(S)-2-Amino-3-(1-methyl-1h-indol-3-yl)propanoic acid
| Title | Journal |
|---|---|
| Addition of an indoleamine 2,3,-dioxygenase inhibitor to B cell-depletion therapy blocks autoreactive B cell activation and recurrence of arthritis in K/BxN mice. | Arthritis and rheumatism 20120701 |
| Activation of indoleamine 2,3-dioxygenase in patients with scrub typhus and its role in growth restriction of Orientia tsutsugamushi. | PLoS neglected tropical diseases 20120701 |
| Effects of indoleamine 2,3-dioxygenases in carbon tetrachloride-induced hepatitis model of rats. | Cell biochemistry and function 20120601 |
| Lipopolysaccharide-pretreated plasmacytoid dendritic cells ameliorate experimental chronic kidney disease. | Kidney international 20120501 |
| Suppression of azoxymethane-induced colonic preneoplastic lesions in rats by 1-methyltryptophan, an inhibitor of indoleamine 2,3-dioxygenase. | Cancer science 20120501 |
| L-tryptophan-kynurenine pathway metabolites regulate type I IFNs of acute viral myocarditis in mice. | Journal of immunology (Baltimore, Md. : 1950) 20120415 |
| Novel indoleamine 2,3-dioxygenase-1 inhibitors from a multistep in silico screen. | Bioorganic & medicinal chemistry 20120201 |
| Novel Cβ-Cγ bond cleavages of tryptophan-containing peptide radical cations. | Journal of the American Society for Mass Spectrometry 20120201 |
| Opposing biological functions of tryptophan catabolizing enzymes during intracellular infection. | The Journal of infectious diseases 20120101 |
| The role of indoleamine 2,3-dioxygenase in a mouse model of neuroinflammation-induced depression. | Journal of Alzheimer's disease : JAD 20120101 |
| IDO and regulatory T cell support are critical for cytotoxic T lymphocyte-associated Ag-4 Ig-mediated long-term solid organ allograft survival. | Journal of immunology (Baltimore, Md. : 1950) 20120101 |
| The role of indoleamine 2, 3 dioxygenase in regulating host immunity to leishmania infection. | Journal of biomedical science 20120101 |
| Modulation of tumor tolerance in primary central nervous system malignancies. | Clinical & developmental immunology 20120101 |
| Natural CD4+ T-cell responses against indoleamine 2,3-dioxygenase. | PloS one 20120101 |
| Targeting multiple-myeloma-induced immune dysfunction to improve immunotherapy outcomes. | Clinical & developmental immunology 20120101 |
| Altered tryptophan metabolism as a paradigm for good and bad aspects of immune privilege in chronic inflammatory diseases. | Frontiers in immunology 20120101 |
| The indoleamine 2,3-dioxygenase inhibitor 1-methyl-tryptophan suppresses mitochondrial function, induces aerobic glycolysis and decreases interleukin-10 production in human lymphocytes. | Immunological investigations 20120101 |
| On the interactions between mesenchymal stem cells and regulatory T cells for immunomodulation in transplantation. | Frontiers in immunology 20120101 |
| The antioxidant role of xanthurenic acid in the Aedes aegypti midgut during digestion of a blood meal. | PloS one 20120101 |
| Influence of tryptophan contained in 1-Methyl-Tryptophan on antimicrobial and immunoregulatory functions of indoleamine 2,3-dioxygenase. | PloS one 20120101 |
| The mechanism of formation of N-formylkynurenine by heme dioxygenases. | Journal of the American Chemical Society 20111012 |
| SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. | The Journal of biological chemistry 20110909 |
| Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. | Nature medicine 20110901 |
| The role of indoleamine 2, 3-dioxygenase in lepromatous leprosy immunosuppression. | Clinical and experimental immunology 20110801 |
| Discovery and preliminary SARs of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. | European journal of medicinal chemistry 20110701 |
| Contribution of dehydroepiandrosterone sulfate and progesterone to in vitro regulation of tolerogenic activity of IFN-α-induced dendritic cells. | Bulletin of experimental biology and medicine 20110601 |
| Vascular expression, activity and function of indoleamine 2,3-dioxygenase-1 following cerebral ischaemia-reperfusion in mice. | Naunyn-Schmiedeberg's archives of pharmacology 20110501 |
| Regulation of colonic epithelial cell turnover by IDO contributes to the innate susceptibility of SCID mice to Trichuris muris infection. | Parasite immunology 20110401 |
