synergistic effecor for CpG oligonucleotide to enhance the progression of human lung cancer cells.

Cancer biology & therapy 20120701

Therapeutic treatment with ethyl pyruvate attenuates the severity of liver injury in rats with severe acute pancreatitis.

Pancreas 20120701

Decontamination of green onions and baby spinach by vaporized ethyl pyruvate.

Journal of food protection 20120601

Ethyl pyruvate reduces ventilation-induced neutrophil infiltration and oxidative stress.

Experimental biology and medicine (Maywood, N.J.) 20120601

Ethyl pyruvate promotes spinal cord repair by ameliorating the glial microenvironment.

British journal of pharmacology 20120501

Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo.

Oncology reports 20120501

HMGB1: a potential therapeutic target for myocardial ischemia and reperfusion injury.

International journal of cardiology 20120322

Ethyl pyruvate ameliorates albuminuria and glomerular injury in the animal model of diabetic nephropathy.

American journal of physiology. Renal physiology 20120301

Differences in lipopolysaccharide- and lipoteichoic acid-induced cytokine/chemokine expression.

Intensive care medicine 20120201

Peculiarity of methoxy group-substituted phenylhydrazones in Fischer indole synthesis.

Proceedings of the Japan Academy. Series B, Physical and biological sciences 20120111

Chiral ammonium-capped rhodium(0) nanocatalysts: synthesis, characterization, and advances in asymmetric hydrogenation in neat water.

ChemSusChem 20120109

Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats.

Molecular biology reports 20120101

An in vitro spinal cord slice preparation for recording from lumbar motoneurons of the adult mouse.

Journal of neurophysiology 20120101

Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction.

PloS one 20120101

Ethyl pyruvate reduces liver injury at early phase but impairs regeneration at late phase in acetaminophen overdose.

Critical care (London, England) 20120101

Ethyl pyruvate for the treatment of acetaminophen intoxication: alternative to N-acetylcysteine?

Critical care (London, England) 20120101

Reperfusion strategies in the management of extremity vascular injury with ischaemia.

The British journal of surgery 20120101

Accelerated rejection of the second transplants of immunogenic tumor in mice under inhibition of indoleamine 2,3-dioxygenase activity by ethyl pyruvate.

Experimental oncology 20120101

Toll-like receptors in ischaemia and its potential role in the pathophysiology of muscle damage in critical limb ischaemia.

Cardiology research and practice 20120101

Small interference RNA targeting TLR4 gene effectively attenuates pulmonary inflammation in a rat model.

Journal of biomedicine & biotechnology 20120101

Reactive oxygen species and inhibitors of inflammatory enzymes, NADPH oxidase, and iNOS in experimental models of Parkinson's disease.

Mediators of inflammation 20120101

Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.

PloS one 20120101

Therapeutic effect of captopril, pentoxifylline, and cordyceps sinensis in pre-hepatic portal hypertensive rats.

Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 20120101

Ethyl pyruvate attenuates formalin-induced inflammatory nociception by inhibiting neuronal ERK phosphorylation.

Molecular pain 20120101

Glutathione supplementation attenuates lipopolysaccharide-induced mitochondrial dysfunction and apoptosis in a mouse model of acute lung injury.

Frontiers in physiology 20120101

Immunological and nonimmunological effects of indoleamine 2,3-dioxygenase on breast tumor growth and spontaneous metastasis formation.

Clinical & developmental immunology 20120101

Dengue virus infection mediates HMGB1 release from monocytes involving PCAF acetylase complex and induces vascular leakage in endothelial cells.

PloS one 20120101

Uric acid and HMGB1 are involved in the induction of autoantibodies elicited in mice infected with mouse hepatitis virus A59.

Autoimmunity 20111201

[Ethyl pyruvate inhibited HMGB1 expression induced by LPS in macrophages].

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20111201

Inhaled nitric oxide aggravates phosgene model of acute lung injury.

Inhalation toxicology 20111101

Ethyl 2-[(carbamothioyl-amino)-imino]-propano-ate.

Acta crystallographica. Section E, Structure reports online 20110801

Metabolic agents that enhance ATP can improve cognitive functioning: a review of the evidence for glucose, oxygen, pyruvate, creatine, and L-carnitine.

Nutrients 20110801

Ethyl pyruvate rescues nigrostriatal dopaminergic neurons by regulating glial activation in a mouse model of Parkinson's disease.

