Home Sulfos Benzenesulfonamide

Benzenesulfonamide

CAS No.:
98-10-2
Catalog Number:
AG0034HP
Molecular Formula:
C6H7NO2S
Molecular Weight:
157.1903
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
98%
In Stock USA
United States
$13
- +
25g
98%
In Stock USA
United States
$19
- +
100g
98%
In Stock USA
United States
$50
- +
500g
99%(GC)
In Stock USA
United States
$132
- +
Product Description
Catalog Number:
AG0034HP
Chemical Name:
Benzenesulfonamide
CAS Number:
98-10-2
Molecular Formula:
C6H7NO2S
Molecular Weight:
157.1903
MDL Number:
MFCD00007930
IUPAC Name:
benzenesulfonamide
InChI:
InChI=1S/C6H7NO2S/c7-10(8,9)6-4-2-1-3-5-6/h1-5H,(H2,7,8,9)
InChI Key:
KHBQMWCZKVMBLN-UHFFFAOYSA-N
SMILES:
NS(=O)(=O)c1ccccc1
EC Number:
202-637-1
NSC Number:
5341
RTECS Number:
DA9380000
Properties
Complexity:
186  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
157.02g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
157.187g/mol
Monoisotopic Mass:
157.02g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
68.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.3  
Literature
Title Journal
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Dependence of avidity on linker length for a bivalent ligand-bivalent receptor model system. Journal of the American Chemical Society 20120111
5-HT₂c receptor selectivity and structure-activity relationship of N-methyl-N-(1-methylpiperidin-4-yl)benzenesulfonamide analogs. Bioorganic & medicinal chemistry letters 20120101
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FT-IR, FT-Raman and quantum chemical calculations of (E)-N-carbamimidoyl-4-((3,4-dimethoxybenzylidene) amino) benzenesulfonamide. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111215
Radiosynthesis of three [11C]ureido-substituted benzenesulfonamides as PET probes for carbonic anhydrase IX in tumors. Bioorganic & medicinal chemistry letters 20111201
Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents. European journal of medicinal chemistry 20111201
Synthesis, in vitro anticancer screening and radiosensitizing evaluation of some new 4-[3-(substituted)thioureido]-N-(quinoxalin-2-yl)-benzenesulfonamide derivatives. Acta pharmaceutica (Zagreb, Croatia) 20111201
Synthesis and acrosin inhibitory activity of substituted 4-amino-N-(diaminomethylene) benzenesulfonamide derivatives. Bioorganic & medicinal chemistry letters 20111115
A double prodrug system for colon targeting of benzenesulfonamide COX-2 inhibitors. Bioorganic & medicinal chemistry letters 20111115
Rhodium-catalyzed annulation of N-benzoylsulfonamide with isocyanide through C-H activation. Chemistry (Weinheim an der Bergstrasse, Germany) 20111104
Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships. European journal of medicinal chemistry 20111101
2,4-Dichloro-N-(3,5-dimethyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20111101
4-Chloro-N-(3,4-dichloro-phen-yl)-2-methyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20111101
Identification of novel small molecule inhibitors of 4-diphosphocytidyl-2-C-methyl-D-erythritol (CDP-ME) kinase of Gram-negative bacteria. Bioorganic & medicinal chemistry 20111001
Design and synthesis of new N-(5-trifluoromethyl)-1H-1,2,4-triazol-3-yl benzenesulfonamides as possible antimalarial prototypes. Molecules (Basel, Switzerland) 20110920
Synthesis of rhodamine B-benzenesulfonamide conjugates and their inhibitory activity against human α- and bacterial/fungal β-carbonic anhydrases. Bioorganic & medicinal chemistry letters 20110915
Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the 'hydrophobic wall' of carbonic anhydrase. Journal of the American Chemical Society 20110907
Synthesis and in vivo evaluation of [O-methyl-11C] N-[3,5-dichloro-2-(methoxy)phenyl]-4-(methoxy)-3-(1-piperazinyl)benzenesulfonamide as an imaging probe for 5-HT6 receptors. Bioorganic & medicinal chemistry 20110901
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1-Benzyl-2,5-diphenyl-3-tosylimidazol-idin-4-one. Acta crystallographica. Section E, Structure reports online 20110901
4-(3-Methyl-5-phenyl-1H-pyrazol-1-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20110901
4-(3,7-Dimethyl-4-oxo-4,5-dihydro-isoxazolo[4,5-d]pyridazin-5-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20110901
4-(5-Oxo-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20110901
4-(3-Methyl-4,5-dihydro-1H-benzo[g]indazol-1-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20110901
Using covalent dimers of human carbonic anhydrase II to model bivalency in immunoglobulins. Journal of the American Chemical Society 20110803
