Home Other Building Blocks 9H-Pyrido[3,4-b]indole

9H-Pyrido[3,4-b]indole

CAS No.:
244-63-3
Catalog Number:
AG0034F8
Molecular Formula:
C11H8N2
Molecular Weight:
168.1946
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
97%
In Stock USA
United States
$75
- +
5g
97%
In Stock USA
United States
$282
- +
10g
97%
In Stock USA
United States
$507
- +
Product Description
Catalog Number:
AG0034F8
Chemical Name:
9H-Pyrido[3,4-b]indole
CAS Number:
244-63-3
Molecular Formula:
C11H8N2
Molecular Weight:
168.1946
MDL Number:
MFCD00004956
IUPAC Name:
9H-pyrido[3,4-b]indole
InChI:
InChI=1S/C11H8N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-7,13H
InChI Key:
AIFRHYZBTHREPW-UHFFFAOYSA-N
SMILES:
c1ccc2c(c1)[nH]c1c2ccnc1
EC Number:
205-959-0
UNII:
94HMA1I78O
NSC Number:
84417
Properties
Complexity:
193  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
168.069g/mol
Formal Charge:
0
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
168.199g/mol
Monoisotopic Mass:
168.069g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
28.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor. Toxicology and applied pharmacology 20170515
Monoamine oxidase inhibitory activity in tobacco particulate matter: Are harman and norharman the only physiologically relevant inhibitors? Neurotoxicology 20170301
Inhibition of the aryl hydrocarbon receptor prevents Western diet-induced obesity. Model for AHR activation by kynurenine via oxidized-LDL, TLR2/4, TGFβ, and IDO1. Toxicology and applied pharmacology 20160601
Content of heterocyclic amines and polycyclic aromatic hydrocarbons in pork, beef and chicken barbecued at home by Danish consumers. Meat science 20130101
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
Antioxidant capacity and inhibitory effect of grape seed and rosemary extract in marinades on the formation of heterocyclic amines in fried beef patties. Food chemistry 20120915
Detection of bioactive exometabolites produced by the filamentous marine cyanobacterium Geitlerinema sp. Marine biotechnology (New York, N.Y.) 20120801
Beta-carboline alkaloids derived from the ascidian Synoicum sp. Bioorganic & medicinal chemistry 20120701
6-Meth-oxy-1-(4-meth-oxy-phen-yl)-1,2,3,4-tetra-hydro-9H-β-carbolin-2-ium acetate. Acta crystallographica. Section E, Structure reports online 20120501
Charged behaviour from neutral ligands: synthesis and properties of N-heterocyclic pseudo-amides. Chemistry (Weinheim an der Bergstrasse, Germany) 20120402
Bis(6-meth-oxy-1-methyl-2,3,4,9-tetra-hydro-1H-β-carbolin-2-ium) tetra-chloridozincate(II) dihydrate. Acta crystallographica. Section E, Structure reports online 20120401
Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorganic & medicinal chemistry letters 20120301
Effects of apomorphine and β-carbolines on firing rate of neurons in the ventral pallidum in the rats. Behavioural brain research 20120201
Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen. Bioorganic & medicinal chemistry 20120201
Vitamin e supplementation with rauwolfia vomitoria root bark extract improves hematological indices. North American journal of medical sciences 20120201
Administration of harmine and imipramine alters creatine kinase and mitochondrial respiratory chain activities in the rat brain. Depression research and treatment 20120101
New acetylcholinesterase inhibitors for Alzheimer's disease. International journal of Alzheimer's disease 20120101
The role of circulating serotonin in the development of chronic obstructive pulmonary disease. PloS one 20120101
Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PloS one 20120101
Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology. International journal of molecular sciences 20120101
Secondary Metabolites from Plants Inhibiting ABC Transporters and Reversing Resistance of Cancer Cells and Microbes to Cytotoxic and Antimicrobial Agents. Frontiers in microbiology 20120101
JKA97, a novel benzylidene analog of harmine, exerts anti-cancer effects by inducing G1 arrest, apoptosis, and p53-independent up-regulation of p21. PloS one 20120101
Mouse models of Down syndrome as a tool to unravel the causes of mental disabilities. Neural plasticity 20120101
Intracerebral injection of low amounts of norharman induces moderate Parkinsonism-like behavioral symptoms in rat. Neurotoxicology and teratology 20120101
Formation of heterocyclic amines during cooking of duck meat. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20120101
A series of beta-carboline derivatives inhibit the kinase activity of PLKs. PloS one 20120101
Molecular insights into human monoamine oxidase (MAO) inhibition by 1,4-naphthoquinone: evidences for menadione (vitamin K3) acting as a competitive and reversible inhibitor of MAO. Bioorganic & medicinal chemistry 20111215
Beta-carboline-3-carboxamide derivatives as promising antileishmanial agents. Annals of tropical medicine and parasitology 20111201
Molecular analysis and structure-activity relationship modeling of the substrate/inhibitor interaction site of plasma membrane monoamine transporter. The Journal of pharmacology and experimental therapeutics 20111101
Synthesis, structures, cellular uptake and apoptosis-inducing properties of highly cytotoxic ruthenium-Norharman complexes. Dalton transactions (Cambridge, England : 2003) 20110914
The Arabidopsis phi class glutathione transferase AtGSTF2: binding and regulation by biologically active heterocyclic ligands. The Biochemical journal 20110815
Inhibition of the bioactivation of the neurotoxin MPTP by antioxidants, redox agents and monoamine oxidase inhibitors. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110801
[Simultaneous determination of 9 heterocyclic aromatic amine in poultry products by solid-phase extraction-high performance liquid chromatography]. Se pu = Chinese journal of chromatography 20110801
In vitro and in vivo activities of Peganum harmala extract against Leishmania major. Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences 20110801
Dietary inhibitors of monoamine oxidase A. Journal of neural transmission (Vienna, Austria : 1996) 20110701
β-Carboline (norharman). Acta crystallographica. Section C, Crystal structure communications 20110701
[Fingerprint research and multi-component quantitative analysis of Kumu injection by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701
Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology 20110601
The inhibition activity of selected beta-carboline alkaloids on enzymes of acetylcholinesterase and butyrylcholinesterase. Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20110601
SPE/RP-HPLC using C1 columns: an environmentally friendly alternative to conventional reverse-phase separations for quantitation of beta-carboline alkaloids in human serum samples. Analytical and bioanalytical chemistry 20110401
Effects of harmane and other β-carbolines on apomorphine-induced licking behavior in rat. Pharmacology, biochemistry, and behavior 20110401
Screening of non-polar heterocyclic amines in urine by microextraction in packed sorbent-fluorimetric detection and confirmation by capillary liquid chromatography. Talanta 20110215
Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. Bioorganic & medicinal chemistry 20110215
3-benzylamino-β-carboline derivatives induce apoptosis through G2/M arrest in human carcinoma cells HeLa S-3. European journal of medicinal chemistry 20110201
Hazardous compounds in tobacco smoke. International journal of environmental research and public health 20110201
Effects of spider venom toxin PWTX-I (6-Hydroxytrypargine) on the central nervous system of rats. Toxins 20110201
Norharmane: old yet highly selective dual channel ratiometric fluoride and hydrogen sulfate ion sensor. The Analyst 20110121
