2-Fluoroadenine
| Title | Journal |
|---|---|
| Aberrant cyclization affords a C-6 modified cyclic adenosine 5'-diphosphoribose analogue with biological activity in Jurkat T cells. | Journal of medicinal chemistry 20120223 |
| Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase. | Cancer gene therapy 20110601 |
| Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancer. | BMC cancer 20110101 |
| Structural basis for enzymatic evolution from a dedicated ADP-ribosyl cyclase to a multifunctional NAD hydrolase. | The Journal of biological chemistry 20091002 |
| Diastereocontrolled electrophilic fluorinations of 2-deoxyribonolactone: syntheses of all corresponding 2-deoxy-2-fluorolactones and 2'-deoxy-2'-fluoro-NAD+s. | The Journal of organic chemistry 20090821 |
| A limited sampling schedule to estimate individual pharmacokinetic parameters of fludarabine in hematopoietic cell transplant patients. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090815 |
| Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. | Protein science : a publication of the Protein Society 20090501 |
| Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. | PloS one 20090101 |
| Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. | Journal of experimental & clinical cancer research : CR 20090101 |
| Key labeling technologies to tackle sizeable problems in RNA structural biology. | International journal of molecular sciences 20080601 |
| Cloning and functional expression of a novel Gi protein-coupled receptor for adenine from mouse brain. | Molecular pharmacology 20080201 |
| Prodrug converting enzyme gene delivery by L. monocytogenes. | BMC cancer 20080101 |
| Comparison of gene targeting efficiencies in two mosses suggests that it is a conserved feature of Bryophyte transformation. | Biotechnology letters 20071001 |
| [(3)H]Adenine is a suitable radioligand for the labeling of G protein-coupled adenine receptors but shows high affinity to bacterial contaminations in buffer solutions. | Purinergic signalling 20070901 |
| Nicotinamide 2-fluoroadenine dinucleotide unmasks the NAD+ glycohydrolase activity of Aplysia californica adenosine 5'-diphosphate ribosyl cyclase. | Biochemistry 20070403 |
| Preparation of a fludarabine intermediate via selective alkylation of 2-fluoroadenine. | Nucleosides, nucleotides & nucleic acids 20060101 |
| Cytosine arabinoside affects multiple cellular factors and induces drug resistance in human lymphoid cells. | Biochemical pharmacology 20050801 |
| Identification of a subversive substrate of Trichomonas vaginalis purine nucleoside phosphorylase and the crystal structure of the enzyme-substrate complex. | The Journal of biological chemistry 20050610 |
| Oligotide, a defibrotide derivative, protects human microvascular endothelial cells against fludarabine-induced activation, damage and allogenicity. | Bone marrow transplantation 20050501 |
| Evidence for the functional expression and pharmacological characterization of adenine receptors in native cells and tissues. | Molecular pharmacology 20050301 |
| Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer. | Nucleosides, nucleotides & nucleic acids 20050101 |
| Preclinical evaluation of a prostate-targeted gene-directed enzyme prodrug therapy delivered by ovine atadenovirus. | Gene therapy 20041101 |
| Enzymatic synthesis and 19F NMR studies of 2-fluoroadenine-substituted RNA. | Journal of the American Chemical Society 20040929 |
| Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. | Journal of medicinal chemistry 20040226 |
| Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease. | The journal of gene medicine 20040101 |
| Synthesis of 2-fluoronoraristeromycin and its inhibitory activity against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase. | Bioorganic & medicinal chemistry letters 20031117 |
| Convenient synthesis of 2'-deoxy-2-fluoroadenosine from 2-fluoroadenine. | Nucleosides, nucleotides & nucleic acids 20031001 |
| Synthesis of carbocyclic and acyclic nucleosides possessing 2-fluoroadenine derivatives and their inhibitory activities against Plasmodium falciparum SAH hydrolase. | Nucleic acids research. Supplement (2001) 20030101 |
| Fludarabine induces apoptosis, activation, and allogenicity in human endothelial and epithelial cells: protective effect of defibrotide. | Blood 20020701 |
| Gene therapy for prostate cancer delivered by ovine adenovirus and mediated by purine nucleoside phosphorylase and fludarabine in mouse models. | Gene therapy 20020601 |
| Interactions between 2-fluoroadenine 9-beta-D-arabinofuranoside and the kinase inhibitor UCN-01 in human leukemia and lymphoma cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20010201 |