Moderate chemical modifications of WAY-100635 improve the selectivity for 5-HT1A versus D4 receptors.

Bioorganic & medicinal chemistry letters 20120715

Antiarrhythmic properties of phenylpiperazine derivatives of phenytoin with α₁-adrenoceptor affinities.

Bioorganic & medicinal chemistry 20120401

FT-IR and Raman spectroscopic and quantum chemical investigations of some metal halide complexes of 1-phenylpiperazine.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20120301

3-(Adamantan-1-yl)-4-phenyl-1-[(4-phenyl-piperazin-1-yl)meth-yl]-1H-1,2,4-triazole-5(4H)-thione.

Acta crystallographica. Section E, Structure reports online 20120201

[Design, synthesis and characterization of cyanopyrrolidine-bearing compounds as DPP-4 inhibitors].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20120201

Structure-activity relationships of 2-amino-3-aroyl-4-[(4-arylpiperazin-1-yl)methyl]thiophenes. Part 2: Probing the influence of diverse substituents at the phenyl of the arylpiperazine moiety on allosteric enhancer activity at the A₁ adenosine receptor.

Bioorganic & medicinal chemistry 20120115

Bivalent molecular probes for dopamine D2-like receptors.

Bioorganic & medicinal chemistry 20120101

Rates of 5 common antidepressant side effects among new adult and adolescent cases of depression: a retrospective US claims study.

Clinical therapeutics 20120101

How full is our antihypertensives pipeline?

Journal of pharmacology & pharmacotherapeutics 20120101

Synthesis and evaluation of a series of 2-substituted-5-thiopropylpiperazine (piperidine)-1,3,4-oxadiazoles derivatives as atypical antipsychotics.

PloS one 20120101

Synthesis and vibrational spectroscopic analysis of some Hofmann type clathrates.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20111101

Ligand discovery from a dopamine D3 receptor homology model and crystal structure.

Nature chemical biology 20111101

10α-Hy-droxy-4,9-dimethyl-13-[(4-phenyl-piperazin-1-yl)meth-yl]-3,8,15-trioxatetra-cyclo-[10.3.0.0.0]tetra-decan-14-one.

Acta crystallographica. Section E, Structure reports online 20111101

Synthesis and anticonvulsant activity of new 1-[2-oxo-2-(4-phenylpiperazin-1-yl)ethyl]pyrrolidine-2,5-diones.

Bioorganic & medicinal chemistry letters 20111001

Molecular dynamics study of small molecule inhibitors of the Bcl-2 family.

Proteins 20110901

Biophysical mapping of the adenosine A2A receptor.

Journal of medicinal chemistry 20110714

Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum.

Neuroreport 20110713

Synthesis and antibacterial activity of pentacyclines: a novel class of tetracycline analogs.

Journal of medicinal chemistry 20110609

N-(3-fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl)arylcarboxamides as selective dopamine D3 receptor ligands: critical role of the carboxamide linker for D3 receptor selectivity.

Journal of medicinal chemistry 20110526

The identification of the 2-phenylphthalazin-1(2H)-one scaffold as a new decorable core skeleton for the design of potent and selective human A3 adenosine receptor antagonists.

Journal of medicinal chemistry 20110414

Histidine 6.55 is a major determinant of ligand-biased signaling in dopamine D2L receptor.

Molecular pharmacology 20110301

The clinical toxicology of the designer 'party pills' benzylpiperazine and trifluoromethylphenylpiperazine.

Clinical toxicology (Philadelphia, Pa.) 20110301

The effects of the 4-(4-Methylpiperazine)phenyl group on nucleosides and oligonucleotides: cellular delivery, detection, and stability.

Chemistry, an Asian journal 20110201

Evaluation of the D3 dopamine receptor selective agonist/partial agonist PG01042 on L-dopa dependent animal involuntary movements in rats.

Neuropharmacology 20110101

Antidepressant-like activity of the phenylpiperazine pyrrolidin-2-one derivatives in mice.

Pharmacological reports : PR 20110101

A novel structural framework for α(1A/D)-adrenoceptor selective antagonists identified using subtype selective pharmacophores.

PloS one 20110101

Structure-cardiovascular activity relationships in a group of new 8-alkylamino-1,3-dimethyl-7-(2-hydroxy-3-aminopropyl)-3,7-dihydro-1H-purine-2,6-diones.

