Home Other Building Blocks 2-Methyl-2-thiopseudourea hemisulfate hemihydrate

2-Methyl-2-thiopseudourea hemisulfate hemihydrate

CAS No.:
867-44-7
Catalog Number:
AG0033DZ
Molecular Formula:
C4H14N4O4S3
Molecular Weight:
278.3734
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
98%
In Stock USA
United States
$13
- +
25g
98%
In Stock USA
United States
$19
- +
100g
98%(HPLC)
In Stock USA
United States
$48
- +
250g
98%(HPLC)
In Stock USA
United States
$66
- +
500g
98%(HPLC)
In Stock USA
United States
$108
- +
Product Description
Catalog Number:
AG0033DZ
Chemical Name:
2-Methyl-2-thiopseudourea hemisulfate hemihydrate
CAS Number:
867-44-7
Molecular Formula:
C4H14N4O4S3
Molecular Weight:
278.3734
MDL Number:
MFCD20488604
IUPAC Name:
methyl carbamimidothioate;sulfuric acid
InChI:
InChI=1S/2C2H6N2S.H2O4S/c2*1-5-2(3)4;1-5(2,3)4/h2*1H3,(H3,3,4);(H2,1,2,3,4)
InChI Key:
BZZXQZOBAUXLHZ-UHFFFAOYSA-N
SMILES:
OS(=O)(=O)O.CSC(=N)N.CSC(=N)N
EC Number:
212-759-7
UNII:
H834R05C26
Properties
Complexity:
124  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
278.018g/mol
Formal Charge:
0
Heavy Atom Count:
15  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
278.36g/mol
Monoisotopic Mass:
278.018g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
233A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
The comparative proteomics analysis revealed the modulation of inducible nitric oxide on the immune response of scallop Chlamys farreri. Fish & shellfish immunology 20141001
The regulatory role of the NO/cGMP signal transduction cascade during larval attachment and metamorphosis of the barnacle Balanus (=Amphibalanus) amphitrite. The Journal of experimental biology 20121101
Effect of S-methylisothiourea in acetaminophen-induced hepatotoxicity in rat. Naunyn-Schmiedeberg's archives of pharmacology 20121101
Protective effects of melatonin and S-methylisothiourea on mechlorethamine induced nephrotoxicity. The Journal of surgical research 20120601
The role of iNOS inhibitors on lung injury induced by gastrointestinal decontamination agents aspiration. Journal of molecular histology 20120601
Cytochrome-c mediated a bystander response dependent on inducible nitric oxide synthase in irradiated hepatoma cells. British journal of cancer 20120227
Effects of nitric oxide on the survival and neuritogenesis of cerebellar Purkinje neurons. Journal of molecular neuroscience : MN 20120201
15-Hydroxyeicosatetraenoic acid (15-HETE) protects pulmonary artery smooth muscle cells from apoptosis via inducible nitric oxide synthase (iNOS) pathway. Prostaglandins & other lipid mediators 20120101
S-methylisothiourea induces apoptosis of herpes simplex virus-1-infected microglial cells. Inflammation 20111001
Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. Experimental eye research 20111001
Impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated parotid artery of the alloxan-induced diabetic rabbit. European journal of oral sciences 20111001
Regional difference in inflammatory response to LPS-injection in the brain: role of microglia cell density. Journal of neuroimmunology 20110915
Inhibition of iNOS reduces the therapeutic effects of ozone in acute necrotizing pancreatitis: an in vivo animal study. Scandinavian journal of clinical and laboratory investigation 20110901
Role of nitric oxide in the regulation of fibrogenic factors in experimental liver fibrosis in mice. Histology and histopathology 20110201
Protein kinase A-dependent neuronal nitric oxide synthase activation mediates the enhancement of baroreflex response by adrenomedullin in the nucleus tractus solitarii of rats. Journal of biomedical science 20110101
Synthetic studies on novel 1,4-dihydro-2-methylthio-4,4,6-trisubstituted pyrimidine-5-carboxylic acid esters and their tautomers. Chemical & pharmaceutical bulletin 20110101
Hemodynamic effects of inducible nitric oxide synthase inhibition combined with sildenafil during acute pulmonary embolism. Nitric oxide : biology and chemistry 20101215
Effect of selective inhibitors of nitric oxide synthesis on the course of experimental hemorrhagic shock. Bulletin of experimental biology and medicine 20101001
Inhibition of nitric oxide synthesis during induced cholestasis ameliorates hepatocellular injury by facilitating S-nitrosothiol homeostasis. Laboratory investigation; a journal of technical methods and pathology 20100101