| Spontaneous cytotoxic T-Cell reactivity against indoleamine 2,3-dioxygenase-2. | Cancer research 20110315 |
| Expression of indoleamine 2,3-dioxygenase in acute myeloid leukemia and the effect of its inhibition on cultured leukemia blast cells. | Medical oncology (Northwood, London, England) 20110301 |
| Indol-2-yl ethanones as novel indoleamine 2,3-dioxygenase (IDO) inhibitors. | Bioorganic & medicinal chemistry 20110215 |
| Interferon-γ regulates the proliferation and differentiation of mesenchymal stem cells via activation of indoleamine 2,3 dioxygenase (IDO). | PloS one 20110101 |
| Uremic toxins inhibit transport by breast cancer resistance protein and multidrug resistance protein 4 at clinically relevant concentrations. | PloS one 20110101 |
| The indoleamine-2,3-dioxygenase (IDO) inhibitor 1-methyl-D-tryptophan upregulates IDO1 in human cancer cells. | PloS one 20110101 |
| An observational cohort study of the kynurenine to tryptophan ratio in sepsis: association with impaired immune and microvascular function. | PloS one 20110101 |
| Myelin-phagocytosing macrophages modulate autoreactive T cell proliferation. | Journal of neuroinflammation 20110101 |
| Metabolomic profiling reveals a role for androgen in activating amino acid metabolism and methylation in prostate cancer cells. | PloS one 20110101 |
| Involvement of indoleamine 2,3-dioxygenase in impairing tumor-infiltrating CD8 T-cell functions in esophageal squamous cell carcinoma. | Clinical & developmental immunology 20110101 |
| Tryptophan transport in human fibroblast cells-a functional characterization. | International journal of tryptophan research : IJTR 20110101 |
| Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons. | International journal of tryptophan research : IJTR 20110101 |
| Upregulated expression of indoleamine 2, 3-dioxygenase in primary breast cancer correlates with increase of infiltrated regulatory T cells in situ and lymph node metastasis. | Clinical & developmental immunology 20110101 |
| Fibroblastic reticular cells from lymph nodes attenuate T cell expansion by producing nitric oxide. | PloS one 20110101 |
| Suppression of humoral immune response to hepatitis B surface antigen vaccine in BALB/c mice by 1-methyl-tryptophan co-administration. | Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences 20110101 |
| Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression. | Transplantation 20101227 |
| Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells. | Haematologica 20101201 |
| Pancreatic islet transplants and IDO: when starving the enemy does you good. | Diabetes 20100901 |
| A combination of the metabolic enzyme inhibitor APO866 and the immune adjuvant L-1-methyl tryptophan induces additive antitumor activity. | Experimental biology and medicine (Maywood, N.J.) 20100701 |
| Rational design of indoleamine 2,3-dioxygenase inhibitors. | Journal of medicinal chemistry 20100211 |
| Inhibition of allogeneic T-cell response by Kupffer cells expressing indoleamine 2,3-dioxygenase. | World journal of gastroenterology 20100207 |
| DC expressing transgene Foxp3 are regulatory APC. | European journal of immunology 20100201 |
| The role of indoleamine 2,3-dioxygenase in retinal pigment epithelial cell-mediated immune modulation. | Ocular immunology and inflammation 20100101 |
| Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: role of B7-H1 and IDO. | Immunology and cell biology 20100101 |
| Therapeutic cancer vaccines in combination with conventional therapy. | Journal of biomedicine & biotechnology 20100101 |
| Divergent modulation of Chlamydia pneumoniae infection cycle in human monocytic and endothelial cells by iron, tryptophan availability and interferon gamma. | Immunobiology 20100101 |
| Psychological stress-induced, IDO1-dependent tryptophan catabolism: implications on immunosuppression in mice and humans. | PloS one 20100101 |
| Indoleamine 2,3-dioxygenase: is it an immune suppressor? | Cancer journal (Sudbury, Mass.) 20100101 |
| Trends in cancer immunotherapy. | Clinical Medicine Insights. Oncology 20100101 |
| IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease. | International journal of tryptophan research : IJTR 20100101 |
