Home Nitros 1-Methyl-3-nitro-1-nitrosoguanidine

1-Methyl-3-nitro-1-nitrosoguanidine

CAS No.:
70-25-7
Catalog Number:
AG0032SW
Molecular Formula:
C2H5N5O3
Molecular Weight:
147.0928
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Purity
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Product Description
Catalog Number:
AG0032SW
Chemical Name:
1-Methyl-3-nitro-1-nitrosoguanidine
CAS Number:
70-25-7
Molecular Formula:
C2H5N5O3
Molecular Weight:
147.0928
MDL Number:
MFCD00007034
IUPAC Name:
1-methyl-3-nitro-1-nitrosoguanidine
InChI:
InChI=1S/C2H5N5O3/c1-6(5-8)2(3)4-7(9)10/h1H3,(H2,3,4)
InChI Key:
VZUNGTLZRAYYDE-UHFFFAOYSA-N
SMILES:
O=NN(C(=N)N[N+](=O)[O-])C
EC Number:
200-730-1
UNII:
12H3O2UGSF
NSC Number:
9369
RTECS Number:
MF4200000
UN Number:
1325
Properties
Complexity:
161  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
147.039g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
147.094g/mol
Monoisotopic Mass:
147.039g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
114A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.1  
Literature
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Mercuric dichloride induces DNA damage in human salivary gland tissue cells and lymphocytes. Archives of toxicology 20071101
Interstitial chemotherapy with biodegradable BCNU (Gliadel) wafers in the treatment of malignant gliomas. Therapeutics and clinical risk management 20071001
N-methyl-N'-nitro-N-nitrosoguanidine activates multiple cell death mechanisms in human fibroblasts. DNA and cell biology 20070901
Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair. Cell death and differentiation 20070801
DNA damage induces alternative lengthening of telomeres (ALT) associated promyelocytic leukemia bodies that preferentially associate with linear telomeric DNA. Cancer research 20070801
Animal models of stomach carcinogenesis. Toxicologic pathology 20070801
Exposure to the tobacco smoke constituent 4-aminobiphenyl induces chromosomal instability in human cancer cells. Cancer research 20070801
The cda GenoTox assay: a new and sensitive method for detection of environmental genotoxins, including nitroarenes and aromatic amines. Mutation research 20070728
Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'- nitro-N-nitrosoguanidine. Cancer science 20070701
Proliferation, angiogenesis and apoptosis-associated proteins are molecular targets for chemoprevention of MNNG-induced gastric carcinogenesis by ethanolic Ocimum sanctum leaf extract. Singapore medical journal 20070701
Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures. Journal of ethnopharmacology 20070530
Chemical carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine, is a specific activator of oncogenic Ras. Cell cycle (Georgetown, Tex.) 20070515
Modulatory effects of black tea polyphenols on oxidant-antioxidant profile and expression of proliferation, apoptosis, and angiogenesis-associated proteins in the rat forestomach carcinogenesis model. Journal of gastroenterology 20070501
Heat shock does not induce gammaH2AX foci formation but protects cells from N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity. Mutation research 20070420
Methylation profiles of CpG island loci in major types of human cancers. Journal of Korean medical science 20070401
[Chemopreventive effect of oxymatrine on N-methyl-N'-nitro-N-nitrosoguanidine induced gastrointestinal cancer: experiment with rats]. Zhonghua yi xue za zhi 20070327
Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase. Experimental cell research 20070310
The involvement of ATP produced via (ADP-Ribose)n in the maintenance of DNA replication apparatus during DNA repair. Biological & pharmaceutical bulletin 20070301
Esophageal thermal injury by hot adlay tea. The Korean journal of internal medicine 20070301
Resveratrol protects dopaminergic neurons in midbrain slice culture from multiple insults. Biochemical pharmacology 20070215
Apoptosis in malignant glioma cells triggered by the temozolomide-induced DNA lesion O6-methylguanine. Oncogene 20070111
Human monocytes, but not dendritic cells derived from them, are defective in base excision repair and hypersensitive to methylating agents. Cancer research 20070101
Effects of eradication of Helicobacter pylori on gastric carcinogenesis in experimental models. Journal of gastroenterology 20070101
Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin. International journal of toxicology 20070101
Genome position and gene amplification. Genome biology 20070101
Urodele p53 tolerates amino acid changes found in p53 variants linked to human cancer. BMC evolutionary biology 20070101
[Microbioluminescent study of the general toxicity and mutagenicity of pollutants]. Prikladnaia biokhimiia i mikrobiologiia 20070101
[Induction of the SOS response in Escherichia coli cells under osmotic stress and in the presence of N-methyl-N'-nitro-N-nitrosoguanidine]. Mikrobiologiia 20070101
Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers. Nutrition journal 20070101
Discussion on the use of taxanes for treatment of breast cancers in BRCA1 mutations carriers. Hereditary cancer in clinical practice 20070101
Modulatory effects of black tea polyphenols on rat forestomach carcinogenesis. Toxicology mechanisms and methods 20070101
Comparison of the mutagenic potential of 17 physical and chemical agents analyzed by the flow cytometry mutation assay. Mutation research 20061201
Methylating agents and DNA repair responses: Methylated bases and sources of strand breaks. Chemical research in toxicology 20061201
Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. The Journal of biological chemistry 20061103
DBA/2 mouse skin is unresponsive to dermal tumor promotion by cigarette smoke condensate. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20061101