Neuroprotective effect of s-methylisothiourea in transient focal cerebral ischemia in rat. Nitric oxide : biology and chemistry 20100101
Evaluation of effects of s-methyl isothiourea and melatonin on intestinal ischemia/reperfusion injury in rats. Fetal and pediatric pathology 20100101
Sympathoinhibitory mechanism of moxonidine: role of the inducible nitric oxide synthase in the rostral ventrolateral medulla. Cardiovascular research 20091101
Nitric oxide and superoxide anion differentially activate poly(ADP-ribose) polymerase-1 and Bax to induce nuclear translocation of apoptosis-inducing factor and mitochondrial release of cytochrome c after spinal cord injury. Journal of neurotrauma 20090701
Effect of microglia activation on dopaminergic neuronal injury induced by manganese, and its possible mechanism. Neurotoxicity research 20090701
[Nitrogen monoxide and functional activity of large conductance Ca-activated potassium channels in coronary vessels in rats with limited motor activity]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20090701
Influence of propofol on blood pressure spectrum in sepsis and the role of inducible nitric oxide synthase. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20090601
Endothelial nitric oxide synthase is a critical factor in experimental liver fibrosis. International journal of experimental pathology 20080801
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats. International journal of pediatric otorhinolaryngology 20080801
Melatonin inhibits amphetamine-induced nitric oxide synthase mRNA overexpression in microglial cell lines. Neuroscience letters 20080711
Intermittent hypoxia modulates nitric oxide-dependent vasodilation and capillary perfusion during ischemia-reperfusion-induced damage. American journal of physiology. Heart and circulatory physiology 20080401
The interaction between inhibitors of nitric oxide synthase and cyclooxygenase in formalin-induced pain in mice: an isobolographic study. Anesthesia and analgesia 20080301
Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. The Journal of neuroscience : the official journal of the Society for Neuroscience 20080227
Scavenging of peroxynitrite reduces renal ischemia/reperfusion injury. Renal failure 20080101
Malignant alterations following early blockade of nitric oxide synthase in hypertensive rats. The Chinese journal of physiology 20071231
Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice. Neuroscience 20071205
A triterpenediol from Boswellia serrata induces apoptosis through both the intrinsic and extrinsic apoptotic pathways in human leukemia HL-60 cells. Apoptosis : an international journal on programmed cell death 20071001
Antagonism of lipopolysaccharide-induced blood pressure attenuation and vascular contractility. Arteriosclerosis, thrombosis, and vascular biology 20071001
Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells. Journal of neuroscience research 20070901
Probing the structure and activity of trypsin with amidination. Analytical biochemistry 20070801
Enhanced beta-adrenergic response in rat papillary muscle by inhibition of inducible nitric oxide synthase after myocardial infarction. Acta physiologica (Oxford, England) 20070601
[Animal experimental study of intra-articular injection of S-methylisothiourea for treatment of temporomandibular joint osteoarthrosis]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20070601
Responsiveness to inhaled NO in isolated-perfused lungs from endotoxin-challenged rats is dependent on endogenous nitrite/nitrate synthesis. European journal of anaesthesiology 20070401
Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats. Clinical and experimental pharmacology & physiology 20070401
Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study. European journal of pharmacology 20070205
[Influence of induced nitric oxide synthase expression on apoptosis of thymocyte in burn rats]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20061201
NO-synthase inhibitors provide influence on protective effect of modified endotoxine diphosphoryl lipid A in a rat heart model of ischemic-reperfusion injury. Die Pharmazie 20060601
Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in beta-amyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neuroscience letters 20060515
Phenotypic adaptation of the late preconditioned heart: myocardial oxygen consumption is reduced. Cardiovascular research 20060501