Potassium N-bromo-2-methyl-benzene-sulfonamidate sesquihydrate. Acta crystallographica. Section E, Structure reports online 20110801
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Discovery of pyrrole-indoline-2-ones as Aurora kinase inhibitors with a different inhibition profile. Journal of medicinal chemistry 20100826
Identification of N-(2-(azepan-1-yl)-2-phenylethyl)-benzenesulfonamides as novel inhibitors of GlyT1. Bioorganic & medicinal chemistry letters 20100815
2-Methyl-N-(2-methyl-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100801
N-(4-Chloro-benzo-yl)-2-methyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100801
Cell adhesion to unnatural ligands mediated by a bifunctional protein. Journal of the American Chemical Society 20100721
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Synthesis of quinazolines from N-(2-nitrophenylsulfonyl)iminodiacetate and alpha-(2-nitrophenylsulfonyl)amino ketones via 2H-indazole 1-oxides. The Journal of organic chemistry 20100702
Synthesis and in vitro anticancer screening of some novel 4-[2-amino-3-cyano-4-substituted-5,6,7,8-tetrahydroquinolin-1-(4H)-yl]benzenesulfonamides. European journal of medicinal chemistry 20100701
2,4-Dichloro-N-(3-methyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100701
2,4-Dichloro-N-(3-chloro-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100701
N-(4-Methyl-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100701
New hydroxypyrimidinone-containing sulfonamides as carbonic anhydrase inhibitors also acting as MMP inhibitors. Bioorganic & medicinal chemistry letters 20100615
A rationale for the activity profile of benzenesulfonamide derivatives as cyclooxygenase (COX) inhibitors. European journal of medicinal chemistry 20100601
4-Chloro-N-(3,4-dimethyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100601
N-(Phenyl-sulfon-yl)acetamide. Acta crystallographica. Section E, Structure reports online 20100601
2-Chloro-N-(3-chloro-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100601
2-Chloro-N-(4-methyl-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100601
Correlation analyses on binding affinity of substituted benzenesulfonamides with carbonic anhydrase using ab initio MO calculations on their complex structures. Journal of chemical information and modeling 20100524
3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors. Bioorganic & medicinal chemistry letters 20100515
Thioether benzenesulfonamide inhibitors of carbonic anhydrases II and IV: structure-based drug design, synthesis, and biological evaluation. Bioorganic & medicinal chemistry 20100501
17,18-Dibromo-8-methyl-4,12-ditosyl-3,4,5,6,7,8,9,10,11,12,13,14-dodeca-hydro-2H-benzo[b][1,4,7,11,15]dioxatriaza-cyclo-hepta-decine. Acta crystallographica. Section E, Structure reports online 20100501
N-Phenyl-N-(prop-2-en-1-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100501
N-(4-Hydroxy-phen-yl)benzene-sulfon-amide. Acta crystallographica. Section E, Structure reports online 20100501
N-(3,5-Dichloro-phen-yl)-2,4-dimethyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100501
N-(2,6-Dimethyl-phen-yl)-4-methyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100501
catena-Poly[neodymium(III)-bis-[μ-N-(dimorpholinophosphor-yl)benzene-sulfonamidato]-sodium(I)-bis-[μ-N-(dimorpholinophosphor-yl)benzene-sulfonamidato]]. Acta crystallographica. Section E, Structure reports online 20100401
N-Cyclo-hexyl-4-meth-yl-N-propyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100401
2-Methyl-N-(4-methyl-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100401
2,4-Dimethyl-N-(3-methyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100401
Recognition and binding of a helix-loop-helix peptide to carbonic anhydrase occurs via partly folded intermediate structures. Biophysical journal 20100203
N-(2-Chloro-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100201
N-(4-Chloro-benzo-yl)-4-methyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100201
2-Methyl-N-(3-methyl-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100201
cis-N-(2-Hydroxy-cyclo-hexyl)-p-toluene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100201
Computational study of the interactions between guanine derivatives and cyclin-dependent kinase 2 (CDK2) by CoMFA and QM/MM. Journal of chemical information and modeling 20100101
Synthesis and biological activities of some novel triazoloquinazolines and triazinoquinazolines containing benzenesulfonamide moieties. Arzneimittel-Forschung 20100101