In vitro anti-mutagenic effect of magnolol against direct and indirect mutagens. Mutation research 20061010
Antimutagenic activity of methanolic extract of Ganoderma lucidum and its effect on hepatic damage caused by benzo[a]pyrene. Journal of ethnopharmacology 20060919
A comparative study of using comet assay and gammaH2AX foci formation in the detection of N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA damage. Toxicology in vitro : an international journal published in association with BIBRA 20060901
Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. European journal of medical research 20060830
Xrcc2 deficiency sensitizes cells to apoptosis by MNNG and the alkylating anticancer drugs temozolomide, fotemustine and mafosfamide. Cancer letters 20060808
[Screening of a low alcohol dehydrogenase activity mutant of rhizopus oryzae and the regulation of Zn2+ and Mg2+]. Wei sheng wu xue bao = Acta microbiologica Sinica 20060801
Comparative evaluation of the alkaline comet assay with the micronucleus test for genotoxicity monitoring using aquatic organisms. Ecotoxicology and environmental safety 20060701
Involvement of the drug efflux protein TolC in mutagenicity induced by MNNG or Trp-P-2. Mutation research 20060616
Poly(ADP-ribose) glycohydrolase silencing protects against H2O2-induced cell death. The Biochemical journal 20060615
Effects of co-exposure to extremely low frequency (50 Hz) magnetic fields and xenobiotics determined in vitro by the alkaline comet assay. The Science of the total environment 20060515
dUTP Pyrophosphatase, its appearance in extracellular compartment may serve as a potential biomarker for N-methyl-N'-nitro-N-nitrosoguanidine exposure in mammalian cells. Proteomics 20060501
Sister chromatid exchange and micronuclei in human peripheral blood lymphocytes treated with thyroxine in vitro. Mutation research 20060430
Induced endoplasmic reticulum (ER) stress and binding of over-expressed ER specific chaperone GRP78/BiP with dimerized epidermal growth factor receptor in mammalian cells exposed to low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research 20060411
[The role of JWA in N-methyl-N'-nitro-N-nitrosoguanidine induced human bronchial epithelial cell apoptosis]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20060401
Poly(ADP-ribose) polymerase-1 signaling to mitochondria in necrotic cell death requires RIP1/TRAF2-mediated JNK1 activation. The Journal of biological chemistry 20060331
Cytotoxic and genotoxic effects of resin monomers in human salivary gland tissue and lymphocytes as assessed by the single cell microgel electrophoresis (Comet) assay. Biomaterials 20060301
Proteomic analysis of beryllium-induced genotoxicity in an Escherichia coli mutant model system. Proteomics 20060301
Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage. Cancer science 20060301
Methylation of the O6-methylguanine-DNA methyltransferase promoter suppresses expression in mouse skin tumors and varies with the tumor induction protocol. International journal of cancer 20060201
Proteomic profiling for cellular responses to different concentrations of N-methyl-N'-nitro-N-nitrosoguanidine. Journal of proteome research 20060201
Inhibitory effects of caraway (Carum carvi L. ) and its component on N-methyl-N'-nitro-N-nitrosoguanidine-induced mutagenicity. The journal of medical investigation : JMI 20060201
Strain improvement of Candida tropicalis for the production of xylitol: biochemical and physiological characterization of wild-type and mutant strain CT-OMV5. Journal of microbiology (Seoul, Korea) 20060201
Induction of gastric GIST in rat and establishment of GIST cell line. Cancer letters 20060118
Genistein inhibits radiation-induced activation of NF-kappaB in prostate cancer cells promoting apoptosis and G2/M cell cycle arrest. BMC cancer 20060101
Is translational research compatible with preclinical publication strategies? Radiation oncology (London, England) 20060101
Chemopreventive effects of rofecoxib and folic acid on gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. Chinese journal of digestive diseases 20060101
Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract. Asian Pacific journal of cancer prevention : APJCP 20060101
TILLING is an effective reverse genetics technique for Caenorhabditis elegans. BMC genomics 20060101
Imatinib (STI571) inhibits DNA repair in human leukemia oncogenic tyrosine kinase-expressing cells. Zeitschrift fur Naturforschung. C, Journal of biosciences 20060101
Detection of initiating as well as promoting activity of chemicals by a novel cell transformation assay using v-Ha-ras-transfected BALB/c 3T3 cells (Bhas 42 cells). Mutation research 20051207
Biochemical characterization of N-methyl N'-nitro-N-nitrosoguanidine-induced cadmium resistant mutants of Aspergillus niger. Journal of biosciences 20051201
Function of domains of human O6-alkylguanine-DNA alkyltransferase. Biochemistry 20051122
Role of O6-methylguanine-DNA methyltransferase and effect of O6-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines. Oral oncology 20051101
Genotoxicity of nicotine in mini-organ cultures of human upper aerodigestive tract epithelia. Toxicological sciences : an official journal of the Society of Toxicology 20051101
Differential effects of cisplatin and MNNG on dna mutants of Escherichia coli. Mutation research 20051015
N-methyl-N'-nitro-N-nitrosoguanidine activates cell-cycle arrest through distinct mechanisms activated in a dose-dependent manner. Molecular pharmacology 20051001
Antimutagenic and anti-oxidant activities of the non-steroidal anti-inflammatory drug celecoxib. Clinical and experimental pharmacology & physiology 20051001
