Use of an α3β4 nicotinic acetylcholine receptor subunit concatamer to characterize ganglionic receptor subtypes with specific subunit composition reveals species-specific pharmacologic properties.

Neuropharmacology 20120901

Cholinergic receptor system as a target for treating alcohol abuse and dependence.

Recent patents on CNS drug discovery 20120801

The nicotinic acetylcholine receptors of zebrafish and an evaluation of pharmacological tools used for their study.

Biochemical pharmacology 20120801

Quinolizidine alkaloids from Sophora velutina subsp. zimbabweensis (Fabaceae: Sophoreae).

Natural product communications 20120801

Variations in binding among several agonists at two stoichiometries of the neuronal, α4β2 nicotinic receptor.

Journal of the American Chemical Society 20120718

Live-cell imaging of single receptor composition using zero-mode waveguide nanostructures.

Nano letters 20120711

Structural characterization of binding mode of smoking cessation drugs to nicotinic acetylcholine receptors through study of ligand complexes with acetylcholine-binding protein.

The Journal of biological chemistry 20120706

Neuronal nicotinic receptor ligands modulate chronic nicotine-induced ethanol consumption in C57BL/6J mice.

Pharmacology, biochemistry, and behavior 20120701

Pharmacological chaperoning of nicotinic acetylcholine receptors reduces the endoplasmic reticulum stress response.

Molecular pharmacology 20120601

Pharmacologic characterization of a nicotine-discriminative stimulus in rhesus monkeys.

The Journal of pharmacology and experimental therapeutics 20120601

Nicotinic receptor partial agonists alter catecholamine homeostasis and response to nicotine in PC12 cells.

Neuroscience letters 20120516

Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors.

Natural product reports 20120501

Nicotine receptor partial agonists for smoking cessation.

The Cochrane database of systematic reviews 20120418

A direct method and ICER tables for the estimation of the cost-effectiveness of smoking cessation interventions in general populations: application to a new cytisine trial and other examples.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20120401

Differential expression and function of nicotinic acetylcholine receptors in the urinary bladder epithelium of the rat.

The Journal of physiology 20120315

Subcritical water extraction of alkaloids in Sophora flavescens Ait. and determination by capillary electrophoresis with field-amplified sample stacking.

Journal of pharmaceutical and biomedical analysis 20120125

Cytisine increased smoking cessation in adults.

Annals of internal medicine 20120117

Functional expression of the α7 and α4-containing nicotinic acetylcholine receptors on the neonatal rat carotid body.

Neurochemistry international 20120101

PET Imaging of nicotinic acetylcholine receptors in baboons with 18F-AZAN, a radioligand with improved brain kinetics.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20120101

Atomoxetine treatment for nicotine withdrawal: a pilot double-blind, placebo-controlled, fixed-dose study in adult smokers.

Annals of general psychiatry 20120101

Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina.

The International journal of developmental biology 20120101

Rat thalamic α₄β₂ neuronal nicotinic acetylcholine receptor occupancy assay using LC-MS/MS.

Journal of pharmacological and toxicological methods 20120101

Comparative analysis of quinolizidine alkaloids from different parts of Sophora alopecuroides seeds by UPLC-MS/MS.

Journal of pharmaceutical and biomedical analysis 20120101

The nicotinic acetylcholine receptor as a target for antidepressant drug development.

TheScientificWorldJournal 20120101

Förster resonance energy transfer (FRET) correlates of altered subunit stoichiometry in cys-loop receptors, exemplified by nicotinic α4β2.

International journal of molecular sciences 20120101

[Development of quantitative analyse method for determination of alkaloid cytisin in Spartium junceum L., growing in Georgia].

Georgian medical news 20111201

Differences in neonatal neurotoxicity of brominated flame retardants, PBDE 99 and TBBPA, in mice.

Toxicology 20111028

Exploring behavioral and molecular mechanisms of nicotine reward in adolescent mice.

Biochemical pharmacology 20111015

Patterns of nicotinic receptor antagonism: nicotine discrimination studies.

The Journal of pharmacology and experimental therapeutics 20111001

Placebo-controlled trial of cytisine for smoking cessation.

The New England journal of medicine 20110929

Structure-activity relationship of ibogaine analogs interacting with nicotinic acetylcholine receptors in different conformational states.

The international journal of biochemistry & cell biology 20110901

11C-NS14492 as a novel PET radioligand for imaging cerebral alpha7 nicotinic acetylcholine receptors: in vivo evaluation and drug occupancy measurements.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20110901

Nicotine decreases food intake through activation of POMC neurons.

Science (New York, N.Y.) 20110610

Core modification of cytisine: a modular synthesis.

Angewandte Chemie (International ed. in English) 20110523

Electron impact mass spectral study of halogenated N-acetyl- and N-propionylcytisines.

Rapid communications in mass spectrometry : RCM 20110515

In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait.

Basic & clinical pharmacology & toxicology 20110501

Repeated administration of the GABAB receptor positive modulator BHF177 decreased nicotine self-administration, and acute administration decreased cue-induced reinstatement of nicotine seeking in rats.

Psychopharmacology 20110501

Electrophysiological perspectives on the therapeutic use of nicotinic acetylcholine receptor partial agonists.

The Journal of pharmacology and experimental therapeutics 20110501

Cytisine's potential to be used as a traditional healing method to help indigenous people stop smoking: a qualitative study with Māori.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20110501

Analgesic and antineuropathic drugs acting through central cholinergic mechanisms.