Journal of immunology (Baltimore, Md. : 1950) 20110715

Preventive effects of ethyl pyruvate on endotoxin-induced uveitis in rats.

Investigative ophthalmology & visual science 20110701

Macrophage activation by factors released from acetaminophen-injured hepatocytes: potential role of HMGB1.

Toxicology and applied pharmacology 20110615

In vivo anticoagulant effect of ethyl pyruvate in endotoxemic rats.

Thrombosis research 20110601

Kainic Acid-induced neurotoxicity: targeting glial responses and glia-derived cytokines.

Current neuropharmacology 20110601

Ethyl pyruvate reduces acute lung injury via regulation of iNOS and HO-1 expression in endotoxemic rats.

The Journal of surgical research 20110515

Ethyl pyruvate decreases proinflammatory gene expression in lipopolysaccharide-stimulated equine monocytes.

Veterinary immunology and immunopathology 20110515

Preliminary safety and biological efficacy studies of ethyl pyruvate in normal mature horses.

Equine veterinary journal 20110501

Alternative fluids for prehospital resuscitation: 'pharmacological' resuscitation fluids.

The Journal of trauma 20110501

Ethyl pyruvate, an anti-inflammatory agent, inhibits tumor angiogenesis through inhibition of the NF-κB signaling pathway.

Cancer letters 20110428

Inhibitory mechanism of MMP-9 gene expression by ethyl pyruvate in lipopolysaccharide-stimulated BV2 microglial cells.

Neuroscience letters 20110408

Pyruvate: immunonutritional effects on neutrophil intracellular amino or alpha-keto acid profiles and reactive oxygen species production.

Amino acids 20110401

High-mobility group box 1, oxidative stress, and disease.

Antioxidants & redox signaling 20110401

The first case of competitive heterogeneously catalyzed enantioselective hydrogenation of ketones.

Chemical communications (Cambridge, England) 20110207

Interaction of ethyl pyruvate in vitro with NF-κB subunits, RelA and p50.

European journal of pharmacology 20110110

Effects of ethyl pyruvate and other α-keto carboxylic acid derivatives in a rat model of multivisceral ischemia and reperfusion.

The Journal of surgical research 20110101

Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes.

Endocrinology 20110101

Postischemic treatment with ethyl pyruvate prevents adenosine triphosphate depletion, ameliorates inflammation, and decreases thrombosis in a murine model of hind-limb ischemia and reperfusion.

The Journal of trauma 20110101

A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation.

PloS one 20110101

Higher hypochlorous acid scavenging activity of ethyl pyruvate compared to its sodium salt.

Bioscience, biotechnology, and biochemistry 20110101

The role of receptor for advanced glycation endproducts (RAGE) in infection.

Critical care (London, England) 20110101

Systemically administered ligands of Toll-like receptor 2, -4, and -9 induce distinct inflammatory responses in the murine lung.

Mediators of inflammation 20110101

Trauma is danger.

Journal of translational medicine 20110101

An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function.

PloS one 20110101

Beneficial effects of ethyl pyruvate through inhibiting high-mobility group box 1 expression and TLR4/NF-κB pathway after traumatic brain injury in the rat.

Mediators of inflammation 20110101

Prevention of cataract in diabetic mice by topical pyruvate.

Clinical ophthalmology (Auckland, N.Z.) 20110101

Tissue factor, blood coagulation, and beyond: an overview.

International journal of inflammation 20110101

Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites.

International journal of molecular sciences 20110101

Differential regional expression patterns of α-synuclein, TNF-α, and IL-1β; and variable status of dopaminergic neurotoxicity in mouse brain after Paraquat treatment.

Journal of neuroinflammation 20110101

The beneficial effect of direct peritoneal resuscitation on septic shock in rats.

Journal of biomedicine & biotechnology 20110101

Using Complementary and Alternative Medicines to Target the Host Response during Severe Influenza.

Evidence-based complementary and alternative medicine : eCAM 20101201

HMGB1 activates nuclear factor-κB signaling by RAGE and increases the production of TNF-α in human umbilical vein endothelial cells.

Immunobiology 20101201

Transglutaminase 2 expression induced by lipopolysaccharide stimulation together with NO synthase induction in cultured astrocytes.

Neurochemistry international 20101201

[Effect of ethyl pyruvate on expression of inflammatory factors and mitogen-activated protein kinase proteins in renal ischemic/reperfusion injury in BABL/c mice].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20101201

Ethyl pyruvate has anti-inflammatory and delayed myocardial protective effects after regional ischemia/reperfusion injury.