The apoptosis inhibitory domain of FE65-like protein 1 regulates both apoptotic and caspase-independent programmed cell death mediated by tumor necrosis factor. Biochemical and biophysical research communications 20050923
Apaf-1 deficient mouse fibroblasts are resistant to MNNG and MMS-induced apoptotic death without attenuation of Bcl-2 decline. Toxicology and applied pharmacology 20050901
Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae. Current biology : CB 20050809
Assay to measure CD59 mutations in CHO A(L) cells using flow cytometry. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20050801
Combination of S-allylcysteine and lycopene induces apoptosis by modulating Bcl-2, Bax, Bim and caspases during experimental gastric carcinogenesis. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20050801
A lipidomic study of the effects of N-methyl-N'-nitro-N-nitrosoguanidine on sphingomyelin metabolism. Acta biochimica et biophysica Sinica 20050801
[Cell proliferation inhibitive and apoptosis promoting effects of sanchi extract on GES-1 cell after being transformed by MNNG]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20050801
Comet assay with the fish cell line rainbow trout gonad-2 for in vitro genotoxicity testing of xenobiotics and surface waters. Environmental toxicology and chemistry 20050801
Screening of potential lactobacilli antigenotoxicity by microbial and mammalian cell-based tests. International journal of food microbiology 20050625
Characterization of chemically induced hepatotoxicity in collagen sandwiches of rat hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology 20050601
Induction of apoptosis and inhibition of cyclooxygenase-2 expression by N-methyl-N'-nitro-N-nitrosoguanidine in human leukemia cells. Anti-cancer drugs 20050601
Sphingolipids are involved in N-methyl-N'-nitro-N-nitrosoguanidine-induced epidermal growth factor receptor clustering. Biochemical and biophysical research communications 20050506
Application of a two-stage Syrian hamster embryo cell transformation assay to cigarette smoke particulate matter. Mutation research 20050502
Escherichia coli BTC, a human cytochrome P450 competent tester strain with a high sensitivity towards alkylating agents: involvement of alkyltransferases in the repair of DNA damage induced by aromatic amines. Mutagenesis 20050501
Degradation of human exonuclease 1b upon DNA synthesis inhibition. Cancer research 20050501
Identification of mutation sites on delta6 desaturase genes from Mortierella alpina 1S-4 mutants. Bioscience, biotechnology, and biochemistry 20050501
Plasmodial surface anion channel-independent phloridzin resistance in Plasmodium falciparum. The Journal of biological chemistry 20050429
Nuclear poly(ADP-ribose) polymerase-1 rapidly triggers mitochondrial dysfunction. The Journal of biological chemistry 20050429
Attenuation of N-methyl-N'-nitro-N-nitrosoguanidine induced genotoxicity and oxidative stress by tomato and garlic combination. Life sciences 20050325
High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair. Cell cycle (Georgetown, Tex.) 20050301
N-methyl-N'-nitro-N-nitrosoguanidine interferes with the epidermal growth factor receptor-mediated signaling pathway. Mutation research 20050301
The alkylating carcinogen N-methyl-N'-nitro-N-nitrosoguanidine activates the plasminogen activator inhibitor-1 gene through sequential phosphorylation of p53 by ATM and ATR kinases. Thrombosis and haemostasis 20050301
Modulation effect of tea polyphenol toward N-methyl-N'-nitro-N-nitrosoguanidine-induced precancerous gastric lesion in rats. The Journal of nutritional biochemistry 20050301
[Apoptosis-promoting effect of Panax notoginseng extracts on MNNG-transformed GES-1 cells]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20050301
[Gene expression profiles in early stage of BALB/c 3T3 cells' transformation promoted with 12-O-tetradecanoylphorbol-13-acetate]. Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine] 20050301
Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood. Mutation research 20050207
NAD+ as a metabolic link between DNA damage and cell death. Journal of neuroscience research 20050101
The monofunctional alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine triggers apoptosis through p53-dependent and -independent pathways. Toxicology and applied pharmacology 20050101
Polyamines modulate carcinogen-induced mutagenesis in vivo. Environmental and molecular mutagenesis 20050101
Novel mutation method for increased cellulase production. Journal of applied microbiology 20050101
Recognition and binding of mismatch repair proteins at an oncogenic hot spot. BMC molecular biology 20050101
Genotoxic effects of pentachlorophenol, lindane, transfluthrin, cyfluthrin, and natural pyrethrum on human mucosal cells of the inferior and middle nasal conchae. American journal of rhinology 20050101
Symbiotic effectiveness of a siderophore overproducing mutant of Mesorhizobium ciceri. Polish journal of microbiology 20050101
The distribution of SNPs in human gene regulatory regions. BMC genomics 20050101
Combination chemoprevention of experimental gastric carcinogenesis by s-allylcysteine and lycopene: modulatory effects on glutathione redox cycle antioxidants. Journal of medicinal food 20050101
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proceedings of the National Academy of Sciences of the United States of America 20041221
Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo. DNA repair 20041202
Dark lumen magnetic resonance colonography in a rodent polyp model: initial experience and demonstration of feasibility. Investigative radiology 20041201
N-methyl-N'-nitro-N-nitrosoguanidine sensitivity, mutator phenotype and sequence specificity of spontaneous mutagenesis in FEN-1-deficient cells. Mutation research 20041122