The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease. International journal of molecular sciences 20110101
Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO). PloS one 20110101
Analysis of additivity and synergism in the anti-plasmodial effect of purified compounds from plant extracts. Malaria journal 20110101
Harmine activates intrinsic and extrinsic pathways of apoptosis in B16F-10 melanoma. Chinese medicine 20110101
Antioxidant activity of beta-carboline derivatives. Acta poloniae pharmaceutica 20110101
Synthesis of 1-substituted carbazolyl-1,2,3,4-tetrahydro- and carbazolyl-3,4-dihydro-β-carboline analogs as potential antitumor agents. Marine drugs 20110101
β-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sites. PloS one 20110101
Antibacterial activity of some selected medicinal plants of Pakistan. BMC complementary and alternative medicine 20110101
Impact of synaptic neurotransmitter concentration time course on the kinetics and pharmacological modulation of inhibitory synaptic currents. Frontiers in cellular neuroscience 20110101
Blood harmane concentrations in 497 individuals relative to coffee, cigarettes, and food consumption on the morning of testing. Journal of toxicology 20110101
Phenobarbital but Not Diazepam Reduces AMPA/kainate Receptor Mediated Currents and Exerts Opposite Actions on Initial Seizures in the Neonatal Rat Hippocampus. Frontiers in cellular neuroscience 20110101
Comparative Effects of α-, β-, and γ-Carbolines on Platelet Aggregation and Lipid Membranes. Journal of toxicology 20110101
Studies on anti-metastatic and anti-invasive effects of harmine using highly metastatic murine B16F-10 melanoma cells. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20110101
Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model. Advances in pharmacological sciences 20110101
Kinase inhibitors from marine sponges. Marine drugs 20110101
Recently confirmed apoptosis-inducing lead compounds isolated from marine sponge of potential relevance in cancer treatment. Marine drugs 20110101
Long term exposure to norharman exacerbates 6-hydroxydopamine-induced parkinsonism: possible involvement of L-type Ca2+ channels. Behavioural brain research 20101220
Harmine inhibits tumour specific neo-vessel formation by regulating VEGF, MMP, TIMP and pro-inflammatory mediators both in vivo and in vitro. European journal of pharmacology 20101215
Anti-oxidant and Anti-hypercholesterolemic Activities of Wasabia japonica. Evidence-based complementary and alternative medicine : eCAM 20101201
Beta-carboline alkaloids harmaline and harmalol induce melanogenesis through p38 mitogen-activated protein kinase in B16F10 mouse melanoma cells. BMB reports 20101201
Capillary liquid chromatography with diode array and mass spectrometry detection for heterocyclic aromatic amine determination in ready-to-eat food treated with electron-beam irradiation. Journal of chromatography. A 20101022
Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects. Fitoterapia 20101001
Fractionation and identification of organic nitrogen species from bio-oil produced by fast pyrolysis of sewage sludge. Bioresource technology 20101001
Synthesis and bioactivity of beta-carboline derivatives. Natural product communications 20101001
Beta-carboline alkaloids bind DNA. Journal of photochemistry and photobiology. B, Biology 20100802
Regulation of dioxin receptor function by different beta-carboline alkaloids. Archives of toxicology 20100801
Synthesis and evaluation of beta-carboline derivatives as inhibitors of human immunodeficiency virus. Bioorganic & medicinal chemistry letters 20100801
Eudistomidin G, a new beta-carboline alkaloid from the Okinawan marine tunicate Eudistoma glaucus and structure revision of eudistomidin B. Bioorganic & medicinal chemistry letters 20100715
Kinesin spindle protein (KSP) inhibitors with 2,3-fused indole scaffolds. Journal of medicinal chemistry 20100708
Simultaneous determination of six non-polar heterocyclic amines in meat samples by supercritical fluid extraction-capillary electrophoresis under fluorimetric detection. Electrophoresis 20100701
Construction of indole- and isoquinoline-fused nitrogen-containing heterocycles through copper-catalyzed multi-component reaction. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20100701
Photosensitized cleavage of plasmidic DNA by norharmane, a naturally occurring beta-carboline. Organic & biomolecular chemistry 20100607
Tandem intramolecular photocycloaddition-retro-Mannich fragmentation as a route to spiro[pyrrolidine-3,3'-oxindoles]. Total synthesis of (+/-)-coerulescine, (+/-)-horsfiline, (+/-)-elacomine, and (+/-)-6-deoxyelacomine. The Journal of organic chemistry 20100604
Design, synthesis and 3D-QSAR of beta-carboline derivatives as potent antitumor agents. European journal of medicinal chemistry 20100601
Beta-carboline alkaloids from the stems of Picrasma quassioides. Magnetic resonance in chemistry : MRC 20100601
Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. Journal of medicinal chemistry 20100513
A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency. Journal of medicinal chemistry 20100422
Synthesis and cytotoxic evaluation of N2-benzylated quaternary beta-carboline amino acid ester conjugates. European journal of medicinal chemistry 20100401
Electrophysiological characterization of harmane-induced activation of mesolimbic dopamine neurons. European journal of pharmacology 20100310
Electrospray MS-based characterization of beta-carbolines--mutagenic constituents of thermally processed meat. Molecular nutrition & food research 20100301
beta-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20100301
Context dependent benzodiazepine modulation of GABA(A) receptor opening frequency. Current neuropharmacology 20100301
A beta-carboline alkaloid from the Papua New Guinea marine sponge hyrtios reticulatus. Journal of natural products 20100226
The beta-carboline alkaloid harmine inhibits BCRP and can reverse resistance to the anticancer drugs mitoxantrone and camptothecin in breast cancer cells. Phytotherapy research : PTR 20100101
Substituted tetrahydro-beta-carbolines as potential agents for the treatment of human papillomavirus infection. Bioorganic & medicinal chemistry letters 20100101
The effect of eurycoma longifolia Jack on spermatogenesis in estrogen-treated rats. Clinics (Sao Paulo, Brazil) 20100101
Marine drugs from sponge-microbe association--a review. Marine drugs 20100101
Disease resistance in the drywood termite, Incisitermes schwarzi: does nesting ecology affect immunocompetence? Journal of insect science (Online) 20100101
Are known cyanotoxins involved in the toxicity of picoplanktonic and filamentous North Atlantic marine cyanobacteria? Marine drugs 20100101
Investigation into the in vivo effects of five novel tacrine/ferulic acid and beta-carboline derivatives on scopolamine-induced cognitive impairment in rats using radial maze paradigm. Arzneimittel-Forschung 20100101
Beta-carboline alkaloids and essential tremor: exploring the environmental determinants of one of the most prevalent neurological diseases. TheScientificWorldJournal 20100101
Effects of cooking variables on formation of heterocyclic amines (HCA) in roasted pork and mackerel. Journal of toxicology and environmental health. Part A 20100101
Gene expression signature-based screening identifies new broadly effective influenza a antivirals. PloS one 20100101
Antiviral lead compounds from marine sponges. Marine drugs 20100101
Immense essence of excellence: marine microbial bioactive compounds. Marine drugs 20100101
Arylalkylamine-, beta-carboline-, quinolizine- and azecine-derived compounds and their in vitro interaction with the ionotropic 5-HT3 receptor: search for new lead structures. Arzneimittel-Forschung 20100101