Tamsulosin-induced severe hypotension during general anesthesia: a case report. Journal of medical case reports 20100101
Pharmacophore elucidation and molecular docking studies on 5-phenyl-1-(3-pyridyl)-1h-1,2,4-triazole-3-carboxylic acid derivatives as COX-2 inhibitors. Scientia pharmaceutica 20100101
[Synthesis and investigation on antidiabetic activity of 4-(1-aryl-3-oxo-5-phenylpentylamino) benzenesulfonamide]. Yao xue xue bao = Acta pharmaceutica Sinica 20100101
N-Cyclo-hexyl-N-ethyl-4-methyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20100101
N,N'-Bis(phenyl-sulfon-yl)succinamide. Acta crystallographica. Section E, Structure reports online 20100101
N,N'-Bis(phenyl-sulfon-yl)maleamide. Acta crystallographica. Section E, Structure reports online 20100101
Environmentally sensitive fluorescent sensors based on synthetic peptides. Sensors (Basel, Switzerland) 20100101
Radiolabelling of proteins with fluorine-18 via click chemistry. Chemical communications (Cambridge, England) 20091228
Thermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitors. ChemMedChem 20091201
N-Benzyl-N-cyclo-hexyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091201
4-Benzene-sulfonamido-benzoic acid. Acta crystallographica. Section E, Structure reports online 20091201
N-Cyclo-hexyl-N-(prop-2-en-1-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091201
N-Benzyl-N-cyclo-hexyl-4-methyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091201
N-(4-Chloro-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091201
N-Cyclo-hexyl-N-propyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091201
4-Methyl-N-(2-methyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091201
Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists. Bioorganic & medicinal chemistry letters 20091101
In vivo and in vitro anti-leishmanial activities of 4-nitro-N-pyrimidin- and N-pyrazin-2-ylbenzenesulfonamides, and N2-(4-nitrophenyl)-N1-propylglycinamide. Bioorganic & medicinal chemistry 20091101
2,2-Dimethyl-N-(phenyl-sulfon-yl)acetamide. Acta crystallographica. Section E, Structure reports online 20091101
N-(3-Chloro-benzo-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091101
N-(2,5-Dimethyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091101
N-Cyclohexyl-N-methylbenzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091101
Theoretical characterization of substrate access/exit channels in the human cytochrome P450 3A4 enzyme: involvement of phenylalanine residues in the gating mechanism. The journal of physical chemistry. B 20091001
N-Benzo-ylbenzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20091001
Carbonic anhydrase inhibitors. Inhibition of the Rv1284 and Rv3273 beta-carbonic anhydrases from Mycobacterium tuberculosis with diazenylbenzenesulfonamides. Bioorganic & medicinal chemistry letters 20090901
2-Chloro-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20090901
N-(2-Formyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20090901
N-(2-Acetyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20090901
o-Toluene-sulfonamide: a redetermination. Acta crystallographica. Section E, Structure reports online 20090901
4-[(Z)-(2-Eth-oxy-4-oxochroman-3-yl-idene)methyl-amino]benzene-sulfonamide monohydrate. Acta crystallographica. Section E, Structure reports online 20090801
2,4-Dichloro-N-(3,4-dichloro-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20090801
In vitro pharmacological characterization of a novel allosteric modulator of alpha 7 neuronal acetylcholine receptor, 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744), exhibiting unique pharmacological profile. The Journal of pharmacology and experimental therapeutics 20090701
Hybrid molecules between benzenesulfonamides and active antimicrobial benzo[d]isothiazol-3-ones. European journal of medicinal chemistry 20090601
Toward the development of metal-based synthetic nucleases: DNA binding and oxidative DNA cleavage of a mixed copper(II) complex with N-(9H-purin-6-yl)benzenesulfonamide and 1,10-phenantroline. Antitumor activity in human Caco-2 cells and Jurkat T lymphocytes. Evaluation of p53 and Bcl-2 proteins in the apoptotic mechanism. Journal of inorganic biochemistry 20090601
Sodium N-chloro-2-methyl-benzene-sulfonamidate sesquihydrate. Acta crystallographica. Section E, Structure reports online 20090601
4-Methyl-N-phenyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20090601
Discovery of 4-(5-(4-chlorophenyl)-2-methyl-3-propionyl-1H-pyrrol-1-yl)benzenesulfonamide (A-867744) as a novel positive allosteric modulator of the alpha7 nicotinic acetylcholine receptor. Journal of medicinal chemistry 20090528