Recent patents on CNS drug discovery 20110501

Nicotinic receptor agonist-induced salivation and its cellular mechanism in parotid acini of rats.

Autonomic neuroscience : basic & clinical 20110426

Expression of water-soluble, ligand-binding concatameric extracellular domains of the human neuronal nicotinic receptor alpha4 and beta2 subunits in the yeast Pichia pastoris: glycosylation is not required for ligand binding.

The Journal of biological chemistry 20110318

The effects of nicotine, varenicline, and cytisine on schedule-controlled responding in mice: differences in α4β2 nicotinic receptor activation.

European journal of pharmacology 20110301

From toxins targeting ligand gated ion channels to therapeutic molecules.

Toxins 20110301

Nicotine receptor partial agonists for smoking cessation.

The Cochrane database of systematic reviews 20110216

Lobeline and cytisine reduce voluntary ethanol drinking behavior in male C57BL/6J mice.

Progress in neuro-psychopharmacology & biological psychiatry 20110115

Expression of functional human α6β2β3* acetylcholine receptors in Xenopus laevis oocytes achieved through subunit chimeras and concatamers.

Molecular pharmacology 20110101

Dianicline, a novel α4β2 nicotinic acetylcholine receptor partial agonist, for smoking cessation: a randomized placebo-controlled clinical trial.

Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 20110101

[Serotonin syndrome in the course of drug-poisoning--case presentation].

Przeglad lekarski 20110101

Re-evaluation of nicotinic acetylcholine receptors in rat brain by a tissue-segment binding assay.

Frontiers in pharmacology 20110101

Study protocol for a non-inferiority trial of cytisine versus nicotine replacement therapy in people motivated to stop smoking.

BMC public health 20110101

Characterizing low affinity epibatidine binding to α4β2 nicotinic acetylcholine receptors with ligand depletion and nonspecific binding.

BMC biophysics 20110101

Nicotine receptor partial agonists for smoking cessation.

The Cochrane database of systematic reviews 20101208

Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation.

Journal of medicinal chemistry 20101125

Identification of 9-fluoro substituted (-)-cytisine derivatives as ligands with high affinity for nicotinic receptors.

Bioorganic & medicinal chemistry letters 20101115

Quantitative analysis of the heteromeric neuronal nicotinic receptors in the rat hippocampus.

Journal of neurochemistry 20101101

86Rb+ efflux mediated by alpha4beta2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization.

Biochemical pharmacology 20101015

Alpha3* and alpha 7 nAChR-mediated Ca2+ transient generation in IMR-32 neuroblastoma cells.

Neurochemistry international 20101001

A new cytisine-type alkaloid from the stem bark of Maackia amurensis.

Natural product research 20101001

Molecular determinants for competitive inhibition of alpha4beta2 nicotinic acetylcholine receptors.

Molecular pharmacology 20100901

alpha4beta2 Nicotinic acetylcholine receptors, willing if able.

British journal of pharmacology 20100801

The neuronal nicotinic alpha4beta2 receptor has a high maximal probability of being open.

British journal of pharmacology 20100801

N-Methyl-2-thio-cytisine.

Acta crystallographica. Section E, Structure reports online 20100801

Choline promotes nicotinic receptor alpha4 + beta2 up-regulation.

The Journal of biological chemistry 20100625

Novel tricyclic Delta(2)-isoxazoline and 3-oxo-2-methyl-isoxazolidine derivatives: synthesis and binding affinity at neuronal nicotinic acetylcholine receptor subtypes.

Bioorganic & medicinal chemistry 20100615

In silico characterization of cytisinoids docked into an acetylcholine binding protein.

Bioorganic & medicinal chemistry letters 20100615

Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.

Neuropharmacology 20100601

Synthetic α-conotoxin mutants as probes for studying nicotinic acetylcholine receptors and in the development of novel drug leads.

Toxins 20100601

Increase in locomotor activity after acute administration of the nicotinic receptor agonist 3-bromocytisine in rats.

European journal of pharmacology 20100525

Vertical ionization potentials of nucleobases in a fully solvated DNA environment.

The journal of physical chemistry. B 20100506

Activation and inhibition of mouse muscle and neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.

The Journal of pharmacology and experimental therapeutics 20100501

Preparation and recognition performance of cytisine alkaloid-imprinted material prepared using novel surface molecular imprinting technique.

Journal of separation science 20100501

Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence.

British journal of pharmacology 20100501

Cytisine induces autonomic cardiovascular responses via activations of different nicotinic receptors.

Autonomic neuroscience : basic & clinical 20100419

Biochemical and functional properties of distinct nicotinic acetylcholine receptors in the superior cervical ganglion of mice with targeted deletions of nAChR subunit genes.

The European journal of neuroscience 20100301

Pharmacokinetics of cytisine after single intravenous and oral administration in rabbits.

Interdisciplinary toxicology 20100301

Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats.

Interdisciplinary toxicology 20100301

Nicotinic ligands modulate ethanol-induced dopamine function in mice.

Pharmacology 20100101

Human α3β4 neuronal nicotinic receptors show different stoichiometry if they are expressed in Xenopus oocytes or mammalian HEK293 cells.

PloS one 20100101

Varenicline for smoking cessation: efficacy, safety, and treatment recommendations.

Patient preference and adherence 20100101

α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.

The open medicinal chemistry journal 20100101

Biological basis of tobacco addiction: Implications for smoking-cessation treatment.

Indian journal of psychiatry 20100101

[Simple therapeutic options in counteracting tobacco smoking].

Przeglad lekarski 20100101

Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats.