The astroglial-derived S100beta protein stimulates the expression of nitric oxide synthase in rodent macrophages through p38 MAP kinase activation. Life sciences 20060501
COX-2 mediates morphine-induced delayed cardioprotection via an iNOS-dependent mechanism. Life sciences 20060425
Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain research 20060421
Toll-like receptor 4, nitric oxide, and myocardial depression in endotoxemia. Shock (Augusta, Ga.) 20060101
Mechanism of hepatic heme oxygenase-1 induction by isoflurane. Anesthesiology 20060101
Reinforcement therapy using nitric oxide synthase inhibitors against endotoxin shock in dogs. Surgery today 20060101
Nitric oxide- and superoxide-dependent mitochondrial signaling in endotoxin-induced apoptosis in the rostral ventrolateral medulla of rats. Free radical biology & medicine 20050901
High levels of endogenous nitric oxide produced after burn injury in rats arrest activated T lymphocytes in the first G1 phase of the cell cycle and then induce their apoptosis. Experimental cell research 20050515
Inducible nitric oxide synthase inhibition potentiates multiple organ dysfunction induced by endotoxin in conscious rats. Journal of cardiovascular pharmacology 20050501
Inhibition of iNOS with S-methylisothiourea was impaired in wound healing in caustic esophageal burn. International journal of pediatric otorhinolaryngology 20050401
Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in Brewer's yeast induced pyrexia in mice: an isobolographic study. European journal of pharmacology 20050328
[Inhibition of nitric oxide synthesis during bacterial shock does not prevent development of resistant hypotension and death in rats]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) 20050101
[Platelet aggregation in modulation of the pathway L-arginine-NO in rats with cerebral ischemia]. Patologicheskaia fiziologiia i eksperimental'naia terapiia 20050101
Involvement of inducible nitric oxide synthase in renal failure after mild hemorrhage. Legal medicine (Tokyo, Japan) 20041001
Pharmacological manipulation of nitric oxide levels in mouse follicle cultures demonstrates key role of extrafollicular control of ovulation. Human reproduction (Oxford, England) 20040801
Inducible nitric oxide synthase mediates delayed cardioprotection induced by morphine in vivo: evidence from pharmacologic inhibition and gene-knockout mice. Anesthesiology 20040701
Inhibition of NOS2 ameliorates cardiac remodeling, improves heart function after myocardial infarction in rats. Basic research in cardiology 20040701
Modulation of iNOS activity in age-related cardiac dysfunction. Life sciences 20040625
Decrease in arterial pressure induced by adrenomedullin in the hypothalamic paraventricular nucleus is mediated by nitric oxide and GABA. Regulatory peptides 20040615
Inducible nitric oxide synthase inhibition in cyclophosphamide induced hemorrhagic cystitis in rats. Urological research 20040601
COX-2 and iNOS in opioid-induced delayed cardioprotection in the intact rat. Life sciences 20040528
Down-regulation of cytochrome P450 proteins and its activities by Shiga-like toxin II from Escherichia coli O157:H7. Biochemical pharmacology 20040415
Sublethal simulated ischemia promotes delayed resistance against ischemia via ATP-sensitive (K+) channels in murine myocytes: role of PKC and iNOS. Antioxidants & redox signaling 20040401
Improvement of intestinal motility using S-methylisothiourea in postoperative ileus. American journal of surgery 20040101
Involvement of nitric oxide and hyperbaric oxygen in the pathogenesis of cyclophosphamide induced hemorrhagic cystitis in rats. The Journal of urology 20031201
Effect of nitric oxide synthase inhibitor on proteoglycan metabolism in repaired articular cartilage in rabbits. Chinese journal of traumatology = Zhonghua chuang shang za zhi 20031201
Modulation of nerve growth factor-induced activation of MAP kinase in PC12 cells by inhibitors of nitric oxide synthase. Journal of neurochemistry 20031201
Reversal of the effect of albumin on gut barrier function in burn by the inhibition of inducible isoform of nitric oxide synthase. Archives of surgery (Chicago, Ill. : 1960) 20031101
Lipopolysaccharide down-regulates inducible nitric oxide synthase expression in swine heart in vivo. Biochemical and biophysical research communications 20030801
Downregulation of angiotensin subtype 1 receptor in rostral ventrolateral medulla during endotoxemia. Hypertension (Dallas, Tex. : 1979) 20030701
