Home Halogens 1-(3-chlorophenyl)piperazine

1-(3-chlorophenyl)piperazine

CAS No.:
6640-24-0
Catalog Number:
AG0033OG
Molecular Formula:
C10H13ClN2
Molecular Weight:
196.6766
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
96%
In Stock USA
United States
$69
- +
5g
96%
In Stock USA
United States
$225
- +
10g
96%
In Stock USA
United States
$413
- +
Product Description
Catalog Number:
AG0033OG
Chemical Name:
1-(3-chlorophenyl)piperazine
CAS Number:
6640-24-0
Molecular Formula:
C10H13ClN2
Molecular Weight:
196.6766
MDL Number:
MFCD00040732
IUPAC Name:
1-(3-chlorophenyl)piperazine
InChI:
InChI=1S/C10H13ClN2/c11-9-2-1-3-10(8-9)13-6-4-12-5-7-13/h1-3,8,12H,4-7H2
InChI Key:
VHFVKMTVMIZMIK-UHFFFAOYSA-N
SMILES:
Clc1cccc(c1)N1CCNCC1
EC Number:
229-654-7
UNII:
REY0CNO998
NSC Number:
49307
Properties
Complexity:
157  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
196.077g/mol
Formal Charge:
0
Heavy Atom Count:
13  
Hydrogen Bond Acceptor Count:
2  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
196.678g/mol
Monoisotopic Mass:
196.077g/mol
Rotatable Bond Count:
1  
Topological Polar Surface Area:
15.3A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7  
Literature
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Enhanced 5-HT2C receptor signaling is associated with haloperidol-induced 'early onset' vacuous chewing in rats: implications for antipsychotic drug therapy. Psychopharmacology 20051001
Chronic treatment with duloxetine is necessary for an anxiolytic-like response in the mouse zero maze: the role of the serotonin transporter. Psychopharmacology 20051001
Effect of 5-hydroxytryptamine on neurogenic vasoconstriction in the isolated, autoperfused hindquarters of the rat. Clinical and experimental pharmacology & physiology 20051001
Inhibition of serotonin transporters by cocaine and meprylcaine through 5-TH2C receptor stimulation facilitates their seizure activities. Brain research 20050928
Does the panic attack activate the hypothalamic-pituitary-adrenal axis? Anais da Academia Brasileira de Ciencias 20050901
The AGNP-TDM Expert Group Consensus Guidelines: focus on therapeutic monitoring of antidepressants. Dialogues in clinical neuroscience 20050901
Updated overview of the putative role of the serotoninergic system in obsessive-compulsive disorder. Neuropsychiatric disease and treatment 20050901
Association of the promoter polymorphism -1438G/A of the 5-HT2A receptor gene with behavioral impulsiveness and serotonin function in women with bulimia nervosa. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 20050805
Serotonergic/glutamatergic interactions: potentiation of phencyclidine-induced stimulus control by citalopram. Pharmacology, biochemistry, and behavior 20050701
Analgesic therapy in postherpetic neuralgia: a quantitative systematic review. PLoS medicine 20050701
Responsiveness of 5-HT(1A) and 5-HT2 receptors in the rat orbitofrontal cortex after long-term serotonin reuptake inhibition. Journal of psychiatry & neuroscience : JPN 20050701
Brain angiotensin and anxiety-related behavior: the transgenic rat TGR(ASrAOGEN)680. Brain research 20050607
The use of sudden darkness in mice: a behavioural and pharmacological approach. Psychopharmacology 20050601
Metabolism of designer drugs of abuse. Current drug metabolism 20050601
Endophenotypes in the personality disorders. Dialogues in clinical neuroscience 20050601
Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on ethanol discrimination in the rat. Alcohol (Fayetteville, N.Y.) 20050601
Reinforced spatial alternation as an animal model of obsessive-compulsive disorder (OCD): investigation of 5-HT2C and 5-HT1D receptor involvement in OCD pathophysiology. Biological psychiatry 20050515
Trazodone and its active metabolite m-chlorophenylpiperazine as partial agonists at 5-HT1A receptors assessed by [35S]GTPgammaS binding. Journal of psychopharmacology (Oxford, England) 20050501
Effects of serotonin and serotonergic agonists and antagonists on the production of tumor necrosis factor alpha and interleukin-6. Psychiatry research 20050430
Effect of the activation of central 5-HT2C receptors by the 5-HT2C agonist mCPP on blood pressure and heart rate in rats. Brain research 20050408
Measurement and characterization of energy intake in the mouse. Current protocols in pharmacology 20050401
Agonist diversity in 5-HT(2C) receptor-mediated weight control in rats. Psychopharmacology 20050301
