Aicar
| Title | Journal |
|---|---|
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Impact of glucagon-like peptide-1 (7-36) amide, isosteviol and 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside on leucine-mediated α-cell dysfunction. | Diabetes, obesity & metabolism 20121101 |
| Surgery: No benefit of acadesine in CABG. | Nature reviews. Cardiology 20120901 |
| Effect of adenosine-regulating agent acadesine on morbidity and mortality associated with coronary artery bypass grafting: the RED-CABG randomized controlled trial. | JAMA 20120711 |
| Suppression of adipose lipolysis by long-chain fatty acid analogs. | Journal of lipid research 20120501 |
| Inhibition of AMP-activated protein kinase α (AMPKα) by doxorubicin accentuates genotoxic stress and cell death in mouse embryonic fibroblasts and cardiomyocytes: role of p53 and SIRT1. | The Journal of biological chemistry 20120309 |
| 5-Aminoimidazole-4-carboxyamide ribonucleoside induces G(1)/S arrest and Nanog downregulation via p53 and enhances erythroid differentiation. | Stem cells (Dayton, Ohio) 20120201 |
| Novel approach to meta-analysis of microarray datasets reveals muscle remodeling-related drug targets and biomarkers in Duchenne muscular dystrophy. | PLoS computational biology 20120201 |
| Post-treatment with the combination of 5-aminoimidazole-4-carboxyamide ribonucleoside and carnitine improves renal function after ischemia/reperfusion injury. | Shock (Augusta, Ga.) 20120101 |
| Metabolomics of the effect of AMPK activation by AICAR on human umbilical vein endothelial cells. | International journal of molecular medicine 20120101 |
| 5-aminoimidazole-4-carboxamide riboside enhances effect of ionizing radiation in PC3 prostate cancer cells. | International journal of radiation oncology, biology, physics 20111201 |
| Activated AMPK inhibits PPAR-{alpha} and PPAR-{gamma} transcriptional activity in hepatoma cells. | American journal of physiology. Gastrointestinal and liver physiology 20111001 |
| Deficiency of insulin-like growth factor 1 reduces vulnerability to chronic alcohol intake-induced cardiomyocyte mechanical dysfunction: role of AMPK. | Journal of cellular and molecular medicine 20110801 |
| Acute therapeutic use of 5-aminoimidazole-4-carboxamide ribonucleoside extends survival interval in response to severe hemorrhagic shock. | Shock (Augusta, Ga.) 20110801 |
| Activation of AMP-activated protein kinase may not be involved in AICAR- and metformin-mediated meiotic arrest in bovine denuded and cumulus-enclosed oocytes in vitro. | Zygote (Cambridge, England) 20110501 |
| Glucosensing by GnRH neurons: inhibition by androgens and involvement of AMP-activated protein kinase. | Molecular endocrinology (Baltimore, Md.) 20110501 |
| Genistein, resveratrol, and 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside induce cytochrome P450 4F2 expression through an AMP-activated protein kinase-dependent pathway. | The Journal of pharmacology and experimental therapeutics 20110401 |
| Contraction-induced skeletal muscle FAT/CD36 trafficking and FA uptake is AMPK independent. | Journal of lipid research 20110401 |
| Enhancement of extracellular purine nucleoside accumulation by Bacillus strains through genetic modifications of genes involved in nucleoside export. | Journal of industrial microbiology & biotechnology 20110101 |
| Potential role of adenosine monophosphate-activated protein kinase in regulation of energy metabolism in dairy goat mammary epithelial cells. | Journal of dairy science 20110101 |
| Novel trends in the treatment of cardiovascular disorders: site- and event- selective adenosinergic drugs. | Current medicinal chemistry 20110101 |
| AICAR induces apoptosis independently of AMPK and p53 through up-regulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells. | Blood 20101021 |
| Studies on ligand binding to histidine triad nucleotide binding protein 1. | Bioorganic & medicinal chemistry 20100915 |
| Peroxisome proliferator-activated receptor gamma coactivator 1alpha or 1beta overexpression inhibits muscle protein degradation, induction of ubiquitin ligases, and disuse atrophy. | The Journal of biological chemistry 20100618 |
| Avoiding stroke during cardiac surgery. | Seminars in cardiothoracic and vascular anesthesia 20100601 |
| Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. | Arteriosclerosis, thrombosis, and vascular biology 20100501 |
| AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies. | Expert opinion on investigational drugs 20100401 |
| AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC. | American journal of physiology. Endocrinology and metabolism 20100201 |
| Germline deletion of AMP-activated protein kinase beta subunits reduces bone mass without altering osteoclast differentiation or function. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20100101 |
| AICAR (5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside) increases the production of toxic molecules and affects the profile of cytokines release in LPS-stimulated rat primary microglial cultures. | Neurotoxicology 20100101 |
| Whole blood transcriptomics in cardiac surgery identifies a gene regulatory network connecting ischemia reperfusion with systemic inflammation. | PloS one 20100101 |
| AMP-activated protein kinase enhances the expression of muscle-specific ubiquitin ligases despite its activation of IGF-1/Akt signaling in C2C12 myotubes. | Journal of cellular biochemistry 20091001 |
| Intra-arterial AICA-riboside administration induces NO-dependent vasodilation in vivo in human skeletal muscle. | American journal of physiology. Endocrinology and metabolism 20090901 |
| Adenosine and adenosine receptors: Newer therapeutic perspective. | Indian journal of pharmacology 20090601 |
| Blunting of AICAR-induced human skeletal muscle glucose uptake in type 2 diabetes is dependent on age rather than diabetic status. | American journal of physiology. Endocrinology and metabolism 20090501 |
| The regulation of p53 by phosphorylation: a model for how distinct signals integrate into the p53 pathway. | Aging 20090501 |
| AMP-activated protein kinase pathway: a potential therapeutic target in cardiometabolic disease. | Clinical science (London, England : 1979) 20090401 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20090301 |
| Kinase activity-independent suppression of p73alpha by AMP-activated kinase alpha (AMPKalpha). | Oncogene 20090219 |
| Beyond AICA riboside: in search of new specific AMP-activated protein kinase activators. | IUBMB life 20090101 |
| AICAR activates the pluripotency transcriptional network in embryonic stem cells and induces KLF4 and KLF2 expression in fibroblasts. | BMC pharmacology 20090101 |
| Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death. | PloS one 20090101 |
| Is ZMP the toxic metabolite in Lesch-Nyhan disease? | Medical hypotheses 20081101 |
| The need for a multi-level biochemical approach to defeat cancer that will also support the host. | Medical hypotheses 20081001 |
| Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance. | Reproduction (Cambridge, England) 20080901 |
| Acadesine, an adenosine-regulating agent with the potential for widespread indications. | Expert opinion on pharmacotherapy 20080801 |
| Role of AMP-activated protein kinase in autophagy and proteasome function. | Biochemical and biophysical research communications 20080509 |
| Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 gene expression by 5-aminoimidazole-4-carboxamide riboside is independent of AMP-activated protein kinase. | Journal of cellular biochemistry 20080215 |
| Acadesine: AICA riboside, ARA 100, arasine, GP 1 110. | Drugs in R&D 20080101 |
| Macropinocytosis is decreased in diabetic mouse macrophages and is regulated by AMPK. | BMC immunology 20080101 |
| 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICA-riboside) as a targeting agent for therapy of patients with acute lymphoblastic leukemia: are we there and are there pitfalls? | Journal of pediatric hematology/oncology 20071201 |
| The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells. | Journal of molecular endocrinology 20071001 |
| Ischemic preconditioning: protection against myocardial necrosis and apoptosis. | Vascular health and risk management 20071001 |
| A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. | Brain research 20070907 |
| 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men. | Diabetes 20070801 |
| 5-Aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside stimulates tyrosine hydroxylase activity and catecholamine secretion by activation of AMP-activated protein kinase in PC12 cells. | Journal of neuroendocrinology 20070801 |
| Covariate heterogeneity in meta-analysis: criteria for deciding between meta-regression and individual patient data. | Statistics in medicine 20070710 |
| AMP-activated protein kinase-independent inhibition of hepatic mitochondrial oxidative phosphorylation by AICA riboside. | The Biochemical journal 20070615 |