Investigation of the fate of sulfonamides downgradient of a decommissioned sewage farm near Berlin, Germany. Journal of contaminant hydrology 20090512
Ligand-directed tosyl chemistry for protein labeling in vivo. Nature chemical biology 20090501
Synthesis and biological evaluation of novel pyrazoles and pyrazolo[3,4-d]pyrimidines incorporating a benzenesulfonamide moiety. Archiv der Pharmazie 20090401
N-(3,4-Dimethyl-phen-yl)-4-methyl-benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20090401
Addition reactions of chloro- or iodomethyllithium to imines. Synthesis of enantiopure aziridines and beta-chloroamines. The Journal of organic chemistry 20090320
Synthesis and biological evaluation of sulfonylurea and thiourea derivatives substituted with benzenesulfonamide groups as potential hypoglycemic agents. Bioorganic & medicinal chemistry letters 20090315
Improvement of monolithic solid material by utilization of spacer for identification of the target using affinity resins. Bioorganic & medicinal chemistry letters 20090301
Carbonic anhydrase inhibitors: two-prong versus mono-prong inhibitors of isoforms I, II, IX, and XII exemplified by photochromic cis-1,2-alpha-dithienylethene derivatives. Bioorganic & medicinal chemistry letters 20090301
Ethyl 2-[N-(2-Formyl-phen-yl)benzene-sulfonamido]acetate. Acta crystallographica. Section E, Structure reports online 20090301
A novel class of allosteric modulators of AMPA/Kainate receptors. Bioorganic & medicinal chemistry letters 20090215
Synthesis and biological evaluation of benzenesulfonamide-substituted 4-(6-alkylpyridin-2-yl)-5-(quinoxalin-6-yl)imidazoles as transforming growth factor-beta type 1 receptor kinase inhibitors. European journal of medicinal chemistry 20090201
Synthesis of some pyrazolyl benzenesulfonamide derivatives as dual anti-inflammatory antimicrobial agents. Journal of enzyme inhibition and medicinal chemistry 20090201
N-(2,3-Dimethyl-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20090201
Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase. Journal of the American Chemical Society 20090121
Synthesis and antiinflammatory activity of some new 1,3,5-trisubstituted pyrazolines bearing benzene sulfonamide. Bioorganic & medicinal chemistry letters 20090101
Label-free determination of protein-ligand binding constants using mass spectrometry and validation using surface plasmon resonance and isothermal titration calorimetry. Journal of molecular recognition : JMR 20090101
Synthesis and Antiviral Studies of Novel N-Sulphonamidomethyl piperazinyl Fluoroquinolones. Indian journal of pharmaceutical sciences 20090101
Dual inhibitors of matrix metalloproteinases and carbonic anhydrases: iminodiacetyl-based hydroxamate-benzenesulfonamide conjugates. Journal of medicinal chemistry 20081225
Synthesis of biologically active N-methyl derivatives of amidines and cyclized five-membered products of amidines with oxalyl chloride. European journal of medicinal chemistry 20081201
Recent improvements in the development of A(2B) adenosine receptor agonists. Purinergic signalling 20081201
Effect of the oral absorption of benzenesulfonanilide-type cyclooxygenase-1 inhibitors on analgesic action and gastric ulcer formation. Journal of pharmaceutical sciences 20081201
N-(3,5-Dichloro-phen-yl)benzene-sulfonamide. Acta crystallographica. Section E, Structure reports online 20081101
External pH influences the transcriptional profile of the carbonic anhydrase, CAH-4b in Caenorhabditis elegans. Molecular and biochemical parasitology 20081001
Tetra-aquabis-(2-sulfamoylbenzoato)manganese(II). Acta crystallographica. Section E, Structure reports online 20081001
Residual ligand entropy in the binding of p-substituted benzenesulfonamide ligands to bovine carbonic anhydrase II. Journal of the American Chemical Society 20080917
Chromofluorescent indicator for intracellular Zn2+/Hg2+ dynamic exchange. Organic letters 20080904
Photophysical and complexation properties of benzenesulfonamide derivatives with different donor and acceptor moieties. Journal of fluorescence 20080901
Tetramethylcyclopropyl analogue of the leading antiepileptic drug, valproic acid: evaluation of the teratogenic effects of its amide derivatives in NMRI mice. Birth defects research. Part A, Clinical and molecular teratology 20080901
Chemometrical examination of active parameters and interactions in flow injection-capillary electrophoresis. Electrophoresis 20080901
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorganic & medicinal chemistry letters 20080815
