7H-Pyrrolo[2,3-d]pyrimidine
| Title | Journal |
|---|---|
| Pyrrolo[2,3-d]pyrimidines active as Btk inhibitors. | Expert opinion on therapeutic patents 20171201 |
| Targeting conserved water molecules: design of 4-aryl-5-cyanopyrrolo[2,3-d]pyrimidine Hsp90 inhibitors using fragment-based screening and structure-based optimization. | Bioorganic & medicinal chemistry 20121115 |
| Identification and synthesis of substituted pyrrolo[2,3-d]pyrimidines as novel firefly luciferase inhibitors. | Bioorganic & medicinal chemistry 20120915 |
| Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines. | Organic & biomolecular chemistry 20120607 |
| N⁴-(3-Bromophenyl)-7-(substituted benzyl) pyrrolo[2,3-d]pyrimidines as potent multiple receptor tyrosine kinase inhibitors: design, synthesis, and in vivo evaluation. | Bioorganic & medicinal chemistry 20120401 |
| First total synthesis of a naturally occurring iodinated 5'-deoxyxylofuranosyl marine nucleoside. | Marine drugs 20120401 |
| Pyrrolo[3,2-d]pyrimidine derivatives as type II kinase insert domain receptor (KDR) inhibitors: CoMFA and CoMSIA studies. | International journal of molecular sciences 20120101 |
| Nuclear targeting of IGF-1 receptor in orbital fibroblasts from Graves' disease: apparent role of ADAM17. | PloS one 20120101 |
| Synthesis of new pyrroles of potential anti-inflammatory activity. | Archiv der Pharmazie 20111201 |
| Synthesis and anti-HIV-1 activity of 4-substituted-7-(2'-deoxy-2'-fluoro-4'-azido-β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine analogues. | Bioorganic & medicinal chemistry letters 20111115 |
| 2-Amino-4-methyl-5-phenylethyl substituted-7-N-benzyl-pyrrolo[2,3-d]pyrimidines as novel antitumor antimitotic agents that also reverse tumor resistance. | Bioorganic & medicinal chemistry 20110715 |
| New condensed pyrroles of potential biological interest syntheses and structure-activity relationship studies. | European journal of medicinal chemistry 20110701 |
| Insulin-like growth factor-I receptor inhibition by specific tyrosine kinase inhibitor NVP-AEW541 in endometrioid and serous papillary endometrial cancer cell lines. | Gynecologic oncology 20110501 |
| Discovery of pyrrolo[2,3-d]pyrimidin-4-ones as corticotropin-releasing factor 1 receptor antagonists with a carbonyl-based hydrogen bonding acceptor. | Bioorganic & medicinal chemistry letters 20110415 |
| Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance. | Journal of medicinal chemistry 20101125 |
| Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents. | European journal of medicinal chemistry 20101101 |
| Synthesis of novel pyrrole and pyrrolo[2,3-d]pyrimidine derivatives bearing sulfonamide moiety for evaluation as anticancer and radiosensitizing agents. | Bioorganic & medicinal chemistry letters 20101101 |
| Targeting the proton-coupled folate transporter for selective delivery of 6-substituted pyrrolo[2,3-d]pyrimidine antifolate inhibitors of de novo purine biosynthesis in the chemotherapy of solid tumors. | Molecular pharmacology 20101001 |
| Toward pyrrolo[2,3-d]pyrimidine scaffolds. | The Journal of organic chemistry 20100806 |
| Synthesis and biological evaluation of some thio containing pyrrolo [2,3-d]pyrimidine derivatives for their anti-inflammatory and anti-microbial activities. | European journal of medicinal chemistry 20100701 |
| 7-(5-Methyl-sulfanyl-β-d-erythrofuran-osyl)-7H-pyrrolo-[2,3-d]pyrimidin-4-amine monohydrate (MT-tubercidin·H(2)O). | Acta crystallographica. Section E, Structure reports online 20100701 |
| Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives and evaluation of their activities against human colon cancer cell lines. | European journal of medicinal chemistry 20100401 |
| 5-Chloro-N-[2-(1H-imidazol-4-yl)eth-yl]-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine. | Acta crystallographica. Section E, Structure reports online 20100101 |