| Methotrexate and erythro-9-(2-hydroxynon-3-yl) adenine therapy for rat adjuvant arthritis and the effect of methotrexate on in vivo purine metabolism. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070601 |
| Interference with energy metabolism by 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside induces HPV suppression in cervical carcinoma cells and apoptosis in the absence of LKB1. | The Biochemical journal 20070501 |
| 5-Aminoimidazole-4-carboxamide riboside sensitizes TRAIL- and TNF{alpha}-induced cytotoxicity in colon cancer cells through AMP-activated protein kinase signaling. | Molecular cancer therapeutics 20070501 |
| Effect of acute activation of 5'-AMP-activated protein kinase on glycogen regulation in isolated rat skeletal muscle. | Journal of applied physiology (Bethesda, Md. : 1985) 20070301 |
| A role for AMP-activated protein kinase in diabetes-induced renal hypertrophy. | American journal of physiology. Renal physiology 20070201 |
| Metabolic signature of breast cancer cell line MCF-7: profiling of modified nucleosides via LC-IT MS coupling. | BMC biochemistry 20070101 |
| Diagnosing AICA-ribosiduria by capillary electrophoresis. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20061020 |
| Methotrexate enhances the antianabolic and antiproliferative effects of 5-aminoimidazole-4-carboxamide riboside. | Molecular cancer therapeutics 20060901 |
| Post-reperfusion myocardial infarction: long-term survival improvement using adenosine regulation with acadesine. | Journal of the American College of Cardiology 20060704 |
| Moving preconditioning from bench to bedside. | Journal of the American College of Cardiology 20060704 |
| Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation. | Diabetes 20060601 |
| Adiponectin suppression of high-glucose-induced reactive oxygen species in vascular endothelial cells: evidence for involvement of a cAMP signaling pathway. | Diabetes 20060601 |
| MDM2 antagonists activate p53 and synergize with genotoxic drugs in B-cell chronic lymphocytic leukemia cells. | Blood 20060515 |
| Relationship between 5-aminoimidazole-4-carboxamide-ribotide and AMP-activated protein kinase activity in the perfused mouse heart. | American journal of physiology. Heart and circulatory physiology 20060301 |
| α2 isoform-specific activation of 5'adenosine monophosphate-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-β-D-ribonucleoside at a physiological level activates glucose transport and increases glucose transporter 4 in mouse skeletal muscle. | Metabolism: clinical and experimental 20060301 |
| A3 adenosine receptors and mitogen-activated protein kinases in lung injury following in vivo reperfusion. | Critical care (London, England) 20060101 |
| AMPK or ZMPK? | Medical hypotheses 20060101 |
| Analysis of intracellular nucleotides by capillary electrophoresis-mass spectrometry. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Synthesis and mass spectrometric fragmentation characteristics of imidazole ribosides-analogs of intermediates of purine de novo synthetic pathway. | Nucleosides, nucleotides & nucleic acids 20060101 |
| 5 '-Amino-4-imidazolecarboxamide riboside induces apoptosis in human neuroblastoma cells via the mitochondrial pathway. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Anti-lipolytic action of AMP-activated protein kinase in rodent adipocytes. | The Journal of biological chemistry 20050701 |
| Combination of 5-fluorouracil and genistein induces apoptosis synergistically in chemo-resistant cancer cells through the modulation of AMPK and COX-2 signaling pathways. | Biochemical and biophysical research communications 20050701 |
| AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells. | Biochemical and biophysical research communications 20050701 |
| Enhanced insulin-stimulated glycogen synthesis in response to insulin, metformin or rosiglitazone is associated with increased mRNA expression of GLUT4 and peroxisomal proliferator activator receptor gamma co-activator 1. | Diabetologia 20050601 |
| 5-amino-imidazole carboxamide riboside acutely potentiates glucose-stimulated insulin secretion from mouse pancreatic islets by KATP channel-dependent and -independent pathways. | Biochemical and biophysical research communications 20050520 |
| Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. | Cancer research 20050315 |
| AMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell line. | The Journal of biological chemistry 20050211 |
| Acadesine induces apoptosis in B cells from mantle cell lymphoma and splenic marginal zone lymphoma. | Leukemia 20050201 |