2,2,2-Trimethyl-N-(phenyl-sulfon-yl)-acetamide. Acta crystallographica. Section E, Structure reports online 20080801
2,2-Dichloro-N-(phenyl-sulfon-yl)-acetamide. Acta crystallographica. Section E, Structure reports online 20080801
Affinity-labeling-based introduction of a reactive handle for natural protein modification. Chemistry, an Asian journal 20080707
Carbonic anhydrase inhibitors: design of spin-labeled sulfonamides incorporating TEMPO moieties as probes for cytosolic or transmembrane isozymes. Bioorganic & medicinal chemistry letters 20080615
Exploration of physicochemical properties and molecular modelling studies of 2-sulfonyl-phenyl-3-phenyl-indole analogs as cyclooxygenase-2 inhibitors. European journal of medicinal chemistry 20080601
Similar sulfonamides with different crystal structures: sulfasymazine and sulfatriazine. Acta crystallographica. Section C, Crystal structure communications 20080601
Antidiabetic activity of N-(6-substituted-1,3-benzothiazol-2-yl)benzenesulfonamides. Bioorganic & medicinal chemistry letters 20080501
2-[N-(X-chlorophenyl)carbamoyl]benzenesulfonamide (with X = 2 and 4). Acta crystallographica. Section C, Crystal structure communications 20080501
Functional human 5-HT6 receptor assay for high throughput screening of chemical ligands and binding proteins. Combinatorial chemistry & high throughput screening 20080501
Behaviour and biodegradation of sulfonamides (p-TSA, o-TSA, BSA) during drinking water treatment. Chemosphere 20080401
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozymes I and II and tumor-associated isozymes IX and XII with S-substituted 4-chloro-2-mercapto-5-methyl-benzenesulfonamides. Bioorganic & medicinal chemistry 20080401
Design and synthesis of N-(3,5-difluoro-4-hydroxyphenyl)benzenesulfonamides as aldose reductase inhibitors. Bioorganic & medicinal chemistry 20080401
Electrophysiological characterization of a novel Kv channel blocker N,N'-[oxybis(2,1-ethanediyloxy-2,1-ethanediyl) ]bis(4-methyl)-benzenesulfonamide found in virtual screening. Acta pharmacologica Sinica 20080401
Ethyl 2-(bromo-meth-yl)-5-meth-oxy-1-phenyl-sulfonyl-1H-indole-3-carboxyl-ate. Acta crystallographica. Section E, Structure reports online 20080401
Identification and significance of sulphonamides (p-TSA, o-TSA, BSA) in an urban water cycle (Berlin, Germany). Water research 20080301
Selective COX-2 inhibitors. Part 2: synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides. Bioorganic & medicinal chemistry 20080301
Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes. Purinergic signalling 20080301
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. Bioorganic & medicinal chemistry 20080215
Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2alpha: optimization of in vitro potency and rat pharmacokinetics for oral efficacy. Bioorganic & medicinal chemistry 20080201
Metal-based sulfonamides: their preparation, characterization and in-vitro antibacterial, antifungal & cytotoxic properties. X-ray structure of 4-[(2-hydroxybenzylidene) amino] benzenesulfonamide. Journal of enzyme inhibition and medicinal chemistry 20080201
Ethyl 2-[(phenyl-sulfan-yl)meth-yl]-1-(phenyl-sulfon-yl)-1H-indole-3-carboxyl-ate. Acta crystallographica. Section E, Structure reports online 20080201
(2-Methyl-1-phenyl-sulfonyl-1H-indol-3-yl)methanol. Acta crystallographica. Section E, Structure reports online 20080201
Carbonic anhydrase inhibitors: copper(II) complexes of polyamino-polycarboxylamido aromatic/heterocyclic sulfonamides are very potent inhibitors of the tumor-associated isoforms IX and XII. Bioorganic & medicinal chemistry letters 20080115
New celecoxib derivatives as anti-inflammatory agents. Journal of medicinal chemistry 20080110
Identification of N-(quinolin-8-yl)benzenesulfonamides as agents capable of down-regulating NFkappaB activity within two separate high-throughput screens of NFkappaB activation. Bioorganic & medicinal chemistry letters 20080101
An efficient solvent-free synthesis of benzoxanthenes catalyzed by BSA or O-TSA. Preparative biochemistry & biotechnology 20080101
Antimicrobial activity of some sulfonamide derivatives on clinical isolates of Staphylococus aureus. Annals of clinical microbiology and antimicrobials 20080101
Binding modes of two novel non-nucleoside reverse transcriptase inhibitors, YM-215389 and YM-228855, to HIV type-1 reverse transcriptase. Antiviral chemistry & chemotherapy 20080101
Small molecule inhibitors of integrin alpha2beta1. Journal of medicinal chemistry 20071101
