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Design, synthesis, and evaluation of 3,5-disubstituted 7-azaindoles as Trk inhibitors with anticancer and antiangiogenic activities.

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Novel pyrazole derivatives as anticancer and radiosensitizing agents.

Arzneimittel-Forschung 20120301

Synthesis and antibacterial activity against ralstonia solanacearum for novel hydrazone derivatives containing a pyridine moiety.

Chemistry Central journal 20120101

Solvent effects in the excited-state tautomerization of 7-azaindole: a theoretical study.

The journal of physical chemistry. B 20111222

Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).

Bioorganic & medicinal chemistry letters 20111201

Theoretical studies for excited-state tautomerization in the 7-azaindole-(CH3OH)n (n = 1 and 2) complexes in the gas phase.

The journal of physical chemistry. A 20111201

Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II).

Bioorganic & medicinal chemistry letters 20111201

Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two metals, two mechanisms.

The Journal of organic chemistry 20111104

Structure of 7-azaindole···2-fluoropyridine dimer in a supersonic jet: competition between N-H···N and N-H···F interactions.

The journal of physical chemistry. A 20110922

Structure-based design and optimization of potent renin inhibitors on 5- or 7-azaindole-scaffolds.

Bioorganic & medicinal chemistry letters 20110915

Excited state electron transfer precedes proton transfer following irradiation of the hydrogen-bonded single water complex of 7-azaindole with UV light.

The Journal of chemical physics 20110828

From insertion of rhodium acetate paddlewheels into functionalized 7-azaindole hydrogen-bonded dimers to infinite architectures.

Dalton transactions (Cambridge, England : 2003) 20110728

Selectivity of kinase inhibitor fragments.

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A theoretical study on excited state double proton transfer reaction of a 7-azaindole dimer: an ab initio potential energy surface and its empirical valence bond model.

Physical chemistry chemical physics : PCCP 20110621

Synthesis and characterisation of group nine transition metal complexes containing new mesityl and naphthyl based azaindole scorpionate ligands.

Dalton transactions (Cambridge, England : 2003) 20110614

Anomalously slow proton transport of a water molecule.

The journal of physical chemistry. B 20110519

The reaction of azoles with 17-chloro-16-formylandrosta-5,16-dien-3β-yl-acetate: synthesis and structural elucidation of novel 16-azolylmethylene-17-oxoandrostanes.

Steroids 20110501

Tuning protein autoinhibition by domain destabilization.

Nature structural & molecular biology 20110501

Scaffold-hopping strategy: synthesis and biological evaluation of 5,6-fused bicyclic heteroaromatics to identify orally bioavailable anticancer agents.

Journal of medicinal chemistry 20110428

Intermolecular vibrational modes and orientational dynamics of cooperative hydrogen-bonding dimer of 7-azaindole in solution.

The Journal of chemical physics 20110428

Design and synthesis of 1-(2-alkanamidoethyl)-6-methoxy-7-azaindole derivatives as potent melatonin agonists.

Bioorganic & medicinal chemistry letters 20110415

Photon induced isomerization in the first excited state of the 7-azaindole-(H2O)3 cluster.

Physical chemistry chemical physics : PCCP 20110407

Inhibition of light-induced tautomerization of 7-azaindole by phenol: indications of proton-coupled electron/energy transfer quenching.

The journal of physical chemistry. A 20110317

Targeting BRAFV600E with PLX4720 displays potent antimigratory and anti-invasive activity in preclinical models of human thyroid cancer.

The oncologist 20110301

Strong agostic-type interactions in ruthenium benzylidene complexes containing 7-azaindole based scorpionate ligands.

Dalton transactions (Cambridge, England : 2003) 20110128

Azaindoles as potent CRTH2 receptor antagonists.

Bioorganic & medicinal chemistry letters 20110115

Excited-state double proton transfer of 7-azaindole dimers in a low-temperature organic glass.

Photochemistry and photobiology 20110101

Discovery of new azaindole-based PI3Kα inhibitors: apoptotic and antiangiogenic effect on cancer cells.

Bioorganic & medicinal chemistry letters 20101215

Synthesis of new pyrrolo[2,3-d]pyrimidine derivatives as antibacterial and antifungal agents.

European journal of medicinal chemistry 20101101

Excited-state triple-proton transfer in 7-azaindole(H(2)O)(2) and reaction path studied by electronic spectroscopy in the gas phase and quantum chemical calculations.

The journal of physical chemistry. A 20101028

Recent experimental advances on excited-state intramolecular proton coupled electron transfer reaction.

Accounts of chemical research 20101019

Palladium-catalyzed amination of unprotected halo-7-azaindoles.

Organic letters 20101015

Luminescence and reactivity of 7-azaindole derivatives and complexes.