MNNG-induced mutations in the adult gill and hepatopancreas and in embryos of rpsL transgenic zebrafish. Mutation research 20041122
[Inhibiting effects of Panax notoginseng extracts on proliferation of GES-1 cells and MNNG-transformed GES-1 cells]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20041101
Induction of apoptosis and G2/M arrest by N-methyl-N'-nitro-N-nitrosoguanidine in human prostate carcinoma cells. Mutation research 20041010
A protective role for matrix metalloproteinase-3 in squamous cell carcinoma. Cancer research 20041001
In vivo detection of gastric cancer in rats by electron paramagnetic resonance imaging. Cancer research 20040915
Protective effect of tomato against N-methyl-N'-nitro-N-nitrosoguanidine-induced in vivo clastogenicity and oxidative stress. Nutrition (Burbank, Los Angeles County, Calif.) 20040901
Characterization of Streptomyces scabies mutants deficient in melanin biosynthesis. Canadian journal of microbiology 20040901
Poly(ADP-ribose) glycohydrolase as a target for neuroprotective intervention: assessment of currently available pharmacological tools. European journal of pharmacology 20040816
Transient adenoviral N-methylpurine DNA glycosylase overexpression imparts chemotherapeutic sensitivity to human breast cancer cells. Molecular cancer therapeutics 20040801
Induction of the mitochondrial permeability transition by the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. Sorting cause and consequence of mitochondrial dysfunction. Biochimica et biophysica acta 20040723
The use of mini-organ cultures of human upper aerodigestive tract epithelia in ecogenotoxicology. Mutation research 20040711
Depleted dopamine in gastric cancer tissues: dopamine treatment retards growth of gastric cancer by inhibiting angiogenesis. Clinical cancer research : an official journal of the American Association for Cancer Research 20040701
Response of REV3 promoter to N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research 20040604
Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase. Genes & development 20040601
Persistence of gene expression changes in stomach mucosae induced by short-term N-methyl-N'-nitro-N-nitrosoguanidine treatment and their presence in stomach cancers. Mutation research 20040518
Effect of duodenogastric reflux on N-methyl-N'-nitro-N-nitrosoguanidine-induced glandular stomach tumorigenesis in Helicobacter pylori-infected Mongolian gerbils. Oncology reports 20040501
Poly(ADP-ribose) polymerase-1-mediated cell death in astrocytes requires NAD+ depletion and mitochondrial permeability transition. The Journal of biological chemistry 20040430
Bloodstream form-specific up-regulation of silent vsg expression sites and procyclin in Trypanosoma brucei after inhibition of DNA synthesis or DNA damage. The Journal of biological chemistry 20040402
Loss of ATM sensitizes against O6-methylguanine triggered apoptosis, SCEs and chromosomal aberrations. DNA repair 20040401
Protein phosphatase inhibitor-1 mRNA expression correlates with neoplastic transformation of epithelial liver cells and progression of hepatocellular carcinomas. International journal of oncology 20040401
An investigation of DNA excision repair capacity in human CD4+ T cell clones as a function of age in vitro. Experimental gerontology 20040401
Enhanced stimulation of chromosomal translocations by radiomimetic DNA damaging agents and camptothecin in Saccharomyces cerevisiae rad9 checkpoint mutants. Mutation research 20040322
Exposure of mouse skin to organic peroxides: subchronic effects related to carcinogenic potential. Carcinogenesis 20040301
Genotoxicity and cytotoxicity of dental materials in human lymphocytes as assessed by the single cell microgel electrophoresis (comet) assay. Journal of dentistry 20040301
The Neurospora crassa mus-19 gene is identical to the qde-3 gene, which encodes a RecQ homologue and is involved in recombination repair and postreplication repair. Current genetics 20040201
Chemoprevention of gastric cancer by celecoxib in rats. Gut 20040201
Cloning and sequencing of the ura3 and ura5 genes, and isolation and characterization of uracil auxotrophs of the fungus Mortierella alpina 1S-4. Bioscience, biotechnology, and biochemistry 20040201
Developing a genetic system in Deinococcus radiodurans for analyzing mutations. Genetics 20040201
Protective effects of ethanolic neem leaf extract on N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity and oxidative stress in mice. Drug and chemical toxicology 20040201
Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1. Oncogene 20040115
Msh2 deficiency does not contribute to cisplatin resistance in mouse embryonic stem cells. Oncogene 20040108
Characterization of components of the mismatch repair machinery in Trypanosoma brucei. Molecular microbiology 20040101
N-methyl-N'-nitro-N-nitrosoguanidine-induced senescence-like growth arrest in colon cancer cells is associated with loss of adenomatous polyposis coli protein, microtubule organization, and telomeric DNA. Molecular cancer 20040101
Proteomic analysis of cellular responses to low concentration N-methyl-N'-nitro-N-nitrosoguanidine in human amnion FL cells. Environmental and molecular mutagenesis 20040101
Improvement of carotenoid-synthesizing yeast Rhodotorula rubra by chemical mutagenesis. Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101
Anti-stress activity of Propionibacterium freudenreichii : identification of a reactivative protein. Antonie van Leeuwenhoek 20040101
Protective effect of S-allylcysteine and lycopene in combination against N-methyl-N'-nitro-N-nitrosoguanidine-induced genotoxicity. Polish journal of pharmacology 20040101