| Understanding the roles of the kynurenine pathway in multiple sclerosis progression. | International journal of tryptophan research : IJTR 20100101 |
| Role of the immunosuppressive enzyme indoleamine 2,3-dioxygenase in the progression of ovarian carcinoma. | Gynecologic oncology 20091101 |
| IDO and outcomes in ovarian cancer. | Gynecologic oncology 20091101 |
| Inhibitory substrate binding site of human indoleamine 2,3-dioxygenase. | Journal of the American Chemical Society 20090916 |
| Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer. | Cancer research 20090701 |
| IDO inhibits T-cell function through suppressing Vav1 expression and activation. | Cancer biology & therapy 20090701 |
| The immunoregulatory enzyme IDO paradoxically drives B cell-mediated autoimmunity. | Journal of immunology (Baltimore, Md. : 1950) 20090615 |
| CTLA-4 is required by CD4+CD25+ Treg to control CD4+ T-cell lymphopenia-induced proliferation. | European journal of immunology 20090601 |
| Origins and functional basis of regulatory CD11c+CD8+ T cells. | European journal of immunology 20090601 |
| Soluble mediators from mesenchymal stem cells suppress T cell proliferation by inducing IL-10. | Experimental & molecular medicine 20090531 |
| Lipopolysaccharide-induced depressive-like behavior is mediated by indoleamine 2,3-dioxygenase activation in mice. | Molecular psychiatry 20090501 |
| Allostimulatory activity of bone marrow-derived plasmacytoid dendritic cells is independent of indoleamine dioxygenase but regulated by inducible costimulator ligand expression. | Human immunology 20090501 |
| Inhibition of indoleamine 2, 3-dioxygenase-mediated tryptophan catabolism accelerates crescentic glomerulonephritis. | Clinical and experimental immunology 20090501 |
| Prevention of spontaneous tumor development in a ret transgenic mouse model by ret peptide vaccination with indoleamine 2,3-dioxygenase inhibitor 1-methyl tryptophan. | Cancer research 20090501 |
| Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. | Journal of the American College of Surgeons 20090501 |
| Combined effect of antiretroviral therapy and blockade of IDO in SIV-infected rhesus macaques. | Journal of immunology (Baltimore, Md. : 1950) 20090401 |
| Tryptophan catabolites regulate mucosal sensitization to ovalbumin in respiratory airways. | Allergy 20090301 |
| IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism. | Cancer immunology, immunotherapy : CII 20090101 |
| Simultaneous Foxp3 and IDO expression is associated with sentinel lymph node metastases in breast cancer. | BMC cancer 20090101 |
| The paradoxical patterns of expression of indoleamine 2,3-dioxygenase in colon cancer. | Journal of translational medicine 20090101 |
| The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase. | PloS one 20090101 |
| Expression of indoleamine 2,3-dioxygenase in nasopharyngeal carcinoma impairs the cytolytic function of peripheral blood lymphocytes. | BMC cancer 20090101 |
| Kynurenine pathway metabolites in humans: disease and healthy States. | International journal of tryptophan research : IJTR 20090101 |
| The physiological action of picolinic Acid in the human brain. | International journal of tryptophan research : IJTR 20090101 |
| Cell cycle arrest by kynurenine in lens epithelial cells. | Investigative ophthalmology & visual science 20081201 |
| Critical role of indoleamine 2,3-dioxygenase in tumor resistance to repeated treatments with targeted IFNgamma. | Molecular cancer therapeutics 20081201 |
| Is IDO a key enzyme bridging the gap between tumor escape and tolerance induction? | Langenbeck's archives of surgery 20081101 |
| The indoleamine 2,3-dioxygenase pathway is essential for human plasmacytoid dendritic cell-induced adaptive T regulatory cell generation. | Journal of immunology (Baltimore, Md. : 1950) 20081015 |
| Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. | The Biochemical journal 20080915 |
| Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2,3-dioxygenase inhibitors. | Bioorganic & medicinal chemistry 20080915 |
| Structure based development of phenylimidazole-derived inhibitors of indoleamine 2,3-dioxygenase. | Journal of medicinal chemistry 20080828 |