m-CPP, a 5-HT2C receptor agonist that modifies the perfusion pressure of the hindquarter vascular bed of anesthetized rat. Pharmacology 20050201
Anxiogenic treatments do not increase fear-potentiated startle in mice. Biological psychiatry 20050101
Serotonergic 5-HT2C receptors as a potential therapeutic target for the design antiepileptic drugs. Current topics in medicinal chemistry 20050101
Serotonergic systems associated with arousal and vigilance behaviors following administration of anxiogenic drugs. Neuroscience 20050101
Pharmacological challenge with a serotonin 1D agonist in alcohol dependence. BMC psychiatry 20050101
Effects of the 5-HT7 receptor antagonists SB-269970 and DR 4004 in autoshaping Pavlovian/instrumental learning task. Behavioural brain research 20041206
Thermogenic effect of YM348, a novel 5-HT2C-receptor agonist, in rats. The Journal of pharmacy and pharmacology 20041201
Anxiety-like state associates with taste to produce conditioned taste aversion. Biological psychiatry 20041201
Behavioral effects of serotonin and serotonin agonists in two crayfish species, Procambarus clarkii and Orconectes rusticus. Comparative biochemistry and physiology. Part A, Molecular & integrative physiology 20041201
Behavioral phenotype of pre-proenkephalin-deficient mice on diverse congenic backgrounds. Psychopharmacology 20041101
Neuroimaging and 5-HT2C receptor polymorphism: a HMPAO-SPECT study in healthy male probands using mCPP-challenge of the 5-HT2C receptor. Pharmacopsychiatry 20041101
Reduced hypophagic effects of d-fenfluramine and the 5-HT2C receptor agonist mCPP in 5-HT1B receptor knockout mice. Psychopharmacology 20041001
Behavioural effects of rapid intravenous administration of meta-chlorophenylpiperazine in patients with panic disorder and controls. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20041001
Increased repetitive behaviours and prolactin responsivity to oral m-chlorophenylpiperazine in adults with autism spectrum disorders. The international journal of neuropsychopharmacology 20040901
Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice. Progress in neuro-psychopharmacology & biological psychiatry 20040901
A 5-HT2C agonist elicits hyperactivity and oral dyskinesia with hypophagia in rabbits. Physiology & behavior 20040801
Chronic treatment with fluvoxamine desensitizes 5-HT2C receptor-mediated hypolocomotion in rats. Pharmacology, biochemistry, and behavior 20040801
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors. Naunyn-Schmiedeberg's archives of pharmacology 20040801
Pharmacokinetics of m-chlorophenylpiperazine after intravenous and oral administration in healthy male volunteers: implication for the pharmacodynamic profile. Pharmacopsychiatry 20040701
Vasoconstrictor responses to 5-hydroxytryptamine in the autoperfused hindquarters of spontaneously hypertensive rats. Pharmacology 20040601
Serotonin function, personality-trait variations, and childhood abuse in women with bulimia-spectrum eating disorders. The Journal of clinical psychiatry 20040601
New arylpiperazine 5-HT(1A) receptor ligands containing the pyrimido[2,1-f]purine fragment: synthesis, in vitro, and in vivo pharmacological evaluation. Journal of medicinal chemistry 20040506
Indoline derivatives as 5-HT(2C) receptor agonists. Bioorganic & medicinal chemistry letters 20040503
mCPP-induced hyperactivity in 5-HT2C receptor mutant mice is mediated by activation of multiple 5-HT receptor subtypes. Neuropharmacology 20040401
Relationship between anorexia and loss of serotonin uptake sites in brain of mice and rats receiving d-norfenfluramine or d-fenfluramine. Pharmacology, biochemistry, and behavior 20040301
The application of the principles of clinical drug development to pharmacological challenge tests of the serotonergic system. Journal of psychopharmacology (Oxford, England) 20040301
Antiallodynic effects of intrathecally administered 5-HT(2C) receptor agonists in rats with nerve injury. Pain 20040301
m-Chlorophenylpiperazine (mCPP) modulates the discriminative stimulus effects of cocaine through actions at the 5-HT2C receptor. Behavioral neuroscience 20040201
Molecular cloning and pharmacological characterization of the guinea pig 5-HT1E receptor. European journal of pharmacology 20040126
Neurobiological correlates of diagnosis and underlying traits in patients with borderline personality disorder compared with normal controls. Psychiatry research 20040101