Yonsei medical journal 20101101

Ethyl pyruvate diminishes the endotoxin-induced inflammatory response of bovine mammary endothelial cells.

Journal of dairy science 20101101

Ethyl pyruvate downregulates tumor necrosis factor alpha and interleukin (IL)-6 and upregulates IL-10 in lipopolysaccharide-stimulated canine peripheral blood mononuclear cells.

The Journal of veterinary medical science 20101001

Beneficial effects of sodium or ethyl pyruvate after traumatic brain injury in the rat.

Experimental neurology 20101001

Cell to Cell Interaction Can Activate Membrane-bound APRIL Which Are Expressed on Inflammatory Macrophages.

Immune network 20101001

Ethyl pyruvate stabilizes hypoxia-inducible factor 1 alpha via stimulation of the TCA cycle.

Cancer letters 20100928

HMGB1 release and redox regulates autophagy and apoptosis in cancer cells.

Oncogene 20100923

Ethyl pyruvate prevents inflammatory responses and organ damage during resuscitation in porcine hemorrhage.

Shock (Augusta, Ga.) 20100801

Inhibition by ethyl pyruvate of the nuclear translocation of nuclear factor-kappaB in cultured lung epithelial cells.

Pulmonary pharmacology & therapeutics 20100801

The biochemical basis for the anti-inflammatory and cytoprotective actions of ethyl pyruvate and related compounds.

Biochemical pharmacology 20100715

Association between high-mobility group box-1 protein release and immune function of dendritic cells in thermal injury.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20100701

Responses of cultured human keratocytes and myofibroblasts to ethyl pyruvate: a microarray analysis of gene expression.

Investigative ophthalmology & visual science 20100601

Ethyl pyruvate prevents intestinal inflammatory response and oxidative stress in a rat model of extrahepatic cholestasis.

The Journal of surgical research 20100515

Diastereoselective synthesis of fused [1,3]oxazines from ethyl pyruvate, activated acetylenes and N-heterocycles.

Molecular diversity 20100501

Hypertonic sodium pyruvate solution is more effective than Ringer's ethyl pyruvate in the treatment of hemorrhagic shock.

Shock (Augusta, Ga.) 20100501

Intraocular penetration of pyruvate following its topical administration in mice.

Molecular and cellular biochemistry 20100501

Cancer and inflammation: promise for biologic therapy.

Journal of immunotherapy (Hagerstown, Md. : 1997) 20100501

Metabolic imaging in the anesthetized rat brain using hyperpolarized [1-13C] pyruvate and [1-13C] ethyl pyruvate.

Magnetic resonance in medicine 20100501

Ethyl pyruvate has a neuroprotective effect through activation of extracellular signal-regulated kinase in Parkinson's disease model.

Biochemical and biophysical research communications 20100409

[Influence of splenic high mobility group box-1 protein on immune function of regulatory T lymphocytes in scald rats].

Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20100401

Ethyl (2E)-2-(hydroxy-imino)propanoate.

Acta crystallographica. Section E, Structure reports online 20100401

Role of high-mobility group box 1 protein in the pathogenesis of intestinal barrier injury in rats with severe acute pancreatitis.

Pancreas 20100301

Ethyl pyruvate protects against hypoxic-ischemic brain injury via anti-cell death and anti-inflammatory mechanisms.

Neurobiology of disease 20100301

Immunotherapeutic suppression of indoleamine 2,3-dioxygenase and tumor growth with ethyl pyruvate.

Cancer research 20100301

Highly diastereoselective synthesis of modified nucleosides via an asymmetric multicomponent reaction.

Chemical communications (Cambridge, England) 20100227

Ethyl pyruvate inhibits peroxynitrite-induced DNA damage and hydroxyl radical generation: implications for neuroprotection.

Neurochemical research 20100201

Natural alkaloids and synthetic relatives as chiral templates of the Orito's reaction.

Chirality 20100101

Combination treatment with ethyl pyruvate and aspirin enhances neuroprotection in the postischemic brain.

Neurotoxicity research 20100101

LucidDraw: efficiently visualizing complex biochemical networks within MATLAB.

BMC bioinformatics 20100101

Peritoneal inflammation after twenty-week exposure to dialysis solution: effect of solution versus catheter-foreign body reaction.