Pharmacological reports : PR 20110101

Oxidation of fluoroquinolone antibiotics and structurally related amines by chlorine dioxide: Reaction kinetics, product and pathway evaluation.

Water research 20101201

Search for influence of spatial properties on affinity at α1-adrenoceptor subtypes for phenylpiperazine derivatives of phenytoin.

Bioorganic & medicinal chemistry letters 20101015

Analysis of phenylpiperazine-like stimulants in human hair as trimethylsilyl derivatives by gas chromatography-mass spectrometry.

Journal of chromatography. A 20101001

1-Phenyl-piperazine-1,4-diium bis-(hydrogen sulfate).

Acta crystallographica. Section E, Structure reports online 20101001

Novel tricyclic pyrazole BRAF inhibitors with imidazole or furan central scaffolds.

Bioorganic & medicinal chemistry 20100915

4-Phenyl-piperazin-1-ium dihydrogen phosphate.

Acta crystallographica. Section E, Structure reports online 20100901

[3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen.

Synapse (New York, N.Y.) 20100601

Design of new dopamine D2 receptor ligands: biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581.

Bioorganic & medicinal chemistry letters 20100501

Synthesis and evaluation of a set of 4-phenylpiperidines and 4-phenylpiperazines as D2 receptor ligands and the discovery of the dopaminergic stabilizer 4-[3-(methylsulfonyl)phenyl]-1-propylpiperidine (huntexil, pridopidine, ACR16).

Journal of medicinal chemistry 20100325

Dopamine D3 receptor selective ligands with varying intrinsic efficacies at adenylyl cyclase inhibition and mitogenic signaling pathways.

Synapse (New York, N.Y.) 20100301

Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors.

Bioorganic & medicinal chemistry 20100301

Molecular modeling study of 4-phenylpiperazine and 4-phenyl-1,2,3,6-tetrahydropyridine derivatives: a new step towards the design of high-affinity 5-HT1A ligands.

Bioorganic & medicinal chemistry letters 20100201

Animal violence demystified.

Frontiers in behavioral neuroscience 20100101

Metabotropic glutamate receptors: potential drug targets for psychiatric disorders.

The open medicinal chemistry journal 20100101

[(18)F]-labeled 2-methoxyphenylpiperazine derivative as a potential brain positron emission tomography imaging agent.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20091101

Construction of drug screening cell model and application to new compounds inhibiting FITC-fibrinogen binding to CHO cells expressing human alphaIIbbeta3.

European journal of pharmacology 20090915

[(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization.

Synapse (New York, N.Y.) 20090901

Dopamine D2, D3, and D4 selective phenylpiperazines as molecular probes to explore the origins of subtype specific receptor binding.

Journal of medicinal chemistry 20090813

Design, synthesis and dopamine D4 receptor binding activities of new N-heteroaromatic 5/6-ring Mannich bases.

Bioorganic & medicinal chemistry 20090701

Acaricidal properties of piperazine and its derivatives against house-dust and stored-food mites.

Pest management science 20090601

1-Chloro-2-(4-phenyl-piperazin-1-yl)ethanone.

Acta crystallographica. Section E, Structure reports online 20090601

Discovery process and pharmacological characterization of 2-(S)-(4-fluoro-2-methylphenyl)piperazine-1-carboxylic acid [1-(R)-(3,5-bis-trifluoromethylphenyl)ethyl]methylamide (vestipitant) as a potent, selective, and orally active NK1 receptor antagonist.

Journal of medicinal chemistry 20090528

Application of a library of artificial receptors formed by the self-organization of N-lipidated peptides immobilized on cellulose in studying the effects of the incorporation of a fluorine atom.

Journal of combinatorial chemistry 20090101

Evaluation of D2 and D3 dopamine receptor selective compounds on L-dopa-dependent abnormal involuntary movements in rats.

Neuropharmacology 20090101

Synthesis and pharmacological evaluation of new 1-[3-(4-phenylpiperazin-1-yl)-propyl]- and 1-[3-(4-phenylpiperidine)-propyl]- 3-aryl-3-alkyl-pyrrolidin-2-one derivatives with antiarrhythmic and antihypertensive activity.