Alcohol (Fayetteville, N.Y.) 20091201

Gene regulation of alpha4beta2 nicotinic receptors: microarray analysis of nicotine-induced receptor up-regulation and anti-inflammatory effects.

Journal of neurochemistry 20091101

Involvement of nicotinic and muscarinic receptors in the endogenous cholinergic modulation of the balance between excitation and inhibition in the young rat visual cortex.

Cerebral cortex (New York, N.Y. : 1991) 20091001

In vivo effects of 3-iodocytisine: pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites.

Neuropharmacology 20090901

Nicotinic plant poisoning.

Clinical toxicology (Philadelphia, Pa.) 20090901

Synthesis, binding, and modeling studies of new cytisine derivatives, as ligands for neuronal nicotinic acetylcholine receptor subtypes.

Journal of medicinal chemistry 20090723

Modulation of ethanol drinking-in-the-dark by mecamylamine and nicotinic acetylcholine receptor agonists in C57BL/6J mice.

Psychopharmacology 20090701

Rat neuronal nicotinic acetylcholine receptors containing alpha7 subunit: pharmacological properties of ligand binding and function.

Acta pharmacologica Sinica 20090601

Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2.

Bioorganic & medicinal chemistry letters 20090501

Antidepressant-like effects of nicotine and reduced nicotinic receptor binding in the Fawn-Hooded rat, an animal model of co-morbid depression and alcoholism.

Progress in neuro-psychopharmacology & biological psychiatry 20090430

Fatal cytisine intoxication and analysis of biological samples with LC-MS/MS.

Forensic science international 20090415

Cytisine-based nicotinic partial agonists as novel antidepressant compounds.

The Journal of pharmacology and experimental therapeutics 20090401

Smoking in pregnancy and lactation: a review of risks and cessation strategies.

European journal of clinical pharmacology 20090401

Single-channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor.

FEBS letters 20090318

Analysis of toxic alkaloids in body samples.

Forensic science international 20090310

Pentameric concatenated (alpha4)(2)(beta2)(3) and (alpha4)(3)(beta2)(2) nicotinic acetylcholine receptors: subunit arrangement determines functional expression.

British journal of pharmacology 20090301

Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons.

The Journal of physiology 20090115

Effects of the nicotinic receptor partial agonists varenicline and cytisine on the discriminative stimulus effects of nicotine in rats.

Pharmacology, biochemistry, and behavior 20090101

Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro.

Neurochemistry international 20090101

Reducing stillbirths: behavioural and nutritional interventions before and during pregnancy.

BMC pregnancy and childbirth 20090101

Visual hallucinations associated with varenicline: a case report.

Journal of medical case reports 20090101

Clinical utility of varenicline for smokers with medical and psychiatric comorbidity.

International journal of chronic obstructive pulmonary disease 20090101

Smoking cessation: an economic analysis and review of varenicline.

ClinicoEconomics and outcomes research : CEOR 20090101

First total synthesis of (+/-)-3-hydroxy-11-norcytisine: structure confirmation and biological characterization.

Organic letters 20081204

Actions of quinolizidine alkaloids on Periplaneta americana nicotinic acetylcholine receptors.

Pest management science 20081201

Discovery and optimization of substituted piperidines as potent, selective, CNS-penetrant alpha4beta2 nicotinic acetylcholine receptor potentiators.

Bioorganic & medicinal chemistry letters 20081001

Nicotinic receptor partial agonists as novel compounds for the treatment of smoking cessation.

Expert opinion on investigational drugs 20081001

Partial nicotinic acetylcholine (alpha4beta2) agonists as promising new medications for smoking cessation.

Indian journal of pharmacology 20081001

The influence of the nitrogen substitution in three cytisine derivatives as ligands for the neuronal nAChRs: a structural and theoretical study.

Chemistry & biodiversity 20080901

Tobacco smoking cessation management: integrating varenicline in current practice.

Vascular health and risk management 20080801

In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: implications for Parkinson's Disease.

European journal of pharmacology 20080728

The nicotinic activation of the denervated sympathetic neuron of the rat.

Neuroscience 20080717

Nicotine receptor partial agonists for smoking cessation.

The Cochrane database of systematic reviews 20080716

Simultaneous determination of thirteen plant alkaloids in a human specimen by SPE and HPLC.

Journal of separation science 20080701

Nicotinic receptor subtypes in rat subfornical organ neurons and glial cells.

Neuroscience 20080626

Smoking cessation therapy with varenicline.

International journal of chronic obstructive pulmonary disease 20080601

Chronic nicotine and dizocilpine effects on nicotinic and NMDA glutamatergic receptor regulation: interactions with clozapine actions and attentional performance in rats.

Progress in neuro-psychopharmacology & biological psychiatry 20080515

Role of negatively charged amino acids in beta 4 F-loop in activation and desensitization of alpha 3 beta 4 rat neuronal nicotinic receptors.

Biochimica et biophysica acta 20080401

Deconstructing cytisine: The syntheses of (+/-)-cyfusine and (+/-)-cyclopropylcyfusine, fused ring analogs of cytisine.

Bioorganic & medicinal chemistry letters 20080401

Varenicline in the treatment of tobacco dependence.

Neuropsychiatric disease and treatment 20080401

Basic instinct: design, synthesis and evaluation of (+)-sparteine surrogates for asymmetric synthesis.

Chemical communications (Cambridge, England) 20080214

Elimination of rat spinal substance P receptor bearing neurons dissociates cardiovascular and nocifensive responses to nicotinic agonists.