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20100101

Proline-Glycine-Proline (PGP) and High Mobility Group Box Protein-1 (HMGB1): Potential Mediators of Cystic Fibrosis Airway Inflammation.

The open respiratory medicine journal 20100101

Novel insights for systemic inflammation in sepsis and hemorrhage.

Mediators of inflammation 20100101

DAMPening inflammation by modulating TLR signalling.

Mediators of inflammation 20100101

Ethyl pyruvate therapy attenuates experimental severe arthritis caused by type II collagen (CII) in the mouse (CIA).

International journal of immunopathology and pharmacology 20100101

Current and emerging strategies for the treatment and management of systemic lupus erythematosus based on molecular signatures of acute and chronic inflammation.

Journal of inflammation research 20100101

Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.

American journal of respiratory cell and molecular biology 20091201

Ethyl pyruvate enhances intra-resuscitation hemodynamics in prolonged ventricular fibrillation arrest.

Resuscitation 20091201

Autophagy inhibition in combination cancer treatment.

Current opinion in investigational drugs (London, England : 2000) 20091201

Diastereoselective synthesis of fused [1,3]thiazolo[1,3]oxazins and [1,3]oxazino[2,3-b][1,3]benzothiazoles.

Molecular diversity 20091101

Modulation of intracellular ROS levels by TIGAR controls autophagy.

The EMBO journal 20091007

Shape-selective enantioselective hydrogenation on Pt nanoparticles.

Journal of the American Chemical Society 20090902

Ethyl pyruvate decreases HMGB1 release and ameliorates murine colitis.

Journal of leukocyte biology 20090901

Ethyl pyruvate administration inhibits hepatic tumor growth.

Journal of leukocyte biology 20090901

Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.

Molecular cancer therapeutics 20090901

Beneficial effects of ethyl pyruvate in a mouse model of spinal cord injury.

Shock (Augusta, Ga.) 20090801

Treatment with green tea extract attenuates secondary inflammatory response in an experimental model of spinal cord trauma.

Naunyn-Schmiedeberg's archives of pharmacology 20090801

Can we predict the effects of NF-kappaB inhibition in sepsis? Studies with parthenolide and ethyl pyruvate.

Expert opinion on investigational drugs 20090801

[Effects of ethyl pyruvate on injuries of sepsis in mice].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20090801

Ethyl pyruvate modulates adhesive and secretory reactions in human lung epithelial cells.

Life sciences 20090605

A phase II multicenter double-blind placebo-controlled study of ethyl pyruvate in high-risk patients undergoing cardiac surgery with cardiopulmonary bypass.

Journal of cardiothoracic and vascular anesthesia 20090601

Ethyl pyruvate attenuates spinal cord ischemic injury with a wide therapeutic window through inhibiting high-mobility group box 1 release in rabbits.

Anesthesiology 20090601

Anti-inflammatory resuscitation improves survival in hemorrhage with trauma.

The Journal of trauma 20090601

The Stimulation of CD147 Induces MMP-9 Expression through ERK and NF-kappaB in Macrophages: Implication for Atherosclerosis.

Immune network 20090601

Ethyl pyruvate ameliorates liver injury secondary to severe acute pancreatitis.

The Journal of surgical research 20090515

Effect of ethyl pyruvate on physical and immunological barriers of the small intestine in a rat model of sepsis.

The Journal of trauma 20090501

Neuroprotective effects of ethyl pyruvate on brain energy metabolism after ischemia-reperfusion injury: a 31P-nuclear magnetic resonance study.

Neurochemical research 20090401

Ethyl pyruvate improves survival in awake hemorrhage.

Journal of molecular medicine (Berlin, Germany) 20090401

The effect of high-mobility group box 1 protein on activity of regulatory T cells after thermal injury in rats.

Shock (Augusta, Ga.) 20090301

Ethyl pyruvate protects colonic anastomosis from ischemia-reperfusion injury.

Surgical innovation 20090301

Anti-inflammatory adjuvant in resuscitation fluids improves survival in hemorrhage.

Critical care medicine 20090301

Would you like your colloid straight or with a twist of an anti-inflammatory antioxidant?

Critical care medicine 20090301

Antioxidant effect of ethyl pyruvate in respiring neonatal cerebrocortical slices after H(2)O(2) stress.

Neurochemistry international 20090201

Ethyl pyruvate reduces the development of zymosan-induced generalized inflammation in mice.