Modification of human 5-HT(2C) receptor function by Cys23Ser, an abundant, naturally occurring amino-acid substitution. Molecular psychiatry 20040101
Pharmacological profile of YM348, a novel, potent and orally active 5-HT2C receptor agonist. European journal of pharmacology 20040101
Bulimia nervosa with co-morbid avoidant personality disorder: behavioural characteristics and serotonergic function. Psychological medicine 20040101
Serotonergic dissection of obsessive compulsive symptoms: a challenge study with m-chlorophenylpiperazine and sumatriptan. Neuropsychobiology 20040101
Serotoninergics attenuate hyperlocomotor activity in rats. Potential new therapeutic strategy for hyperactivity. Neurotoxicity research 20040101
Substitution profiles of N-methyl-D-aspartate antagonists in ethanol-discriminating inbred mice. Alcohol (Fayetteville, N.Y.) 20040101
5-HT2C receptors inhibit and 5-HT1A receptors activate the generation of spike-wave discharges in a genetic rat model of absence epilepsy. Experimental neurology 20031201
Depression of mGluR-mediated IPSCs by 5-HT in dopamine neurons of the rat substantia nigra pars compacta. The European journal of neuroscience 20031101
Implications of compulsive and impulsive traits for serotonin status in women with bulimia nervosa. Psychiatry research 20031015
A PET study after treatment with an anxiety-provoking agent, m-chlorophenyl-piperazine, in conscious rhesus monkeys. Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20030901
Agonist actions of dihydroergotamine at 5-HT2B and 5-HT2C receptors and their possible relevance to antimigraine efficacy. British journal of pharmacology 20030901
Involvement of 5-HT(2) receptor in imipramine-induced hyperglycemia in mice. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030901
Central 5-HT2B/2C and 5-HT3 receptor stimulation decreases salt intake in sodium-depleted rats. Brain research 20030815
Regulation of septo-hippocampal activity by 5-hydroxytryptamine(2C) receptors. The Journal of pharmacology and experimental therapeutics 20030801
Discriminative stimulus effects of m-chlorophenylpiperazine as a model of the role of serotonin receptors in anxiety. Life sciences 20030801
MDMA exposure alters cognitive and electrophysiological sensitivity to rapid tryptophan depletion in rhesus monkeys. Pharmacology, biochemistry, and behavior 20030801
Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze. European journal of pharmacology 20030725
Higher-end serotonin receptors: 5-HT(5), 5-HT(6), and 5-HT(7). Journal of medicinal chemistry 20030703
Neuroendocrine response to the serotonin agonist M-chlorophenylpiperazine in women with menstrual status migrainosus. Neuroendocrinology 20030701
m-CPP-induced self-grooming is mediated by 5-HT2C receptors. Behavioural brain research 20030616
Effects of single and repeated electroconvulsive shock on the social and agonistic behaviour of resident rats. Neuropharmacology 20030601
Screening for and validated quantification of amphetamines and of amphetamine- and piperazine-derived designer drugs in human blood plasma by gas chromatography/mass spectrometry. Journal of mass spectrometry : JMS 20030601
Oral administration of the 5-HT2Creceptor agonist, mCPP, reduces body weight gain in rats over 28 days as a result of maintained hypophagia. Psychopharmacology 20030501
Experimental anxiety and antiepileptics: the effects of valproate and vigabatrin in the mirrored chamber test. Methods and findings in experimental and clinical pharmacology 20030501
Effects of m-CPP in altering neuronal function: blocking depolarization in invertebrate motor and sensory neurons but exciting rat dorsal horn neurons. Brain research 20030418
Serotonin induces tonic firing in layer V pyramidal neurons of rat prefrontal cortex during postnatal development. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation. Cephalalgia : an international journal of headache 20030301
Reduced social interaction following 3,4-methylenedioxymethamphetamine is not associated with enhanced 5-HT 2C receptor responsivity. Neuropharmacology 20030301
The glycine transporter-1 inhibitors NFPS and Org 24461: a pharmacological study. Pharmacology, biochemistry, and behavior 20030301
Induction of c-Fos expression in specific areas of the fear circuitry in rat forebrain by anxiogenic drugs. Biological psychiatry 20030215