| The preference of tryptophan for membrane interfaces: insights from N-methylation of tryptophans in gramicidin channels. | The Journal of biological chemistry 20080808 |
| [Potential endogenous immunological self-protection of uveal melanoma by indoleamine 2,3-dioxygenase]. | Klinische Monatsblatter fur Augenheilkunde 20080801 |
| Enhancement of dendritic cell-tumor fusion vaccine potency by indoleamine-pyrrole 2,3-dioxygenase inhibitor, 1-MT. | Journal of cancer research and clinical oncology 20080501 |
| Modulation of invariant natural killer T cell cytokine responses by indoleamine 2,3-dioxygenase. | Immunology letters 20080415 |
| Antimicrobial and immunoregulatory effects mediated by human lung cells: role of IFN-gamma-induced tryptophan degradation. | FEMS immunology and medical microbiology 20080301 |
| Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cells. | Blood 20080215 |
| Increased striatal serotonin synthesis following cortical resection in children with intractable epilepsy. | Epilepsy research 20080201 |
| The role of tryptophan metabolism in iNOS transcription and nitric oxide production by chicken macrophage cells upon treatment with interferon gamma. | Immunology letters 20080129 |
| Peripheral T-cell tolerance associated with prostate cancer is independent from CD4+CD25+ regulatory T cells. | Cancer research 20080101 |
| Th1 disabled function in response to TLR4 stimulation of monocyte-derived DC from patients chronically-infected by hepatitis C virus. | PloS one 20080101 |
| Low dose Zebularine treatment enhances immunogenicity of tumor cells. | Cancer letters 20071108 |
| Uveal melanoma expression of indoleamine 2,3-deoxygenase: establishment of an immune privileged environment by tryptophan depletion. | Experimental eye research 20071101 |
| Enhancement of the sensitivity of the whole-blood gamma interferon assay for diagnosis of Mycobacterium bovis infections in cattle. | Clinical and vaccine immunology : CVI 20071101 |
| Effect of Kidney-replenishing herb on the indoleamine 2,3-dioxygenase of human syncytiotrophoblasts cultured in vitro and the balance of helper T-cell cytokines. | Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 20071101 |
| Nitric oxide and indoleamine 2,3-dioxygenase mediate CTLA4Ig-induced survival in heart allografts in rats. | Transplantation 20071027 |
| Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege. | Journal of immunology (Baltimore, Md. : 1950) 20071015 |
| Tumor immune escape mediated by indoleamine 2,3-dioxygenase. | Immunology letters 20070815 |
| Interferon-gamma does not break, but promotes the immunosuppressive capacity of adult human mesenchymal stem cells. | Clinical and experimental immunology 20070801 |
| Novel tryptophan catabolic enzyme IDO2 is the preferred biochemical target of the antitumor indoleamine 2,3-dioxygenase inhibitory compound D-1-methyl-tryptophan. | Cancer research 20070801 |
| Foxp3+CD25+ T regulatory cells stimulate IFN-gamma-independent CD152-mediated activation of tryptophan catabolism that provides dendritic cells with immune regulatory activity in mice unresponsive to staphylococcal enterotoxin B. | Journal of immunology (Baltimore, Md. : 1950) 20070715 |
| Transient upregulation of indoleamine 2,3-dioxygenase in dendritic cells by human chorionic gonadotropin downregulates autoimmune diabetes. | Diabetes 20070601 |
| Indoleamine 2, 3-dioxygenase expression in cells of human acute monocyte leukemia (M(5)) and acute lymphocyte leukemia and therapeutic effect of its inhibitor 1-methyl tryptophan. | Zhongguo shi yan xue ye xue za zhi 20070601 |
| HIV inhibits CD4+ T-cell proliferation by inducing indoleamine 2,3-dioxygenase in plasmacytoid dendritic cells. | Blood 20070415 |
| Pharmacological targeting of IDO-mediated tolerance for treating autoimmune disease. | Current drug metabolism 20070401 |
| Inhibition of indoleamine 2,3-dioxygenase in dendritic cells by stereoisomers of 1-methyl-tryptophan correlates with antitumor responses. | Cancer research 20070115 |
| Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. | Blood 20070101 |
| Inhibition of indoleamine 2,3-dioxygenase-mediated tryptophan catabolism accelerates collagen-induced arthritis in mice. | Arthritis research & therapy 20070101 |