Critical care medicine 20090101

Heme Oxygenase-1 is an Essential Cytoprotective Component in Oxidative Tissue Injury Induced by Hemorrhagic Shock.

Journal of clinical biochemistry and nutrition 20090101

Ethyl pyruvate reduces mortality in an endotoxin-induced severe acute lung injury mouse model.

Respiratory research 20090101

The Impact of Adenosine Fast Induction of Myocardial Arrest during CABG on Myocardial Expression of Apoptosis-Regulating Genes Bax and Bcl-2.

Cardiology research and practice 20090101

Methyl-2-acetamidoacrylate, an ethyl pyruvate analog, decreases sepsis-induced acute kidney injury in mice.

American journal of physiology. Renal physiology 20081201

Stereoselective reduction of carbonyl compounds with Actinomycete: purification and characterization of three alpha-keto ester reductases from Streptomyces avermitilis.

Bioscience, biotechnology, and biochemistry 20081201

1-(1-Naphthyl)ethylamine adsorption on platinum surfaces: on the mechanism of chiral modification in catalysis.

Journal of the American Chemical Society 20081105

The effect of ethyl pyruvate on dapsone-induced methemoglobinemia in rats.

Clinical toxicology (Philadelphia, Pa.) 20081101

Relationship between high-mobility group box 1 protein release and T-cell suppression in rats after thermal injury.

Shock (Augusta, Ga.) 20081001

The role of high mobility group box1 in pulmonary fibrosis.

American journal of respiratory cell and molecular biology 20081001

Ethyl pyruvate has an anti-inflammatory effect by inhibiting ROS-dependent STAT signaling in activated microglia.

Free radical biology & medicine 20081001

Polar [3 + 2] cycloaddition of ketones with electrophilically activated carbonyl ylides. Synthesis of spirocyclic dioxolane indolinones.

Organic & biomolecular chemistry 20080907

Ethyl pyruvate and ethyl lactate down-regulate the production of pro-inflammatory cytokines and modulate expression of immune receptors.

Biochemical pharmacology 20080901

The role of high-mobility group box-1 in renal ischemia and reperfusion injury and the effect of ethyl pyruvate.

Transplantation proceedings 20080901

Delayed ethyl pyruvate therapy attenuates experimental severe acute pancreatitis via reduced serum high mobility group box 1 levels in rats.

World journal of gastroenterology 20080728

Systemic release of high mobility group box 1 protein during severe murine influenza.

Journal of immunology (Baltimore, Md. : 1950) 20080715

Ethyl pyruvate modulates acute inflammatory reactions in human endothelial cells in relation to the NF-kappaB pathway.

British journal of pharmacology 20080701

Synphos modified Pt nanoclusters, their heterogenization by silica sol-gel entrapment, and catalytic activity in hydrogenolysis of bicyclo[2.2.2]oct-7-enes and hydrogenation of ethyl pyruvate.

Nanotechnology 20080604

Effects of ethyl pyruvate on myocardial apoptosis and expression of Bcl-2 and Bax proteins after ischemia-reperfusion in rats.

Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20080601

Synthesis and biological activity of functionalized indole-2-carboxylates, triazino- and pyridazino-indoles.

Archiv der Pharmazie 20080501

Ethyl pyruvate decreased early nuclear factor-kappaB levels but worsened survival in lipopolysaccharide-challenged mice.

Critical care medicine 20080401

Bull's eye missed by the magic bullet: preclinical investigations, publication bias, and promising new interventions.

Critical care medicine 20080401

Ethyl pyruvate reduces germ cell-specific apoptosis and oxidative stress in rat model of testicular torsion/detorsion.

Journal of pediatric surgery 20080401

Targeting the lipopolysaccharides: still a matter of debate?

Current opinion in anaesthesiology 20080401

Ethyl pyruvate.

Current opinion in anaesthesiology 20080401

Ethyl pyruvate inhibits hypoxic pulmonary vasoconstriction and attenuates pulmonary artery cytokine expression.

The Journal of surgical research 20080301

[Protective effect of ethyl pyruvate on barrier function of intestinal mucosa in dogs with septic shock].

Zhonghua wei chang wai ke za zhi = Chinese journal of gastrointestinal surgery 20080301

Sepsis: from bench to bedside.

Clinics (Sao Paulo, Brazil) 20080201

The effect of ethyl pyruvate on oxidative stress in intestine and bacterial translocation after thermal injury.

