Home Halogens 2,6-Dichloropurine

2,6-Dichloropurine

CAS No.:
5451-40-1
Catalog Number:
AG00331B
Molecular Formula:
C5H2Cl2N4
Molecular Weight:
189.0022
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
95%
In Stock USA
United States
$13
- +
5g
95%
In Stock USA
United States
$19
- +
10g
95%
In Stock USA
United States
$32
- +
25g
95%
In Stock USA
United States
$50
- +
100g
≥98%
In Stock USA
United States
$172
- +
Product Description
Catalog Number:
AG00331B
Chemical Name:
2,6-Dichloropurine
CAS Number:
5451-40-1
Molecular Formula:
C5H2Cl2N4
Molecular Weight:
189.0022
MDL Number:
MFCD09749894
IUPAC Name:
2,6-dichloro-7H-purine
InChI:
InChI=1S/C5H2Cl2N4/c6-3-2-4(9-1-8-2)11-5(7)10-3/h1H,(H,8,9,10,11)
InChI Key:
RMFWVOLULURGJI-UHFFFAOYSA-N
SMILES:
Clc1nc(Cl)c2c(n1)nc[nH]2
EC Number:
226-681-6
NSC Number:
18395
Properties
Complexity:
155  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
187.966g/mol
Formal Charge:
0
Heavy Atom Count:
11  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
188.999g/mol
Monoisotopic Mass:
187.966g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
54.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7  
Literature
Title Journal
Two tautomeric polymorphs of 2,6-dichloropurine. Acta crystallographica. Section C, Crystal structure communications 20111201
Direct C-H arylation of purine on solid phase and its use for chemical libraries synthesis. ACS combinatorial science 20110912
Solid-phase synthesis of highly diverse purine-hydroxyquinolinone bisheterocycles. Journal of combinatorial chemistry 20101108
A class of novel conjugates of substituted purine and Gly-AA-OBzl: synthesis and evaluation of orally analgesic activity. Bioorganic & medicinal chemistry letters 20101015
Inhibition of human immunodeficiency virus type-1 by cdk inhibitors. AIDS research and therapy 20100101
UVC induced oxidation of chloropurines: excited singlet and triplet pathways for the photoreaction. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology 20080901
Two specific drugs, BMS-345541 and purvalanol A induce apoptosis of HTLV-1 infected cells through inhibition of the NF-kappaB and cell cycle pathways. AIDS research and therapy 20080101
New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile. Purinergic signalling 20070901
Structure and synthesis of 6-(substituted-imidazol-1-yl)purines: versatile substrates for regiospecific alkylation and glycosylation at N9. The Journal of organic chemistry 20060526
Synthesis and Ca2+-mobilizing activity of purine-modified mimics of adenophostin A: a model for the adenophostin-Ins(1,4,5)P3 receptor interaction. Journal of medicinal chemistry 20031106
An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines. The Journal of organic chemistry 20030711
Purine and deazapurine nucleosides: synthetic approaches, molecular modelling and biological activity. Farmaco (Societa chimica italiana : 1989) 20030301
Nucleic acid related compounds. 118. Nonaqueous diazotization of aminopurine derivatives. Convenient access to 6-halo- and 2,6-dihalopurine nucleosides and 2'-deoxynucleosides with acyl or silyl halides. The Journal of organic chemistry 20030124
Catalysis of nucleophilic aromatic substitutions in the 2,6,8-trisubstituted purines and application in the synthesis of combinatorial libraries. Molecular diversity 20030101
Nucleic acid related compounds. 116. Nonaqueous diazotization of aminopurine nucleosides. Mechanistic considerations and efficient procedures with tert-butyl nitrite or sodium nitrite. The Journal of organic chemistry 20020920
Adenine and deazaadenine nucleoside and deoxynucleoside analogues: inhibition of viral replication of sheep MVV (in vitro model for HIV) and bovine BHV-1. Bioorganic & medicinal chemistry 20020901
5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors. Journal of medicinal chemistry 20010830
Synthesis and biological activity of 4'-C-hydroxymethyl-2'-fluoro-D-arabinofuranosylpurine nucleosides. Nucleosides, nucleotides & nucleic acids 20010101
Coupling of 2,6-disubstituted purines to ribose-modified sugars. Nucleosides, nucleotides & nucleic acids 20010101
Prevalence and characteristics of multinucleoside-resistant human immunodeficiency virus type 1 among European patients receiving combinations of nucleoside analogues. Antimicrobial agents and chemotherapy 20000801
A new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidine. Antimicrobial agents and chemotherapy 19990801
Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. Biochemical pharmacology 19951109
Properties