Chemical Society reviews 20100801

Excited state charge transfer coupled double proton transfer reaction of 7-azaindole derivatives in methanol: a theoretical study.

The journal of physical chemistry. A 20100729

Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626.

Bioorganic & medicinal chemistry 20100715

New insights into homopiperazine-based 5-HT1A/5-HT7R ligands: synthesis and biological evaluation.

Journal of enzyme inhibition and medicinal chemistry 20100601

Activation energy of the two-proton phototautomerism in 7-azaindole dimer and its medium-dependence.

The journal of physical chemistry. A 20100513

New 7-azaindole palladium and platinum complexes: crystal structures and theoretical calculations. In vitro anticancer activity of the platinum compounds.

Dalton transactions (Cambridge, England : 2003) 20100407

Theoretical studies for the rates and kinetic isotope effects of the excited-state double proton transfer in the 1:1 7-azaindole:H2O complex using variational transition state theory including multidimensional tunneling.

The journal of physical chemistry. A 20100318

Infrared spectroscopy of jet-cooled tautomeric dimer of 7-azaindole: a model system for the ground-state double proton transfer reaction.

The journal of physical chemistry. A 20100311

Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).

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Proton phototransfers in doubly hydrogen bonded dimers: the photophysics of 6,7,8,9-tetrahydro-5H-pyrido[2,3-b]indole dimers.

The journal of physical chemistry. A 20100121

A novel chemotype of kinase inhibitors: Discovery of 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors.

Bioorganic & medicinal chemistry letters 20100101

3D-QSAR and molecular docking studies on derivatives of MK-0457, GSK1070916 and SNS-314 as inhibitors against Aurora B kinase.

International journal of molecular sciences 20100101

Phosphatidylserine increases IKBKAP levels in familial dysautonomia cells.

PloS one 20100101

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Marine drugs 20091201

2-(3,4,5-Trimethoxy-phen-yl)-1H-pyrrolo[2,3-b]pyridine.

Acta crystallographica. Section E, Structure reports online 20091201

Evolving a polymerase for hydrophobic base analogues.

Journal of the American Chemical Society 20091021

Impact of donor-acceptor geometry and metal chelation on photophysical properties and applications of triarylboranes.

Accounts of chemical research 20091020

Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells.

Journal of inorganic biochemistry 20090801

Cell division cycle 7 kinase inhibitors: 1H-pyrrolo[2,3-b]pyridines, synthesis and structure-activity relationships.

Journal of medicinal chemistry 20090723

Synthesis and cytotoxic activity of 5,6-heteroaromatically annulated pyridine-2,4-diamines.

Bioorganic & medicinal chemistry 20090701

Charge transfer interaction of intermolecular hydrogen bonds in 7-azaindole(MeOH)n (n = 1, 2) with IR-dip spectroscopy and natural bond orbital analysis.

The journal of physical chemistry. A 20090625

Spectroscopic study on the structural isomers of 7-azaindole(ethanol)(n) (n=1-3) and multiple-proton transfer reactions in the gas phase.

The Journal of chemical physics 20090614

A new family of metallaboratrane complexes based on 7-azaindole: B-H activation mediated by carbon monoxide.

Chemical communications (Cambridge, England) 20090514

4-Phenyl-7-azaindoles as potent and selective IKK2 inhibitors.

Bioorganic & medicinal chemistry letters 20090501

Beyond 7-azaindole: conjugation effects on intermolecular double hydrogen-atom transfer reactions.

The journal of physical chemistry. A 20090430

Theoretical evidence of barrier-free proton transfer in 7-azaindole-water cluster anions.

The Journal of chemical physics 20090428

Structural insights for design of potent spleen tyrosine kinase inhibitors from crystallographic analysis of three inhibitor complexes.

Chemical biology & drug design 20090401

Probe of the NH bond strength in 1L(a) and 1L(b) states of 7-azaindole with IR-dip spectroscopy: insights into the electronic-state dependence of the multiple proton/hydrogen transfers in hydrogen-bonded clusters.

The journal of physical chemistry. A 20090326

Site-selective azaindole arylation at the azine and azole rings via N-oxide activation.

Organic letters 20090319

Cu(I) and Ag(I) complexes of 7-azaindolyl and 2,2'-dipyridylamino substituted 1,3,5-triazine and benzene: the central core impact on structure, solution dynamics and fluorescence of the complexes.

Dalton transactions (Cambridge, England : 2003) 20090314

Mode-selective vibrational redistribution after spectrally selective N-H stretching mode excitation in intermolecular hydrogen bonds.

The Journal of chemical physics 20090121

Cobalt-catalyzed N-arylation of nitrogen nucleophiles in water.

Chemistry (Weinheim an der Bergstrasse, Germany) 20090101

Impact of the linker groups in bis(7-azaindol-1-yl) chelate ligands on structures and stability of Pt(N,N-L)R(2) complexes.