Harmine and imipramine promote antioxidant activities in prefrontal cortex and hippocampus. Oxidative medicine and cellular longevity 20100101
A highly enantioselective access to tetrahydroisoquinoline and beta-carboline alkaloids with simple noyori-type catalysts in aqueous media. Chemistry (Weinheim an der Bergstrasse, Germany) 20091207
Hollow fibre-supported liquid membrane extraction and LC-MS/MS detection for the analysis of heterocyclic amines in urine samples. Molecular nutrition & food research 20091201
DH166, a beta-carboline derivative, inhibits the kinase activity of PLK1. Cancer biology & therapy 20091201
Structure-activity relationship studies of manzamine A: amidation of positions 6 and 8 of the beta-carboline moiety. Bioorganic & medicinal chemistry 20091115
Acute harmine administration induces antidepressive-like effects and increases BDNF levels in the rat hippocampus. Progress in neuro-psychopharmacology & biological psychiatry 20091113
Synthesis and antiviral activity of beta-carboline derivatives bearing a substituted carbohydrazide at C-3 against poliovirus and herpes simplex virus (HSV-1). European journal of medicinal chemistry 20091101
Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation. The FEBS journal 20091101
The Methyltetrahydro-{beta}-Carbolines in Maca (Lepidium meyenii). Evidence-based complementary and alternative medicine : eCAM 20090901
Molecular determinants of beta-carboline inhibition of the glycine receptor. Journal of neurochemistry 20090901
Tobacco mosaic virus (TMV) inhibitors from Picrasma quassioides Benn. Journal of agricultural and food chemistry 20090812
Carboline alkaloids from Trigonostemon lii. Planta medica 20090801
Photochemistry of norharmane in aqueous solution. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090801
Photophysics and rotational relaxation dynamics of a beta-carboline based fluorophore in cationic alkyltrimethylammonium bromide micelles. Journal of colloid and interface science 20090715
Preparation and characterisation of fried chicken as a laboratory reference material for the analysis of heterocyclic amines. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090715
Synthesis of hybrid analogues of caffeine and eudistomin D and its affinity for adenosine receptors. Bioorganic & medicinal chemistry 20090701
Harmol induces apoptosis by caspase-8 activation independently of Fas/Fas ligand interaction in human lung carcinoma H596 cells. Anti-cancer drugs 20090601
Tabernines A-C, beta-carbolines from the leaves of Tabernaemontana elegans. Journal of natural products 20090601
Advances in marine microbial symbionts in the china sea and related pharmaceutical metabolites. Marine drugs 20090601
Marine antimalarials. Marine drugs 20090601
Photophysics and rotational dynamics of a beta-carboline analogue in nonionic micelles: effect of variation of length of the headgroup and the tail of the surfactant. The journal of physical chemistry. B 20090528
Biological activity of 1,2,3,4-tetrahydro-beta-carboline-3-carboxamides against Trypanosoma cruzi. Acta tropica 20090401
5-Bromo-8-methoxy-1-methyl-beta-carboline, an alkaloid from the New Zealand marine bryozoan Pterocella vesiculosa. Journal of natural products 20090401
Dual emission of temperature-induced betacarboline self-associated hydrogen bond aggregates. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20090301
Analysis of heterocyclic amines and beta-carbolines by liquid chromatography-mass spectrometry in cooked meats commonly consumed in Korea. Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment 20090301
Synthesis and in vitro cytotoxic evaluation of novel 3,4,5-trimethoxyphenyl substituted beta-carboline derivatives. European journal of medicinal chemistry 20090201
The effect of temperature on the stability of compounds used as UV-MALDI-MS matrix: 2,5-dihydroxybenzoic acid, 2,4,6-trihydroxyacetophenone, alpha-cyano-4-hydroxycinnamic acid, 3,5-dimethoxy-4-hydroxycinnamic acid, nor-harmane and harmane. Journal of mass spectrometry : JMS 20090201
Zamamidines A and B, new manzamine alkaloids from the sponge Amphimedon species. Organic letters 20090101
Antiplatelet activity of beta-carboline alkaloids from Perganum harmala: a possible mechanism through inhibiting PLCgamma2 phosphorylation. Vascular pharmacology 20090101
Gas chromatographic analysis of dimethyltryptamine and beta-carboline alkaloids in ayahuasca, an Amazonian psychoactive plant beverage. Phytochemical analysis : PCA 20090101
Floral nectar composition of Peganum harmala L. Natural product research 20090101
beta-carboline alkaloid-enriched extract from the amazonian rain forest tree pao pereira suppresses prostate cancer cells. Journal of the Society for Integrative Oncology 20090101
Optimized HPLC method for analysis of polar and nonpolar heterocyclic amines in cooked meat products. Journal of AOAC International 20090101
Analysis of an RNA adduct formed from aminophenylnorharman. Nucleic acids symposium series (2004) 20090101
Synthesis of novel tadalafil analogues and their evaluation as phosphodiesterase inhibitors and anticancer agents. Arzneimittel-Forschung 20090101
Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation. PloS one 20090101
Smoking induces long-lasting effects through a monoamine-oxidase epigenetic regulation. PloS one 20090101
Acquired auditory-visual synesthesia: A window to early cross-modal sensory interactions. Psychology research and behavior management 20090101
Synthesis and cytotoxic activities of 1-benzylidine substituted beta-carboline derivatives. Bioorganic & medicinal chemistry letters 20081215
Parallel factor analysis of spider fluorophores. Journal of photochemistry and photobiology. B, Biology 20081211
Mana-Hox displays anticancer activity against prostate cancer cells through tubulin depolymerization and DNA damage stress. Naunyn-Schmiedeberg's archives of pharmacology 20081201
DYRK1A phosphorylates caspase 9 at an inhibitory site and is potently inhibited in human cells by harmine. The FEBS journal 20081201
The role of prior stressor controllability and the dorsal raphé nucleus in sucrose preference and social exploration. Behavioural brain research 20081103
3D and quantum QSAR of non-benzodiazepine compounds. European journal of medicinal chemistry 20081101
Antifungal activity of the termite alkaloid norharmane against the mycelial growth of Metarhizium anisopliae and Aspergillus nomius. Journal of invertebrate pathology 20081101
Effect of Peganum harmala or its beta-carboline alkaloids on certain antibiotic resistant strains of bacteria and protozoa from poultry. Phytotherapy research : PTR 20081101
Oxidative metabolism of the bioactive and naturally occurring beta-carboline alkaloids, norharman and harman, by human cytochrome P450 enzymes. Chemical research in toxicology 20081101
Metal-catalyzed reaction of N-(2-indolyl)methyl, N-bis(trimethylsilyl)methyl diazoamides: an entry into the beta-carboline ring system. Chemical communications (Cambridge, England) 20081021
Identification of N,N-dimethyltryptamine and beta-carbolines in psychotropic ayahuasca beverage. Biomedical chromatography : BMC 20081001
Furan oligomers and beta-carbolines from terrestrial streptomycetes. Journal of natural products 20080901
A versatile cyclodehydration reaction for the synthesis of isoquinoline and beta-carboline derivatives. Organic letters 20080821
A case of beta-carboline alkaloid intoxication following ingestion of Peganum harmala seed extract. Forensic science international 20080806
Cytotoxicity of the beta-carboline alkaloids harmine and harmaline in human cell assays in vitro. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080801