| Synthesis of pyrrolo[2,3-d]pyrimidine derivatives and their antiproliferative activity against melanoma cell line. | Bioorganic & medicinal chemistry letters 20091201 |
| Novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potent and orally active STAT6 inhibitors. | Bioorganic & medicinal chemistry 20091001 |
| Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases. | Bioorganic & medicinal chemistry 20090701 |
| Synthesis and antiviral evaluation of 2'-C-methyl analogues of 5-alkynyl- and 6-alkylfurano- and pyrrolo[2,3-d]pyrimidine ribonucleosides. | Nucleosides, nucleotides & nucleic acids 20090501 |
| 8-Aza-7-deazaguanine nucleosides and oligonucleotides with octadiynyl side chains: synthesis, functionalization by the azide-alkyne 'click' reaction and nucleobase specific fluorescence quenching of coumarin dye conjugates. | Organic & biomolecular chemistry 20090407 |
| Electronic and steric effects on the mechanism of the inverse electron demand Diels-Alder reaction of 2-aminopyrroles with 1,3,5-triazines: identification of five intermediates by 1H, 13C, 15N, and 19F NMR spectroscopy. | The Journal of organic chemistry 20090102 |
| Novel antitumor acetamide, pyrrole, pyrrolopyrimidine, thiocyanate, hydrazone, pyrazole, isothiocyanate and thiophene derivatives containing a biologically active pyrazole moiety. | Arzneimittel-Forschung 20090101 |
| Synthesis and discovery of high affinity folate receptor-specific glycinamide ribonucleotide formyltransferase inhibitors with antitumor activity. | Journal of medicinal chemistry 20080828 |
| The effect of 5-alkyl modification on the biological activity of pyrrolo[2,3-d]pyrimidine containing classical and nonclassical antifolates as inhibitors of dihydrofolate reductase and as antitumor and/or antiopportunistic infection agents. | Journal of medicinal chemistry 20080814 |
| Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors. | European journal of medicinal chemistry 20080601 |
| Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents. | Bioorganic & medicinal chemistry 20080515 |
| The insulin-like growth factor-I receptor inhibitor NVP-AEW541 provokes cell cycle arrest and apoptosis in multiple myeloma cells. | British journal of haematology 20080501 |
| A CoMSIA study on the adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues. | Bioorganic & medicinal chemistry 20080501 |
| Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. | Bioorganic & medicinal chemistry letters 20080501 |
| Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities. | Bioorganic & medicinal chemistry 20080301 |
| Biochemical and biological properties of 5-bromotubercidin: differential effects on cellular DNA-directed and viral RNA-directed RNA synthesis. | Bioorganic & medicinal chemistry 20080201 |
| [New furano- and pyrrolo[2,3-d]pyrimidine nucleosides and their 5'-triphosphates: synthesis and biological properties]. | Bioorganicheskaia khimiia 20080101 |
| Inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation on tumor-associated endothelial cells leads to treatment of orthotopic human colon cancer in nude mice. | Neoplasia (New York, N.Y.) 20071201 |
| Role of focal adhesion kinase in human cancer: a potential target for drug discovery. | Anti-cancer agents in medicinal chemistry 20071101 |
| Classical anticytokinins do not interact with cytokinin receptors but inhibit cyclin-dependent kinases. | The Journal of biological chemistry 20070511 |
| Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents. | Bioorganic chemistry 20070201 |
| Furano- and pyrrolo [2,3-d] pyrimidine nucleosides and their 5'-O-triphospates: synthesis and enzymatic activity. | Nucleosides, nucleotides & nucleic acids 20070101 |
| The synthesis and properties of tricyclic analogues of S6-methylthioguanine and O6-methylguanine. | Nucleosides, nucleotides & nucleic acids 20070101 |