Neuropharmacology 20080201

Heterogeneity of nicotinic acetylcholine receptor expression in the caudal nucleus of the solitary tract.

Neuropharmacology 20080201

Cytisine for smoking cessation: a research agenda.

Drug and alcohol dependence 20080101

The language barrier and institutional provincialism in science.

Drug and alcohol dependence 20080101

7-Azaindole derivatives as potential partial nicotinic agonists.

Bioorganic & medicinal chemistry letters 20080101

An update on therapeutics for tobacco dependence.

Expert opinion on pharmacotherapy 20080101

Electron ionization mass spectrometric study of N-benzyl- and N-nitrobenzyl-substituted derivatives of cytisine. II.

Rapid communications in mass spectrometry : RCM 20080101

Bactericidal and fungicidal activities of Calia secundiflora (Ort.) Yakovlev.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20080101

TC-5214 (S-(+)-mecamylamine): a neuronal nicotinic receptor modulator with antidepressant activity.

CNS neuroscience & therapeutics 20080101

Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII.

Journal of neurochemistry 20071001

IBU-octyl-cytisine, a novel bifunctional compound eliciting anti-inflammatory and cholinergic activity, ameliorates CNS inflammation by inhibition of T-cell activity.

International immunopharmacology 20070901

Gene targeting demonstrates that alpha4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine.

Neuropharmacology 20070901

Chemical medicine: novel 10-substituted cytisine derivatives with increased selectivity for alpha4beta2 nicotinic acetylcholine receptors.

ChemMedChem 20070801

Postnatal upregulation of alpha4 and alpha3 nicotinic receptor subunits in the brain of alpha7 nicotinic receptor-deficient mice.

Neuroscience 20070608

Central nicotinic receptors: structure, function, ligands, and therapeutic potential.

ChemMedChem 20070601

Genetic approaches identify differential roles for alpha4beta2* nicotinic receptors in acute models of antinociception in mice.

The Journal of pharmacology and experimental therapeutics 20070601

Catecholamine outflow from mouse and rat brain slice preparations evoked by nicotinic acetylcholine receptor activation and electrical field stimulation.

British journal of pharmacology 20070601

Detection and validated quantification of toxic alkaloids in human blood plasma--comparison of LC-APCI-MS with LC-ESI-MS/MS.

Journal of mass spectrometry : JMS 20070501

Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice.

Neuropharmacology 20070401

Ligands selective for alpha4beta2 but not alpha3beta4 or alpha7 nicotinic receptors generalise to the nicotine discriminative stimulus in the rat.

Psychopharmacology 20070201

Nicotine receptor partial agonists for smoking cessation.

The Cochrane database of systematic reviews 20070124

Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070115

Electron ionization mass spectral study of selected N-amide and N-alkyl derivatives of cytisine.

Rapid communications in mass spectrometry : RCM 20070101

In vitro anticholinesterase activity of various alkaloids.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101

Antisense knockdown of the rat alpha7 nicotinic acetylcholine receptor produces spatial memory impairment.

Neuroscience letters 20061213

An uncontrolled trial of cytisine (Tabex) for smoking cessation.

Tobacco control 20061201

Epibatidine isomers and analogues: structure-activity relationships.

Bioorganic & medicinal chemistry letters 20061101

Roles of nicotinic acetylcholine receptor beta subunits in function of human alpha4-containing nicotinic receptors.

The Journal of physiology 20061001

Age-related alterations of GABAergic input to CA1 pyramidal neurons and its control by nicotinic acetylcholine receptors in rat hippocampus.

Neuroscience 20060929

Deletion of the alpha7, beta2, or beta4 nicotinic receptor subunit genes identifies highly expressed subtypes with relatively low affinity for [3H]epibatidine.

Molecular pharmacology 20060901

Characterization of nicotinic acetylcholine receptors that modulate nicotine-evoked [3H]norepinephrine release from mouse hippocampal synaptosomes.

Molecular pharmacology 20060901

Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.

Molecular pharmacology 20060901

Chemotaxonomy of Portuguese Ulex: quinolizidine alkaloids as taxonomical markers.

Phytochemistry 20060901

alpha4beta2 nicotinic receptors with high and low acetylcholine sensitivity: pharmacology, stoichiometry, and sensitivity to long-term exposure to nicotine.

Molecular pharmacology 20060801

Cytisine for smoking cessation: a literature review and a meta-analysis.

Archives of internal medicine 20060801

Prenatal nicotine exposure alters the nicotinic receptor subtypes that modulate excitation of parasympathetic cardiac neurons in the nucleus ambiguus from primarily alpha3beta2 and/or alpha6betaX to alpha3beta4.

Neuropharmacology 20060701

Synthesis and pharmacological evaluation of novel 9- and 10-substituted cytisine derivatives. Nicotinic ligands of enhanced subtype selectivity.

Journal of medicinal chemistry 20060504

Effects of co-administration of bupropion and nicotinic agonists on the elevated plus-maze test in mice.

Progress in neuro-psychopharmacology & biological psychiatry 20060501

Microsphere-based protease assays and screening application for lethal factor and factor Xa.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501

C3-halogenation of cytisine generates potent and efficacious nicotinic receptor agonists.

European journal of pharmacology 20060424

A flexible strategy for the synthesis of tri- and tetracyclic lupin alkaloids: synthesis of (+)-cytisine, (+/-)-anagyrine, and (+/-)-thermopsine.