Potent and selective antiplasmodial activity of the cyanobacterial alkaloid nostocarboline and its dimers. Bioorganic & medicinal chemistry letters 20080801
The effects of rivastigmine plus selegiline on brain acetylcholinesterase, (Na, K)-, Mg-ATPase activities, antioxidant status, and learning performance of aged rats. Neuropsychiatric disease and treatment 20080801
The use of natural product scaffolds as leads in the search for trypanothione reductase inhibitors. Bioorganic & medicinal chemistry 20080715
Quantitative structure-activity relationship studies of a series of non-benzodiazepine structural ligands binding to benzodiazepine receptor. European journal of medicinal chemistry 20080701
Photophysics of a beta-carboline based non-ionic probe in anionic and zwitterionic liposome membranes. Chemistry and physics of lipids 20080701
Nonsymmetrical beta-carboline dimers from an Ascidian, Didemnum sp. Journal of natural products 20080701
Quantification of heterocyclic aromatic amines in fried meat by HPTLC/UV-FLD and HPLC/UV-FLD: a comparison of two methods. Journal of agricultural and food chemistry 20080625
Effects of harman and norharman on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. European journal of pharmacology 20080610
Indolealkylamines: biotransformations and potential drug-drug interactions. The AAPS journal 20080601
Influence of the presence of methyl cyclodextrins in high-performance liquid chromatography mobile phases on the separation of beta-carboline alkaloids. Journal of chromatography. A 20080530
Electronic structure of the ground and excited states of beta-carboline. Chemphyschem : a European journal of chemical physics and physical chemistry 20080421
Synthesis of eudistomin D analogues and its effects on adenosine receptors. Bioorganic & medicinal chemistry 20080401
Gamma-carboline derivatives with anti-bovine viral diarrhea virus (BVDV) activity. Bioorganic & medicinal chemistry 20080401
Effect of surfactant chain length on the binding interaction of a biological photosensitizer with cationic micelles. The journal of physical chemistry. B 20080327
Daytime Ayahuasca administration modulates REM and slow-wave sleep in healthy volunteers. Psychopharmacology 20080201
The enantioselective total synthesis of a beta-carboline alkaloid, (S)-(-)-dichotomine C. Chemical & pharmaceutical bulletin 20080201
Beta-carboline alkaloids from a Korean tunicate Eudistoma sp. Journal of natural products 20080201
Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme. Journal of the American Chemical Society 20080116
A newly developed assay for the quantitative determination of antimicrobial (anticyanobacterial) activity of both hydrophilic and lipophilic test compounds without any restriction. Microbiological research 20080101
Screening of microalgae for species excreting norharmane, a manifold biologically active indole alkaloid. Microbiological research 20080101
Determination of beta-carboline alkaloids in fruiting bodies of Hygrophorus spp. by liquid chromatography/electrospray ionisation tandem mass spectrometry. Phytochemical analysis : PCA 20080101
Effect of norharmane in vitro on juvenile hormone epoxide hydrolase activity in the lower termite, Reticulitermes speratus. Journal of insect science (Online) 20080101
Degradation of heterocyclic aromatic amines in oil under storage and frying conditions and reduction of their mutagenic potential. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20071101
Identification and occurrence of beta-carboline alkaloids in raisins and inhibition of monoamine oxidase (MAO). Journal of agricultural and food chemistry 20071017
Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model. International journal of cancer 20071015
Direct experimental evidence for a heterogeneous reaction of ozone with bromide at the air-aqueous interface. The journal of physical chemistry. A 20071004
Coupled hydrogen-bonding interactions between beta-carboline derivatives and acetic acid. Magnetic resonance in chemistry : MRC 20071001
Synthesis of 3,8,9-trisubstituted-1,7,9-triaza-fluorene-6-carboxylic acid derivatives as a new class of insulin secretagogues. Bioorganic & medicinal chemistry 20070901
Towards GAG glycomics: analysis of highly sulfated heparins by MALDI-TOF mass spectrometry. Glycobiology 20070901
Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus. Journal of natural products 20070901
Sustained inhibition of brotizolam induced anterograde amnesia by norharmane and retrograde amnesia by L-glutamic acid in mice. Behavioural brain research 20070822
Validation of an ion-pair liquid chromatography-electrospray-tandem mass spectrometry method for the determination of heterocyclic aromatic amines in meat-based infant foods. Food additives and contaminants 20070801
DH334, a beta-carboline anti-cancer drug, inhibits the CDK activity of budding yeast. Cancer biology & therapy 20070801
Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle. Chemistry & biology 20070801
Theoretical and UV spectral study of isomeric 1-(quinolinyl)-beta-carbolines conformations. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701
Differential effects of dopamine melanin on norharman-induced toxicity in PC12 cells. Journal of neural transmission (Vienna, Austria : 1996) 20070701
Antioxidant properties of beta-carboline alkaloids are related to their antimutagenic and antigenotoxic activities. Mutagenesis 20070701
Effect of cyclodextrin nanocavity confinement on the photophysics of a beta-carboline analogue: a spectroscopic study. The journal of physical chemistry. B 20070628
Neuroprotective effects of the beta-carboline abecarnil studied in cultured cortical neurons and organotypic retinal cultures. Neuropharmacology 20070601
Golden opportunities in natural product synthesis: first total synthesis of (-)-isocyclocapitelline and (-)-isochrysotricine by gold-catalyzed allene cycloisomerization. Organic & biomolecular chemistry 20070521
Synthesis of hybrid molecules of caffeine and eudistomin D and its effects on adenosine receptors. Bioorganic & medicinal chemistry 20070501
N-methyltetrahydro-beta-carboline analogs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin are oxidized to neurotoxic beta-carbolinium cations by heme peroxidases. Biochemical and biophysical research communications 20070427
Surfactant chain-length-dependent modulation of the prototropic transformation of a biological photosensitizer: norharmane in anionic micelles. Langmuir : the ACS journal of surfaces and colloids 20070424
Flazinamide, a novel beta-carboline compound with anti-HIV actions. Biochemical and biophysical research communications 20070420
From pyrroles to 1-oxo-2,3,4,9-tetrahydro-1H-beta-carbolines: a new class of orally bioavailable mGluR1 antagonists. Bioorganic & medicinal chemistry letters 20070415
Heterocyclic amines in griddled beef steak analysed using a single extract clean-up procedure. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070401
Solid-phase fluorescence and ionization efficiency in negative-ion matrix-assisted laser desorption/ionization of neutral oligosaccharides: interaction between beta-carboline matrix and ammonium salt. Journal of the American Society for Mass Spectrometry 20070401
Factors influencing the norharman and harman contents in espresso coffee. Journal of agricultural and food chemistry 20070307
Determination of beta-carboline alkaloids in foods and beverages by high-performance liquid chromatography with electrochemical detection at a glassy carbon electrode modified with carbon nanotubes. Analytica chimica acta 20070307
Anticonvulsants in sports: ethical considerations. Epilepsy & behavior : E&B 20070301
Binding interaction of a biological photosensitizer with serum albumins: a biophysical study. Biomacromolecules 20070301