Differential regulation of somatodendritic and nerve terminal dopamine release by serotonergic innervation of substantia nigra. Journal of neurochemistry 20030201
Effect of repeated administration of dexfenfluramine on feeding and brain Fos in mice. Physiology & behavior 20030201
Central serotonergic effects of m-chlorophenylpiperazine (mCPP) among normal control adolescents. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030101
Pharmacological characterization of 5-HT(1B) receptor-mediated inhibition of local excitatory synaptic transmission in the CA1 region of rat hippocampus. British journal of pharmacology 20030101
5-HT1B receptor knockout mice show a compensatory reduction in 5-HT2C receptor function. The European journal of neuroscience 20030101
5-HT2C receptor agonists as potential drugs for the treatment of obesity. Current topics in medicinal chemistry 20030101
Piperazine-derived designer drug 1-(3-chlorophenyl)piperazine (mCPP): GC-MS studies on its metabolism and its toxicological detection in rat urine including analytical differentiation from its precursor drugs trazodone and nefazodone. Journal of analytical toxicology 20030101
Anxiolytic-like profile of propofol, a general anesthetic, in the plus-maze test in mice. Polish journal of pharmacology 20030101
Neuroendocrine response to meta-chlorophenylpiperazine and ipsapirone in relation to anxiety and aggression. Psychiatry research 20021215
Synthesis and pharmacological evaluation of new arylpiperazines. 3-[4-[4-(3-chlorophenyl)-1-piperazinyl]butyl]-quinazolidin-4-one - a dual serotonin 5-HT(1A)/5-HT(2A) receptor ligand with an anxiolytic-like activity. Bioorganic & medicinal chemistry 20021201
Cognitive performance of MDMA-treated rhesus monkeys: sensitivity to serotonergic challenge. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021201
Serotonergic dysregulation in bipolar disorders: a literature review of serotonergic challenge studies. Bipolar disorders 20021201
Antidepressants reduce phosphoinositide-specific phospholipase C (PI-PLC) activity and the mRNA and protein expression of selective PLC beta 1 isozyme in rat brain. Neuropharmacology 20021201
Involvement of 5-HT(2A/2B/2C) receptors on memory formation: simple agonism, antagonism, or inverse agonism? Cellular and molecular neurobiology 20021201
Neurogenetics of emotional reactivity to stress in animals. Dialogues in clinical neuroscience 20021201
Sleep-wake effects of meta-chlorophenyl piperazine and mianserin in the behaviorally depressed rat. European journal of pharmacology 20021122
2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine]. The Journal of pharmacology and experimental therapeutics 20021101
5-HT2C receptor mediation of unconditioned escape behaviour in the unstable elevated exposed plus maze. Psychopharmacology 20021101
The effects of gender and gonadal steroids on the neuroendocrine and temperature response to m-chlorophenylpiperazine in leuprolide-induced hypogonadism in women and men. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021101
In vitro identification of metabolic pathways and cytochrome P450 enzymes involved in the metabolism of etoperidone. Xenobiotica; the fate of foreign compounds in biological systems 20021101
Allelic variants of the serotonin(2C) receptor and neuroendocrinological responses to the serotonin(2C) receptor agonist m-chlorophenylpiperazine in healthy male volunteers. Pharmacopsychiatry 20021101
Effects of GABA(A) compounds on mCPP drug discrimination in rats. Life sciences 20021018
mCPP-induced hypophagia in rats is unaffected by the profile of dietary unsaturated fatty acids. Pharmacology, biochemistry, and behavior 20021001
p-Methylthioamphetamine and 1-(m-chlorophenyl)piperazine, two non-neurotoxic 5-HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5-HT nerve endings in vitro. Journal of neurochemistry 20020901
Are there anxious genes? Dialogues in clinical neuroscience 20020901
5-HT(2C) receptor activation by m-chlorophenylpiperazine detected in humans with fMRI. Neuroreport 20020827
Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients. Therapeutic drug monitoring 20020801
Metachlorophenylpiperazine (m-CPP) induced intracavernous pressure responses in anaesthetized rats. International journal of impotence research 20020801
The effects of serotonin agonists on the hypothalamic regulation of sexual receptivity in Syrian hamsters. Hormones and behavior 20020801