The Journal of surgical research 20080101

[Effect of ethyl pyruvate on indices of tissue oxygenation and perfusion in dogs with septic shock].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20080101

Protective effects of ethyl pyruvate treatment on paraquat-intoxicated rats.

Human & experimental toxicology 20080101

Introduction of an agent-based multi-scale modular architecture for dynamic knowledge representation of acute inflammation.

Theoretical biology & medical modelling 20080101

Bench-to-bedside review: latest results in hemorrhagic shock.

Critical care (London, England) 20080101

Preconditioning of carbon monoxide releasing molecule-derived CO attenuates LPS-induced activation of HUVEC.

International journal of biological sciences 20080101

Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity.

PloS one 20080101

Management of sepsis.

BMJ (Clinical research ed.) 20071103

Intrapulmonary delivery of ethyl pyruvate attenuates lipopolysaccharide- and lipoteichoic acid-induced lung inflammation in vivo.

Shock (Augusta, Ga.) 20071101

Ethyl pyruvate, a potentially effective mitigator of damage after total-body irradiation.

Radiation research 20071101

Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices.

Anesthesiology 20071001

Ethyl pyruvate improves survival and ameliorates distant organ injury in rats with severe acute pancreatitis.

Pancreas 20071001

The protective effect of ethyl pyruvate on lung injury after burn in rats.

Saudi medical journal 20071001

[Effect of ethyl pyruvate on renal high mobility group box-1 protein expression and acute kidney injury in rats with delayed resuscitation after thermal injury].

Zhonghua wai ke za zhi [Chinese journal of surgery] 20070901

Oxidative damage in rat erythrocyte membranes following ethanol intake: effect of ethyl pyruvate.

Chemico-biological interactions 20070830

Role of guiding groups in cinchona-modified platinum for controlling the sense of enantiodifferentiation in the hydrogenation of ketones.

Journal of the American Chemical Society 20070829

Ethyl pyruvate induces necrosis-to-apoptosis switch and inhibits high mobility group box protein 1 release in A549 lung adenocarcinoma cells.

International journal of molecular medicine 20070801

[Advances in high mobility group box-1 protein mediated multiple organ dysfunction and its potential interventional strategies].

Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20070801

Ethyl pyruvate: a novel anti-inflammatory agent.

Journal of internal medicine 20070401

Ethyl pyruvate: a novel treatment for sepsis.

Current drug targets 20070401

Enantioselective hydrogenation of ethyl pyruvate over diop modified Pt nanoclusters. Determination of geometry of the ligand adsorption mode via DRIFTS.

Physical chemistry chemical physics : PCCP 20070221

Beneficial effects of ethyl pyruvate in septic shock from peritonitis.

Archives of surgery (Chicago, Ill. : 1960) 20070201

Promising therapeutic agents for sepsis.

Trends in microbiology 20070101

Protective effect of ethyl pyruvate on msP rat leukocytes damaged by alcohol intake.

Journal of applied toxicology : JAT 20070101

HMGB1 as a potential therapeutic target.

Novartis Foundation symposium 20070101

Ethyl pyruvate: a novel treatment for sepsis.

Novartis Foundation symposium 20070101

The first organocatalytic carbonyl-ene reaction: isomerisation-free C-C bond formations catalysed by H-bonding thio-ureas.

Beilstein journal of organic chemistry 20070101

Bench-to-bedside review: High-mobility group box 1 and critical illness.

Critical care (London, England) 20070101

A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1.

PloS one 20070101

Sulfur mustard toxicity following dermal exposure: role of oxidative stress, and antioxidant therapy.

Journal of burns and wounds 20070101

Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells.

Thrombosis and haemostasis 20061201

Ethyl pyruvate attenuates kainic acid-induced neuronal cell death in the mouse hippocampus.

Journal of neuroscience research 20061115

Haemodynamic and metabolic effects of resuscitation with Ringer's ethyl pyruvate in the acute phase of porcine endotoxaemic shock.

Acta anaesthesiologica Scandinavica 20061101

[Relation between level of expression of high mobility group protein B1 in hepatic tissue with the severity and prognosis of sepsis in rat].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20061101

Is pyruvate an endogenous anti-inflammatory molecule?

Nutrition (Burbank, Los Angeles County, Calif.) 20060901

Introduction to serial reviews on redox signaling in immune function and cellular responses in lung injury and diseases.

