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Avanafil

CAS No.:
330784-47-9
Catalog Number:
AG0034HA
Molecular Formula:
C23H26ClN7O3
Molecular Weight:
483.9506
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
>99%(HPLC)
In Stock USA
United States
$47
- +
25mg
>99%(HPLC)
In Stock USA
United States
$129
- +
1g
95%
In Stock USA
United States
$169
- +
Product Description
Catalog Number:
AG0034HA
Chemical Name:
Avanafil
CAS Number:
330784-47-9
Molecular Formula:
C23H26ClN7O3
Molecular Weight:
483.9506
MDL Number:
MFCD11977961
IUPAC Name:
4-[(3-chloro-4-methoxyphenyl)methylamino]-2-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-N-(pyrimidin-2-ylmethyl)pyrimidine-5-carboxamide
InChI:
InChI=1S/C23H26ClN7O3/c1-34-19-6-5-15(10-18(19)24)11-27-21-17(22(33)28-13-20-25-7-3-8-26-20)12-29-23(30-21)31-9-2-4-16(31)14-32/h3,5-8,10,12,16,32H,2,4,9,11,13-14H2,1H3,(H,28,33)(H,27,29,30)/t16-/m0/s1
InChI Key:
WEAJZXNPAWBCOA-INIZCTEOSA-N
SMILES:
OC[C@@H]1CCCN1c1ncc(c(n1)NCc1ccc(c(c1)Cl)OC)C(=O)NCc1ncccn1
UNII:
DR5S136IVO
Properties
Complexity:
642  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
483.179g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
483.957g/mol
Monoisotopic Mass:
483.179g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
125A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.6  
Literature
Title Journal
An update on pharmacological treatment of erectile dysfunction with phosphodiesterase type 5 inhibitors. Expert opinion on pharmacotherapy 20130701
Avanafil for the treatment of erectile dysfunction: initial data and clinical key properties. Therapeutic advances in urology 20130201
Avanafil for the treatment of erectile dysfunction: a multicenter, randomized, double-blind study in men with diabetes mellitus. Mayo Clinic proceedings 20120901
Re: Efficacy and safety of avanafil for treating erectile dysfunction: results of a multicentre, randomized, double-blind, placebo-controlled trial. The Journal of urology 20120901
Avanafil, a potent and highly selective phosphodiesterase-5 inhibitor for erectile dysfunction. The Journal of urology 20120801
Efficacy and satisfaction rates of oral PDE5is in the treatment of erectile dysfunction secondary to spinal cord injury: a review of literature. The journal of spinal cord medicine 20120701
FDA approves new ED remedy. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20120601
A randomized, double-blind, placebo-controlled evaluation of the safety and efficacy of avanafil in subjects with erectile dysfunction. The journal of sexual medicine 20120401
Avanafil for the treatment of erectile dysfunction. Drugs of today (Barcelona, Spain : 1998) 20120101
Avanafil for treatment of erectile dysfunction: review of its potential. Vascular health and risk management 20120101
cGMP Signaling, Phosphodiesterases and Major Depressive Disorder. Current neuropharmacology 20111201
Novel phosphodiesterase type 5 modulators: a patent survey (2008 - 2010). Expert opinion on therapeutic patents 20111001
Phosphodiesterase (PDE) inhibitors in the treatment of lower urinary tract dysfunction. British journal of clinical pharmacology 20110801
Future prospects in the treatment of erectile dysfunction: focus on avanafil. Drug design, development and therapy 20110101
Avanafil, a new rapid-onset phosphodiesterase 5 inhibitor for the treatment of erectile dysfunction. Expert opinion on investigational drugs 20101101
Tolerability and pharmacokinetics of avanafil, a phosphodiesterase type 5 inhibitor: a single- and multiple-dose, double-blind, randomized, placebo-controlled, dose-escalation study in healthy Korean male volunteers. Clinical therapeutics 20100601
Diagnosis and treatment of erectile dysfunction--a practical update. Journal of medicine and life 20091115
Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. Psychopharmacology 20090101
Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress. Expert opinion on investigational drugs 20080601
Looking to the future for erectile dysfunction therapies. Drugs 20080101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20061201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20061001
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060901
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20040101
Properties