N,N'-(Hexane-1,6-diyl)diacetamide
Title | Journal |
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O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. | The Journal of biological chemistry 20160722 |
Cancer Differentiating Agent Hexamethylene Bisacetamide Inhibits BET Bromodomain Proteins. | Cancer research 20160415 |
Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein. | The Journal of biological chemistry 20121019 |
Entry of herpes simplex virus type 1 (HSV-1) into the distal axons of trigeminal neurons favors the onset of nonproductive, silent infection. | PLoS pathogens 20120501 |
Bis-pyrrolyl-tetrazolyl derivatives as hybrid polar compounds: A case of lipophilic functional bioisosterism with bis-acetamides. | European journal of medicinal chemistry 20120401 |
Transient reversal of episome silencing precedes VP16-dependent transcription during reactivation of latent HSV-1 in neurons. | PLoS pathogens 20120201 |
7SK snRNA: a noncoding RNA that plays a major role in regulating eukaryotic transcription. | Wiley interdisciplinary reviews. RNA 20120101 |
A flexible model of HIV-1 latency permitting evaluation of many primary CD4 T-cell reservoirs. | PloS one 20120101 |
DNA replication fading as proliferating cells advance in their commitment to terminal differentiation. | Scientific reports 20120101 |
Vorinostat approved in Japan for treatment of cutaneous T-cell lymphomas: status and prospects. | OncoTargets and therapy 20120101 |
Potentiation of NMDA receptor-dependent cell responses by extracellular high mobility group box 1 protein. | PloS one 20120101 |
Distribution and shedding of the membrane phosphatidylserine during maturation and aging of erythroid cells. | Biochimica et biophysica acta 20111201 |
Cholesterol esterification during differentiation of mouse erythroleukemia (Friend) cells. | Hematology reports 20110831 |
Determination of hexamethylene bisacetamide, an antineoplastic compound, in mouse and human plasma by LC-MS/MS. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110801 |
NPMc(+) AML cell line shows differential protein expression and lower sensitivity to DNA-damaging and p53-inducing anticancer compounds. | Cell cycle (Georgetown, Tex.) 20110615 |
New insights into the control of HIV-1 transcription: when Tat meets the 7SK snRNP and super elongation complex (SEC). | Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 20110601 |
Aberrant expression and localization of hnRNP-A2/B1 is a common event in human gastric adenocarcinoma. | Journal of gastroenterology and hepatology 20110101 |
Mouse embryonic stem cells inhibit murine cytomegalovirus infection through a multi-step process. | PloS one 20110101 |
P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells. | BMC cancer 20110101 |
Somatic mutagenesis with a Sleeping Beauty transposon system leads to solid tumor formation in zebrafish. | PloS one 20110101 |
Protein phosphatase-1 activates CDK9 by dephosphorylating Ser175. | PloS one 20110101 |
DMSO-Free Programmed Cryopreservation of Fully Dissociated and Adherent Human Induced Pluripotent Stem Cells. | Stem cells international 20110101 |
Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells. | PloS one 20110101 |
Antivirals reduce the formation of key Alzheimer's disease molecules in cell cultures acutely infected with herpes simplex virus type 1. | PloS one 20110101 |
Localization and altered expression of nucleophosmin in the nuclear matrix during the differentiation of human hepatocarcinoma SMMC-7721 cells induced by HMBA. | Cancer investigation 20101201 |
Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake. | The Biochemical journal 20101115 |
Occupational exposure to HDI: progress and challenges in biomarker analysis. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101001 |
Sequential changes in chromatin structure during transcriptional activation in the beta globin LCR and its target gene. | The international journal of biochemistry & cell biology 20100901 |
HMBA depolymerizes microtubules, activates mitotic checkpoints and induces mitotic block in MCF-7 cells by binding at the colchicine site in tubulin. | Biochemical pharmacology 20100701 |
Aberrant expression of nuclear matrix proteins during HMBA-induced differentiation of gastric cancer cells. | World journal of gastroenterology 20100507 |
Constitutive and Inducible Innate Responses in Cells Infected by HSV-1-Derived Amplicon Vectors. | The open virology journal 20100101 |
Interferon alpha induces establishment of alphaherpesvirus latency in sensory neurons in vitro. | PloS one 20100101 |
