Home Nitros 4-Hydroxy-3-nitrophenylacetic acid

4-Hydroxy-3-nitrophenylacetic acid

CAS No.:
10463-20-4
Catalog Number:
AG00341Z
Molecular Formula:
C8H7NO5
Molecular Weight:
197.1449
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$29
- +
5g
98%
In Stock USA
United States
$117
- +
10g
95%
In Stock USA
United States
$186
- +
25g
98%
In Stock USA
United States
$300
- +
100g
98%
In Stock USA
United States
$900
- +
Product Description
Catalog Number:
AG00341Z
Chemical Name:
4-Hydroxy-3-nitrophenylacetic acid
CAS Number:
10463-20-4
Molecular Formula:
C8H7NO5
Molecular Weight:
197.1449
MDL Number:
MFCD00007122
IUPAC Name:
2-(4-hydroxy-3-nitrophenyl)acetic acid
InChI:
InChI=1S/C8H7NO5/c10-7-2-1-5(4-8(11)12)3-6(7)9(13)14/h1-3,10H,4H2,(H,11,12)
InChI Key:
QBHBHOSRLDPIHG-UHFFFAOYSA-N
SMILES:
OC(=O)Cc1ccc(c(c1)[N+](=O)[O-])O
EC Number:
233-948-0
Properties
Complexity:
236  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
197.032g/mol
Formal Charge:
0
Heavy Atom Count:
14  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
197.146g/mol
Monoisotopic Mass:
197.032g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
103A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.5  
Literature
Title Journal
Early B blasts acquire a capacity for Ig class switch recombination that is lost as they become plasmablasts. European journal of immunology 20111201
Characterization of memory B cells responsible for affinity maturation of anti- (4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies. International immunology 20110401
IL-21 receptor is critical for the development of memory B cell responses. Journal of immunology (Baltimore, Md. : 1950) 20110115
A soluble form of the high affinity IgE receptor, Fc-epsilon-RI, circulates in human serum. PloS one 20110101
Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo. Journal of immunology (Baltimore, Md. : 1950) 20100715
The pericyte and stromal cell marker CD248 (endosialin) is required for efficient lymph node expansion. European journal of immunology 20100701
Augmented antibody response with premature germinal center regression in CD40L transgenic mice. Journal of immunology (Baltimore, Md. : 1950) 20100701
A role for lysosomal-associated protein transmembrane 5 in the negative regulation of surface B cell receptor levels and B cell activation. Journal of immunology (Baltimore, Md. : 1950) 20100701
The amino acid residue at position 95 and the third CDR region in the H chain determine the ceiling affinity and the maturation pathway of an anti-(4-hydroxy-3-nitrophenyl)acetyl antibody. Molecular immunology 20100101
Effects of antibody affinity and antigen valence on molecular forms of immune complexes. Molecular immunology 20091201
Quantification of Modified Tyrosines in Healthy and Diabetic Human Urine using Liquid Chromatography/Tandem Mass Spectrometry. Journal of clinical biochemistry and nutrition 20090101
Intraclonal competition inhibits the formation of high-affinity antibody-secreting cells. Journal of immunology (Baltimore, Md. : 1950) 20081101
Escherichia coli NsrR regulates a pathway for the oxidation of 3-nitrotyramine to 4-hydroxy-3-nitrophenylacetate. Journal of bacteriology 20080901
A role for DRAK2 in the germinal center reaction and the antibody response. Autoimmunity 20080801
ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction. Journal of immunology (Baltimore, Md. : 1950) 20080215
IgM-mediated signaling is required for the development of a normal B cell memory response. Molecular immunology 20080201
Urinary excretion of the nitrotyrosine metabolite 3-nitro-4-hydroxyphenylacetic acid in preterm and term infants. Neonatology 20080101
Thymus-independent class switch recombination is affected by APRIL. Immunology and cell biology 20080101
Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection. Methods in enzymology 20080101
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 20071218
TACI is required for efficient plasma cell differentiation in response to T-independent type 2 antigens. Journal of immunology (Baltimore, Md. : 1950) 20070815
Correction of age-associated deficiency in germinal center response by immunization with immune complexes. Clinical immunology (Orlando, Fla.) 20070801
Recirculating CD4 memory T cells mount rapid secondary responses without major contributions from follicular CD4 effectors and B cells. European journal of immunology 20070601
Analysis of antigen-stimulated B cell migration into germinal centers during the early stage of a T-dependent immune response. Immunology letters 20070315
Strategy for affinity maturation of an antibody with high evolvability to (4-hydroxy-3-nitrophenyl) acetyl hapten. Molecular immunology 20070301
Germinal-center-derived B-cell memory. Advances in experimental medicine and biology 20070101
Novel in vitro screening system for monoclonal antibodies using hypermutating chicken B cell library. Journal of bioscience and bioengineering 20061101
pH-dependent nitration of para-hydroxyphenylacetic acid in the stomach. Free radical biology & medicine 20060915
Characterization of (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific germinal center B cells and antigen-binding B220- cells after primary NP challenge in mice. Journal of immunology (Baltimore, Md. : 1950) 20060815
Re-evaluating the recycling hypothesis in the germinal centre. Immunology and cell biology 20060801
Fc gamma RIIa, not Fc gamma RIIb, is constitutively and functionally expressed on skin-derived human mast cells. Journal of immunology (Baltimore, Md. : 1950) 20060701
Metabolism of 3-nitrotyrosine induces apoptotic death in dopaminergic cells. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060607
Analysis of antigen-specific and naturally occurring IgM and IgA steady-state levels in J-chain negative C57BL/6 mice. Scandinavian journal of immunology 20060601
Initial repertoire of anti-(4-hydroxy-3-nitrophenylacetyl) antibodies as potential donors for effective affinity maturation. Molecular immunology 20060401
