Home Other Building Blocks DL-cycloserine

DL-cycloserine

CAS No.:
68-39-3
Catalog Number:
AG0034SS
Molecular Formula:
C3H6N2O2
Molecular Weight:
102.0919
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
95%
In Stock USA
United States
$50
- +
5g
95%
In Stock USA
United States
$150
- +
Product Description
Catalog Number:
AG0034SS
Chemical Name:
DL-cycloserine
CAS Number:
68-39-3
Molecular Formula:
C3H6N2O2
Molecular Weight:
102.0919
MDL Number:
MFCD00064323
IUPAC Name:
4-amino-1,2-oxazolidin-3-one
InChI:
InChI=1S/C3H6N2O2/c4-2-1-7-5-3(2)6/h2H,1,4H2,(H,5,6)
InChI Key:
DYDCUQKUCUHJBH-UHFFFAOYSA-N
SMILES:
NC1CONC1=O
EC Number:
200-687-9
Properties
Complexity:
92.9  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
102.043g/mol
Formal Charge:
0
Heavy Atom Count:
7  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
102.093g/mol
Monoisotopic Mass:
102.043g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
64.4A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.5  
Literature
Title Journal
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Exposure therapy, D-cycloserine, and functional magnetic resonance imaging in patients with snake phobia: a randomized pilot study. The Journal of clinical psychiatry 20120901
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NMDA/glutamate mechanism of antidepressant-like action of magnesium in forced swim test in mice. Pharmacology, biochemistry, and behavior 20071201
Use of NMR metabolomics to analyze the targets of D-cycloserine in mycobacteria: role of D-alanine racemase. Journal of proteome research 20071201
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The application of exposure therapy and D-cycloserine to the treatment of anorexia nervosa: a preliminary trial. Journal of psychiatric practice 20070701
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Effects of activation and blockade of NMDA receptors on the extinction of a conditioned passive avoidance response in mice with different levels of anxiety. Neuroscience and behavioral physiology 20070601
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Glutamate NMDA receptors within the amygdala participate in the modulatory effect of glucocorticoids on extinction of conditioned fear in rats. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070501
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Effects of D-cycloserine on extinction of learned fear to an olfactory cue. Neurobiology of learning and memory 20070501
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site. Journal of pharmacological sciences 20070501
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Neurobiology of anxiety disorders and implications for treatment. The Mount Sinai journal of medicine, New York 20061101
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Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder. Journal of affective disorders 20060701
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HEGPOL: randomized, placebo controlled, multicenter, double-blind clinical trial to investigate hepatoprotective effects of glycine in the postoperative phase of liver transplantation [ISRCTN69350312]. BMC surgery 20050101
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A pilot study of D-cycloserine in subjects with autistic disorder. The American journal of psychiatry 20041101
Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Archives of general psychiatry 20041101
Self-protection mechanism in D-cycloserine-producing Streptomyces lavendulae. Gene cloning, characterization, and kinetics of its alanine racemase and D-alanyl-D-alanine ligase, which are target enzymes of D-cycloserine. The Journal of biological chemistry 20041029
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Cell-surface alterations in class IIa bacteriocin-resistant Listeria monocytogenes strains. Microbiology (Reading, England) 20040901
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Pharmacotherapy for performance anxiety disorders: occasionally useful but typically contraindicated. Journal of clinical psychology 20040801
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Pharmacological treatments of cerebellar ataxia. Cerebellum (London, England) 20040101
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Molecular cloning of a D-cycloserine resistance gene from D-cycloserine-producing Streptomyces garyphalus. The Journal of antibiotics 20030901
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Effects of antibiotics that inhibit the bacterial peptidoglycan synthesis pathway on moss chloroplast division. Plant & cell physiology 20030701
Mechanisms of activation, inhibition and specificity: crystal structures of the NMDA receptor NR1 ligand-binding core. The EMBO journal 20030616
D-cycloserine for the treatment of ataxia in spinocerebellar degeneration. Journal of the neurological sciences 20030615
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A side reaction of alanine racemase: transamination of cycloserine. Biochemistry 20030520
Subunit interaction of monomeric alanine racemases from four Shigella species in catalytic reaction. FEMS microbiology letters 20030425
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N(2)-substituted D,L-cycloserine derivatives: synthesis and evaluation as alanine racemase inhibitors. The Journal of antibiotics 20030201
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Pilot-controlled trial of D-cycloserine for the treatment of post-traumatic stress disorder. The international journal of neuropsychopharmacology 20021201
Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations. Neurobiology of learning and memory 20020901
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Response of Escherichia coli hypermutators to selection pressure with antimicrobial agents from different classes. The Journal of antimicrobial chemotherapy 20020601
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Excitatory and inhibitory responses of dopamine neurons in the ventral tegmental area to nicotine. Synapse (New York, N.Y.) 20020315
Facilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of D-cycloserine as assessed with fear-potentiated startle in rats. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020315
Placebo-controlled trial of D-cycloserine added to conventional neuroleptics, olanzapine, or risperidone in schizophrenia. The American journal of psychiatry 20020301
Enhancing synaptic plasticity and cellular resilience to develop novel, improved treatments for mood disorders. Dialogues in clinical neuroscience 20020301
Impaired visual memory in rats reared in isolation is reversed by D-cycloserine in the adult rat. European journal of pharmacology 20020215
Effects of scopolamine and D-cycloserine on non-spatial reference memory in rats. Behavioural brain research 20020201
D-cycloserine for Alzheimer's disease. The Cochrane database of systematic reviews 20020101
A case series of D-cycloserine added to donepezil in the treatment of Alzheimer's disease. The Journal of neuropsychiatry and clinical neurosciences 20020101
Involvement of cholinergic and glutamatergic functions in working memory impairment induced by interleukin-1beta in rats. European journal of pharmacology 20011102
Augmentation strategies in the treatment of schizophrenia. CNS spectrums 20011101
Management of negative symptoms of schizophrenia. Current psychiatry reports 20011001
RS 67333 and D-cycloserine accelerate learning acquisition in the rat. Neuropharmacology 20010901
Effects of N-methyl-D-aspartate agonists and antagonists in rats discriminating amphetamine. Behavioural pharmacology 20010901
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Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010401
Synergic activity of D-cycloserine and beta-chloro-D-alanine against Mycobacterium tuberculosis. The Journal of antimicrobial chemotherapy 20010201
The role of murMN operon in penicillin resistance and antibiotic tolerance of Streptococcus pneumoniae. Microbial drug resistance (Larchmont, N.Y.) 20010101
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