Methylglyoxal-derived beta-carbolines formed from tryptophan and its derivates in the Maillard reaction. Amino acids 20070201
Validation of a new planar chromatographic method for quantification of the heterocyclic aromatic amines most frequently found in meat. Analytical and bioanalytical chemistry 20070201
Synthesis and evaluation of antitumor activity of novel N-acyllavendamycin analogues and quinoline-5,8-diones. Bioorganic & medicinal chemistry 20070101
Risk assessment of ritual use of oral dimethyltryptamine (DMT) and harmala alkaloids. Addiction (Abingdon, England) 20070101
Detection of aminophenylnorharman, a possible endogenous mutagenic and carcinogenic compound, in human urine samples. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20070101
beta-Carboline alkaloids: biochemical and pharmacological functions. Current medicinal chemistry 20070101
From the behavioral pharmacology of beta-carbolines to seizures, anxiety, and memory. TheScientificWorldJournal 20070101
Identification of the endogenous key substrates of the human organic cation transporter OCT2 and their implication in function of dopaminergic neurons. PloS one 20070101
Plants used traditionally to treat malaria in Brazil: the archives of Flora Medicinal. Journal of ethnobiology and ethnomedicine 20070101
Mapping of oxidative stress responses of human tumor cells following photodynamic therapy using hexaminolevulinate. BMC genomics 20070101
Pharmacology of the beta-carboline FG-7,142, a partial inverse agonist at the benzodiazepine allosteric site of the GABA A receptor: neurochemical, neurophysiological, and behavioral effects. CNS drug reviews 20070101
Synthesis, crystal structure and biological activity of beta-carboline based selective CDK4-cyclin D1 inhibitors. Organic & biomolecular chemistry 20061221
Efficient and sensitive method for quantitative analysis of alkaloids in hardinggrass (Phalaris aquatica L.). Journal of agricultural and food chemistry 20061213
Monoamine oxidase A rather than monoamine oxidase B inhibition increases nicotine reinforcement in rats. The European journal of neuroscience 20061201
Receptor-based pharmacophores for serotonin 5-HT7R antagonists-implications to selectivity. Journal of medicinal chemistry 20061116
6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters 20061115
Anti-prostate cancer activity of a beta-carboline alkaloid enriched extract from Rauwolfia vomitoria. International journal of oncology 20061101
Activation of aminophenylnorharman, aminomethylphenylnorharman and aminophenylharman to genotoxic metabolites by human N-acetyltransferases and cytochrome P450 enzymes expressed in Salmonella typhimurium umu tester strains. Mutagenesis 20061101
Effects of beta-carboline alkaloids on the object recognition task in mice. Life sciences 20061026
Effect of red wine marinades on the formation of heterocyclic amines in fried chicken breast. Journal of agricultural and food chemistry 20061018
Synthesis and cytotoxic activities of beta-carboline amino acid ester conjugates. Bioorganic & medicinal chemistry 20061015
Design of beta-carboline derivatives as DNA-targeting antitumor agents. European journal of medicinal chemistry 20061001
Parkinson's disease-like syndrome in rats induced by 2,9-dimethyl-beta-carbolinium ion, a beta-carboline occurring in the human brain. Behavioural pharmacology 20060901
Inhibition of neuronal nitric oxide synthase activity by N1-acetyl-5-methoxykynuramine, a brain metabolite of melatonin. Journal of neurochemistry 20060901
Partial least squares-based multivariate spectral calibration method for simultaneous determination of beta-carboline derivatives in Peganum harmala seed extracts. Analytica chimica acta 20060811
Monoamine oxidase inhibitors allow locomotor and rewarding responses to nicotine. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060801
Neurotoxic mechanisms of 2,9-dimethyl-beta-carbolinium ion in primary dopaminergic culture. Journal of neurochemistry 20060801
Effect of nanocavity confinement on the rotational relaxation dynamics: 3-acetyl-4-oxo-6,7-dihydro-12H indolo-[2,3-a] quinolizine in micelles. The Journal of chemical physics 20060728
Analysis of monoamine oxidase enzymatic activity by reversed-phase high performance liquid chromatography and inhibition by beta-carboline alkaloids occurring in foods and plants. Journal of chromatography. A 20060707
Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20060701
Phytochemical and pharmacological study of roots and leaves of Guiera senegalensis J.F. Gmel (Combretaceae). Journal of ethnopharmacology 20060630
Antimalarial activity of a new family of analogues of manzamine A. Organic letters 20060608
A selective small molecule IkappaB Kinase beta inhibitor blocks nuclear factor kappaB-mediated inflammatory responses in human fibroblast-like synoviocytes, chondrocytes, and mast cells. The Journal of pharmacology and experimental therapeutics 20060601
Identification of norharman as the cytotoxic compound produced by the sponge (Hymeniacidon perleve)-associated marine bacterium Pseudoalteromonas piscicida and its apoptotic effect on cancer cells. Biotechnology and applied biochemistry 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Beta-carboline derivatives: novel photosensitizers that intercalate into DNA to cause direct DNA damage in photodynamic therapy. Biochemical and biophysical research communications 20060414
Norharman-induced motoric impairment in mice: neurodegeneration and glial activation in substantia nigra. Journal of neural transmission (Vienna, Austria : 1996) 20060301
In vitro and ex vivo distribution of [3H]harmane, an endogenous beta-carboline, in rat brain. Neuropharmacology 20060301
Preparation, structure and spasmolytic activities of some derivatives of harmine series of alkaloids. Natural product research 20060301
The alkaloid alstonine: a review of its pharmacological properties. Evidence-based complementary and alternative medicine : eCAM 20060301
Effect of chlorine as substituent on the photochemistry and acid-base properties of beta-carboline alkaloids. Journal of photochemistry and photobiology. B, Biology 20060201
Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee. Life sciences 20060118
Syntheses of new substituted triazino tetrahydroisoquinolines and beta-carbolines as novel antileishmanial agents. European journal of medicinal chemistry 20060101
Antialgal, antibacterial and antifungal activity of two metabolites produced and excreted by cyanobacteria during growth. Microbiological research 20060101
2,9-Dimethyl-beta-carbolinium, a neurotoxin occurring in human brain, is a potent inducer of apoptosis as 1-methyl-4-phenylpyridinium. Neuroscience 20060101
Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice. Cell division 20060101
Toxicity and metabolism of the chloral-derived mammalian alkaloid 1-trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) in PC12 cells. Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101
DNA binding properties of 9-substituted harmine derivatives. Biochemical and biophysical research communications 20051223
beta-Carboline alkaloid suppresses NF-kappaB transcriptional activity through inhibition of IKK signaling pathway. Journal of toxicology and environmental health. Part A 20051210
Isolation and chemical characterization of PwTx-II: a novel alkaloid toxin from the venom of the spider Parawixia bistriata (Araneidae, Araneae). Toxicon : official journal of the International Society on Toxinology 20051201
The beta-carboline analog Mana-Hox causes mitotic aberration by interacting with DNA. Chemistry & biology 20051201