A remarkable accelerating effect of Ag-salt on intramolecular cyclization of o-(1-alkynyl)benzenesulfonamides. The Journal of organic chemistry 20071026
A strategy for designing 'multi-prong' enzyme inhibitors by incorporating selective ligands to the liposomal surface. Chemical communications (Cambridge, England) 20070828
Design, synthesis and pharmacological evaluation of 4-[2-alkylthio-5(4)-(4-substitutedphenyl)imidazole-4(5)yl]benzenesulfonamides as selective COX-2 inhibitors. Acta pharmacologica Sinica 20070801
Quantitative determination of three sulfonamides in environmental water samples using liquid chromatography coupled to electrospray tandem mass spectrometry. Journal of chromatography. A 20070720
Structure-based design of 2-arylamino-4-cyclohexylmethoxy-5-nitroso-6-aminopyrimidine inhibitors of cyclin-dependent kinase 2. Organic & biomolecular chemistry 20070521
Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II. Journal of the American Chemical Society 20070502
Pharmacophoric 2-hydroxyalkyl benzenesulfonamide: a single-step synthesis from benzenesulfonamide via hemiaminal. European journal of medicinal chemistry 20070401
Carbonic anhydrase inhibitors: inhibition of cytosolic/tumor-associated isoforms I, II, and IX with iminodiacetic carboxylates/hydroxamates also incorporating benzenesulfonamide moieties. Bioorganic & medicinal chemistry letters 20070315
Synthesis and in vivo evaluation of [18F]-4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide as a PET imaging probe for COX-2 expression. Bioorganic & medicinal chemistry 20070215
Dependence of effective molarity on linker length for an intramolecular protein-ligand system. Journal of the American Chemical Society 20070207
Thermodynamic parameters for the association of fluorinated benzenesulfonamides with bovine carbonic anhydrase II. Chemistry, an Asian journal 20070108
Strategies for controlled placement of nanoscale building blocks. Nanoscale research letters 20070101
Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands. Journal of medicinal chemistry 20061214
Thiol-mediated anchoring of ligands to self-assembled monolayers for studies of biospecific interactions. Langmuir : the ACS journal of surfaces and colloids 20061121
Synthesis and in vitro antitumor evaluation of some indeno[1,2-c]pyrazol(in)es substituted with sulfonamide, sulfonylurea(-thiourea) pharmacophores, and some derived thiazole ring systems. Bioorganic & medicinal chemistry 20061001
Intracellular inhibition of carboxylesterases by benzil: modulation of CPT-11 cytotoxicity. Molecular cancer therapeutics 20060901
Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors. Journal of medicinal chemistry 20060824
Urotensin-II blockade with SB-611812 attenuates cardiac dysfunction in a rat model of coronary artery ligation. Journal of molecular and cellular cardiology 20060801
Sorption-desorption of flucarbazone and propoxycarbazone and their benzenesulfonamide and triazolinone metabolites in two soils. Pest management science 20060701
Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori. Bioorganic & medicinal chemistry letters 20060415
Molecular structure and conformations of benzenesulfonamide: gas electron diffraction and quantum chemical calculations. The Journal of organic chemistry 20060414
Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode. Bioorganic & medicinal chemistry letters 20060401
Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs. Journal of medicinal chemistry 20060323
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with 'two-prong' inhibitors reveal the molecular basis of high affinity. Journal of the American Chemical Society 20060308
Carbonic anhydrase inhibitors: Valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II 'selective' inhibitor celecoxib. Bioorganic & medicinal chemistry letters 20060115
Downregulation of survivin expression and concomitant induction of apoptosis by celecoxib and its non-cyclooxygenase-2-inhibitory analog, dimethyl-celecoxib (DMC), in tumor cells in vitro and in vivo. Molecular cancer 20060101
Short communication inhibitory activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N-(4,6-dimethylpyrimidin-2-yl) benzenesulphonamide and its derivatives against orthopoxvirus replication in vitro. Antiviral chemistry & chemotherapy 20060101
CC 05, a novel anti-inflammatory compound, exerts its effect by inhibition of cyclooxygenase-2 activity. European journal of pharmacology 20050927
QSAR analysis of thiazole benzenesulfonamide substituted 3-pyridylethanolamines as beta3-adrenergic receptor agonist. Bioorganic & medicinal chemistry letters 20050615