Mechanisms and consequences of methylating agent-induced SCEs and chromosomal aberrations: a long road traveled and still a far way to go. Cytogenetic and genome research 20040101
Prevention and repair of DNA damage by selected phytochemicals as measured by single cell gel electrophoresis. Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer 20040101
Effects of aqueous extracts of garlic (Allium sativum) and neem (Azadirachta indica) leaf on hepatic and blood oxidant-antioxidant status during experimental gastric carcinogenesis. Journal of medicinal food 20040101
Proteome analysis of gastric cancer metastasis by two-dimensional gel electrophoresis and matrix assisted laser desorption/ionization-mass spectrometry for identification of metastasis-related proteins. Journal of proteome research 20040101
[Evaluation of genotoxic and/or co-genotoxic effects in cells exposed in vitro to extremely-low frequency electromagnetic fields]. Annali di igiene : medicina preventiva e di comunita 20040101
The exceptionally high rate of spontaneous mutations in the polymerase delta proofreading exonuclease-deficient Saccharomyces cerevisiae strain starved for adenine. BMC genetics 20040101
Lignin-stimulated reduction of oxidative DNA lesions in testicular cells and lymphocytes of sprague-dawley rats in vitro and ex vivo. Nutrition and cancer 20040101
Differences in responses of plant hairy roots to chemical toxicity compared between primary and ramified roots. Environmental sciences : an international journal of environmental physiology and toxicology 20040101
Enhanced production of L-lactic acid by ammonia-tolerant mutant strain Rhizopus sp. MK-96-1196. Journal of bioscience and bioengineering 20040101
N-methyl-N'-nitro-N-nitrosoguanidine. Report on carcinogens : carcinogen profiles 20040101
Genotoxic effects of vanadium pentoxide on human peripheral lymphocytes and mucosal cells of the upper aerodigestive tract. International journal of environmental health research 20031201
beta-Catenin mutations and nuclear accumulation during progression of rat stomach adenocarcinomas. Cancer science 20031201
Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n'-nitro-N-nitrosoguanidine. Cancer research 20031201
Differential expression of genes related to levels of mucosal cell proliferation among multiple rat strains by using oligonucleotide microarrays. Mammalian genome : official journal of the International Mammalian Genome Society 20031201
MNNG induces dramatic DNA damage and non-apoptotic changes in cervical carcinoma HeLa cells. Annals of the New York Academy of Sciences 20031201
Polyozellus multiplex, a Korean wild mushroom, as a potent chemopreventive agent against stomach cancer. Life sciences 20031107
Apoptosis induced by MNNG in human TK6 lymphoblastoid cells is p53 and Fas/CD95/Apo-1 related. Mutation research 20031101
Antimutagenic activity of phenylpropanoids from clove (Syzygium aromaticum). Journal of agricultural and food chemistry 20031022
Poly ADP-ribose polymerase (PARP) inhibitors transiently protect leukemia cells from alkylating agent induced cell death by three different effects. European journal of medical research 20031022
Antimutagenic activity of flavonoids from Chrysanthemum morifolium. Bioscience, biotechnology, and biochemistry 20031001
N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced in vivo clastogenicity: protective effects of aqueous neem leaf extract. Die Pharmazie 20031001
[Proteomic analysis of cellular responses to low concentration of N-methyl-N'-nitro-N-nitrosoguanidine in human amnion FL cells]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031001
[Cloning and bioinformatics of human REV3 gene promoter region and its response to carcinogen N-methyl-N'-nitro-N-nitrosoguanidine]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences 20031001
The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells. Cancer research 20030915
NAD+ repletion prevents PARP-1-induced glycolytic blockade and cell death in cultured mouse astrocytes. Biochemical and biophysical research communications 20030905
Ischemic preconditioning by caspase cleavage of poly(ADP-ribose) polymerase-1. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030903
Enhancement by interleukin-1 beta of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats: a possible mechanism for Helicobacter pylori-associated gastric carcinogenesis. Cancer letters 20030820
Non-apoptogenic killing of hela cervical carcinoma cells after short exposure to the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Journal of cellular biochemistry 20030815
Comparative scoring of micronucleated reticulocytes in rat peripheral blood by flow cytometry and microscopy. Toxicological sciences : an official journal of the Society of Toxicology 20030801
Activation of protein kinase A and clustering of cell surface receptors by N-methyl-N'-nitro-N-nitrosoguanidine are independent of genomic DNA damage. Mutation research 20030725
Expression of survivin in human gastric carcinoma and gastric carcinoma model of rats. World journal of gastroenterology 20030715
Application of Euglena gracilis cells to comet assay: evaluation of DNA damage and repair. Mutation research 20030708
Gene expression patterns as potential molecular biomarkers for malignant transformation in human keratinocytes treated with MNNG, arsenic, or a metal mixture. Toxicological sciences : an official journal of the Society of Toxicology 20030701
Chemoprotective effects of ethanolic extract of neem leaf against MNNG-induced oxidative stress. Die Pharmazie 20030701
Enhancement of carcinogen-induced malignant cell transformation by prostaglandin F(2 alpha). Toxicology 20030630
[Morphological transformation of mouse NIH3T3 cells induced by nickel refining dusts in vitro]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20030601
Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis. World journal of gastroenterology 20030515
Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1. The EMBO journal 20030501
Global expression analysis of N-methyl-N'-nitro-N-nitrosoguanidine-induced rat stomach carcinomas using oligonucleotide microarrays. Carcinogenesis 20030501
Suppression by iron chelator phenanthroline of sodium chloride-enhanced gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Cancer letters 20030227
Myenteric denervation reduces the incidence of gastric tumors in rats. Cancer letters 20030210
p16 hypermethylation during gastric carcinogenesis of Wistar rats by N-methyl-N'-nitro-N-nitrosoguanidine. Mutation research 20030205
[Preservation of mucosal specimens before processing in the alkaline single cell microgel electrophoresis assay]. HNO 20030201
Molecular and cellular influences of butylated hydroxyanisole on Chinese hamster V79 cells treated with N-methyl-N'-nitro-N-nitrosoguanidine: antimutagenicity of butylated hydroxyanisole. Environmental and molecular mutagenesis 20030101
The QDE-3 homologue RecQ-2 co-operates with QDE-3 in DNA repair in Neurospora crassa. Current genetics 20030101
Anticlastogenic, antigenotoxic and apoptotic activity of epigallocatechin gallate: a green tea polyphenol. Mutation research 20030101
Isolation and characterisation of phycobiliprotein rich mutant of cyanobacterium Synechocystis sp. Acta biologica Hungarica 20030101
Competition among Bradyrhizobium strains for nodulation of green gram (Vigna radiata): use of dark-nodule strain. Folia microbiologica 20030101
Altered expression of zinc finger proteins, ADAMs, and integrin-related proteins following treatment of cultured human cells with a low concentration of N-methyl-N'-nitro-N-nitrosoguanidine. Environmental and molecular mutagenesis 20030101
Selection of biochemical mutants of Aspergillus niger resistant to some abiotic stresses with increased inulinase production. Journal of applied microbiology 20030101
Ethanolic neem leaf extract protects against N-methyl -N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis in Wistar rats. Asian Pacific journal of cancer prevention : APJCP 20030101
Genetic determination of ploidy level in Xanthophyllomyces dendrorhous. Antonie van Leeuwenhoek 20030101
Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: a meta-analysis. BMC cancer 20030101
Abnormal expression of gastric mucin in human and rat aberrant crypt foci during colon carcinogenesis. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20030101
Role of APC and DNA mismatch repair genes in the development of colorectal cancers. Molecular cancer 20030101
Effect of S-allylcysteine on oxidant-antioxidant status during N-methyl-N'-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats. Asia Pacific journal of clinical nutrition 20030101
Reduction of genotoxic effects of the carcinogen N-methyl-N'-nitro-N-nitrosoguanidine by dietary lignin in mammalian cells cultured in vitro. Nutrition and cancer 20030101
Quinoprotein alcohol dehydrogenase is involved in catabolic acetate production, while NAD-dependent alcohol dehydrogenase in ethanol assimilation in Acetobacter pasteurianus SKU1108. Journal of bioscience and bioengineering 20030101
Chemoprotection against N-methyl-n'-nitro-N-nitrosoguanidine-induced oxidative stress by s-allylcysteine, a garlic constituent, in wistar rats. Toxicology mechanisms and methods 20030101
Distinction of carcinogens from mutagens by induction of liver cell foci in a model for detection of initiation activity. Cancer letters 20021215
Antiperoxidative effects of lycopene during N-methyl-N'-nitro-N-nitrosoguanidine-induced gastric carcinogenesis. Fitoterapia 20021201
Characterization of gene expression changes associated with MNNG, arsenic, or metal mixture treatment in human keratinocytes: application of cDNA microarray technology. Environmental health perspectives 20021201
ATM is activated in response to N-methyl-N'-nitro-N-nitrosoguanidine-induced DNA alkylation. The Journal of biological chemistry 20021011
Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens. Carcinogenesis 20021001
Serum trace elements status of rabbits supplemented with Nigella sativa, vitamins C and E, and selenium against damage by N-methyl-N'-nitro-N-nitrosoguanidine. Biological trace element research 20021001
Appearance of osteonectin-expressing fibroblastic cells in early rat stomach carcinogenesis and stomach tumors induced with N-methyl-N'-nitro-N-nitrosoguanidine. Japanese journal of cancer research : Gann 20020901
Effects of weaning by surrogate mothers (ACI) on tumor development in SD rats treated with methylnitrosourea (MNU) and/or N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Hiroshima journal of medical sciences 20020901
Effects of N-methyl-N'-nitro-N-nitrosoguanidine on the human colorectal polyps consecutively maintained in SCID mice. Cancer letters 20020828
Cadmium affects genes involved in growth regulation during two-stage transformation of Balb/3T3 cells. Toxicology 20020815
Effects of vitamins C and E on cytotoxicity induced by N-nitroso compounds, N-nitrosomorpholine and N-methyl-N'-nitro-N-nitrosoguanidine in Caco-2 and V79 cell lines. Cancer letters 20020808
Pseudouridine, an antimutagenic substance in beer towards N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801
Cytoprotective features of selenazofurin in hematopoietic cells. International journal of clinical pharmacology and therapeutics 20020801
Dendritic cell appearance and differentiation during early and late stages of rat stomach carcinogenesis. Japanese journal of cancer research : Gann 20020801