Acta poloniae pharmaceutica 20090101

SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression.

European journal of pharmacology 20081119

Probe compounds to quantify cation exchange and complexation interactions of ciprofloxacin with soils.

Environmental science & technology 20081115

Design, synthesis, and acetylcholinesterase inhibitory activity of novel coumarin analogues.

Bioorganic & medicinal chemistry 20080901

NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds.

Bioorganic & medicinal chemistry 20080901

FT-IR spectroscopic investigation of some Hofmann type complexes: M(1-phenylpiperazine)2Ni(CN)4 (M=Ni, Co, Cd, Pd or Mn).

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080701

1-(4-Chloro-phen-yl)piperazine-1,4-diium tetra-chlorido-zincate(II) monohydrate.

Acta crystallographica. Section E, Structure reports online 20080701

Synthesis, alpha 1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin.

Bioorganic & medicinal chemistry 20080601

Pharmacokinetic evaluation of LASSBio-579: an N-phenylpiperazine antipsychotic prototype.

The Journal of pharmacy and pharmacology 20080601

(Phenylpiperazinyl-butyl)oxindoles as selective 5-HT7 receptor antagonists.

Journal of medicinal chemistry 20080424

Determination of lipophilicity of alpha-(4-phenylpiperazine) derivatives of N-benzylamides using chromatographic and computational methods.

Biomedical chromatography : BMC 20080401

Serotonergic neurotransmission mediates hypothermia induced by the N-phenylpiperazine antipsychotic prototypes LASSBio-579 and LASSBio-581.

Pharmacology, biochemistry, and behavior 20080301

Trazodone for Alzheimer's disease: a naturalistic follow-up study.

Archives of gerontology and geriatrics 20080101

Two new phenylpiperazines with atypical antipsychotic potential.

Bioorganic & medicinal chemistry letters 20071101

From tyrosine to glycine: synthesis and biological activity of potent antagonists of the purinergic P2X7 receptor.

Journal of medicinal chemistry 20070726

FT-IR and NMR investigation of 1-phenylpiperazine: a combined experimental and theoretical study.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20070701

Synthesis and in vitro evaluation of substituted phenyl-piperazinyl-phenyl oxazolidinones against Gram-positive bacteria.

Chemical biology & drug design 20070401

Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp.

Journal of industrial microbiology & biotechnology 20070301

Adsorption and oxidation of fluoroquinolone antibacterial agents and structurally related amines with goethite.

Chemosphere 20070101

Patented small molecule inhibitors in the ubiquitin proteasome system.

BMC biochemistry 20070101

Novel potent neuropeptide Y Y5 receptor antagonists: synthesis and structure-activity relationships of phenylpiperazine derivatives.

Bioorganic & medicinal chemistry 20061115

Binding of sulfonyl-containing arylalkylamines at human 5-HT6 serotonin receptors.

Journal of medicinal chemistry 20060824

BACE-1 inhibitory activities of new substituted phenyl-piperazine coupled to various heterocycles: chromene, coumarin and quinoline.

Bioorganic & medicinal chemistry letters 20060401

Binding and photocleavage of cationic porphyrin-phenylpiperazine hybrids to DNA.

Biophysical chemistry 20060201

In vitro metabolism studies of (18)F-labeled 1-phenylpiperazine using mouse liver S9 fraction.

Nuclear medicine and biology 20060201

Hepatic metabolism of two alpha-1A-adrenergic receptor antagonists, phthalimide-phenylpiperazine analogs (RWJ-69205 and RWJ-69471), in the rat, dog and human.

European journal of drug metabolism and pharmacokinetics 20060101

Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents.

Bioorganic & medicinal chemistry letters 20051101

Synthesis of potent and selective serotonin 5-HT1B receptor ligands.

Bioorganic & medicinal chemistry letters 20051101

Complete assignments of 1H and 13C NMR data for ten phenylpiperazine derivatives.

Magnetic resonance in chemistry : MRC 20051001

Pharmacokinetics and tissue distribution of a new heterocyclic N-phenylpiperazine derivative (LASSBio-581) in rats.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20051001

[A study of physicochemical properties of 2-, 3-, 4-alkoxyphenylcarbamic acid derivatives with a substituted N-phenylpiperazine moiety in the basic part].