Angewandte Chemie (International ed. in English) 20060403

Activation of nicotinic ACh receptors with alpha4 subunits induces adenosine release at the rat carotid body.

British journal of pharmacology 20060401

Autoradiography of 2-[18F]F-A-85380 on nicotinic acetylcholine receptors in the porcine brain in vitro.

Synapse (New York, N.Y.) 20060315

Mouse beta-TC6 insulinoma cells: high expression of functional alpha3beta4 nicotinic receptors mediating membrane potential, intracellular calcium, and insulin release.

Molecular pharmacology 20060301

Electrophysiological characterization of nicotinic acetylcholine receptors in cat petrosal ganglion neurons in culture: effects of cytisine and its bromo derivatives.

Brain research 20060209

Cholinergic receptor subtypes in the olfactory bulbectomy model of depression.

Brain research bulletin 20060130

Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.

Brain research bulletin 20060130

Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native alpha3beta4* nicotinic receptors.

Neuroscience letters 20060109

Subtypes of neuronal nicotinic acetylcholine receptors involved in nicotine-induced phosphorylation of extracellular signal-regulated protein kinase in PC12h cells.

Neuroscience letters 20060109

Cyclooxygenase-2 mediates microglial activation and secondary dopaminergic cell death in the mouse MPTP model of Parkinson's disease.

Journal of neuroinflammation 20060101

Phytochemical differences between Calia secundiflora (Leguminosae) growing at two sites in Mexico.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101

Cytisine for the treatment of nicotine addiction: from a molecule to therapeutic efficacy.

Pharmacological reports : PR 20060101

Extracellular domain nicotinic acetylcholine receptors formed by alpha4 and beta2 subunits.

The Journal of biological chemistry 20051202

Mutations of a conserved lysine residue in the N-terminal domain of alpha7 nicotinic receptors affect gating and binding of nicotinic agonists.

Molecular pharmacology 20051201

Long-term exposure to the new nicotinic antagonist 1,2-bisN-cytisinylethane upregulates nicotinic receptor subtypes of SH-SY5Y human neuroblastoma cells.

British journal of pharmacology 20051201

From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research.

Drug discovery today 20051201

3,5-Bicyclic aryl piperidines: a novel class of alpha4beta2 neuronal nicotinic receptor partial agonists for smoking cessation.

Bioorganic & medicinal chemistry letters 20051115

Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes.

European journal of pharmacology 20051107

In vitro evidence and age-related changes for nicotinic but not muscarinic acetylcholine receptors in the central nervous system of Sepia officinalis.

Neuroscience letters 20051028

A robust homogeneous binding assay for alpha4beta2 nicotinic acetylcholine receptor.

Acta pharmacologica Sinica 20051001

Concise synthesis of (+/-)-cytisine via lithiation of N-Boc-bispidine.

Organic letters 20050929

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

Journal of medicinal chemistry 20050728

Nicotinic ACh receptors in area postrema neurons of immature rat brain.

Neuroscience letters 20050624

In pursuit of alpha4beta2 nicotinic receptor partial agonists for smoking cessation: carbon analogs of (-)-cytisine.

Bioorganic & medicinal chemistry letters 20050615

Nicotinic agonists, antagonists, and modulators from natural sources.

Cellular and molecular neurobiology 20050601

Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation.

Journal of medicinal chemistry 20050519

Selective modulation of neuronal nicotinic acetylcholine receptor channel subunits by Go-protein subunits.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20050406

High-affinity epibatidine binding of functional, human alpha7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells.

The Journal of pharmacology and experimental therapeutics 20050401

The subunit composition and pharmacology of alpha-Conotoxin MII-binding nicotinic acetylcholine receptors studied by a novel membrane-binding assay.

Neuropharmacology 20050401

Do naïve ruminants degrade alkaloids in the rumen?

Journal of chemical ecology 20050401

Nicotinic AChR in subclassified capsaicin-sensitive and -insensitive nociceptors of the rat DRG.

Journal of neurophysiology 20050301

Cholinergic drugs potentiate human nicotinic alpha4beta2 acetylcholine receptors by a competitive mechanism.

European journal of pharmacology 20050221

Selective deletion of the alpha5 subunit differentially affects somatic-dendritic versus axonally targeted nicotinic ACh receptors in mouse.

The Journal of physiology 20050215

Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors.

Bioorganic & medicinal chemistry letters 20050215

Genetic correlation between the free-choice oral consumption of nicotine and alcohol in C57BL/6JxC3H/HeJ F2 intercross mice.

Behavioural brain research 20050210

Conformational mobility of immobilized alpha3beta2, alpha3beta4, alpha4beta2, and alpha4beta4 nicotinic acetylcholine receptors.

Analytical chemistry 20050201

Evidence for functional nicotinic receptors on pancreatic beta cells.

Metabolism: clinical and experimental 20050201

Syntheses of (+)-cytisine, (-)-kuraramine, (-)-isokuraramine, and (-)-jussiaeiine A.

The Journal of organic chemistry 20050121

Diversity of nicotinic receptors mediating Cl- current in Lymnaea neurons distinguished with specific agonists and antagonist.

Neuroscience letters 20050120

Subunit composition of nicotinic receptors in monkey striatum: effect of treatments with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine or L-DOPA.

Molecular pharmacology 20050101

Synthesis and evaluation of nicotine alpha4beta2 receptor radioligand, 5-(3'-18F-fluoropropyl)-3-(2-(S)-pyrrolidinylmethoxy)pyridine, in rodents and PET in nonhuman primate.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20050101

Smoking during early pregnancy affects the expression pattern of both nicotinic and muscarinic acetylcholine receptors in human first trimester brainstem and cerebellum.