| The syntheses and properties of tricyclic pyrrolo[2,3-d]pyrimidine analogues of S6-methylthioguanine and O6-methylguanine. | Organic & biomolecular chemistry 20060507 |
| Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21WAF1/CIP1 pathway. | Cancer science 20060501 |
| Progress in 7-deazapurine - pyrrolo[2,3-d]pyrimidine - ribonucleoside synthesis. | Current topics in medicinal chemistry 20060101 |
| Novel antitumor and radioprotective sulfonamides containing pyrrolo [2,3-d]pyrimidines. | Arzneimittel-Forschung 20060101 |
| Synthesis of N-{4-[(2,4-diamino-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid and N-{4-[(2-amino-4-oxo-5-methyl-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)thio]benzoyl}-L-glutamic acid as dual inhibitors of dihydrofolate reductase and thymidylate synthase and as potential antitumor agents. | Journal of medicinal chemistry 20051117 |
| Synthesis and antimicrobial screening of some fused heterocyclic pyrroles. | Acta pharmaceutica (Zagreb, Croatia) 20050901 |
| Synthesis and biological evaluation of acyclic 3-[(2-hydroxyethoxy)methyl] analogues of antiviral furo- and pyrrolo[2,3-d]pyrimidine nucleosides. | Journal of medicinal chemistry 20050714 |
| Synthesis and properties of 7-substituted 7-deazapurine (pyrrolo[2,3-d]pyrimidine) 2'-deoxyribonucleosides. | Current protocols in nucleic acid chemistry 20050701 |
| Role of insulin-like growth factor 1 receptor signalling in cancer. | British journal of cancer 20050620 |
| Induction of apoptosis in human leukemia cells by MCS-C2 via caspase-dependent Bid cleavage and cytochrome c release. | Cancer letters 20050608 |
| Synthesis of classical, three-carbon-bridged 5-substituted furo[2,3-d]pyrimidine and 6-substituted pyrrolo[2,3-d]pyrimidine analogues as antifolates. | Journal of medicinal chemistry 20041230 |
| Synthesis and enzymatic evaluation of xanthine oxidase-activated prodrugs based on inhibitors of thymidine phosphorylase. | Bioorganic & medicinal chemistry letters 20041101 |
| AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity. | Cancer research 20040715 |
| A TOPS-MODE approach to predict adenosine kinase inhibition. | Bioorganic & medicinal chemistry letters 20040621 |
| In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase. | Cancer cell 20040301 |
| A new and efficient synthesis of pyrrolo[2,3-d]pyrimidine anticancer agents: Alimta (LY231514, MTA), homo-Alimta, TNP-351, and some aryl 5-substituted pyrrolo[2,3-d]pyrimidines. | The Journal of organic chemistry 20031226 |
| Synthesis and evaluation of optically pure dioxolanes as inhibitors of hepatitis C virus RNA replication. | Bioorganic & medicinal chemistry letters 20031215 |
| Novel synthesis and antifungal activity of pyrrole and pyrrolo[2,3-d]pyrimidine derivatives containing sulfonamido moieties. | Farmaco (Societa chimica italiana : 1989) 20020801 |
| N(7)-substituted-5-aryl-pyrrolo[2,3-d]pyrimidines represent a versatile class of potent inhibitors of the tyrosine kinase c-Src. | Mini reviews in medicinal chemistry 20020601 |
| QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach. | Bioorganic & medicinal chemistry letters 20020325 |
| Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases. | Journal of molecular biology 20011102 |
| Tyrosine kinase inhibitors: from rational design to clinical trials. | Medicinal research reviews 20011101 |
| Pyrrolo[2,3-d]pyrimidine thymidylate synthase inhibitors: design and synthesis of one-carbon bridge derivatives. | Chemical & pharmaceutical bulletin 20011001 |
| Chemical modification of aryl-1,2,3,6-tetrahydropyridinopyrimidine derivative to discover corticotropin-releasing factor(1) receptor antagonists: aryl-1,2,3,6-tetrahydropyridino-purine, -3H-1,2,3-triazolo[4,5-d)pyrimidine, -purin-8-one, and -7H-pyrrolo[2,3-d]pyrimidine derivatives. | Bioorganic & medicinal chemistry 20010501 |