Hepcidin induces HIV-1 transcription inhibited by ferroportin. | Retrovirology 20100101 |
Content-based microarray search using differential expression profiles. | BMC bioinformatics 20100101 |
De novo synthesis of VP16 coordinates the exit from HSV latency in vivo. | PLoS pathogens 20090301 |
Hexamethylene bisacetamide can convert nonpermissive human cells to a permissive state for expressing the major immediate-early genes of human cytomegalovirus by up-regulating NF-kappaB activity. | Virology 20090120 |
Control of stochastic gene expression by host factors at the HIV promoter. | PLoS pathogens 20090101 |
Gene therapy: the end of the rainbow? | Head & neck oncology 20090101 |
Properties of virion transactivator proteins encoded by primate cytomegaloviruses. | Virology journal 20090101 |
P-TEFb- the final frontier. | Cell division 20090101 |
Wnt pathway reprogramming during human embryonal carcinoma differentiation and potential for therapeutic targeting. | BMC cancer 20090101 |
Molecular control of HIV-1 postintegration latency: implications for the development of new therapeutic strategies. | Retrovirology 20090101 |
A potential novel combination therapy targeting survivin in renal cancer cells: Inhibition of survivin expression by topotecan and hexamethylene bisacetamide. | Molecular medicine reports 20090101 |
Discordant varicella-zoster virus glycoprotein C expression and localization between cultured cells and human skin vesicles. | Virology 20081220 |
Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy. | Cell cycle (Georgetown, Tex.) 20081201 |
[Molecular mechanism underlying differentiation of HL-60 cells induced by hexamethylene bisacetamide]. | Zhongguo shi yan xue ye xue za zhi 20081001 |
HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. | Cancer research 20080901 |
[Expression and localization of hnRNP A2/B1 during differentiation of human osteosarcoma MG-63 cells induced by HMBA]. | Ai zheng = Aizheng = Chinese journal of cancer 20080701 |
PP2B and PP1alpha cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling. | Genes & development 20080515 |
Hexamethylene bisacetamide inhibits malignant phenotype in T-ALL cell lines. | Leukemia research 20080501 |
Hexamethylene bisacetamide as a treatment for T-cell leukemia (T-ALL). | Leukemia research 20080501 |
Non-random subcellular distribution of variant EKLF in erythroid cells. | Experimental cell research 20080415 |
Hexamethylbisacetamide and disruption of human immunodeficiency virus type 1 latency in CD4(+) T cells. | The Journal of infectious diseases 20080415 |
Effect of hexamethylene bisacetamide (HMBA) on the microtubular system of Tetrahymena pyriformis. | Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology 20080201 |
Hexamethylene bisacetamide leads to reduced helper virus-free HSV-1 amplicon expression titers via suppression of ICP0. | The journal of gene medicine 20080201 |
[Localization of prohibitin in nuclear matrix and its expressive alteration during the differentiation of human osteosarcoma MG-63 cells induced by HMBA]. | Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20080201 |
PU.1 is dispensable to block erythroid differentiation in Friend erythroleukemia cells. | Leukemia research 20080101 |
Relationship between the induction of leukemia cell differentiation and the enhancement of reporter gene expression in 3T3 Swiss cells. | Leukemia research 20080101 |
Histone modifications associated with herpes simplex virus type 1 genomes during quiescence and following ICP0-mediated de-repression. | The Journal of general virology 20080101 |
Overexpression of CDC2/CyclinB1 in gliomas, and CDC2 depletion inhibits proliferation of human glioma cells in vitro and in vivo. | BMC cancer 20080101 |
Detailed characterization of the mouse embryonic stem cell transcriptome reveals novel genes and intergenic splicing associated with pluripotency. | BMC genomics 20080101 |
Multi-stage Friend murine erythroleukemia: molecular insights into oncogenic cooperation. | Retrovirology 20080101 |
Defeating cancer with antidepressants. | Ecancermedicalscience 20080101 |
HMBA releases P-TEFb from HEXIM1 and 7SK snRNA via PI3K/Akt and activates HIV transcription. | PLoS pathogens 20071001 |
HEXIM1 and the control of transcription elongation: from cancer and inflammation to AIDS and cardiac hypertrophy. | Cell cycle (Georgetown, Tex.) 20070801 |
Alteration of nuclear matrix-intermediate filament system and differential expression of nuclear matrix proteins during human hepatocarcinoma cell differentiation. | World journal of gastroenterology 20070528 |