Neuroscience 20050101

Determination of quinolizidine alkaloids in Sophora tonkinensis by HPCE.

Phytochemical analysis : PCA 20050101

A phytochemical study of the quinolizidine alkaloids from Genista tenera by gas chromatography-mass spectrometry.

Phytochemical analysis : PCA 20050101

Effects on serotonin of (-)nicotine and dimethylphenylpiperazinium in the dorsal raphe and nucleus accumbens of freely behaving rats.

Neuroscience 20050101

Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization.

Science (New York, N.Y.) 20041105

Pharmacology of the neuronal nicotinic acetylcholine receptor of cultured Kenyon cells of the honeybee, Apis mellifera.

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology 20041001

A-186253, a specific antagonist of the alpha 4 beta 2 nAChRs: its properties and potential to study brain nicotinic acetylcholine receptors.

Neuropharmacology 20040901

Ablation of primary afferent terminals reduces nicotinic receptor expression and the nociceptive responses to nicotinic agonists in the spinal cord.

Journal of neurocytology 20040901

Evaluation of (+)-sparteine-like diamines for asymmetric synthesis.

The Journal of organic chemistry 20040820

Maternal exposure to nicotine and chlorpyrifos, alone and in combination, leads to persistently elevated expression of glial fibrillary acidic protein in the cerebellum of the offspring in late puberty.

Archives of toxicology 20040801

A short synthesis of (+/-)-cytisine.

Organic & biomolecular chemistry 20040707

Binding and functional activity of nicotinic cholinergic receptors in selected rat brain regions are increased following long-term but not short-term nicotine treatment.

Journal of neurochemistry 20040701

Subunit composition and pharmacology of two classes of striatal presynaptic nicotinic acetylcholine receptors mediating dopamine release in mice.

Molecular pharmacology 20040601

Studies toward labeling cytisine with [11C]phosgene: rapid synthesis of a delta-lactam involving a new chemoselective lithiation-annulation method.

The Journal of organic chemistry 20040528

Prenatal nicotine exposure alters the response to nicotine administration in adolescence: effects on cholinergic systems during exposure and withdrawal.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040501

Total enantioselective synthesis of (-)-cytisine.

Organic letters 20040219

Expression and function of neuronal nicotinic ACh receptors in rat microvascular endothelial cells.

American journal of physiology. Heart and circulatory physiology 20040201

Nicotinic acetylcholine receptors in mouse and rat optic nerves.

Journal of neurophysiology 20040201

Characterization of nicotinic receptors inducing noradrenaline release and absence of nicotinic autoreceptors in human neocortex.

Brain research bulletin 20040201

Recent developments in the synthesis of nicotinic acetylcholine receptor ligands.

Current topics in medicinal chemistry 20040101

ABT-089: pharmacological properties of a neuronal nicotinic acetylcholine receptor agonist for the potential treatment of cognitive disorders.

CNS drug reviews 20040101

[Application of bisalkaloid derivatives of dicarboxylic acids based on lupinine, anabasine and cytisine as cholinesterase inhibitors of various origin].

Zhurnal evoliutsionnoi biokhimii i fiziologii 20040101

Functional role of nicotinic acetylcholine receptors in apoptosis in HL-60 cell line.

European journal of pharmacology 20031215

Subtype-selective up-regulation by chronic nicotine of high-affinity nicotinic receptors in rat brain demonstrated by receptor autoradiography.

The Journal of pharmacology and experimental therapeutics 20031201

Characterization of human alpha 4 beta 2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells.

Molecular pharmacology 20031201

Pharmacological characterization of dopamine, norepinephrine and serotonin release in the rat prefrontal cortex by neuronal nicotinic acetylcholine receptor agonists.

Brain research 20031114

The effects of beta3 subunit incorporation on the pharmacology and single channel properties of oocyte-expressed human alpha3beta4 neuronal nicotinic receptors.

The Journal of biological chemistry 20031107

Rigidified acetylcholine mimics: conformational requirements for binding to neuronal nicotinic receptors.

Bioorganic & medicinal chemistry letters 20031103

Characterization of neuronal nicotinic acetylcholine receptors in the membrane of unmyelinated human C-fiber axons by in vitro studies.

Journal of neurophysiology 20031101

Beta-amyloid peptide activates non-alpha7 nicotinic acetylcholine receptors in rat basal forebrain neurons.

Journal of neurophysiology 20031101

A structural model of agonist binding to the alpha3beta4 neuronal nicotinic receptor.

British journal of pharmacology 20031101

Potentiation of evoked calcitonin gene-related peptide release from oral mucosa: a potential basis for the pro-inflammatory effects of nicotine.

The European journal of neuroscience 20031101

Nitrogen substitution modifies the activity of cytisine on neuronal nicotinic receptor subtypes.

European journal of pharmacology 20030620

Localization of [3H]nicotine, [3H]cytisine, [3H]epibatidine, and [125I]alpha-bungarotoxin binding sites in the brain of Macaca mulatta.

The Journal of comparative neurology 20030616

Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells.

Neuroscience letters 20030612

3D QSAR analyses-guided rational design of novel ligands for the (alpha4)2(beta2)3 nicotinic acetylcholine receptor.

Journal of medicinal chemistry 20030522

Spontaneously hypertensive rats: further evaluation of age-related memory performance and cholinergic marker expression.

Journal of psychiatry & neuroscience : JPN 20030501

Expression and functional characterisation of a human chimeric nicotinic receptor with alpha6beta4 properties.