Nostocarboline: isolation and synthesis of a new cholinesterase inhibitor from Nostoc 78-12A. Journal of natural products 20051201
Conformationally constrained N1-arylsulfonyltryptamine derivatives as 5-HT6 receptor antagonists. Bioorganic & medicinal chemistry letters 20051101
Harmane inhibits serotonergic dorsal raphe neurons in the rat. Psychopharmacology 20051101
Isolation of mutagenic beta-carboline derivatives after nitrite treatment of maillard reaction mixtures and analysis of these compounds from foodstuffs and human urine. Bioscience, biotechnology, and biochemistry 20051101
Investigation of the separation of heterocyclic aromatic amines by reversed phase ion-pair liquid chromatography coupled with tandem mass spectrometry: the role of ion pair reagents on LC-MS/MS sensitivity. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051025
Design, synthesis and in vitro and in vivo antitumor activities of novel beta-carboline derivatives. European journal of medicinal chemistry 20051001
Isolation and characterization of norharmane from Reticulitermes termites (Isoptera: Rhinotermitidae). Journal of economic entomology 20051001
Effects of harmaline on anxiety-related behavior in mice. Physiology & behavior 20050915
Design, synthesis and bioactivities of TAR RNA targeting beta-carboline derivatives based on Tat-TAR interaction. European journal of medicinal chemistry 20050901
High-affinity binding of beta-carbolines to imidazoline I2B receptors and MAO-A in rat tissues: norharman blocks the effect of morphine withdrawal on DOPA/noradrenaline synthesis in the brain. European journal of pharmacology 20050822
Tangutorine induces p21 expression and abnormal mitosis in human colon cancer HT-29 cells. Biochemical pharmacology 20050715
Photochemistry of the alkaloids eudistomin N (6-bromo-nor-harmane) and eudistomin O (8-bromo-nor-harmane) and other bromo-beta-carbolines. Journal of photochemistry and photobiology. B, Biology 20050701
Gesashidine A, a beta-carboline alkaloid with an imidazole ring from a Thorectidae sponge. Journal of natural products 20050701
Toxocara canis: search for a potential drug amongst beta-carboline alkaloids--in vitro and mouse studies. Experimental parasitology 20050601
Synthesis and evaluation of beta-carbolinium cations as new antimalarial agents based on pi-delocalized lipophilic cation (DLC) hypothesis. Chemical & pharmaceutical bulletin 20050601
Alkaloids and aromatics of Cyathobasis fruticulosa (Bunge) Aellen. Journal of natural products 20050601
Developmental regulation of beta-carboline-induced inhibition of glycine-evoked responses depends on glycine receptor beta subunit expression. Molecular pharmacology 20050501
Characterization of some synthetic Ru and Ir complexes by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Journal of mass spectrometry : JMS 20050501
Comparison of the Protective Effect of Indole beta-carbolines and R-(-)-deprenyl Against Nitrogen Species-Induced Cell Death in Experimental Culture Model of Parkinson's Disease. Journal of clinical neurology (Seoul, Korea) 20050401
In-source and postsource decay in negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of neutral oligosaccharides. Analytical chemistry 20050315
Encapsulation of norharmane in cyclodextrin: formation of 1:1 and 1:2 inclusion complexes. Journal of photochemistry and photobiology. B, Biology 20050301
Synthesis and in vitro cytotoxic evaluation of 1,3-bisubstituted and 1,3,9-trisubstituted beta-carboline derivatives. European journal of medicinal chemistry 20050301
Agonistic effects of the beta-carboline DMCM revealed in GABA(A) receptor gamma 2 subunit F77I point-mutated mice. Neuropharmacology 20050301
Lack of combination hepatocarcinogenicity of harman, norharman and amitrole when given with NaNO2 in the rat. The Journal of toxicological sciences 20050201
Human monoamine oxidase is inhibited by tobacco smoke: beta-carboline alkaloids act as potent and reversible inhibitors. Biochemical and biophysical research communications 20050114
Photophysics in motionally constrained bioenvironment: interaction of norharmane with bovine serum albumin. Photochemistry and photobiology 20050101
Beta-carbolines induce apoptosis in cultured cerebellar granule neurons via the mitochondrial pathway. Neuropharmacology 20050101
Red maca (Lepidium meyenii) reduced prostate size in rats. Reproductive biology and endocrinology : RB&E 20050101
Permissive nicotine regulation as a complement to traditional tobacco control. BMC public health 20050101
Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines. BMC pharmacology 20050101
Fluorescence quenching of beta-carboline alkaloids in micellar media. A study to select the adequate surfactant to use in analytical techniques. Luminescence : the journal of biological and chemical luminescence 20050101
Beta-carboline and quinoline alkaloids in root cultures and intact plants of Peganum harmala. Zeitschrift fur Naturforschung. C, Journal of biosciences 20050101
Comprehensive photochemistry and photophysics of land- and marine-based beta-carbolines employing time-resolved emission and flash transient spectroscopy. Photochemistry and photobiology 20050101
Addition of various carbohydrates to beef burgers affects the formation of heterocyclic amines during frying. Journal of agricultural and food chemistry 20041215
New beta-carboline alkaloids from the Andaman Sea sponge Dragmacidon sp. Journal of natural products 20041201
Relative exposure to beta-carbolines norharman and harman from foods and tobacco smoke. Food additives and contaminants 20041101
The putative imidazoline receptor agonist, harmane, promotes intracellular calcium mobilisation in pancreatic beta-cells. European journal of pharmacology 20041006
Carcinogenicity of aminophenylnorharman, a possible novel endogenous mutagen, formed from norharman and aniline, in F344 rats. Carcinogenesis 20041001
Norharman and alcohol-dependency in male Wistar rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001
Synthesis, acute toxicities, and antitumor effects of novel 9-substituted beta-carboline derivatives. Bioorganic & medicinal chemistry 20040901
Analysis of alpha- and beta-carbolines in mainstream smoke of reference cigarettes by gas chromatography-mass spectrometry. Journal of chromatography. A 20040813
Identification of cytochrome P-450s involved in the formation of APNH from norharman with aniline. Mutation research 20040808
Antibiotic-mediated release of tumour necrosis factor alpha and norharman in patients with hospital-acquired pneumonia and septic encephalopathy. Intensive care medicine 20040801
Synthesis and antimycobacterial activity of some beta-carboline alkaloids. Natural product research 20040801
A comparative molecular field analysis of cytotoxic beta-carboline analogs. Acta pharmacologica Sinica 20040701
A fast assembly of pentacyclic benz[f]indolo[2,3-a]quinolizidine core by tandem intermolecular formal aza-[3 + 3] cycloaddition/Pictet-Spengler cyclization: a formal synthesis of (+/-)-tangutorine. The Journal of organic chemistry 20040625
Synthesis and biological evaluation of novel beta-carboline derivatives as Tat-TAR interaction inhibitors. Bioorganic & medicinal chemistry letters 20040621
Characterization of the cytotoxic mechanism of Mana-Hox, an analog of manzamine alkaloids. Biochimica et biophysica acta 20040611
Cytotoxic alkaloids from the marine sponge Thorectandra sp. Natural product research 20040601
Dopamine transporter-mediated cytotoxicity of beta-carbolinium derivatives related to Parkinson's disease: relationship to transporter-dependent uptake. Journal of neurochemistry 20040501
Photophysics of norharmane in micellar environments: a fluorometric study. Biophysical chemistry 20040501