| Indoleamine 2,3-dioxygenase (IDO) is involved in promoting the development of anterior chamber-associated immune deviation. | Immunology letters 20061115 |
| Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata. | Journal of natural products 20061001 |
| 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. | Journal of immunology (Baltimore, Md. : 1950) 20060801 |
| Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO. | Journal of immunology (Baltimore, Md. : 1950) 20060701 |
| 4-1BB-mediated amelioration of experimental autoimmune uveoretinitis is caused by indoleamine 2,3-dioxygenase-dependent mechanisms. | Cytokine 20060601 |
| Perinatal immunotoxicity: why adult exposure assessment fails to predict risk. | Environmental health perspectives 20060401 |
| Indoleamine 2,3-dioxygenase protects corneal endothelial cells from UV mediated damage. | Experimental eye research 20060301 |
| Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast. | Biotechnology journal 20060301 |
| Influenza-induced expression of indoleamine 2,3-dioxygenase enhances interleukin-10 production and bacterial outgrowth during secondary pneumococcal pneumonia. | The Journal of infectious diseases 20060115 |
| Systemic application of CpG-rich DNA suppresses adaptive T cell immunity via induction of IDO. | European journal of immunology 20060101 |
| Indoleamine 2,3 dioxygenase and human leucocyte antigen-G inhibit the T-cell alloproliferative response through two independent pathways. | Immunology 20051101 |
| Linking two immuno-suppressive molecules: indoleamine 2,3 dioxygenase can modify HLA-G cell-surface expression. | Biology of reproduction 20050901 |
| Indolamine 2,3-dioxygenase is expressed in the CNS and down-regulates autoimmune inflammation. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801 |
| Prediction of genotoxicity of chemical compounds by statistical learning methods. | Chemical research in toxicology 20050601 |
| Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines. | Cell research 20050301 |
| Interferon-gamma-modified dendritic cells suppress B cell function and ameliorate the development of experimental autoimmune myasthenia gravis. | Clinical and experimental immunology 20041101 |
| Antigen-specific T cell functions are suppressed over the estrogen-dendritic cell-indoleamine 2,3-dioxygenase axis. | Steroids 20040901 |
| Indoleamine 2,3-dioxygenase: distribution and function in the developing human placenta. | Journal of reproductive immunology 20040401 |
| Indoleamine 2,3-dioxygenase activity and L-tryptophan transport in human breast cancer cells. | Biochimica et biophysica acta 20040210 |
| Cell surface expression of MHC class I antigen is suppressed in indoleamine 2,3-dioxygenase genetically modified keratinocytes: implications in allogeneic skin substitute engraftment. | Human immunology 20040201 |
| Comparative effects of L-tryptophan and 1-methyl-tryptophan on immunoregulation induced by sperm, human pre-implantation embryo and trophoblast supernatants. | American journal of reproductive immunology (New York, N.Y. : 1989) 20031001 |
| Interferon-gamma independent oxidation of melatonin by macrophages. | Journal of pineal research 20030101 |
| Tryptophan pyrrole ring cleavage enzymes in placenta. | Advances in experimental medicine and biology 20030101 |
| Instruction of translating ribosome by nascent peptide. | Science (New York, N.Y.) 20020913 |
| Potential regulatory function of human dendritic cells expressing indoleamine 2,3-dioxygenase. | Science (New York, N.Y.) 20020913 |
| FcepsilonRI induces the tryptophan degradation pathway involved in regulating T cell responses. | Journal of immunology (Baltimore, Md. : 1950) 20020815 |
| Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis. | Journal of neuroimmunology 20020801 |
| Tryptophan degradation by human placental indoleamine 2,3-dioxygenase regulates lymphocyte proliferation. | The Journal of physiology 20010815 |
| Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles. | The Journal of physiology 20010301 |
| The role of L-tryptophan transport in L-tryptophan degradation by indoleamine 2,3-dioxygenase in human placental explants. | The Journal of physiology 20010301 |
| Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts. | Transplantation proceedings 20010101 |