European journal of pharmacology 20030411

Differential physiologic responses of alpha7 nicotinic acetylcholine receptors to beta-amyloid1-40 and beta-amyloid1-42.

Journal of neurobiology 20030401

Attenuation of cell adhesion in lymphocytes is regulated by CYTIP, a protein which mediates signal complex sequestration.

The EMBO journal 20030303

Deficiency of nicotinic acetylcholine receptor beta 4 subunit causes autonomic cardiac and intestinal dysfunction.

Molecular pharmacology 20030301

Cytisine derivatives as ligands for neuronal nicotine receptors and with various pharmacological activities.

Farmaco (Societa chimica italiana : 1989) 20030301

Halogenated cytisine derivatives as agonists at human neuronal nicotinic acetylcholine receptor subtypes.

Neuropharmacology 20030301

Cytisine binds with similar affinity to nicotinic alpha4beta2 receptors on the cell surface and in homogenates.

Brain research 20030103

Blockade of nicotine-induced locomotor sensitization by a novel neurotensin analog in rats.

European journal of pharmacology 20030101

Modulation of inhibitory synaptic activity by a non-alpha4beta2, non-alpha7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord.

Pain 20030101

Bisalkaloid derivatives of dicarboxylic acids on the basis of lupinine, anabasine, and cytisine as reversible cholinesterase inhibitors.

Doklady. Biochemistry and biophysics 20030101

Quinolizidine alkaloid profiles of two taxa of Teline maderensis.

Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101

Nicotinic ACh receptor subtypes on gastrointestinally projecting neurones in the dorsal motor vagal nucleus of the rat.

The Journal of physiology 20021215

(+)-2,3-dehydro-10-oxo-alpha-isosparteine in Uresiphita reversalis larvae fed on Cytisus monspessulanus leaves.

Phytochemistry 20021201

Acetylcholine receptors and thresholds for convulsions from flurothyl and 1,2-dichlorohexafluorocyclobutane.

Anesthesia and analgesia 20021201

Influence of cytisine on catecholamine release in isolated perfused rat adrenal glands.

Archives of pharmacal research 20021201

Declines in different beta2* nicotinic receptor populations in monkey striatum after nigrostriatal damage.

The Journal of pharmacology and experimental therapeutics 20021101

Fast synaptic transmission mediated by alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in lamina X neurones of neonatal rat spinal cord.

The Journal of physiology 20021101

Nicotinic receptors regulate the release of glycine onto lamina X neurones of the rat spinal cord.

Neuropharmacology 20021101

Nicotinic receptor gene cluster on rat chromosome 8 in nociceptive and blood pressure hyperresponsiveness.

Physiological genomics 20021029

A readily-accessible (+)-sparteine surrogate.

Journal of the American Chemical Society 20021009

Differential regulation of nicotinic receptor-mediated neurotransmitter release following chronic (-)-nicotine administration.

Neuropharmacology 20021001

Study of the calcium dynamics of the human alpha4beta2, alpha3beta4 and alpha1beta1gammadelta nicotinic acetylcholine receptors.

Naunyn-Schmiedeberg's archives of pharmacology 20020901

Comparative pharmacology of rat and human alpha7 nAChR conducted with net charge analysis.

British journal of pharmacology 20020901

Pharmacological properties of nicotinic acetylcholine receptors expressed by guinea pig small intestinal myenteric neurons.

The Journal of pharmacology and experimental therapeutics 20020901

Pharmacological evaluation of a Br-76 analog of epibatidine: a potent ligand for studying brain nicotinic acetylcholine receptors.

Synapse (New York, N.Y.) 20020801

Characterization of epibatidine binding to medial habenula: potential role in analgesia.

The Journal of pharmacology and experimental therapeutics 20020801

Measuring nicotinic receptors with characteristics of alpha4beta2, alpha3beta2 and alpha3beta4 subtypes in rat tissues by autoradiography.

Journal of neurochemistry 20020801

Recent progress in the development of subtype selective nicotinic acetylcholine receptor ligands.

Current drug targets. CNS and neurological disorders 20020801

Autonomic function in mice lacking alpha5 neuronal nicotinic acetylcholine receptor subunit.

The Journal of physiology 20020715

Synthesis and biological evaluation at nicotinic acetylcholine receptors of N-arylalkyl- and N-aryl-7-azabicyclo[2.2.1]heptanes.

Journal of medicinal chemistry 20020704

FT-IR spectroscopic, AM1 and PM3 computational studies of conformation of natural products: cytisine.

Talanta 20020610

Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.

Molecular pharmacology 20020601

First and second transmembrane segments of alpha3, alpha4, beta2, and beta4 nicotinic acetylcholine receptor subunits influence the efficacy and potency of nicotine.

Molecular pharmacology 20020601

Differential rate responses to nicotine in rat heart: evidence for two classes of nicotinic receptors.

The Journal of pharmacology and experimental therapeutics 20020601

Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice.

Journal of neurochemistry 20020601

Cytisine derivatives as high affinity nAChR ligands: synthesis and comparative molecular field analysis.

Farmaco (Societa chimica italiana : 1989) 20020601

A non-alpha7 nicotinic acetylcholine receptor modulates excitatory input to hippocampal CA1 interneurons.

Journal of neurophysiology 20020301

Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020215

Protons enhance the gating kinetics of the alpha3/beta4 neuronal nicotinic acetylcholine receptor by increasing its apparent affinity to agonists.