Free radical biology & medicine 20060701

Pyruvate is an endogenous anti-inflammatory and anti-oxidant molecule.

Medical science monitor : international medical journal of experimental and clinical research 20060501

Determination of geometric orientation of adsorbed cinchonidine on Pt and Fe and quiphos on Pt nanoclusters via DRIFTS.

Physical chemistry chemical physics : PCCP 20060321

[Effect of treatment with ethyl pyruvate on multiple organ dysfunction and mortality following delayed resuscitation after burn injury in rat].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060301

[Effect of ethyl pyruvate on peroxidation injury of intestinal mucosa in rats with severe abdominal infection].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20060301

Treatment of severe sepsis: where next? Current and future treatment approaches after the introduction of drotrecogin alfa.

Vascular health and risk management 20060301

Highly enantioselective direct reductive coupling of conjugated alkynes and alpha-ketoesters via rhodium-catalyzed asymmetric hydrogenation.

Journal of the American Chemical Society 20060125

Oxidative damage to lens in culture: reversibility by pyruvate and ethyl pyruvate.

Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20060101

Bench-to-bedside review: critical illness-associated cognitive dysfunction--mechanisms, markers, and emerging therapeutics.

Critical care (London, England) 20060101

The ethyl pyruvate analogues, diethyl oxaloproprionate, 2-acetamidoacrylate, and methyl-2-acetamidoacrylate, exhibit anti-inflammatory properties in vivo and/or in vitro.

Biochemical pharmacology 20051125

Anti-inflammatory mechanism is involved in ethyl pyruvate-mediated efficacious neuroprotection in the postischemic brain.

Brain research 20051026

Efficiency in isotetronic acid synthesis via a diamine-acid couple catalyzed ethyl pyruvate homoaldol reaction.

Organic letters 20051013

Inhibition of the cerebral ischemic injury by ethyl pyruvate with a wide therapeutic window.

Stroke 20051001

The cytokine activity of HMGB1--extracellular escape of the nuclear protein.

Chang Gung medical journal 20051001

Ethyl pyruvate improves systemic and hepatosplanchnic hemodynamics and prevents lipid peroxidation in a porcine model of resuscitated hyperdynamic endotoxemia.

Critical care medicine 20050901

Neonicotinoid nitroguanidine insecticide metabolites: synthesis and nicotinic receptor potency of guanidines, aminoguanidines, and their derivatives.

Chemical research in toxicology 20050901

Ethyl pyruvate ameliorates ileus induced by bowel manipulation in mice.

Surgery 20050901

[Effects of ethyl pyruvate on splenocyte proliferation and apoptosis in burn rats with delayed resuscitation].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050701

Dendrimer-enhanced MRI as a diagnostic and prognostic biomarker of sepsis-induced acute renal failure in aged mice.

Kidney international 20050601

Oxoester oxidoreductase activities in new isolates of Pichia anomala from apple, grape and cane juices.

FEMS yeast research 20050401

Future strategies in the treatment of acute renal failure: growth factors, stem cells, and other novel therapies.

Current opinion in pediatrics 20050401

Ethyl pyruvate inhibits nuclear factor-kappaB-dependent signaling by directly targeting p65.

The Journal of pharmacology and experimental therapeutics 20050301

Ringer's ethyl pyruvate in hemorrhagic shock and resuscitation does not improve early hemodynamics or tissue energetics.

Shock (Augusta, Ga.) 20050301

Ethyl pyruvate enhances ATP levels, reduces oxidative stress and preserves cardiac function in a rat model of off-pump coronary bypass.

Heart, lung & circulation 20050301

Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis.

European journal of pharmacology 20050131

Ethyl pyruvate ameliorates liver ischemia-reperfusion injury by decreasing hepatic necrosis and apoptosis.

Transplantation 20050127

[Effects of ethyl pyruvate on cell-mediated immune function in rats with delayed resuscitation after burn injury].

Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050101

Bench-to-bedside review: Amelioration of acute renal impairment using ethyl pyruvate.

Critical care (London, England) 20050101

Ethyl pyruvate reduces liver injury in a murine model of extrahepatic cholestasis.

Shock (Augusta, Ga.) 20041001

Synthesis of cladobotryal, CJ16,169, and CJ16,170.

Organic letters 20040819

Native versus recombinant high-mobility group B1 proteins: functional activity in vitro.