Carbonic anhydrase inhibitors. Inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with Schiff's bases incorporating chromone and aromatic sulfonamide moieties, and their zinc complexes. Bioorganic & medicinal chemistry letters 20050615
Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents. Bioorganic & medicinal chemistry 20050415
Design, synthesis, and biological evaluation of N-acetyl-2-carboxybenzenesulfonamides: a novel class of cyclooxygenase-2 (COX-2) inhibitors. Bioorganic & medicinal chemistry 20050401
Carbonic anhydrase inhibitors: X-ray crystal structure of a benzenesulfonamide strong CA II and CA IX inhibitor bearing a pentafluorophenylaminothioureido tail in complex with isozyme II. Bioorganic & medicinal chemistry letters 20050401
Benzenesulfonamide analogs of fluoroquinolones. Antibacterial activity and QSAR studies. European journal of medicinal chemistry 20050401
Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor. Journal of medicinal chemistry 20050324
Spacer-based selectivity in the binding of 'two-prong' ligands to recombinant human carbonic anhydrase I. Biochemistry 20050308
Studies of non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: synthesis and structure-activity relationships of 2-cyano and 2-hydroxy thiazolidenebenzenesulfonamide derivatives. Bioorganic & medicinal chemistry 20050215
QSAR studies on benzene sulfonamide carbonic anhydrase inhibitors: need of hydrophobic parameter for topological modeling of binding constants of sulfonamides to human CA-II. Bioorganic & medicinal chemistry letters 20050215
Novel use of chemical shift in NMR as molecular descriptor: a first report on modeling carbonic anhydrase inhibitory activity and related parameters. Bioorganic & medicinal chemistry letters 20050215
Characterization of beta3-adrenergic receptor: determination of pharmacophore and 3D QSAR model for beta3 adrenergic receptor agonism. Journal of computer-aided molecular design 20050201
Predictive flip regression: a technique for QSAR of derivatives of symmetric molecules. Journal of chemical information and modeling 20050101
In situ click chemistry: enzyme-generated inhibitors of carbonic anhydrase II. Angewandte Chemie (International ed. in English) 20041217
Studies of nonnucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Design and synthesis of thiazolidenebenzenesulfonamides. Bioorganic & medicinal chemistry 20041201
Pharmacomodulation of a sulfamide 5-HT6 receptor ligand. Journal of enzyme inhibition and medicinal chemistry 20041201
Topological modeling of lipophilicity, diuretic activity, and carbonic inhibition activity of benzene sulfonamides: a molecular connectivity approach. Bioorganic & medicinal chemistry letters 20041115
Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives. Bioorganic & medicinal chemistry letters 20041115
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating 1,2,4-triazine moieties. Bioorganic & medicinal chemistry letters 20041101
Two-prong inhibitors for human carbonic anhydrase II. Journal of the American Chemical Society 20041020
Novel synthesis of 3,4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal. Journal of medicinal chemistry 20040923
Protein surface-assisted enhancement in the binding affinity of an inhibitor for recombinant human carbonic anhydrase-II. Journal of the American Chemical Society 20040908
Synthesis and antiviral activity of P1' arylsulfonamide azacyclic urea HIV protease inhibitors. Bioorganic & medicinal chemistry letters 20040802
Synthesis, antiviral, and anti-HIV-1 integrase activities of 3-aroyl-1,1-dioxo-1,4,2-benzodithiazines. Bioorganic & medicinal chemistry 20040701
Rewiring cell adhesion. Journal of the American Chemical Society 20040602
A versatile polypeptide platform for integrated recognition and reporting: affinity arrays for protein-ligand interaction analysis. Chemistry (Weinheim an der Bergstrasse, Germany) 20040517
New heteroarylbenzenesulphonamides as matrix metalloproteinase inhibitors. Bioorganic & medicinal chemistry letters 20040308
Abeta aggregation inhibitors. Part 1: Synthesis and biological activity of phenylazo benzenesulfonamides. Bioorganic & medicinal chemistry letters 20040308
QSAR study on benzenesulphonamide carbonic anhydrase inhibitors: topological approach using Balaban index. Bioorganic & medicinal chemistry 20040215
Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors. Bioorganic & medicinal chemistry letters 20040119
Application of CoMFA and CoMSIA 3D-QSAR and docking studies in optimization of mercaptobenzenesulfonamides as HIV-1 integrase inhibitors. Journal of medicinal chemistry 20040115