Molecular pharmacology 20020201

[3H]Epibatidine binding to bovine adrenal medulla: evidence for alpha3beta4* nicotinic receptors.

Neuroscience letters 20020125

Loss of nicotinic receptors in monkey striatum after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment is due to a decline in alpha-conotoxin MII sites.

Molecular pharmacology 20020101

Differential nicotinic receptor expression in monkey basal ganglia: effects of nigrostriatal damage.

Neuroscience 20020101

2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.

Journal of medicinal chemistry 20011220

Relationship between the increased cell surface alpha7 nicotinic receptor expression and neuroprotection induced by several nicotinic receptor agonists.

Journal of neuroscience research 20011115

[125/123I] 5-Iodo-3-pyridyl ethers. syntheses and binding to neuronal nicotinic acetylcholine receptors.

Nuclear medicine and biology 20011101

Chemical composition, nutritive value, and toxicology evaluation of Mexican wild lupins.

Journal of agricultural and food chemistry 20011101

Characterization of the functional subunit combination of nicotinic acetylcholine receptors in bovine adrenal chromaffin cells.

Neuroscience letters 20011026

Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes.

Journal of neurophysiology 20011001

Indolizidine and quinolizidine alkaloids.

Natural product reports 20011001

Spinal nicotinic receptor activity in a genetic model of hypertension.

Clinical and experimental hypertension (New York, N.Y. : 1993) 20011001

Agonist regulation of rat alpha 3 beta 4 nicotinic acetylcholine receptors stably expressed in human embryonic kidney 293 cells.

Molecular pharmacology 20010901

Activity of cytisine and its brominated isosteres on recombinant human alpha7, alpha4beta2 and alpha4beta4 nicotinic acetylcholine receptors.

Journal of neurochemistry 20010901

Differential effect of nicotinic agonists on the [3H]norepinephrine release from rat hippocampal slices.

Neurochemical research 20010901

Differential effects of chronic drug treatment on alpha3* and alpha7 nicotinic receptor binding sites, in hippocampal neurones and SH-SY5Y cells.

British journal of pharmacology 20010801

Synthesis and in vivo studies of the stereoisomers of N-[11C]methyl-homoepibatidine.

Nuclear medicine and biology 20010801

Characterization of human alpha4beta2 neuronal nicotinic receptors stably expressed in SH-EP1 cells.

Neurochemical research 20010601

In vitro effects of nicotine on mitochondrial respiration and superoxide anion generation.

Brain research 20010504

Syntheses and evaluation of halogenated cytisine derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands.

European journal of medicinal chemistry 20010401

Investigation of nicotine binding to THP-1 cells: evidence for a non-cholinergic binding site.

Biochemical pharmacology 20010315

Effect of nicotine on cerebellar granule neuron development.

The European journal of neuroscience 20010101

Nicotinic agonists stimulate acetylcholine release from mouse interpeduncular nucleus: a function mediated by a different nAChR than dopamine release from striatum.

Journal of neurochemistry 20010101

Alcohol preference: association with reduced striatal nicotinic receptors.

Alcohol and alcoholism (Oxford, Oxfordshire) 20010101

Nicotine-induced alterations in the expression of nicotinic receptors in primary cultures from human prenatal brain.

Neuroscience 20010101

Prenatal nicotine exposure is associated with an increase in [125I]epibatidine binding in discrete cortical regions in rats.

Pharmacology, biochemistry, and behavior 20001001

Chick optic lobe contains a developmentally regulated alpha2alpha5beta2 nicotinic receptor subtype.

Molecular pharmacology 20000801

Genetic and pharmacological strategies identify a behavioral function of neuronal nicotinic receptors.

Behavioural brain research 20000801

GTS-21, a mixed nicotinic receptor agonist/antagonist, does not affect the nicotine cue.

Pharmacology, biochemistry, and behavior 19991001

Inducible, heterologous expression of human alpha7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line.

Brain research 19990417

Promiscuous coassembly of serotonin 5-HT3 and nicotinic alpha4 receptor subunits into Ca(2+)-permeable ion channels.

Proceedings of the National Academy of Sciences of the United States of America 19980915

ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vitro characterization.

The Journal of pharmacology and experimental therapeutics 19980501

Characterization of human recombinant neuronal nicotinic acetylcholine receptor subunit combinations alpha2beta4, alpha3beta4 and alpha4beta4 stably expressed in HEK293 cells.

The Journal of pharmacology and experimental therapeutics 19980201

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine]: I. A potent and selective cholinergic channel modulator with neuroprotective properties.

The Journal of pharmacology and experimental therapeutics 19971001

Tacrine interacts with an allosteric activator site on alpha 4 beta 2 nAChRs in M10 cells.

Neuroreport 19960902

Pharmacology of the nicotinic acetylcholine receptor from fetal rat muscle expressed in Xenopus oocytes.

European journal of pharmacology 19960815

Stable expression, pharmacologic properties and regulation of the human neuronal nicotinic acetylcholine alpha 4 beta 2 receptor.

The Journal of pharmacology and experimental therapeutics 19960101

Regulation of alpha 4 beta 2 nicotinic acetylcholine receptors in M10 cells following treatment with nicotinic agents.

Neuroreport 19950126

A subtype of nicotinic cholinergic receptor in rat brain is composed of alpha 4 and beta 2 subunits and is up-regulated by chronic nicotine treatment.

Molecular pharmacology 19920101

Mediation of nicotine-induced convulsions by central nicotinic receptors of the 'C6' type.

Neuropharmacology 19830301