Ceska a Slovenska farmacie : casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 20050901

Oxidative transformation of fluoroquinolone antibacterial agents and structurally related amines by manganese oxide.

Environmental science & technology 20050615

Electrospray ionization mass and tandem mass spectra of a series of N-pyrazolylmethyl and N-triazolylmethyl N-phenylpiperazines: new dopaminergic ligands with potential antipsychotic properties.

Journal of mass spectrometry : JMS 20050601

Prediction of genotoxicity of chemical compounds by statistical learning methods.

Chemical research in toxicology 20050601

Synthesis of 3-arylpiperazinylalkylpyrrolo[3,2-d]pyrimidine-2,4-dione derivatives as novel, potent, and selective alpha1-adrenoceptor ligands.

Journal of medicinal chemistry 20050407

Reinforcing and discriminative stimulus effects of 1-benzylpiperazine and trifluoromethylphenylpiperazine in rhesus monkeys.

Drug and alcohol dependence 20050214

Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

Bioorganic & medicinal chemistry 20050103

Interaction of arylpiperazines with the dopamine receptor D2 binding site.

Arzneimittel-Forschung 20050101

Synthesis and 5-HT1A/5-HT2A activity of some butyl analogs in the group of phenylpiperazine alkyl pyrimido[2,1-f]theophyllines.

Pharmacological reports : PR 20050101

Synthesis and biological evaluation of new thiazolyl/benzothiazolyl-amides, derivatives of 4-phenyl-piperazine.

Farmaco (Societa chimica italiana : 1989) 20050101

Comorbidity issues in the pharmacological treatment of Pathological Gambling: a critical review.

Clinical practice and epidemiology in mental health : CP & EMH 20050101

Fluorous reagents and scavengers versus solid-supported reagents and scavengers, a reaction rate and kinetic comparison.

Molecular diversity 20050101

Synthesis and evaluation of in vivo activity of diphenylhydantoin basic derivatives.

European journal of medicinal chemistry 20041201

Acute psychosis following ingestion of 'Rapture'.

Australasian psychiatry : bulletin of Royal Australian and New Zealand College of Psychiatrists 20041201

Synthesis of novel N-alkyl carbamates of a-substituted amides of g-hydroxybutyric acid as potential acetylcholinesterase inhibitors.

Acta poloniae pharmaceutica 20041201

Electrophoretic behavior and pKa determination of quinolones with a piperazinyl substituent by capillary zone electrophoresis.

Journal of chromatography. A 20041008

Modeling of the D2 dopamine receptor arylpiperazine binding site for 1-[2-[5-(1H-benzimidazole-2-thione)]ethyl]-4-arylpiperazines.

Archiv der Pharmazie 20040901

New substituted piperazines as ligands for melanocortin receptors. Correlation to the X-ray structure of 'THIQ'.

Journal of medicinal chemistry 20040826

Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype.

Bioorganic & medicinal chemistry letters 20040802

Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry.

Therapeutic drug monitoring 20040801

Phenylpiperazinylmethylheterocycle derivatives: synthesis and dopamine receptor binding profiles.

Archiv der Pharmazie 20040701

1- and 2-substituted naphthalenes: a new class of potential hypotensive agents.

Bioorganic & medicinal chemistry letters 20040607

Discovery of a potent and selective alpha v beta 3 integrin antagonist with strong inhibitory activity against neointima formation in rat balloon injury model.

Bioorganic & medicinal chemistry letters 20040517

Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.

Journal of medicinal chemistry 20040422

Synthesis, screening, and molecular modeling of new potent and selective antagonists at the alpha 1d adrenergic receptor.

Journal of medicinal chemistry 20040408

Synthesis and serotonergic activity of variously substituted (3-amido)phenylpiperazine derivatives and benzothiophene-4-piperazine derivatives: novel antagonists for the vascular 5-HT1B receptor.

European journal of medicinal chemistry 20040401

Chemistry, pharmacology, toxicology, and hepatic metabolism of designer drugs of the amphetamine (ecstasy), piperazine, and pyrrolidinophenone types: a synopsis.

