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| Title | Journal |
|---|---|
| The stabilization of hypoxia inducible factor modulates differentiation status and inhibits the proliferation of mouse embryonic stem cells. | Chemico-biological interactions 20160125 |
| Featured Article: Hypoxia-inducible factor-1α dependent nuclear entry of factor inhibiting HIF-1. | Experimental biology and medicine (Maywood, N.J.) 20151101 |
| Targeting the hypoxia-sensing pathway in clinical hematology. | Stem cells translational medicine 20140201 |
| Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells. | The international journal of biochemistry & cell biology 20131101 |
| Selective stabilization of HIF-1α in renal tubular cells by 2-oxoglutarate analogues. | The American journal of pathology 20121101 |
| Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor in dental pulp-derived cells. | Journal of endodontics 20121101 |
| α-Ketoglutarate-related inhibitors of HIF prolyl hydroxylases are substrates of renal organic anion transporters 1 (OAT1) and 4 (OAT4). | Pflugers Archiv : European journal of physiology 20121001 |
| Activation of the prolyl-hydroxylase oxygen-sensing signal cascade leads to AMPK activation in cardiomyocytes. | Journal of cellular and molecular medicine 20120901 |
| Increased activation of the hypoxia-inducible factor pathway in varicose veins. | Journal of vascular surgery 20120501 |
| Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases. | Journal of medicinal chemistry 20120412 |
| Prolyl hydroxylase inhibitors increase the production of vascular endothelial growth factor by periodontal fibroblasts. | Journal of periodontal research 20120401 |
| HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice. | Journal of hepatology 20120201 |
| Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α. | Neurobiology of disease 20120201 |
| Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism. | Journal of dermatological science 20120201 |
| Systemic preconditioning by a prolyl hydroxylase inhibitor promotes prevention of skin flap necrosis via HIF-1-induced bone marrow-derived cells. | PloS one 20120101 |
| Hypoxia-inducible factor activation protects the kidney from gentamicin-induced acute injury. | PloS one 20120101 |
| Inverse correlation between metallothioneins and hypoxia-inducible factor 1 alpha in colonocytes and experimental colitis. | Biochemical and biophysical research communications 20111216 |
| Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase. | Molecular and cellular biochemistry 20111201 |
| Dimethyloxalyglycine stimulates the early stages of gastrointestinal repair processes through VEGF-dependent mechanisms. | Laboratory investigation; a journal of technical methods and pathology 20111201 |
| Activation of hypoxia-inducible factor-1 protects airway epithelium against oxidant-induced barrier dysfunction. | American journal of physiology. Lung cellular and molecular physiology 20111201 |
| Hypoxia induced expression of histone lysine demethylases: implications in oxygen-dependent retinal neovascular diseases. | Biochemical and biophysical research communications 20111118 |
| Hypoxia-inducible factor regulates expression of surfactant protein in alveolar type II cells in vitro. | American journal of respiratory cell and molecular biology 20111101 |
| Curcumin provides potential protection against the activation of hypoxia and prolyl 4-hydroxylase inhibitors on prostate-specific antigen expression in human prostate carcinoma cells. | Molecular nutrition & food research 20111101 |
| Longitudinal quantification of inflammation in the murine dextran sodium sulfate-induced colitis model using μPET/CT. | Inflammatory bowel diseases 20111001 |
| Inhibition of prolyl hydroxylase domain-containing protein downregulates vascular angiotensin II type 1 receptor. | Hypertension (Dallas, Tex. : 1979) 20110901 |
| The hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative activation of macrophages and IL-10 production by B1 cells. | Shock (Augusta, Ga.) 20110901 |
| Dimethyloxalylglycine stabilizes HIF-1α in cultured human endothelial cells and increases random-pattern skin flap survival in vivo. | Plastic and reconstructive surgery 20110801 |
| Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1α and VEGF production and improves functional recovery after acute ischemia/reperfusion. | Surgery 20110801 |
| Apigenin down-regulates the hypoxia response genes: HIF-1α, GLUT-1, and VEGF in human pancreatic cancer cells. | The Journal of surgical research 20110515 |
| Metabolic reprogramming by HIF-1 promotes the survival of bone marrow-derived angiogenic cells in ischemic tissue. | Blood 20110505 |
| [Effects of dimethyloxalyl glycine on hypoxic-ischemic brain damage in newborn rats]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110501 |
| Hypoxia-inducible factor-1α-dependent protection from intestinal ischemia/reperfusion injury involves ecto-5'-nucleotidase (CD73) and the A2B adenosine receptor. | Journal of immunology (Baltimore, Md. : 1950) 20110401 |
| Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1α-mediated apoptosis. | British journal of cancer 20110329 |
| HIF1alpha synergizes with glucocorticoids to promote BFU-E progenitor self-renewal. | Blood 20110324 |
| Structural basis for human PHF2 Jumonji domain interaction with metal ions. | Journal of molecular biology 20110211 |
| Hydroxylase inhibition attenuates colonic epithelial secretory function and ameliorates experimental diarrhea. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201 |
| Neuroprotection by dimethyloxalylglycine following permanent and transient focal cerebral ischemia in rats. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20110101 |
| Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells. | Biological & pharmaceutical bulletin 20110101 |
| Activation of Hif1α by the prolylhydroxylase inhibitor dimethyoxalyglycine decreases radiosensitivity. | PloS one 20110101 |
| von Hippel-Lindau β-domain-luciferase fusion protein as a bioluminescent hydroxyproline sensor for a hypoxia-inducible factor prolyl hydroxylase assay. | Analytical biochemistry 20101215 |
| Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade. | American journal of physiology. Renal physiology 20101201 |
| Hydroxylase inhibition abrogates TNF-alpha-induced intestinal epithelial damage by hypoxia-inducible factor-1-dependent repression of FADD. | Journal of immunology (Baltimore, Md. : 1950) 20101115 |
| Hypoxia and preeclampsia: increased expression of urocortin 2 and urocortin 3. | Reproductive sciences (Thousand Oaks, Calif.) 20100901 |
| Force field design and molecular dynamics simulations of factor-inhibiting HIF-1 and its complex with known inhibitors: implications for rational inhibitor design. | Journal of molecular graphics & modelling 20100901 |
| Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. | Journal of medicinal chemistry 20100812 |
| Acute hypoxia induces HIF-independent monocyte adhesion to endothelial cells through increased intercellular adhesion molecule-1 expression: the role of hypoxic inhibition of prolyl hydroxylase activity for the induction of NF-kappa B. | Journal of immunology (Baltimore, Md. : 1950) 20100801 |
| Hydroxylase inhibition reduces synaptic transmission and protects against a glutamate-induced ischemia in the CA1 region of the rat hippocampus. | Neuroscience 20100602 |
| Regulation of the matricellular proteins CYR61 (CCN1) and NOV (CCN3) by hypoxia-inducible factor-1{alpha} and transforming-growth factor-{beta}3 in the human trophoblast. | Endocrinology 20100601 |
| Prolyl hydroxylase EGLN3 regulates skeletal myoblast differentiation through an NF-kappaB-dependent pathway. | The Journal of biological chemistry 20100319 |
| Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. | American journal of physiology. Renal physiology 20100301 |
| FoxO proteins mediate hypoxic induction of connective tissue growth factor in endothelial cells. | The Journal of biological chemistry 20100212 |
| Attenuation of myocardial injury by postconditioning: role of hypoxia inducible factor-1alpha. | Basic research in cardiology 20100101 |
| Activation of hypoxia-inducible factor attenuates renal injury in rat remnant kidney. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20100101 |
| Increased chemoresistance induced by inhibition of HIF-prolyl-hydroxylase domain enzymes. | Cancer science 20100101 |
| Inhibition of prolyl hydroxylase domain-containing protein suppressed lipopolysaccharide-induced TNF-alpha expression. | Arteriosclerosis, thrombosis, and vascular biology 20091201 |
| Combined analysis of hypoxia-inducible factor 1 alpha and metallothionein indicates an aggressive subtype of colorectal carcinoma. | International journal of colorectal disease 20091101 |
| Hypoxia interferes with connective tissue growth factor (CTGF) gene expression in human proximal tubular cell lines. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20091101 |
| Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice. | Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20091001 |
| Interferon-gamma induces prolyl hydroxylase (PHD)3 through a STAT1-dependent mechanism in human endothelial cells. | Arteriosclerosis, thrombosis, and vascular biology 20090901 |
| Adenosine A2A receptor is a unique angiogenic target of HIF-2alpha in pulmonary endothelial cells. | Proceedings of the National Academy of Sciences of the United States of America 20090630 |
| Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors. | Bioorganic & medicinal chemistry letters 20090515 |
| Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic neurons. | Molecular pharmacology 20090501 |
| Prolyl hydroxylase inhibitor dimethyloxalylglycine enhances mesenchymal stem cell survival. | Journal of cellular biochemistry 20090401 |
| Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. | Molecular & cellular proteomics : MCP 20090301 |
| Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease. | Nature reviews. Drug discovery 20090201 |
| HIF-1 attenuates Ref-1 expression in endothelial cells: reversal by siRNA and inhibition of geranylgeranylation. | Vascular pharmacology 20090101 |