Tricarboxylic acid cycle substrates prevent PARP-mediated death of neurons and astrocytes. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020701
Reactive oxygen species generated by PAH o-quinones cause change-in-function mutations in p53. Chemical research in toxicology 20020601
Profiling and selection of genes differentially expressed in the pylorus of rat strains with different proliferative responses and stomach cancer susceptibility. Carcinogenesis 20020601
Thiourea toxicity in mouse C3H/10T1/2 cells expressing human flavin-dependent monooxygenase 3. Biochemical pharmacology 20020601
Establishment of cisplatin-resistant variants of human neuroblastoma cell lines, TGW and GOTO, and their drug cross-resistance profiles. Cancer chemotherapy and pharmacology 20020601
Cytotoxic and antimutagenic stilbenes from seeds of Paeonia lactiflora. Archives of pharmacal research 20020601
Potent antimutagenic and their anti-lipid peroxidative effect of kaikasaponin III and tectorigenin from the flower of Pueraria thunbergiana. Archives of pharmacal research 20020601
Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Bioscience, biotechnology, and biochemistry 20020601
Production of hydroxyl free radical in the xanthine oxidase system with addition of 1-methyl-3-nitro-1-nitrosoguanidine. Free radical research 20020601
Promoting effects of combined antioxidant and sodium nitrite treatment on forestomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine. Cancer letters 20020408
Polyetheretherketone--cytotoxicity and mutagenicity in vitro. Biomaterials 20020401
[Analysis of function of the 452 bp sequence proceeding the pgiB gene in Bacillus stearothermophilus]. Wei sheng wu xue bao = Acta microbiologica Sinica 20020401
Low expression of cyclin D2 in G2/M-arrested and transformed proliferating Balb/3T3 cells. The Journal of veterinary medical science 20020301
Antimutagenicity of Murdannia loriformis in the Salmonella mutation assay and its inhibitory effects on azoxymethane-induced DNA methylation and aberrant crypt focus formation in male F344 rats. The journal of medical investigation : JMI 20020201
Prevention of N-methyl-N'-nitro-N-nitrosoguanidine and saturated sodium chloride-induced gastric carcinogenesis in Wistar rats by lycopene. European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20020201
Further evaluation of an in vivo micronucleus test on rat and mouse skin: results with five skin carcinogens. Mutation research 20020115
Green fluorescent protein-based biosensor for detecting SOS-inducing activity of genotoxic compounds. Journal of microbiological methods 20020101
Vitamin C and quercetin modulate DNA-damaging effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Plant foods for human nutrition (Dordrecht, Netherlands) 20020101
Development, characterization, and preliminary evaluation of a temperature-sensitive mutant of Ornithobacterium rhinotracheale for potential use as a live vaccine in turkeys. Avian diseases 20020101
Inhibition by long-term fermented miso of induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine in CD (SD) rats. Oncology reports 20020101
The influence of pylorus-preserving partial gastrectomy on carcinogenesis of residual gastric mucosa in the rat. Surgery today 20020101
Duodenogastric reflux and gastric stump carcinoma. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20020101
Genomic comparisons among Escherichia coli strains B, K-12, and O157:H7 using IS elements as molecular markers. BMC microbiology 20020101
N-Methyl-N'-nitro-N-nitrosoguanidine. Report on carcinogens : carcinogen profiles 20020101
Lack of mutagenic and co-mutagenic effects of magnetic fields during magnetic resonance imaging. Journal of magnetic resonance imaging : JMRI 20011201
Spontaneous and MNNG-induced reversion of an EGFP construct in HeLa cells: an assay for observing mutations in living cells by fluorescent microscopy. Human mutation 20011201
Attenuation of catalase activity in the malignant phenotype plays a functional role in an in vitro model for tumor progression. Cancer letters 20011128
Repair of O(6)-methylguanine is not affected by thymine base pairing and the presence of MMR proteins. Mutation research 20011101
Contribution of apoptosis to responses in the comet assay. Mutation research 20011018
Roles of DNA fragmentation factor and poly(ADP-ribose) polymerase in an amplification phase of tumor necrosis factor-induced apoptosis. The Journal of biological chemistry 20011012
Poly(ADP-ribose) glycohydrolase mediates oxidative and excitotoxic neuronal death. Proceedings of the National Academy of Sciences of the United States of America 20011009
p53 Phosphorylation at serine 15 is required for transcriptional induction of the plasminogen activator inhibitor-1 (PAI-1) gene by the alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine. The Journal of biological chemistry 20010928
Partial chemical/structural elucidation of anti-mutagenic compounds from corn. Toxicology 20010925
Quantification of changes in c-myc mRNA levels in normal human bronchial epithelial (NHBE) and lung adenocarcinoma (A549) cells following chemical treatment. Toxicological sciences : an official journal of the Society of Toxicology 20010901
hMSH3 overexpression and cellular response to cytotoxic anticancer agents. Carcinogenesis 20010801
Suppression of chemical mutagen-induced SOS response by alkylphenols from clove (Syzygium aromaticum) in the Salmonella typhimurium TA1535/pSK1002 umu test. Journal of agricultural and food chemistry 20010801
Biological production of optically active muconolactones by Rhodococcus rhodochrous. Applied microbiology and biotechnology 20010801
[Role of hydrogen peroxide in promoting proliferation and transformation of rat liver oval cell line WB-F344]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae 20010801
