Home Other Building Blocks 7,8-Dihydroxyflavone hydrate

7,8-Dihydroxyflavone hydrate

CAS No.:
38183-03-8
Catalog Number:
AG0034DP
Molecular Formula:
C15H10O4
Molecular Weight:
254.2375
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$134
- +
5g
98%
In Stock USA
United States
$449
- +
Product Description
Catalog Number:
AG0034DP
Chemical Name:
7,8-Dihydroxyflavone hydrate
CAS Number:
38183-03-8
Molecular Formula:
C15H10O4
Molecular Weight:
254.2375
MDL Number:
MFCD00006836
IUPAC Name:
7,8-dihydroxy-2-phenylchromen-4-one
InChI:
InChI=1S/C15H10O4/c16-11-7-6-10-12(17)8-13(19-15(10)14(11)18)9-4-2-1-3-5-9/h1-8,16,18H
InChI Key:
COCYGNDCWFKTMF-UHFFFAOYSA-N
SMILES:
Oc1ccc2c(c1O)oc(cc2=O)c1ccccc1
EC Number:
253-812-4
NSC Number:
750341
Properties
Complexity:
384  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
254.058g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
254.241g/mol
Monoisotopic Mass:
254.058g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
66.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.3  
Literature
Title Journal
Pharmacological Bypass of Cockayne Syndrome B Function in Neuronal Differentiation. Cell reports 20160322
7,8-Dihydroxyflavone, a TrkB agonist, attenuates behavioral abnormalities and neurotoxicity in mice after administration of methamphetamine. Psychopharmacology 20140101
Optimization of a small tropomyosin-related kinase B (TrkB) agonist 7,8-dihydroxyflavone active in mouse models of depression. Journal of medicinal chemistry 20121011
7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats. Journal of neurochemistry 20120801
Fear extinction and BDNF: translating animal models of PTSD to the clinic. Genes, brain, and behavior 20120701
7,8-dihydroxyflavone induces G1 arrest of the cell cycle in U937 human monocytic leukemia cells via induction of the Cdk inhibitor p27 and downregulation of pRB phosphorylation. Oncology reports 20120701
7,8-Dihydroxyflavone exhibits anti-inflammatory properties by downregulating the NF-κB and MAPK signaling pathways in lipopolysaccharide-treated RAW264.7 cells. International journal of molecular medicine 20120601
7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats. Hippocampus 20120301
7,8-dihydroxyflavone exhibits therapeutic efficacy in a mouse model of Rett syndrome. Journal of applied physiology (Bethesda, Md. : 1985) 20120301
The novel TrkB receptor agonist 7,8-dihydroxyflavone enhances neuromuscular transmission. Muscle & nerve 20120201
7,8-dihydroxyflavone, a small-molecule TrkB agonist, reverses memory deficits and BACE1 elevation in a mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120101
Activation of TrkB by 7,8-dihydroxyflavone prevents fear memory defects and facilitates amygdalar synaptic plasticity in aging. Journal of Alzheimer's disease : JAD 20120101
A novel relationship between the radical-scavenging activity of flavonoids and enthalpy of formation revealed with Hartree-Fock computations and thermochemical deduction. Redox report : communications in free radical research 20120101
Brain-derived neurotrophic factor enhances calcium regulatory mechanisms in human airway smooth muscle. PloS one 20120101
Epigenetic enhancement of BDNF signaling rescues synaptic plasticity in aging. The Journal of neuroscience : the official journal of the Society for Neuroscience 20111207
Vulnerability to depression: from brain neuroplasticity to identification of biomarkers. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110907
Antioxidant activity of 7,8-dihydroxyflavone provides neuroprotection against glutamate-induced toxicity. Neuroscience letters 20110725
Effect of 7,8-dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. The American journal of psychiatry 20110201
Toward neurotrophin-based therapeutics. The American journal of psychiatry 20110201
Behavioral and endocrine consequences of simultaneous exposure to two different stressors in rats: interaction or independence? PloS one 20110101
Structure of flavonoids influences the degree inhibition of Benzo(a)pyrene - induced DNA damage and micronuclei in HepG2 cells. Neoplasma 20110101
Synergistic activation of dopamine D1 and TrkB receptors mediate gain control of synaptic plasticity in the basolateral amygdala. PloS one 20110101
Structure-function relationships of inhibition of human cytochromes P450 1A1, 1A2, 1B1, 2C9, and 3A4 by 33 flavonoid derivatives. Chemical research in toxicology 20101220
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Characterization of an O-methyltransferase from Streptomyces avermitilis MA-4680. Journal of microbiology and biotechnology 20100901
An efficient and economical MTT assay for determining the antioxidant activity of plant natural product extracts and pure compounds. Journal of natural products 20100723
[Effect of seven kinds of flavonoids on recombinant human protein tyrosine phosphatase]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100501
A selective TrkB agonist with potent neurotrophic activities by 7,8-dihydroxyflavone. Proceedings of the National Academy of Sciences of the United States of America 20100209
Reliability of bond dissociation enthalpy calculated by the PM6 method and experimental TEAC values in antiradical QSAR of flavonoids. Bioorganic & medicinal chemistry 20100101
Deoxygedunin, a natural product with potent neurotrophic activity in mice. PloS one 20100101
Effects of brain-derived neurotrophic factor on local inflammation in experimental stroke of rat. Mediators of inflammation 20100101
Acidity of hydroxyl groups: an overlooked influence on antiradical properties of flavonoids. The Journal of organic chemistry 20090403
Preventive effect of 7,8-dihydroxyflavone against oxidative stress induced genotoxicity. Biological & pharmaceutical bulletin 20090201
Empirically predicted 13C NMR chemical shifts for 8-hydroxyflavone starting from 7,8,4'-trihydroxyflavone and from 7,8-dihydroxyflavone. Magnetic resonance in chemistry : MRC 20080701
Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. Journal of molecular graphics & modelling 20061101
Human NAD(P)H:quinone oxidoreductase inhibition by flavonoids in living cells. Free radical biology & medicine 20050715
Catecholic flavonoids acting as telomerase inhibitors. Journal of medicinal chemistry 20041216
A flexible data analysis tool for chemical genetic screens. Chemistry & biology 20041101
P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1. Proceedings of the National Academy of Sciences of the United States of America 20031209
Different catalytic properties and inhibitor responses of the goldfish brain and ovary aromatase isozymes. General and comparative endocrinology 20010801
Flavonolignan and flavone inhibitors of a Staphylococcus aureus multidrug resistance pump: structure-activity relationships. Journal of medicinal chemistry 20010118
Steroid hormone activity of flavonoids and related compounds. Breast cancer research and treatment 20000701
Anti-AIDS agents, 10. Acacetin-7-O-beta-D-galactopyranoside, an anti-HIV principle from Chrysanthemum morifolium and a structure-activity correlation with some related flavonoids. Journal of natural products 19940101
Flavones are inhibitors of HIV-1 proteinase. Biochemical and biophysical research communications 19921030
Differential inhibitory effects of various flavonoids on the activities of reverse transcriptase and cellular DNA and RNA polymerases. European journal of biochemistry 19900705
Properties