Home Other Building Blocks 2,2'-Azobis(2-amidinopropane) dihydrochloride

2,2'-Azobis(2-amidinopropane) dihydrochloride

CAS No.:
2997-92-4
Catalog Number:
AG0032WK
Molecular Formula:
C8H20Cl2N6
Molecular Weight:
271.1906
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
97%
In Stock USA
United States
$44
- +
25g
97%
In Stock USA
United States
$62
- +
100g
97%
In Stock USA
United States
$91
- +
Product Description
Catalog Number:
AG0032WK
Chemical Name:
2,2'-Azobis(2-amidinopropane) dihydrochloride
CAS Number:
2997-92-4
Molecular Formula:
C8H20Cl2N6
Molecular Weight:
271.1906
MDL Number:
MFCD00142725
IUPAC Name:
2-[(1-amino-1-imino-2-methylpropan-2-yl)diazenyl]-2-methylpropanimidamide;dihydrochloride
InChI:
InChI=1S/C8H18N6.2ClH/c1-7(2,5(9)10)13-14-8(3,4)6(11)12;;/h1-4H3,(H3,9,10)(H3,11,12);2*1H
InChI Key:
LXEKPEMOWBOYRF-UHFFFAOYSA-N
SMILES:
NC(=N)C(/N=N/C(C(=N)N)(C)C)(C)C.Cl.Cl
EC Number:
221-070-0
UNII:
7381JDR72F
Properties
Complexity:
248  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
270.113g/mol
Formal Charge:
0
Heavy Atom Count:
16  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
271.19g/mol
Monoisotopic Mass:
270.113g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
125A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
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Involvement of ERK AND p38 MAP kinase in AAPH-induced COX-2 expression in HaCaT cells. Chemistry and physics of lipids 20040401
Kinetic comparisons of anthocyanin reactivities towards 2,2'-azobis(2-amidinopropane) (AAPH) radicals, hydrogen peroxide and tert-buthylhydroperoxide by capillary zone electrophoresis. Chemical & pharmaceutical bulletin 20040401
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Correlation studies of plasma paraoxonase activity and uric acid concentration with AAPH-Induced erythrocyte hemolysis in hemodialysis patients. Artificial organs 20040301
Ultrasound-induced killing of monocytic U937 cells enhanced by 2,2'-azobis(2-amidinopropane) dihydrochloride. Cancer science 20040201
The hypolipidemic natural product Commiphora mukul and its component guggulsterone inhibit oxidative modification of LDL. Atherosclerosis 20040201
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Selenoprotein P protects low-density lipoprotein against oxidation. Free radical research 20040201
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Effect of the number of flavanol units on the antioxidant activity of procyanidin fractions isolated from chocolate. Journal of agricultural and food chemistry 20031105
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Free radical scavenging efficiency of Nano-Se in vitro. Free radical biology & medicine 20031001
Selective psychostimulant sensitization by food restriction: differential changes in accumbens shell and core dopamine. The European journal of neuroscience 20031001
Thiyl radical reaction with thymine: absolute rate constant for hydrogen abstraction and comparison to benzylic C-H bonds. Chemical research in toxicology 20030901
Oxidative damage to a supercoiled DNA by water soluble peroxyl radicals characterized with DNA repair enzymes. Chemical research in toxicology 20030901
Protein hydroperoxides are a major product of low density lipoprotein oxidation during copper, peroxyl radical and macrophage-mediated oxidation. Free radical research 20030901
Oxalomalate, a competitive inhibitor of NADP+-dependent isocitrate dehydrogenase, enhances lipid peroxidation-mediated oxidative damage in U937 cells. Archives of biochemistry and biophysics 20030801
Antioxidant activities of natural vitamin E formulations. Journal of nutritional science and vitaminology 20030801
In vitro glycoxidation of insoluble fibrous type I collagen: solubilization and advanced glycation end products. Journal of protein chemistry 20030801
In vivo and in vitro antioxidant properties of furosemide. Life sciences 20030711
Activity and location of olive oil phenolic antioxidants in liposomes. Chemistry and physics of lipids 20030601
A free radical initiator, 2,2'-azobis (2-aminopropane) dihydrochloride enhances hyperthermia-induced apoptosis in human uterine cervical cancer cell lines. Free radical research 20030601
Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC(FL))) of plasma and other biological and food samples. Journal of agricultural and food chemistry 20030521