| Prolyl hydroxylase inhibition attenuates post-ischemic cardiac injury via induction of endoplasmic reticulum stress genes. | Vascular pharmacology 20090101 |
| Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1alpha. | The Biochemical journal 20081215 |
| A novel mode of action of YC-1 in HIF inhibition: stimulation of FIH-dependent p300 dissociation from HIF-1{alpha}. | Molecular cancer therapeutics 20081201 |
| HIF-1alpha inhibition ameliorates neonatal brain injury in a rat pup hypoxic-ischemic model. | Neurobiology of disease 20080901 |
| Hypoxia-inducible factor-1 is central to cardioprotection: a new paradigm for ischemic preconditioning. | Circulation 20080708 |
| O(2)-sensing signal cascade: clamping of O(2) respiration, reduced ATP utilization, and inducible fumarate respiration. | American journal of physiology. Cell physiology 20080701 |
| Induction of carbonic anhydrase IX by hypoxia and chemical disruption of oxygen sensing in rat fibroblasts and cardiomyocytes. | Pflugers Archiv : European journal of physiology 20080501 |
| DHEA decreases HIF-1alpha accumulation under hypoxia in human pulmonary artery cells: potential role in the treatment of pulmonary arterial hypertension. | The Journal of steroid biochemistry and molecular biology 20080301 |
| The hydroxylase inhibitor dimethyloxalylglycine is protective in a murine model of colitis. | Gastroenterology 20080101 |
| Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. | Arthritis research & therapy 20080101 |
| Prolyl hydroxylase inhibitors delay neuronal cell death caused by trophic factor deprivation. | Journal of neurochemistry 20071201 |
| HIF-1 regulates hypoxia- and insulin-induced expression of apelin in adipocytes. | American journal of physiology. Endocrinology and metabolism 20071201 |
| Hypoxia-inducible factor 1alpha is involved in the prostaglandin metabolism of osteoarthritic cartilage through up-regulation of microsomal prostaglandin E synthase 1 in articular chondrocytes. | Arthritis and rheumatism 20071201 |
| Hypoxia stimulates degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase through accumulation of lanosterol and hypoxia-inducible factor-mediated induction of insigs. | The Journal of biological chemistry 20070914 |
| Effect of chemical stabilizers of hypoxia-inducible factors on early lung development. | American journal of physiology. Lung cellular and molecular physiology 20070901 |
| HIF stabilizing agents: shotgun or scalpel? | American journal of physiology. Lung cellular and molecular physiology 20070901 |
| Prolyl hydroxylase inhibitor treatment confers whole-animal hypoxia tolerance. | Acta physiologica (Oxford, England) 20070601 |
| Hypoxia inducible factor-1 modulates hemin-induced IL-8 secretion in microvascular endothelium. | Microvascular research 20070501 |
| Toxic effects of cobalt in primary cultures of mouse astrocytes. Similarities with hypoxia and role of HIF-1alpha. | Biochemical pharmacology 20070301 |
| The prolyl hydroxylase oxygen-sensing pathway is cytoprotective and allows maintenance of mitochondrial membrane potential during metabolic inhibition. | American journal of physiology. Cell physiology 20070201 |
| Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. | Oncogene 20070111 |
| Expression of HIF prolyl hydroxylase isozymes in growth plate chondrocytes: relationship between maturation and apoptotic sensitivity. | Journal of cellular physiology 20070101 |
| Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. | The Journal of biological chemistry 20060602 |
| Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. | Biochemical and biophysical research communications 20060310 |
| [HIF-1alpha, HIF-2alpha and VHL mRNA expression in different cell lines during hypoxia]. | Ukrains'kyi biokhimichnyi zhurnal (1999 ) 20060101 |
| Kinetic and spectroscopic investigation of CoII, NiII, and N-oxalylglycine inhibition of the FeII/alpha-ketoglutarate dioxygenase, TauD. | Biochemical and biophysical research communications 20051209 |
| HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. | American journal of physiology. Heart and circulatory physiology 20050801 |
| Activation of hypoxia-induced transcription in normoxia. | Experimental cell research 20050515 |
| Nitric oxide reverses desferrioxamine- and hypoxia-evoked HIF-1alpha accumulation--implications for prolyl hydroxylase activity and iron. | Experimental cell research 20050515 |
| Oligomycin inhibits HIF-1alpha expression in hypoxic tumor cells. | American journal of physiology. Cell physiology 20050501 |
| OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. | Molecular cell 20050218 |
| Expression and hypoxia-responsiveness of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4 in mammary gland malignant cell lines. | Acta biochimica Polonica 20050101 |
| Inhibition of endogenous HIF inactivation induces angiogenesis in ischaemic skeletal muscles of mice. | The Journal of physiology 20041001 |
| Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. | The Journal of biological chemistry 20021018 |