Inflammation 20040801

Ethyl pyruvate ameliorates distant organ injury in a murine model of acute necrotizing pancreatitis.

Critical care medicine 20040701

Ethyl pyruvate: a simple solution?

Critical care medicine 20040701

Ethyl pyruvate preserves cardiac function and attenuates oxidative injury after prolonged myocardial ischemia.

The Journal of thoracic and cardiovascular surgery 20040501

Ethyl pyruvate: a novel treatment for sepsis and shock.

Minerva anestesiologica 20040501

Direct catalytic asymmetric aldol reactions of pyruvates: scope and mechanism.

Organic & biomolecular chemistry 20040407

Identification of catalyst surface species during asymmetric platinum-catalysed hydrogenation in a 'supercritical' solvent.

Chemical communications (Cambridge, England) 20040321

Evidence that glutathione depletion is a mechanism responsible for the anti-inflammatory effects of ethyl pyruvate in cultured lipopolysaccharide-stimulated RAW 264.7 cells.

The Journal of pharmacology and experimental therapeutics 20040101

8th Annual Toronto Critical Care Medicine Symposium, 30 October-1 November 2003, Toronto, Ontario, Canada.

Critical care (London, England) 20040101

Investigation of chiral reactions: the structural detection of new hydrogenated isocinchona alkaloids from mixtures without isolation using electrospray ionization tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM 20040101

Ethyl pyruvate provides durable protection against inflammation-induced intestinal epithelial barrier dysfunction.

Shock (Augusta, Ga.) 20031201

Dose-dependent effects of ethyl pyruvate in mice subjected to mesenteric ischemia and reperfusion.

Intensive care medicine 20031101

Ethyl pyruvate decreases sepsis-induced acute renal failure and multiple organ damage in aged mice.

Kidney international 20031101

Ethyl pyruvate ameliorates acute alcohol-induced liver injury and inflammation in mice.

The Journal of laboratory and clinical medicine 20031101

Catalytic enantioselective transamination of alpha-keto esters: an organic approach to enzymatic reactions.

Chemical communications (Cambridge, England) 20031021

Ringer's ethyl pyruvate solution: a novel resuscitation fluid for the treatment of hemorrhagic shock and sepsis.

The Journal of trauma 20030501

Ethyl pyruvate ameliorates intestinal epithelial barrier dysfunction in endotoxemic mice and immunostimulated caco-2 enterocytic monolayers.

The Journal of pharmacology and experimental therapeutics 20030101

Ethyl pyruvate: a novel anti-inflammatory agent.

Critical care medicine 20030101

Hydrogenation of cinchona alkaloids over supported Pt catalyst.

Chirality 20030101

Investigations in chiral reactions: identification of new adducts in the reactions of ethyl pyruvate with acetic anhydride and pyridine.

Rapid communications in mass spectrometry : RCM 20030101

Resuscitation with Ringer's ethyl pyruvate solution prolongs survival and modulates plasma cytokine and nitrite/nitrate concentrations in a rat model of lipopolysaccharide-induced shock.

Shock (Augusta, Ga.) 20021201

Possible mechanism for involvement of cysteine in aroma production in wine.

Journal of agricultural and food chemistry 20021009

Structural characterization of acetylpyridinium-ethyl pyruvate adducts by electrospray ionization mass spectrometry.

Journal of mass spectrometry : JMS 20021001

Ethyl pyruvate modulates inflammatory gene expression in mice subjected to hemorrhagic shock.

American journal of physiology. Gastrointestinal and liver physiology 20020701

Resuscitation from hemorrhagic shock with Ringer's ethyl pyruvate solution improves survival and ameliorates intestinal mucosal hyperpermeability in rats.

Shock (Augusta, Ga.) 20020601

Unexpected change of the sense of the enantioselective hydrogenation of ethyl pyruvate catalyzed by a Pt-alumina-cinchona alkaloid system.

Chemical communications (Cambridge, England) 20020521

Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution.

Current opinion in clinical nutrition and metabolic care 20020301

A highly atom efficient, solvent promoted addition of tetraallylic, tetraallenic, and tetrapropargylic stannanes to carbonyl compounds.

The Journal of organic chemistry 20011116

Ringer's ethyl pyruvate solution ameliorates ischemia/reperfusion-induced intestinal mucosal injury in rats.

Critical care medicine 20010801

Ringer's ethyl pyruvate solution: a novel resuscitation fluid.

Minerva anestesiologica 20010401