Homocysteine strongly enhances metal-catalyzed LDL oxidation in the presence of cystine and cysteine. Atherosclerosis 20030501
Oxidative damage to catalase induced by peroxyl radicals: functional protection by melatonin and other antioxidants. Free radical research 20030501
Grape and grape seed extract capacities at protecting LDL against oxidation generated by Cu2+, AAPH or SIN-1 and at decreasing superoxide THP-1 cell production. A comparison to other extracts or compounds. Free radical research 20030501
Effect of prooxidant agents added at the morula/blastocyst stage on bovine embryo development, cell death and glutathione content. Zygote (Cambridge, England) 20030501
In vitro study of the relationship between the structure of ginsenoside and its antioxidative or prooxidative activity in free radical induced hemolysis of human erythrocytes. Journal of agricultural and food chemistry 20030423
ESR study of a biological assay on whole blood: antioxidant efficiency of various vitamins. Biochimica et biophysica acta 20030407
The cell membrane as a biosensor of oxidative stress induced by radiation exposure: a multiparameter investigation. Radiation research 20030401
Species differences in the susceptibility of erythrocytes exposed to free radicals in vitro. Veterinary research communications 20030401
Synthesis and antioxidant properties of a new lipophilic ascorbic acid analogue. Bioorganic & medicinal chemistry 20030320
Protection against oxidative protein damage induced by metal-catalyzed reaction or alkylperoxyl radicals: comparative effects of melatonin and other antioxidants. Biochimica et biophysica acta 20030317
Prooxidant and antioxidant properties of human serum ultrafiltrates toward LDL: important role of uric acid. Journal of lipid research 20030301
Protective effect of imidazolopyrazinone antioxidants on ischemia/reperfusion injury. Bioorganic & medicinal chemistry letters 20030224
Effect of different metal ions on the oxidative damage and antioxidant capacity of hyaluronic acid. Archives of biochemistry and biophysics 20030201
Docosahexaenoic acid-containing phosphatidylethanolamine in the external layer of liposomes protects docosahexaenoic acid from 2,2'-azobis(2-aminopropane)dihydrochloride-mediated lipid peroxidation. Archives of biochemistry and biophysics 20030201
Inhibitory effects of Oren-Gedoku-To (Huanglian-Jie-Du-Tang) on free radical-induced lysis of human red blood cells. Phytotherapy research : PTR 20030201
Inhibitory effects of triterpenes isolated from Hoelen on free radical-induced lysis of red blood cells. Phytotherapy research : PTR 20030201
Rate of free-radical oxidation of C18 diene and triene fatty acids in aqueous micellar solutions and effectiveness of beta-carotene as an inhibitor of their oxidation. Biochemistry. Biokhimiia 20030201
Inhibition of free radical-induced peroxidation of rat liver microsomes by resveratrol and its analogues. Biochimica et biophysica acta 20030120
Inhibition of LDL oxidation by flavonoids in relation to their structure and calculated enthalpy. Phytochemistry 20030101
Ethanolamine plasmalogens prevent the oxidation of cholesterol by reducing the oxidizability of cholesterol in phospholipid bilayers. Journal of lipid research 20030101
Antioxidative effect of citrus essential oil components on human low-density lipoprotein in vitro. Bioscience, biotechnology, and biochemistry 20030101
Inhibition of protein hydroperoxide formation by protein thiols. Redox report : communications in free radical research 20030101
Ethanolamine plasmalogens protect cholesterol-rich liposomal membranes from oxidation caused by free radicals. Chemistry and physics of lipids 20021201
Intestinal motility disorder induced by free radicals: a new model mimicking oxidative stress in gut. Pharmacological research 20021201
Lipid peroxidation-mediated cytotoxicity and DNA damage in U937 cells. Biochimie 20021201
Phase II enzyme-inducing and antioxidant activities of beetroot (Beta vulgaris L.) extracts from phenotypes of different pigmentation. Journal of agricultural and food chemistry 20021106
Protection by estrogens of biological damage by 2,2'-azobis(2-amidinopropane) dihydrochloride. The Journal of steroid biochemistry and molecular biology 20021101
Structure-antioxidant activity relationships of flavonoids: a re-examination. Free radical research 20021101