Attenuation by ambroxol of monochloramine-enhanced gastric carcinogenesis: a possible prevention against Helicobacter pylori-associated gastric carcinogenesis. Cancer letters 20010726
Low concentration N-methyl-N'-nitro-N-nitrosoguanidine activates DNA polymerase-beta expression via cyclic-AMP-protein kinase A-cAMP response element binding protein pathway. Mutation research 20010701
Cell cycle was disturbed in the MNNG-induced initiation stage during in vitro two-stage transformation of Balb/3T3 cells. Toxicology 20010621
Msh-2 suppresses in vivo mutation in a gene dose and lesion dependent manner. Oncogene 20010614
Improvement of in vitro two-stage transformation assay and determination of the promotional effect of cadmium. Toxicology in vitro : an international journal published in association with BIBRA 20010601
Sequential histopathological changes in vivo after suicide gene therapy of gastric cancer induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats. Japanese journal of cancer research : Gann 20010601
p53-dependent transcriptional regulation of the APC promoter in colon cancer cells treated with DNA alkylating agents. The Journal of biological chemistry 20010525
Anti-genotoxicity of trans-anethole and eugenol in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010501
Effect of mild whole body hyperthermia on cytotoxic action of N-methyl-N'-nitro-N-nitrosoguanidine in Swiss mice. Toxicology letters 20010408
Mutagen sensitivity of nasopharyngeal cancer patients. Mutation research 20010405
Acquired resistance of melanoma cells to the antineoplastic agent fotemustine is caused by reactivation of the DNA repair gene MGMT. International journal of cancer 20010401
Cadmium-induced alterations of connexin expression in the promotion stage of in vitro two-stage transformation. Toxicology 20010321
Development and application of a sensitive and rapid immunoassay for the quantitation of N7-methyldeoxyguanosine in DNA samples. Chemical research in toxicology 20010301
Alkylating agent and chromatin structure determine sequence context-dependent formation of alkylpurines. Journal of molecular biology 20010216
[The role of Helicobacter pylori infection and effect of eradication in experimental animal models of gastric carcinogenesis]. Nihon rinsho. Japanese journal of clinical medicine 20010201
Isolation and characterization of the Enterobacter cloacae cheR mutant defective in phosphate taxis. Bioscience, biotechnology, and biochemistry 20010201
Topoisomerase I-mediated cytotoxicity of N-methyl-N'-nitro-N-nitrosoguanidine: trapping of topoisomerase I by the O6-methylguanine. Cancer research 20010101
Differences in carcinogenesis by the length of carcinogen exposure period in rat colon. Digestive diseases and sciences 20010101
[Extracellular protein of propionic acid bacteria inhibits induced mutation in strains of Salmonella typhimurium]. Mikrobiologiia 20010101
Joint effects of citrus peel use and black tea intake on the risk of squamous cell carcinoma of the skin. BMC dermatology 20010101
[Characteristics of mutants of Streptomyces peucetius subsp. caesius ATCC 27952 resistant to anthracycline antibiotics]. Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20010101
L-glutamate production by lysozyme-sensitive Corynebacterium glutamicum ltsA mutant strains. BMC biotechnology 20010101
Induction by bombesin of peritoneal metastasis of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats. Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association 20010101
Protection of N-methyl-N'-nitro-N-nitrosoguanidine-induced in vivo clastogenicity by aqueous garlic extract. Asia Pacific journal of clinical nutrition 20010101
Novel DNA repair alkyltransferase from Caenorhabditis elegans. Environmental and molecular mutagenesis 20010101
Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride in rats. Anticancer research 20010101
Isolation and analysis of lipase-overproducing mutants of Serratia marcescens. Journal of bioscience and bioengineering 20010101
Promoting effects of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on rat glandular stomach carcinogenesis initiated with N-methyl-N'-nitro-N-nitrosoguanidine. Cancer research 19990501
A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage. Carcinogenesis 19980601
Strain differences in mouse skin tumorigenesis by the promotion of 12-o-tetradecanoylphorbol-13-acetate or benzoyl peroxide. Oncology reports 19950501
Effects of caffeine on glandular stomach carcinogenesis induced in rats by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 19950101
Dissociation of sensitivities to tumor promotion and progression in outbred and inbred SENCAR mice. Cancer research 19920615
Expression of human O6-methylguanine-DNA methyltransferase in a DNA excision repair-deficient Chinese hamster ovary cell line and its response to certain alkylating agents. Cancer research 19920101
Induction of altered hepatocellular foci of hamster for a possible short-term assay for carcinogens. Research communications in chemical pathology and pharmacology 19890301
[Promoting effect of bile acids on gastric carcinogenesis induced by MNNG in rats]. Nihon Geka Gakkai zasshi 19890101
Effects of sodium chloride, saccharin, phenobarbital and aspirin on gastric carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine. Gan 19840601
Experimental models for gastric leiomyosarcoma. The effects of N-methyl-N'-nitro-N-nitrosoguanidine in combination with stress, aspirin, or sodium taurocholate. Cancer 19840301
Cocarcinogenic action of aspirin on gastric tumors induced by N-nitroso-N-methylnitroguanidine in rats. Journal of the National Cancer Institute 19830601
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