Clinical investigations of the therapeutic potential of ayahuasca: rationale and regulatory challenges. Pharmacology & therapeutics 20040501
Pi-delocalized beta-carbolinium cations as potential antimalarials. Bioorganic & medicinal chemistry letters 20040405
[Synthesis of 1-indole substituted beta-carboline alkaloid and its derivatives and evaluation of their preliminary antitumor activities]. Yao xue xue bao = Acta pharmaceutica Sinica 20040401
High-performance liquid chromatographic analysis of beta-carbolines in human scalp hair. Journal of chromatography. A 20040326
Occurrence of heterocyclic amines in several home-cooked meat dishes of the Spanish diet. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040325
Exposure to beta-carbolines norharman and harman. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040325
Mutagens formed from beta-carbolines with aromatic amines. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040325
Regulation and biochemistry of mouse molybdo-flavoenzymes. The DBA/2 mouse is selectively deficient in the expression of aldehyde oxidase homologues 1 and 2 and represents a unique source for the purification and characterization of aldehyde oxidase. The Journal of biological chemistry 20040305
Long-term retention of neurotoxic beta-carbolines in brain neuromelanin. Journal of neural transmission (Vienna, Austria : 1996) 20040201
The effects of imidazoline agents on the aggregation of human platelets. The Journal of pharmacy and pharmacology 20040201
In vitro activity of the beta-carboline alkaloids harmane, harmine, and harmaline toward parasites of the species Leishmania infantum. Experimental parasitology 20040101
Characterization of humic substances by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 20040101
A new efficient synthetic methodology for tetrahydroisoquinoline and tetrahydro-beta-carboline derivatives using the Pictet-Spengler reaction. Molecular diversity 20040101
Effect of diazepam on the CNS excitation and behavioural changes induced by harmaline and its newly synthesized analogues. Pakistan journal of pharmaceutical sciences 20040101
Effects of the beta-carbolines, harmane and pinoline, on insulin secretion from isolated human islets of Langerhans. European journal of pharmacology 20031215
Potent genotoxicity of aminophenylnorharman, formed from non-mutagenic norharman and aniline, in the liver of gpt delta transgenic mouse. Carcinogenesis 20031201
Craving for cigarettes among low and high dependent smokers: impact of norharman. Addiction biology 20031201
Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells. Annals of the New York Academy of Sciences 20031201
Effect of harmane on mononeuropathic pain in rats. Annals of the New York Academy of Sciences 20031201
Possibility of the involvement of 9H-pyrido[3,4-b]indole (norharman) in carcinogenesis via inhibition of cytochrome P450-related activities and intercalation to DNA. Mutation research 20031110
Influence of antioxidants in virgin olive oil on the formation of heterocyclic amines in fried beefburgers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20031101
Identification of tryptophan and beta-carboline as paralysins in larvae of the yellow mealworm, Tenebrio molitor. Biochemical and biophysical research communications 20031010
Cytotoxic and antimalarial beta-carboline alkaloids from the roots of Eurycoma longifolia. Journal of natural products 20031001
Detection and characterization of cyclodextrin complexes with beta-carboline derivatives by spectroscopic techniques. Journal of pharmaceutical and biomedical analysis 20030808
Novel IKK inhibitors: beta-carbolines. Bioorganic & medicinal chemistry letters 20030721
Photophysical properties of methyl beta-carboline-3-carboxylate mediated by hydrogen-bonded complexes--a comparative study in different solvents. Biophysical chemistry 20030701
Screening for endogenous substrates reveals that CYP2D6 is a 5-methoxyindolethylamine O-demethylase. Pharmacogenetics 20030601
New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. Journal of natural products 20030601
Spectrofluorimetric determination of manzamine A in spiked human urine and plasma. Die Pharmazie 20030601
Chemical constituents of Taraxacum formosanum. Chemical & pharmaceutical bulletin 20030501
Design, synthesis, and biological evaluation of non-peptidic ligands at the Xenopus laevis skin-melanocortin receptor. European journal of medicinal chemistry 20030501
Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors. Bioorganic & medicinal chemistry letters 20030417
Contribution of individual cytochrome P450 isozymes to the O-demethylation of the psychotropic beta-carboline alkaloids harmaline and harmine. The Journal of pharmacology and experimental therapeutics 20030401
Shishijimicins A-C, novel enediyne antitumor antibiotics from the ascidian Didemnum proliferum(1). Journal of the American Chemical Society 20030226
Isolation and identification of two [(3)H]norharman- ([(3)H]beta-carboline)-binding proteins from rat liver. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030125
Mechanism-based pharmacokinetic/pharmacodynamic modeling of the electroencephalogram effects of GABAA receptor modulators: in vitro-in vivo correlations. The Journal of pharmacology and experimental therapeutics 20030101
Beta-carboline alkaloids from a New Zealand marine bryozoan, Cribricellina cribraria. Natural product research 20030101
Tetrahydroisoquinoline and beta-carboline alkaloids from Haloxylon articulatum (Cav.) Bunge (Chenopodiaceae). Zeitschrift fur Naturforschung. C, Journal of biosciences 20030101
The role of GABA in the pathophysiology and treatment of anxiety disorders. Psychopharmacology bulletin 20030101
Synthesis of beta- and gamma-carbolines by the palladium-catalyzed iminoannulation of alkynes. The Journal of organic chemistry 20021227
Elevation of blood beta-carboline alkaloids in essential tremor. Neurology 20021224
Rhythmicity without synchrony in the electrically uncoupled inferior olive. The Journal of neuroscience : the official journal of the Society for Neuroscience 20021215
Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex, respectively. Psychopharmacology 20021201
Determination of N,N-dimethyltryptamine and beta-carboline alkaloids in human plasma following oral administration of Ayahuasca. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021105
Structure of DNA adduct formed with aminophenylnorharman, being responsible for the comutagenic action of norharman with aniline. Chemical research in toxicology 20021001
In vitro and in vivo formation of aminophenylnorharman from norharman and aniline. Mutation research 20020930
Synthesis and cytotoxic activity of pyridazino[1',6':1,2]pyrido[3,4-b]indol-5-inium derivatives as anti-cancer agents. Bioorganic & medicinal chemistry letters 20020916
Contribution of the alpha1-GABA(A) receptor subtype to the pharmacological actions of benzodiazepine site inverse agonists. Neuropharmacology 20020901
High-performance liquid chromatographic, capillary electrophoretic and capillary electrophoretic-electrospray ionisation mass spectrometric analysis of selected alkaloid groups. Journal of chromatography. A 20020816
Screening for heterocyclic amines in chicken cooked in various ways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801
The biosynthesis of beta-carboline and quinolizidine alkaloids of Alangium lamarckii. Phytochemistry 20020801
5-hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios. Journal of natural products 20020801
Multistep mass spectrometry of heterocyclic amines in a quadrupole ion trap mass analyser. Journal of mass spectrometry : JMS 20020801
Identification and occurrence of the bioactive beta-carbolines norharman and harman in coffee brews. Food additives and contaminants 20020801