Inhibitory effects of Choto-san (Diao-teng-san), and hooks and stems of Uncaria sinensis on free radical-induced lysis of rat red blood cells. Phytomedicine : international journal of phytotherapy and phytopharmacology 20021001
Protein and thiol oxidation in cells exposed to peroxyl radicals is inhibited by the macrophage synthesised pterin 7,8-dihydroneopterin. Biochimica et biophysica acta 20020819
Can ginsenosides protect human erythrocytes against free-radical-induced hemolysis? Biochimica et biophysica acta 20020815
The effect of oxidative stress on ERalpha and ERbeta expression. The Journal of steroid biochemistry and molecular biology 20020801
Large differences in erythrocyte stability between species reflect different antioxidative defense mechanisms. Free radical research 20020701
Evaluation of antioxidative activity of extracts from a brown seaweed, Sargassum siliquastrum. Journal of agricultural and food chemistry 20020619
Protection of oxidative damage by aqueous extract from Antrodia camphorata mycelia in normal human erythrocytes. Life sciences 20020614
Gallic esters of sucrose as efficient radical scavengers in lipid peroxidation. Journal of agricultural and food chemistry 20020605
Inhibitory effects of Keishi-bukuryo-gan on free radical induced lysis of rat red blood cells. Phytotherapy research : PTR 20020601
OxyR regulon controls lipid peroxidation-mediated oxidative stress in Escherichia coli. Journal of biochemistry and molecular biology 20020531
Assessment of pro-oxidant activity of foods by kinetic analysis of crocin bleaching. Journal of agricultural and food chemistry 20020508
Inhibitory effects of cocoa flavanols and procyanidin oligomers on free radical-induced erythrocyte hemolysis. Experimental biology and medicine (Maywood, N.J.) 20020501
Nitroxides inhibit peroxyl radical-mediated DNA scission and enzyme inactivation. Free radical biology & medicine 20020501
Protective activity of green tea against free radical- and glucose-mediated protein damage. Journal of agricultural and food chemistry 20020410
Development and validation of oxygen radical absorbance capacity assay for lipophilic antioxidants using randomly methylated beta-cyclodextrin as the solubility enhancer. Journal of agricultural and food chemistry 20020327
Protective effects of carnosine, homocarnosine and anserine against peroxyl radical-mediated Cu,Zn-superoxide dismutase modification. Biochimica et biophysica acta 20020315
Antioxidative or prooxidative effect of 4-hydroxyquinoline derivatives on free-radical-initiated hemolysis of erythrocytes is due to its distributive status. Biochimica et biophysica acta 20020315
A novel method using 8-hydroperoxy-2'-deoxyguanosine formation for evaluating antioxidative potency. Free radical research 20020301
Responses of anthocyanin-producing and non-producing cells of Glehnia littoralis to radical generators. Phytochemistry 20020101
Effect of human Apo AIV against lipid peroxidation of very low density lipoproteins. Chemistry and physics of lipids 20020101
Retinal photoreceptors of Syrian hamsters undergo oxidative stress during streptozotocin-induced diabetes. Diabetologia 20020101
Assay of total antioxidant capacity: comparison of four methods as applied to human blood plasma. Scandinavian journal of clinical and laboratory investigation 20020101
Synergistic antioxidative properties of phenolics from natural origin toward low-density lipoproteins depend on the oxidation system. Journal of medicinal food 20020101
Kinetics of lipid peroxidation in mixtures of HDL and LDL, mutual effects. Free radical biology & medicine 20011201
Oxidative modification of human ceruloplasmin by peroxyl radicals. Biochimica et biophysica acta 20011107
A method to measure the oxidizability of both the aqueous and lipid compartments of plasma. Free radical biology & medicine 20011101
Properties of St I and St II, two isotoxins isolated from Stichodactyla helianthus: a comparison. Toxicon : official journal of the International Society on Toxinology 20011001
A unique antioxidant activity of phosphatidylserine on iron-induced lipid peroxidation of phospholipid bilayers. Lipids 20011001
Antioxidative activity of 3,4-dihydroxyphenylacetic acid and caffeic acid in rat plasma. Lipids 20011001