Central administration of mCPP, a serotonin 5-HT(2B/2C) agonist, decreases water intake in rats. Pharmacology, biochemistry, and behavior 20020701
Blunted prefrontal cortical 18fluorodeoxyglucose positron emission tomography response to meta-chlorophenylpiperazine in impulsive aggression. Archives of general psychiatry 20020701
Therapeutic and adverse actions of serotonin transporter substrates. Pharmacology & therapeutics 20020701
Ritanserin antagonism of m-chlorophenylpiperazine effects in neuroleptic-free schizophrenics patients: support for serotonin-2 receptor modulation of schizophrenia symptoms. Psychopharmacology 20020601
Treatment of depression associated with the menstrual cycle: premenstrual dysphoria, postpartum depression, and the perimenopause. Dialogues in clinical neuroscience 20020601
Gonadal steroids, brain, and behavior: role of context. Dialogues in clinical neuroscience 20020601
Ethopharmacological analysis of the unstable elevated exposed plus maze, a novel model of extreme anxiety: predictive validity and sensitivity to anxiogenic agents. Psychopharmacology 20020501
Antinociceptive role of 5-HT1A receptors in rat spinal cord. British journal of anaesthesia 20020501
Altered prolactin response to M-chlorophenylpiperazine in monkeys previously treated with 3,4-methylenedioxymethamphetamine (MDMA) or fenfluramine. Synapse (New York, N.Y.) 20020401
Human CYP3A4 and the metabolism of nefazodone and hydroxynefazodone by human liver microsomes and heterologously expressed enzymes. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020401
Serotonin 2C receptor agonists and the behavioural satiety sequence in mice. Pharmacology, biochemistry, and behavior 20020401
Alteration in 5-hydroxytryptamine agonist-induced behaviour following a corticosterone implant in adult rats. Pharmacology, biochemistry, and behavior 20020401
Serotonin releasing agents. Neurochemical, therapeutic and adverse effects. Pharmacology, biochemistry, and behavior 20020401
The nature of the acetylcholine and 5-hydroxytryptamine receptors in buccal smooth muscle of the pest slug Deroceras reticulatum. Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology 20020401
Role of 5-hT2C receptors in the hypophagic effect of m-CPP, ORG 37684 and CP-94,253 in the rat. Progress in neuro-psychopharmacology & biological psychiatry 20020401
The atypical 5-HT2 receptor mediating tachycardia in pithed rats: pharmacological correlation with the 5-HT2A receptor subtype. British journal of pharmacology 20020301
Saccadic peak velocity and EEG as end-points for a serotonergic challenge test. Human psychopharmacology 20020301
Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis. Neuropharmacology 20020201
Effects of fenfluramine, m-CPP and triazolam on repeated-acquisition in squirrel monkeys before and after neurotoxic MDMA administration. Psychopharmacology 20020201
Evaluation of isotryptamine derivatives at 5-HT(2) serotonin receptors. Bioorganic & medicinal chemistry letters 20020121
Perturbations of plasma cortisol and DHEA-S following discontinuation of cocaine use in cocaine addicts. Psychoneuroendocrinology 20020101
Psychomotor slowing, neuroendocrine responses, and behavioral changes after oral administration of meta-chlorophenylpiperazine in normal volunteers. Psychiatry research 20011231
The subjective effects of MDMA and mCPP in moderate MDMA users. Drug and alcohol dependence 20011201
The effect of olanzapine treatment on m-chlorophenylpiperazine-induced hormone release in schizophrenia. Journal of clinical psychopharmacology 20011201
The 5-HT2C/2B receptor agonist m-chlorophenylpiperazine (mCPP) inhibits 2-deoxy-D-glucose (2-DG)-induced hyperphagia in rats. Biological & pharmaceutical bulletin 20011201
Effects of serotonin and serotonin analogs on posture and agonistic behavior in crayfish. Journal of comparative physiology. A, Sensory, neural, and behavioral physiology 20011201
Anxiety-like effects induced by acute fluoxetine, sertraline or m-CPP treatment are reversed by pretreatment with the 5-HT2C receptor antagonist SB-242084 but not the 5-HT1A receptor antagonist WAY-100635. The international journal of neuropsychopharmacology 20011201
m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT(2C) receptors but not 5-HT(2A) or 5-HT(2B) receptors. Behavioural pharmacology 20011201