Tetrahydro-beta-carboline alkaloids that occur in foods and biological systems act as radical scavengers and antioxidants in the ABTS assay. Free radical research 20020801
Identification and occurrence of the novel alkaloid pentahydroxypentyl-tetrahydro-beta-carboline-3-carboxylic acid as a tryptophan glycoconjugate in fruit juices and jams. Journal of agricultural and food chemistry 20020731
1-Trichloromethyl-1,2,3,4-tetrahydro-beta-carboline (TaClo) and related derivatives: chemistry and biochemical effects on catecholamine biosynthesis. Bioorganic & medicinal chemistry 20020701
The anti-epileptic drug levetiracetam reverses the inhibition by negative allosteric modulators of neuronal GABA- and glycine-gated currents. British journal of pharmacology 20020701
Thermodynamic study of small hydrophobic ions at the water-lipid interface. Journal of colloid and interface science 20020701
Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease. Neurochemistry international 20020601
Topographic pharmaco-EEG mapping of the effects of the South American psychoactive beverage ayahuasca in healthy volunteers. British journal of clinical pharmacology 20020601
Natural variations of precursors in pig meat affect the yield of heterocyclic amines--effects of RN genotype, feeding regime, and sex. Journal of agricultural and food chemistry 20020508
The levels of norharman are high enough after smoking to affect monoamineoxidase B in platelets. European journal of pharmacology 20020419
Beta-carbolines as specific inhibitors of cyclin-dependent kinases. Bioorganic & medicinal chemistry letters 20020408
[The effect on other individual presentations of the goldfish by FG7142 injection]. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20020401
Induction of sister chromatid exchanges and chromosome aberrations in cultured mammalian cells treated with aminophenylnorharman formed by norharman with aniline. Mutation research 20020325
Genotoxic and recombinogenic activities of the two beta-carboline alkaloids harman and harmine in Saccharomyces cerevisiae. Mutation research 20020320
Characterization of the discriminable stimulus produced by 2-BFI: effects of imidazoline I(2)-site ligands, MAOIs, beta-carbolines, agmatine and ibogaine. British journal of pharmacology 20020301
Maternal and developmental toxicity in mice by aminophenylnorharman, formed from norharman and aniline. Human & experimental toxicology 20020301
Beta-carboline-carbohydrate hybrids: molecular design, chemical synthesis and evaluation of novel DNA photocleavers. Bioorganic & medicinal chemistry letters 20020225
The impact of smoking and drinking on plasma levels of norharman. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020201
Synergistic in vitro antimalarial activity of plant extracts used as traditional herbal remedies in Mali. Parasitology research 20020201
Indole and beta-carboline alkaloids from Geissospermum sericeum. Journal of natural products 20020101
An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L. seeds extract and its beta-carboline alkaloids. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101
Interaction of folk medicinal plant extracts with human alpha2-adrenoceptor subtypes. Zeitschrift fur Naturforschung. C, Journal of biosciences 20020101
An in vitro study on the kinetics, subcellular distribution and phototoxicity of harmine in human tumor cells. Bollettino chimico farmaceutico 20020101
Potential neurotoxic 'agents provocateurs' in Parkinson's disease. Neurotoxicology and teratology 20020101
[Serum norharman and harman analysis using high pressure liquid chromatography/mass spectrometry and value of beta-carbolines as blood alcohol markers]. Archiv fur Kriminologie 20020101
Total syntheses of beta-carboline alkaloids, (R)-(-)-pyridindolol K1, (R)-(-)-pyridindolol K2, and (R)-(-)-pyridindolol. The Journal of organic chemistry 20011228
Toxicokinetics of tremorogenic natural products, harmane and harmine, in male Sprague-Dawley rats. Journal of toxicology and environmental health. Part A 20011221
Degradation of tetrahydro-beta-carbolines in the presence of nitrite: HPLC-MS analysis of the reaction products. Journal of agricultural and food chemistry 20011201
Genotoxic effects of the alkaloids harman and harmine assessed by comet assay and chromosome aberration test in mammalian cells in vitro. Pharmacology & toxicology 20011201
New cytotoxic N-methylated beta-carboline alkaloids from the marine ascidian Eudistoma gilboverde. Journal of natural products 20011101
beta-carboline binding to imidazoline receptors. Drug and alcohol dependence 20011001
Pharmacokinetics of the beta-carboline norharman in man. Life sciences 20010921
Testicular toxicity in F344 rats by aminophenylnorharman, formed from norharman and aniline. Toxicology and applied pharmacology 20010901
Stimulatory effect of harmane and other beta-carbolines on locus coeruleus neurons in anaesthetized rats. Neuroscience letters 20010810
Why are the terpenoid indole alkaloids of type I homochiral? Chirality 20010801
Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline. Mutation research 20010725
Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives. Journal of natural products 20010701
[Synthetic studies of the bioactive natural products by using the thermal electrocyclic reaction of 6 pi electron systems]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010701
Structures of mutagens produced by the co-mutagen norharman with o- and m-toluidine isomers. Mutation research 20010627
The acute effects of norharman on cocaine self-administration and sensorimotor function in male Wistar rats. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20010601
Psychotogenic properties of benzodiazepine receptor inverse agonists. Psychopharmacology 20010601
Tryptophan: a precursor for the endogenous synthesis of norharman in man. Neuroscience letters 20010511
Reaction of tryptophan with carbohydrates: identification and quantitative determination of novel beta-carboline alkaloids in food. Journal of agricultural and food chemistry 20010501
L-Deprenyl prevents the cell hypoxia induced by dopaminergic neurotoxins, MPP(+) and beta-carbolinium: a microdialysis study in rats. Neuroscience letters 20010420
Exposure of a 'witness rat' to one treated with beta-carboline FG 7142 does not increase dopamine turnover in the medial prefrontal cortex of the 'witness rat'. Neuroscience letters 20010420
Hydrogen bonding NH/pi interactions between betacarboline and methyl benzene derivatives. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20010401
Induction of liver preneoplastic lesions by aminophenylnorharman, formed from norharman and aniline, in male F344 rats. Cancer letters 20010226
Synthesis and biological evaluation of DNA targeting flexible side-chain substituted beta-carboline derivatives. Bioorganic & medicinal chemistry letters 20010226
Canthin-6-one and beta-carboline alkaloids from Eurycoma harmandiana. Phytochemistry 20010201
Cis- and trans-platinum and palladium complexes: a comparative study review as antitumour agents. Bollettino chimico farmaceutico 20010101
Norharman, an indoleamine-derived beta-carboline, but not Trp-P-2, a gamma-carboline, induces apoptotic cell death in human neuroblastoma SH-SY5Y cells. Journal of neural transmission (Vienna, Austria : 1996) 20010101
Effects of beta- and gamma-carboline derivatives of DNA topoisomerase activities. Mutation research 19960201
ELISA of pentosidine, an advanced glycation end product, in biological specimens. Clinical chemistry 19940901
Inhibition of indoleamine 2,3-dioxygenase and tryptophan 2,3-dioxygenase by beta-carboline and indole derivatives. Archives of biochemistry and biophysics 19840801
Properties