Dalton transactions (Cambridge, England : 2003) 20081228

Synthesis of a 7-azaindole by chichibabin cyclization: reversible base-mediated dimerization of 3-picolines.

The Journal of organic chemistry 20081219

Design and synthesis of potent and selective azaindole-based Rho kinase (ROCK) inhibitors.

ChemMedChem 20081201

Cyano analogues of 7-azaindole: probing excited-state charge-coupled proton transfer reactions in protic solvents.

Chemphyschem : a European journal of chemical physics and physical chemistry 20081024

Ab initio QM/MM molecular dynamics study on the excited-state hydrogen transfer of 7-azaindole in water solution.

The journal of physical chemistry. A 20081009

Highly functionalized 7-azaindoles as selective PPAR gamma modulators.

Bioorganic & medicinal chemistry letters 20080901

Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors.

Bioorganic & medicinal chemistry letters 20080815

Distribution and favorable binding sites of pyrroloquinoline and its analogues in a lipid bilayer studied by molecular dynamics simulations.

Biophysical chemistry 20080801

Electronically excited states of water clusters of 7-azaindole: structures, relative energies, and electronic nature of the excited states.

The Journal of chemical physics 20080607

Rotationally resolved electronic spectroscopy of water clusters of 7-azaindole.

The Journal of chemical physics 20080607

Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.

Journal of medicinal chemistry 20080410

Excited-state double proton transfer in model base pairs: the stepwise reaction on the heterodimer of 7-azaindole analogues.

Chemphyschem : a European journal of chemical physics and physical chemistry 20080201

7-Azaindole derivatives as potential partial nicotinic agonists.

Bioorganic & medicinal chemistry letters 20080101

Novel 1-(azacyclyl)-3-arylsulfonyl-1H-pyrrolo[2,3-b]pyridines as 5-HT6 agonists and antagonists.

Bioorganic & medicinal chemistry 20070915

Synthesis and biological activities of isogranulatimide analogues.

Bioorganic & medicinal chemistry 20070901

Laser induced fluorescence spectroscopy of a mixed dimer between 2-pyridone and 7-azaindole.

The journal of physical chemistry. A 20070816

Unraveling the structure of hydrogen bond stretching mode infrared absorption bands: an anharmonic density functional theory study on 7-azaindole dimers.

The Journal of chemical physics 20070807

Cooperative triple-proton/hydrogen atom relay in 7-azaindole(CH3OH)2 in the gas phase: remarkable change in the reaction mechanism from vibrational-mode specific to statistical fashion with increasing internal energy.

The journal of physical chemistry. A 20070531

Rapid evolution of 6-phenylpurine inhibitors of protein kinase B through structure-based design.

Journal of medicinal chemistry 20070517

Synthesis and biological evaluation of 7-azaindole derivatives, synthetic cytokinin analogues.

Bioorganic & medicinal chemistry letters 20070401

Bis-imide granulatimide analogues as potent Checkpoint 1 kinase inhibitors.

European journal of pharmacology 20070112

Synthesis and cross-coupling reactions of 7-azaindoles via a new donor-acceptor cyclopropane.

Organic letters 20060817

Excited state proton transfer in 3-methyl-7-azaindole dimer. Symmetry control.

The journal of physical chemistry. A 20060727

Density functional calculations on the structure, vibrational frequencies and normal modes of 7-Azaindole.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20060701

3-(4-Piperidinyl)indoles and 3-(4-piperidinyl)pyrrolo-[2,3-b]pyridines as ligands for the ORL-1 receptor.

Bioorganic & medicinal chemistry letters 20060701

A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5- fluoronicotinic acid.

The Journal of organic chemistry 20060512

Synthesis and reactivity of N-heterocycle-B(C6F5)3 complexes. 4. Competition between pyridine- and pyrrole-type substrates toward B(C6F5)3: structure and dynamics of 7-B(C6F5)3-7-azaindole and [7-Azaindolium]+[HOB(C6F5)3]-.

Inorganic chemistry 20060220

Charge-transfer pipi* excited state in the 7-azaindole dimer. A hybrid configuration interactions singles/time-dependent density functional theory description.

The journal of physical chemistry. A 20060126

Novel antitumor and radioprotective sulfonamides containing pyrrolo [2,3-d]pyrimidines.

Arzneimittel-Forschung 20060101

Determination of the excited-state structure of 7-azaindole-water cluster using a Franck-Condon analysis.

The Journal of chemical physics 20051208

Excited-state double proton transfer of 7-azaindole in water nanopools.

The journal of physical chemistry. B 20051103

Synthesis and cytotoxicities of 7-aza rebeccamycin analogues bearing various substituents on the sugar moiety, on the imide nitrogen and on the carbazole framework.