Evaluation of the absorption, excretion and metabolism of [14C] etoperidone in man. Xenobiotica; the fate of foreign compounds in biological systems 20011101
Altered responsiveness to 5-HT at the crayfish neuromuscular junction due to chronic p-CPA and m-CPP treatment. Brain research 20011019
Association of serotonin and cortisol indices with childhood abuse in bulimia nervosa. Archives of general psychiatry 20010901
Mapping of brain activation in response to pharmacological agents using fMRI in the rat. Magnetic resonance imaging 20010901
Agonist-induced functional desensitization of recombinant human 5-HT2 receptors expressed in CHO-K1 cells. Biochemical pharmacology 20010815
Self-destructiveness and serotonin function in bulimia nervosa. Psychiatry research 20010805
Pedophilia is accompanied by increased plasma concentrations of catecholamines, in particular epinephrine. Psychiatry research 20010805
Tryptophan hydroxylase gene and major psychoses. Psychiatry research 20010805
SB-243213; a selective 5-HT2C receptor inverse agonist with improved anxiolytic profile: lack of tolerance and withdrawal anxiety. Neuropharmacology 20010801
Altered response to meta-chlorophenylpiperazine in anorexia nervosa: support for a persistent alteration of serotonin activity after short-term weight restoration. The International journal of eating disorders 20010701
Effect of a low tryptophan diet on the prolactin responses to the 5-HT2A agonist DOI in the rat. Pharmacopsychiatry 20010701
The serotonergic 5-HT(2C) agonist m-chlorophenylpiperazine increases weight-supported locomotion without development of tolerance in rats with spinal transections. Experimental neurology 20010601
A neurotoxic dose of 3,4-methylenedioxymethamphetamine (MDMA; ecstasy) to rats results in a long-term defect in thermoregulation. Psychopharmacology 20010601
1-(m-chlorophenyl)piperazine (mCPP) dissociates in vivo serotonin release from long-term serotonin depletion in rat brain. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010501
Dissociation of systemic and hippocampal modulation of rat locomotor activity by 5-HT(2C) receptors. Neuroscience research 20010501
Strain-dependent effects of diazepam and the 5-HT2B/2C receptor antagonist SB 206553 in spontaneously hypertensive and Lewis rats tested in the elevated plus-maze. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20010501
Decreased tryptophan availability but normal post-synaptic 5-HT2c receptor sensitivity in chronic fatigue syndrome. Psychological medicine 20010501
Effects of genetic polymorphism of CYP1A2 inducibility on the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine in depressed Japanese patients. Pharmacology & toxicology 20010501
Effect of aerobic exercise on behavioral and neuroendocrine responses to meta-chlorophenylpiperazine and to ipsapirone in untrained healthy subjects. Psychopharmacology 20010501
Discriminative stimulus properties of indorenate, a 5-HT1A, 5-HT1B and 5-HT2C agonist: a study in rats. Journal of psychopharmacology (Oxford, England) 20010301
Neuroendocrine and behavioral responses to mCPP in Obsessive-Compulsive Disorder. Psychoneuroendocrinology 20010201
Increased m-CPP-induced oral dyskinesia after lesion of serotonergic neurons. Pharmacology, biochemistry, and behavior 20010201
Investigations into migraine pathogenesis: time course for effects of m-CPP, BW723C86 or glyceryl trinitrate on appearance of Fos-like immunoreactivity in rat trigeminal nucleus caudalis (TNC). Cephalalgia : an international journal of headache 20010201
Low versus standard dose mCPP challenge in obsessive-compulsive patients. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101
Lower baseline plasma cortisol and prolactin together with increased body temperature and higher mCPP-induced cortisol responses in men with pedophilia. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20010101
Implications of impulsive and affective symptoms for serotonin function in bulimia nervosa. Psychological medicine 20010101
Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX1) receptors, with downstream 5-HT2C receptor involvement. Psychopharmacology 20010101
m-Chlorophenylpiperazine excites non-dopaminergic neurons in the rat substantia nigra and ventral tegmental area by activating serotonin-2C receptors. Neuroscience 20010101
Inhibition of K(+)-evoked release of rat striatal 5-hydroxytryptamine by an atypical antidepressant: trazodone. Neuropsychobiology 20010101