Therapeutic drug monitoring 20040401

Design, synthesis, and alpha(1)-adrenoceptor binding properties of new arylpiperazine derivatives bearing a flavone nucleus as the terminal heterocyclic molecular portion.

Bioorganic & medicinal chemistry 20040315

Ruthenium-catalyzed anti-Markovnikov hydroamination of vinylarenes.

Journal of the American Chemical Society 20040310

Use of physicochemical calculation of pKa and CLogP to predict phospholipidosis-inducing potential: a case study with structurally related piperazines.

Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20040301

Discovery of transdermal penetration enhancers by high-throughput screening.

Nature biotechnology 20040201

Validated HPLC method for determination of LASSBio-581, a new heterocyclic N-phenylpiperazine derivative, in rat plasma.

Journal of pharmaceutical and biomedical analysis 20031204

Intermolecular, markovnikov hydroamination of vinylarenes with alkylamines.

Journal of the American Chemical Society 20031126

Aryl piperazine melanocortin MC4 receptor agonists.

Bioorganic & medicinal chemistry letters 20031103

Synthesis of totarol amino alcohol derivatives and their antiplasmodial activity and cytotoxicity.

Bioorganic & medicinal chemistry 20031001

New pyrimido[5,4-b]indoles as ligands for alpha(1)-adrenoceptor subtypes.

Journal of medicinal chemistry 20030703

Rhodium-catalyzed anti-Markovnikov hydroamination of vinylarenes.

Journal of the American Chemical Society 20030514

Dopaminergic profile of new heterocyclic N-phenylpiperazine derivatives.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20030501

Synthesis and biological activity of N-arylpiperazine-modified analogues of KN-62, a potent antagonist of the purinergic P2X7 receptor.

Journal of medicinal chemistry 20030410

A multicentre prospective controlled study to determine the safety of trazodone and nefazodone use during pregnancy.

Canadian journal of psychiatry. Revue canadienne de psychiatrie 20030301

Effects of nefazodone on voluntary ethanol consumption induced by isolation stress in young and aged rats.

Pharmacology, biochemistry, and behavior 20021001

Alpha(1)-adrenoceptor antagonists. 4. Pharmacophore-based design, synthesis, and biological evaluation of new imidazo-, benzimidazo-, and indoloarylpiperazine derivatives.

Journal of medicinal chemistry 20020815

Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization.

Pharmacology, biochemistry, and behavior 20020401

Synthesis and antitumor activity of novel pyrimidinyl pyrazole derivatives. II. Optimization of the phenylpiperazine moiety of 1-[5-methyl-1-(2-pyrimidinyl)-4-pyrazolyl]-3-phenylpiperazinyl-1-trans-propenes.

Chemical & pharmaceutical bulletin 20020401

Synthesis, antiarrhythmic, and antihypertensive effects of novel 1-substituted pyrrolidin-2-one and pyrrolidine derivatives with adrenolytic activity.

European journal of medicinal chemistry 20020301

Central nervous system activity of new pyrimidine-8-on[2,1-f]theophylline-9-alkylcarboxylic acids derivatives.

Polish journal of pharmacology 20020101

Investigation of mixed D2/5-HT1A activity of N-heteroarylmethyl-N-phenylpiperazines, N-heteroarylethyl-N-phenylpiperazines and N-heteroarylpropyl-N-phenylpiperazines.

Die Pharmazie 20011001

Quantitative structure-activity relationship study of novel alpha1a-selective adrenoceptor antagonists.

Journal of enzyme inhibition 20011001

1-(Arylpiperazinylamidoalkyl)-pyrimidones: orally active inhibitors of lipoprotein-associated phospholipase A(2).

Bioorganic & medicinal chemistry letters 20010723

Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.

Bioorganic & medicinal chemistry 20010501

Cytotoxic activity of 2-aminomethylene-3(2H)-benzofuranones against human oral tumor cell lines.

Anticancer research 20010101

Synthesis, 5-HT1A and 5-HT2A receptor activity of new 1-phenylpiperazinylpropyl derivatives with arylalkyl substituents in position 7 of purine-2,6-dione.

Polish journal of pharmacology 20010101

Arylpiperazine derivatives of 3-propyl-beta-tetralonohydantoin as new 5-HT1A and 5-HT2A receptor ligands.

Polish journal of pharmacology 20010101