European journal of medicinal chemistry 20051001

The molecular symmetry and electronic spectroscopy of 7-azaindole dimer: its proton-transfer channels.

The Journal of chemical physics 20050915

High resolution electronic spectra of 7-azaindole and its Ar atom van der Waals complex.

The Journal of chemical physics 20050901

Excited-state double-proton transfer in the 7-azaindole dimer in the gas phase. 3. Reaction mechanism studied by picosecond time-resolved REMPI spectroscopy.

The journal of physical chemistry. A 20050623

Study of 7-azaindole in its first four singlet states.

The Journal of chemical physics 20050622

Potent, orally active corticotropin-releasing factor receptor-1 antagonists containing a tricyclic pyrrolopyridine or pyrazolopyridine core.

Journal of medicinal chemistry 20050616

Proton transfer of excited 7-azaindole in reverse-micellar methanol nanopools: even faster than in bulk methanol.

The journal of physical chemistry. B 20050428

Excited-state double-proton transfer in the 7-azaindole dimer in the gas phase. 1. Evidence of complete localization in the lowest excited electronic state of asymmetric isotopomers.

The journal of physical chemistry. A 20050331

Excited-state double-proton transfer in the 7-azaindole dimer in the gas phase. 2. Cooperative nature of double-proton transfer revealed by H/D kinetic isotopic effects.

The journal of physical chemistry. A 20050331

Cu(I) and Zn(II) complexes of 7-azaindole-containing scorpionates: structures, luminescence and fluxionality.

Dalton transactions (Cambridge, England : 2003) 20050207

7-Azaindolyl- and 2,2'-dipyridylamino-functionalized molecular stars with sixfold symmetry: self-assembly, luminescence, and coordination compounds.

Chemistry (Weinheim an der Bergstrasse, Germany) 20050121

Isotopic induction of the excited-state single-proton transfer in 7-azaindole dimer.

Physical chemistry chemical physics : PCCP 20050107

Ionization-induced proton transfer in model DNA base pairs: a theoretical study of the radical ions of the 7-azaindole dimer.

Chemphyschem : a European journal of chemical physics and physical chemistry 20041210

Synthesis and evaluation of fluorine-substituted 1H-pyrrolo[2,3-b]pyridine derivatives for dopamine D4 receptor imaging.

Bioorganic & medicinal chemistry 20041101

Generation of new protein kinase inhibitors utilizing cytochrome p450 mutant enzymes for indigoid synthesis.

Journal of medicinal chemistry 20040603

Preparation of 4-azaindole and 7-azaindole dimers with a bisalkoxyalkyl spacer in order to preferentially target melatonin MT1 receptors over melatonin MT2 receptors.

European journal of medicinal chemistry 20040601

Three-coordinate organoboron compounds BAr2R (Ar = mesityl, R = 7-azaindolyl- or 2,2'-dipyridylamino-functionalized aryl or thienyl) for electroluminescent devices and supramolecular assembly.

Chemistry (Weinheim an der Bergstrasse, Germany) 20040220

Discovery of 4-benzoyl-1-[(4-methoxy-1H- pyrrolo[2,3-b]pyridin-3-yl)oxoacetyl]-2- (R)-methylpiperazine (BMS-378806): a novel HIV-1 attachment inhibitor that interferes with CD4-gp120 interactions.

Journal of medicinal chemistry 20030925

Efficient biosynthetic incorporation of tryptophan and indole analogs in an integral membrane protein.

Protein science : a publication of the Protein Society 20030901

Blue luminescent rigid molecular rods bearing N-7-azaindolyl and 2,2'-dipyridylamino and their Zn(II) and Ag(I) complexes.

Inorganic chemistry 20030421

Syntheses and antiproliferative activities of rebeccamycin analogues bearing two 7-azaindole moieties.

Bioorganic & medicinal chemistry 20030306

Syntheses and antiproliferative activities of 7-azarebeccamycin analogues bearing one 7-azaindole moiety.

Journal of medicinal chemistry 20030213

Rebeccamycin analogues as anti-cancer agents.

European journal of medicinal chemistry 20030201

Carbodiimide-mediated preparation of the tricyclic pyrido[3',2':4,5]pyrrolo[1,2-c]pyrimidine ring system and its application to the synthesis of the potent antitumoral marine alkaloid variolin B and analog.

The Journal of organic chemistry 20030124

Isomerism of bis(7-azaindolyl)methane.

Organic letters 20021114

Synthesis and fluorescence study of 7-azaindole in DNA oligonucleotides replacing a purine base.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20021001

Synthesis of analogs of L-valacyclovir and determination of their substrate activity for the oligopeptide transporter in Caco-2 cells.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020701

Low temperature luminescence behaviours of 7-azatryptophan, 5-hydroxytryptophan and their chromophoric moieties.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20020701