The role of inducible nitric oxide synthase inhibitor, meropenem, and taurine in experimental acute necrotizing pancreatitis. Pancreas 20030501
Effect of venom from the scorpion Leiurus quinquestriatus on rat vascular aortic rings. Journal of basic and clinical physiology and pharmacology 20030101
Increased nitric oxide production by neutrophils from patients with chronic granulomatous disease on trimethoprim-sulfamethoxazole. Nitric oxide : biology and chemistry 20021201
Aminoguanidine inhibits mitogen-activated protein kinase and improves cardiac performance and cardiovascular remodeling in failing hearts of salt-sensitive hypertensive rats. Journal of hypertension 20021201
Nitric oxide modulates myocardial oxygen consumption in the failing heart. Circulation 20020709
Inhibition of NOS II prevents cardiac dysfunction in myocardial infarction and congestive heart failure. American journal of physiology. Heart and circulatory physiology 20020701
Differential activity of NO synthase inhibitors as chemopreventive agents in a primary rat tracheal epithelial cell transformation system. Neoplasia (New York, N.Y.) 20020701
Inhibitors of nitric oxide synthase attenuate nerve growth factor-mediated increases in choline acetyltransferase expression in PC12 cells. Journal of neurochemistry 20020501
Kupffer cells protect liver from ischemia-reperfusion injury by an inducible nitric oxide synthase-dependent mechanism. Shock (Augusta, Ga.) 20020401
Differential effects of selective and non-selective NOS inhibition on renal arginine and protein metabolism during endotoxemia in rats. Clinical nutrition (Edinburgh, Scotland) 20020401
Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines. Clinical science (London, England : 1979) 20020301
[Long-term effect of nitric oxide synthase inhibitor on repair of articular cartilage defects repairing]. Zhonghua yi xue za zhi 20020110
Renal effects of nitric oxide in endotoxemia. American journal of respiratory and critical care medicine 20011115
High levels of nitric oxide production decrease early but increase late survival of Brucella abortus in macrophages. Microbial pathogenesis 20011101
Reduced functional expression and molecular synthesis of inducible nitric oxide synthase in rostral ventrolateral medulla of spontaneously hypertensive rats. Circulation 20011002
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 20011001
Inhibition of inducible nitric oxide synthase reduces bacterial translocation in a rat model of acute pancreatitis. Pancreas 20011001
Intestinal motility in an in vivo rat model of intestinal ischemia-reperfusion with special reference to the effects of nitric oxide on the motility changes. Journal of pediatric gastroenterology and nutrition 20010901
A novel method of studying wound healing. The Journal of surgical research 20010601
Lipopolysaccharide-induced cell cycle arrest in macrophages occurs independently of nitric oxide synthase II induction. Biochimica et biophysica acta 20010528
Expression of inducible nitric oxide synthase in primary culture of rat bladder smooth muscle cells by plasma from cyclophosphamide-treated rats. European journal of pharmacology 20010323
Intestinal ischemia induces late preconditioning against myocardial infarction: a role for inducible nitric oxide synthase. Cardiovascular research 20010201
Inhibition of inducible nitric oxide synthase (iNOS) prevents lung neutrophil deposition and damage in burned rats. Shock (Augusta, Ga.) 20010201
Role of nitric oxide in human gastric cancer cells treated with 5-fluorouracil. Oncology reports 20010101
Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice. Circulation 20000822
Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase. American journal of hypertension 19990201
Expression and function of inducible nitric oxide synthase during rat colon anastomotic healing. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 19990101
Selective iNOS inhibition is superior to norepinephrine in the treatment of rat endotoxic shock. American journal of respiratory and critical care medicine 19980101
Timing of administration of dexamethasone or the nitric oxide synthase inhibitor, nitro-L-arginine methyl ester, is critical for effective treatment of ischaemia-reperfusion injury to rat skeletal muscle. Clinical science (London, England : 1979) 19970801
Properties