QSAR study using topological indices for inhibition of carbonic anhydrase II by sulfanilamides and Schiff bases. Molecular diversity 20040101
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation. Journal of medicinal chemistry 20030911
Sorption-desorption of two 'aged' sulfonylaminocarbonyltriazolinone herbicide metabolites in soil. Journal of agricultural and food chemistry 20030604
Synthesis of 1-(6-chloro-1,1-dioxo-1,4,2-benzodithiazin-3-yl)semi-carbazides and their transformation into 4-chloro-2-mercapto-N-(4,5-dihydro-5-oxo-4-phenyl-1H-1,2,4-triazol-3-yl)benzenesulfonamides as potential anticancer and anti-HIV agents. Farmaco (Societa chimica italiana : 1989) 20030601
Valdecoxib-induced toxic epidermal necrolysis in a patient allergic to sulfa drugs. Pharmacotherapy 20030401
Tripodal ligand incorporating dual fluorescent ionophore: a coordinative control of photoinduced electron transfer. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20030301
Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring. European journal of medicinal chemistry 20030201
Using cyclooxygenase-2 inhibitors as molecular platforms to develop a new class of apoptosis-inducing agents. Journal of the National Cancer Institute 20021204
Diversity in the oxidation of substrates by cytochrome P450 2D6: lack of an obligatory role of aspartate 301-substrate electrostatic bonding. Biochemistry 20020910
An excretion balance and pharmacokinetic study of the novel anticancer agent E7070 in cancer patients. Anti-cancer drugs 20020901
The pharmacokinetics of a thiazole benzenesulfonamide beta 3-adrenergic receptor agonist and its analogs in rats, dogs, and monkeys: improving oral bioavailability. Drug metabolism and disposition: the biological fate of chemicals 20020701
Metabolism of a thiazole benzenesulfonamide derivative, a potent and elective agonist of the human beta3-adrenergic receptor, in rats: identification of a novel isethionic acid conjugate. Drug metabolism and disposition: the biological fate of chemicals 20020701
Effects of soil pH and soil water content on prosulfuron dissipation. Journal of agricultural and food chemistry 20020522
Enantiomeric separation of a thiazolbenzenesulfonamide compound using packed-column subcritical fluid chromatography. Chirality 20020515
Synthesis of unsymmetrical aroyl acyl imides by aminocarbonylation of aryl bromides. The Journal of organic chemistry 20020125
Rational determination of transfer free energies of small drugs across the water-oil interface. Journal of medicinal chemistry 20020103
Synthesis, characterization and antifungal activities of some benzenesulphonylamino acid derivatives. Bollettino chimico farmaceutico 20020101
Synthesis and anti-HIV activity of 4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene) amino]-N(4,6-dimethyl-2-pyrimidinyl)-benzene sulfonamide and its derivatives. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20011201
Comparative study of new benzenesulphonamide fluoroquinolones structurally related to ciprofloxacin against selected ciprofloxacin-susceptible and -resistant Gram-positive cocci. The Journal of antimicrobial chemotherapy 20011101
Subtle differences in dissociation rates of interactions between destabilized human carbonic anhydrase II mutants and immobilized benzenesulfonamide inhibitors probed by a surface plasmon resonance biosensor. Analytical biochemistry 20010915
Two isomorphous benzenesulfonamide crystal structures determined by intermolecular C-H...O, C-H...pi and C-H...Cl interactions. Acta crystallographica. Section C, Crystal structure communications 20010901
Synthesis of optically active N-(2-pyridyloxiran-2-ylmethyl) benzenesulfonamide derivatives and their herbicidal activity. Bioscience, biotechnology, and biochemistry 20010701
Ethenesulfonamide derivatives, a novel class of orally active endothelin-A receptor antagonists. Chemical & pharmaceutical bulletin 20010501
QSAR of antineoplastics IV: Hansch analysis of N-(7-indolyl)benzenesulfonamides against KB human nasopharynx carcinoma, colon 38 murine adenocarcinoma and P388 murine leukemia cell lines. Drug design and discovery 20010101
QSAR of antineoplastics V: Exploration of receptor interaction sites of antitumor N-(7-indolyl)benzenesulfonamides targeting GI phase using electrotopological state atom index. Drug design and discovery 20010101
Design and synthesis of benzoic acid derivatives as influenza neuraminidase inhibitors using structure-based drug design. Journal of medicinal chemistry 19971205
Properties