Carotenoids are degraded by free radicals but do not affect lipid peroxidation in unilamellar liposomes under different oxygen tensions. FEBS letters 20010907
Enhancement of hyperthermia-induced apoptosis by a free radical initiator, 2,2'-azobis (2-amidinopropane) dihydrochloride, in human histiocytic lymphoma U937 cells. Free radical research 20010901
Protection of U937 cells from free radical damage by the macrophage synthesized antioxidant 7,8-dihydroneopterin. Free radical research 20010901
Interactions between apolipoprotein E gene and dietary alpha-tocopherol influence cerebral oxidative damage in aged mice. The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815
Changes in ascorbic acid content in primary cultured rat hepatocytes exposed to 2,2'-azobis (2-amidinopropane) dihydrochloride, a radical initiator. The Journal of veterinary medical science 20010801
Kinetics of peroxidation of linoleic acid incorporated into DPPC vesicles initiated by the thermal decomposition of 2,2'-azobis(2-amidinopropane) dihydrochloride. Chemistry and physics of lipids 20010701
Oxidative stress promotes the development of transformation: involvement of a potent mutagenic lipid peroxidation product, acrolein. Carcinogenesis 20010601
Free radical-induced protein degradation of erythrocyte membrane is influenced by the localization of radical generation. IUBMB life 20010601
Oxidative insult to human red blood cells induced by free radical initiator AAPH and its inhibition by a commercial antioxidant mixture. Life sciences 20010525
Structural damage to proteins caused by free radicals: asessment, protection by antioxidants, and influence of protein binding. Biochemical pharmacology 20010515
Antioxidant activity of tocopherols, tocotrienols, and gamma-oryzanol components from rice bran against cholesterol oxidation accelerated by 2,2'-azobis(2-methylpropionamidine) dihydrochloride. Journal of agricultural and food chemistry 20010401
Determination of peroxy radical-scavenging of lactic acid bacteria. International journal of food microbiology 20010227
Is the oxidation of high-density lipoprotein lipids different than the oxidation of low-density lipoprotein lipids? Biochemistry 20010213
In vitro evaluation of the antioxidant activity and biomembrane interaction of the lazaroid U-74389G. Life sciences 20010209
The alpha-amino group of L-arginine mediates its antioxidant effect. European journal of clinical investigation 20010201
Effect of ethyl esterification of phenolic acids on low-density lipoprotein oxidation. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20010201
Protection of erythrocytes by the macrophage synthesized antioxidant 7,8 dihydroneopterin. Free radical research 20010201
Evaluation of antioxidant activity of epigallocatechin gallate in biphasic model systems in vitro. Molecular and cellular biochemistry 20010201
Activation of caspase-3 by lysosomal cysteine proteases and its role in 2,2'-azobis-(2-amidinopropane)dihydrochloride (AAPH)-induced apoptosis in HL-60 cells. Journal of biochemistry 20010101
Caseins and casein hydrolysates. 2. Antioxidative properties and relevance to lipoxygenase inhibition. Journal of agricultural and food chemistry 20010101
Contribution of haemoglobin and membrane constituents modification to human erythrocyte damage promoted by peroxyl radicals of different charge and hydrophobicity. Free radical research 20010101
5-Aminosalicylic acid protection against oxidative damage to synaptosomal membranes by alkoxyl radicals in vitro. Neurochemical research 20010101
Inhibition of protein oxidation by the macrophage-synthesised antioxidant 7,8-dihydroneopterin. Redox report : communications in free radical research 20010101
The antioxidant activity of BHT and new phenolic compounds PYA and PPA measured by chemiluminescence. Cellular & molecular biology letters 20010101
Hemolysis of human erythrocytes induced by tamoxifen is related to disruption of membrane structure. Biochimica et biophysica acta 20000315
The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Atherosclerosis 19980301
The effect of nitric oxide release rates on the oxidation of human low density lipoprotein. The Journal of biological chemistry 19970822
Protective effects of beta-blockers against 2,2'-azobis(2-amidinopropane)-dihydrochloride-induced damage. Chemico-biological interactions 19950630
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