Modulation of 5-HT(2A) receptor-mediated head-twitch behaviour in the rat by 5-HT(2C) receptor agonists. Pharmacology, biochemistry, and behavior 20010101
Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation 20001205
Cloning, expression, and characterization of ferret 5-HT(3) receptor subunit. European journal of pharmacology 20000707
Agonist high and low affinity state ratios predict drug intrinsic activity and a revised ternary complex mechanism at serotonin 5-HT(2A) and 5-HT(2C) receptors. Synapse (New York, N.Y.) 20000201
Serotonin(2C) receptors appear to mediate genetic sensitivity to cocaine-induced convulsions. Psychopharmacology 19991001
Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions. Psychopharmacology 19990701
High-affinity agonist binding correlates with efficacy (intrinsic activity) at the human serotonin 5-HT2A and 5-HT2C receptors: evidence favoring the ternary complex and two-state models of agonist action. Journal of neurochemistry 19990501
Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, -HT(2B) and 5-HT2C receptors. Naunyn-Schmiedeberg's archives of pharmacology 19990101
Trazodone is metabolized to m-chlorophenylpiperazine by CYP3A4 from human sources. Drug metabolism and disposition: the biological fate of chemicals 19980601
[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor. Naunyn-Schmiedeberg's archives of pharmacology 19980101
Effect of fenfluramine challenge on cocaine craving in addicted male users. The American journal on addictions 19980101
The putative 5-HT1A receptor antagonist DU125530 blocks the discriminative stimulus of the 5-HT1A receptor agonist flesinoxan in pigeons. European journal of pharmacology 19970501
SB 242084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharmacology 19970101
Bupropion plasma levels and CYP2D6 phenotype. Therapeutic drug monitoring 19961001
In vitro and in vivo profile of SB 206553, a potent 5-HT2C/5-HT2B receptor antagonist with anxiolytic-like properties. British journal of pharmacology 19960201
Radiolabelling of the human 5-HT2A receptor with an agonist, a partial agonist and an antagonist: effects on apparent agonist affinities. Biochemical pharmacology 19960112
Post-synaptic 5-HT1A receptor involvement in yawning and penile erections induced by apomorphine, physostigmine and mCPP in rats. Psychopharmacology 19950801
Trazodone treatment increases plasma prolactin concentrations in depressed patients. International clinical psychopharmacology 19950601
Penile erection and yawning induced by 5-HT1C receptor agonists in male rats: relationship with dopaminergic and oxytocinergic transmission. European journal of pharmacology 19940811
Central action of glaucine in rodents. Acta poloniae pharmaceutica 19940101
Prolonged penile erections induced by hydroxyzine: possible mechanism of action. Neuropsychobiology 19940101
d-Fenfluramine- and d-norfenfluramine-induced hypophagia: differential mechanisms and involvement of postsynaptic 5-HT receptors. European journal of pharmacology 19930921
Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. The Journal of biological chemistry 19930825
Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular pharmacology 19930301
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor. Molecular pharmacology 19930301
Trazodone induction of migraine headache through mCPP. The American journal of psychiatry 19920501
Basic central pharmacological properties of thiophosphoric acid alkaloid derivatives from Chelidonium majus L. Polish journal of pharmacology and pharmacy 19920101
Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. Molecular pharmacology 19910801
A pilot placebo-controlled study of chronic m-CPP administration in Alzheimer's disease. Biological psychiatry 19910715
Serotonergic responsivity in obsessive-compulsive disorder. Effects of chronic clomipramine treatment. Archives of general psychiatry 19880201
Central action of ipsapirone, a new anxiolytic drug, on serotoninergic, noradrenergic and dopaminergic functions. Journal of neural transmission 19870101
Central antiserotonergic and antidopaminergic action of pirenperone, a putative 5-HT2 receptor antagonist. Polish journal of pharmacology and pharmacy 19850101
1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole. The Journal of pharmacy and pharmacology 19821001
Properties