| Mechanism of action of Escherichia coli phosphoribosylaminoimidazolesuccinocarboxamide synthetase. | Biochemistry 20050118 |
| 5-aminoimidazole-4-carboxamide riboside (AICAR) enhances GLUT2-dependent jejunal glucose transport: a possible role for AMPK. | The Biochemical journal 20050115 |
| Synthesis of 3-aminoimidazo[4,5-c]pyrazole nucleoside via the N-N bond formation strategy as a [5:5] fused analog of adenosine. | Nucleosides, nucleotides & nucleic acids 20050101 |
| Intracerebroventricular infusion of glucose, insulin, and the adenosine monophosphate-activated kinase activator, 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside, controls muscle glycogen synthesis. | Endocrinology 20040901 |
| AMP-activated protein kinase: the guardian of cardiac energy status. | The Journal of clinical investigation 20040816 |
| AMP-activated protein kinase plays a role in the control of food intake. | The Journal of biological chemistry 20040326 |
| AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. | Journal of neurochemistry 20040301 |
| Okadaic acid-induced, naringin-sensitive phosphorylation of glycine N-methyltransferase in isolated rat hepatocytes. | The Biochemical journal 20030715 |
| Acadesine activates AMPK and induces apoptosis in B-cell chronic lymphocytic leukemia cells but not in T lymphocytes. | Blood 20030501 |
| AMP-activated protein kinase can induce apoptosis of insulin-producing MIN6 cells through stimulation of c-Jun-N-terminal kinase. | Journal of molecular endocrinology 20030401 |
| 5-Aminoimidazole-4-carboxamide riboside induces apoptosis in Jurkat cells, but the AMP-activated protein kinase is not involved. | The Biochemical journal 20030315 |
| AICA-riboside induces apoptosis of pancreatic beta cells through stimulation of AMP-activated protein kinase. | Diabetologia 20030201 |
| 5'-aminoimidazole-4-carboxamide riboside induces apoptosis in human neuroblastoma cells. | Neuroscience 20030101 |
| Protein kinase inhibitors block the stimulation of the AMP-activated protein kinase by 5-amino-4-imidazolecarboxamide riboside. | FEBS letters 20021106 |
| Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis. | Current biology : CB 20020820 |
| Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. | Biochemical and biophysical research communications 20020816 |
| Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes. | Current drug targets. Immune, endocrine and metabolic disorders 20020701 |
| Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells. | The Biochemical journal 20020401 |
| Glycogen-dependent effects of 5-aminoimidazole-4-carboxamide (AICA)-riboside on AMP-activated protein kinase and glycogen synthase activities in rat skeletal muscle. | Diabetes 20020201 |
| 5'-AMP-activated protein kinase phosphorylates IRS-1 on Ser-789 in mouse C2C12 myotubes in response to 5-aminoimidazole-4-carboxamide riboside. | The Journal of biological chemistry 20011214 |
| Activation of acetyl-CoA carboxylase by a glutamate- and magnesium-sensitive protein phosphatase in the islet beta-cell. | Diabetes 20010701 |
| The protective effect of acadesine on lung ischemia-reperfusion injury. | Anesthesia and analgesia 20010301 |
| Effect of 5-aminoimidazole-4-carboxamide riboside (AICA-r) on isolated thoracic aorta responses in streptozotocin-diabetic rats. | Journal of basic and clinical physiology and pharmacology 20010101 |
| AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. | The American journal of physiology 19990701 |
| Acadesine: a unique cardioprotective agent for myocardial ischemia. | Heart disease (Hagerstown, Md.) 19990101 |
| AICA riboside increases AMP-activated protein kinase, fatty acid oxidation, and glucose uptake in rat muscle. | The American journal of physiology 19971201 |
| Acadesine: a new drug that may improve myocardial protection in coronary artery bypass grafting. Results of the first international multicenter study. Multinational Acadesine Study Group. | The Journal of thoracic and cardiovascular surgery 19951001 |
| 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? | European journal of biochemistry 19950415 |
| Acadesine (AICA-riboside): disposition and metabolism of an adenosine-regulating agent. | Journal of clinical pharmacology 19931001 |
| Detection of 5'-phosphoribosyl-4-(N-succinylcarboxamide)-5-aminoimidazole in urine by use of the Bratton-Marshall reaction: identification of patients deficient in adenylosuccinate lyase activity. | Analytical biochemistry 19860701 |