5-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,3-dihydro-1H-1,2,4-triazol-3-one
| Title | Journal |
|---|---|
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| Systems pharmacological analysis of drugs inducing stevens-johnson syndrome and toxic epidermal necrolysis. | Chemical research in toxicology 20150518 |
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| Differential time course of action of 5-HT3 and NK1 receptor antagonists when used with highly and moderately emetogenic chemotherapy (HEC and MEC). | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110901 |
| Palonosetron plus 3-day aprepitant and dexamethasone to prevent nausea and vomiting in patients receiving highly emetogenic chemotherapy. | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer 20110801 |
| Pemirolast reduces cisplatin-induced kaolin intake in rats. | European journal of pharmacology 20110701 |
| [Retrospective analysis of antiemetic effect in patients receiving cisplatin]. | Gan to kagaku ryoho. Cancer & chemotherapy 20110701 |
| The involvement of TRPA1 channel activation in the inflammatory response evoked by topical application of cinnamaldehyde to mice. | Life sciences 20110620 |
| Single-dose fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting associated with cisplatin therapy: randomized, double-blind study protocol--EASE. | Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20110410 |
| Discovery and biological characterization of (2R,4S)-1'-acetyl-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4,4'-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) receptor antagonist clinical candidate. | Journal of medicinal chemistry 20110224 |
| Multicenter, phase II, placebo-controlled, double-blind, randomized study of aprepitant in Japanese patients receiving high-dose cisplatin. | Cancer science 20101101 |
| Case report: delirium due to a diltiazem-fentanyl CYP3A4 drug interaction. | General hospital psychiatry 20100101 |
| The tachykinin NK3 receptor agonist senktide induces locomotor activity in male Mongolian gerbils. | European journal of pharmacology 20081214 |
| Characterization of the occurrence of ifosfamide-induced neurotoxicity with concomitant aprepitant. | Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners 20080901 |
| Metalloelastase in lungs and alveolar macrophages is modulated by extracellular substance P in mice. | American journal of physiology. Lung cellular and molecular physiology 20080701 |
| Antiemetic neurokinin-1 antagonist aprepitant and ifosfamide-induced encephalopathy. | Annals of oncology : official journal of the European Society for Medical Oncology 20070401 |
| Central neurocircuitry associated with emesis. | The American journal of medicine 20011203 |
| Phosphorylated morpholine acetal human neurokinin-1 receptor antagonists as water-soluble prodrugs. | Journal of medicinal chemistry 20000323 |
| Structural optimization affording 2-(R)-(1-(R)-3, 5-bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a potent, orally active, long-acting morpholine acetal human NK-1 receptor antagonist. | Journal of medicinal chemistry 19981105 |