Biodegradation of 3-nitrotyrosine by Burkholderia sp. strain JS165 and Variovorax paradoxus JS171. Applied and environmental microbiology 20060201
Cutting edge: egress of newly generated plasma cells from peripheral lymph nodes depends on beta 2 integrin. Journal of immunology (Baltimore, Md. : 1950) 20050615
Quercetin-dependent inhibition of nitration induced by peroxidase/H2O2/nitrite systems in human saliva and characterization of an oxidation product of quercetin formed during the inhibition. Journal of agricultural and food chemistry 20050504
Insulin-like growth factor-1 controls type 2 T cell-independent B cell response. Journal of immunology (Baltimore, Md. : 1950) 20050501
Dynamic assessment of nitration reactions in vivo. Methods in enzymology 20050101
Affinity maturation of secreted IgM pentamers on B cells. International immunology 20040501
Rectification of age-related impairment in Ig gene hypermutation during a memory response. International immunology 20040401
Functional folding of a cytoplasmic single-chain variable fragment and its use as elutable protein purification tag. Immunology letters 20040329
Segmental flexibility and avidity of IgM in the interaction of polyvalent antigens. Molecular immunology 20040101
Analysis of the germinal center reaction and in vivo long-lived plasma cells. Methods in molecular biology (Clifton, N.J.) 20040101
Ligation of CD27 on B cells in vivo during primary immunization enhances commitment to memory B cell responses. Journal of immunology (Baltimore, Md. : 1950) 20031201
Cutting edge: gamma delta T cells provide help to B cells with altered clonotypes and are capable of inducing Ig gene hypermutation. Journal of immunology (Baltimore, Md. : 1950) 20031115
Nitration of endogenous para-hydroxyphenylacetic acid and the metabolism of nitrotyrosine. The Biochemical journal 20030901
Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function. Journal of immunology (Baltimore, Md. : 1950) 20030715
Why are there so few key mutant clones? The influence of stochastic selection and blocking on affinity maturation in the germinal center. International immunology 20030701
Estimation of the relative affinity of B cell receptor by flow cytometry. Journal of immunological methods 20030501
Thermodynamic and kinetic aspects of antibody evolution during the immune response to hapten. Molecular immunology 20030301
Rapid development of Th2 activity during T cell priming. Clinical & developmental immunology 20030301
Lack of oxidative stress during sustained therapy with isosorbide dinitrate and pentaerythrityl tetranitrate in healthy humans: a randomized, double-blind crossover study. Journal of cardiovascular pharmacology 20030201
B cell selection and affinity maturation during an antibody response in the mouse with limited B cell diversity. Journal of immunology (Baltimore, Md. : 1950) 20021215
TRAIL/Apo-2 ligand induces primary plasma cell apoptosis. Journal of immunology (Baltimore, Md. : 1950) 20021115
Repertoire of antibody response in bone marrow and the memory response are differentially affected in aging mice. Journal of immunology (Baltimore, Md. : 1950) 20021101
Expression of a 4-(hydroxy-3-nitro-phenyl) acetyl (NP) specific equi-murine IgE antibody that mediates histamine release in vitro and a type I skin reaction in vivo. Equine veterinary journal 20021101
Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells. Journal of immunology (Baltimore, Md. : 1950) 20020915
Altered affinity maturation in primary response to (4-hydroxy-3-nitrophenyl) acetyl (NP) after autologous reconstitution of irradiated C57BL/6 mice. Developmental immunology 20020901
Effect of environmental antigens on the Ig diversification and the selection of productive V-J joints in the bursa. Journal of immunology (Baltimore, Md. : 1950) 20020715
The presence of 4-hydroxyphenylacetic acid in human saliva and the possibility of its nitration by salivary nitrite in the stomach. FEBS letters 20020508
Role of antigen receptor affinity in T cell-independent antibody responses in vivo. Nature immunology 20020401
[Exploring high affinity monoclonal antibodies for drug invention]. Nihon rinsho. Japanese journal of clinical medicine 20020301
The impact of H2-DM on humoral immune responses. Journal of immunology (Baltimore, Md. : 1950) 20011201
Development and maintenance of a B220- memory B cell compartment. Journal of immunology (Baltimore, Md. : 1950) 20010801
Inhibition of antigen-induced mediator release from IgE-sensitized cells by a monoclonal anti-Fc epsilon RI alpha-chain receptor antibody: implications for the involvement of the membrane-proximal alpha-chain region in Fc epsilon RI-mediated cell activation. Journal of immunology (Baltimore, Md. : 1950) 20010515
Cigarette smoke impairs neutrophil respiratory burst activation by aldehyde-induced thiol modifications. Toxicology 20010307
Waiting times to appearance and dominance of advantageous mutants: estimation based on the likelihood. Mathematical biosciences 20010301
The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-gamma and not Th1/Th2 imbalance. Journal of immunology (Baltimore, Md. : 1950) 19980701
Three-dimensional structures of the Fab fragment of murine N1G9 antibody from the primary immune response and of its complex with (4-hydroxy-3-nitrophenyl)acetate. Journal of molecular biology 19951124
Murine lupus anti-DNA antibodies cross-react with the hapten (4-hydroxy-5-iodo-3-nitrophenyl)acetyl, but immunization-induced anti-DNA antibodies do not. European journal of immunology 19870401
Hapten-specific T cell response to 4-hydroxy-3-nitrophenyl acetyl. X. Characterization of distinct T cell subsets mediating cutaneous sensitivity responses. Journal of immunology (Baltimore, Md. : 1950) 19810801
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses. The Journal of experimental medicine 19801201
Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. Journal of immunology (Baltimore, Md. : 1950) 19801001
Properties