Proteomic analysis of erythroid differentiation induced by hexamethylene bisacetamide in murine erythroleukemia cells. | Experimental hematology 20070201 |
Down-regulation of CD44 contributes to the differentiation of HL-60 cells induced by ATRA or HMBA. | Cellular & molecular immunology 20070201 |
Temporal variation in the expression of the p53 protein in proliferating and differentiating murine erythroleukaemia cells. | Molecular and cellular biochemistry 20070101 |
Cellular mRNA activates transcription elongation by displacing 7SK RNA. | PloS one 20070101 |
Delayed biosynthesis of varicella-zoster virus glycoprotein C: upregulation by hexamethylene bisacetamide and retinoic acid treatment of infected cells. | Journal of virology 20061001 |
Enhancement of antitumor activity of herpes simplex virus gamma(1)34.5-deficient mutant for oral squamous cell carcinoma cells by hexamethylene bisacetamide. | Cancer gene therapy 20060801 |
Growth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086. | British journal of cancer 20060605 |
The carbonic anhydrase I locus contains a c-Myb target promoter and modulates differentiation of murine erythroleukemia cells. | Oncogene 20060504 |
Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
Following the differentiation of human pluripotent stem cells by proteomic identification of biomarkers. | Stem cells and development 20060401 |
[Changes of nuclear matrix proteins during differentiation of human osteosarcoma MG-63 cells induced by HMBA]. | Fen zi xi bao sheng wu xue bao = Journal of molecular cell biology 20060401 |
Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation. | Journal of cellular physiology 20060301 |
1,6-Diaminohexane contributes to the hexamethylene bisacetamide-induced erythroid differentiation pathway by stimulating Ca2+ release from inositol 1,4,5-trisphosphate-sensitive stores and promoting Ca2+ influx. | Archives of biochemistry and biophysics 20060101 |
Differentiation-inducing therapy for solid tumors. | Current pharmaceutical design 20060101 |
Changes of nuclear matrix proteins following the differentiation of human osteosarcoma MG-63 cells. | Genomics, proteomics & bioinformatics 20060101 |
Interplay between 7SK snRNA and oppositely charged regions in HEXIM1 direct the inhibition of P-TEFb. | The EMBO journal 20051221 |
Inhibitory effect of hexamethylene bisacetamide on replication of human cytomegalovirus. | Archives of virology 20051001 |
Microarray profiling of genes differentially expressed during erythroid differentiation of murine erythroleukemia cells. | Molecules and cells 20050831 |
Protein kinase clk/STY is differentially regulated during erythroleukemia cell differentiation: a bias toward the skipped splice variant characterizes postcommitment stages. | Cell research 20050701 |
Temporal changes in the expression of protein phosphatase 1 and protein phosphatase 2A in proliferating and differentiating murine erythroleukaemia cells. | Cell biology international 20050401 |
A new paradigm in eukaryotic biology: HIV Tat and the control of transcriptional elongation. | PLoS biology 20050201 |
Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation. | The Journal of biological chemistry 20041217 |
HMBA induces cell death and potentiates doxorubicin toxicity in malignant mesothelioma cells. | Cancer chemotherapy and pharmacology 20041101 |
Applying proteomic methodologies to analyze the effect of hexamethylene bisacetamide (HMBA) on proliferation and differentiation of human gastric carcinoma BGC-823 cells. | The international journal of biochemistry & cell biology 20040801 |
Activation of transiently transfected reporter genes in 3T3 Swiss cells by the inducers of differentiation/apoptosis--dimethylsulfoxide, hexamethylene bisacetamide and trichostatin A. | European journal of biochemistry 20040601 |
Differentiation-dependent photodynamic therapy regulated by porphobilinogen deaminase in B16 melanoma. | British journal of cancer 20040504 |
Growth arrest and apoptosis of human hepatocellular carcinoma cells induced by hexamethylene bisacetamide. | World journal of gastroenterology 20040401 |
HMBA-induced differentiation of myeloid leukemic cell lines is associated with altered G1 cell cycle regulators and related genes. | Chinese medical journal 20040301 |
[Effect of HMBA on differentiation and apoptosis of HL-60 and U937 cells and its mechanism]. | Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi 20040301 |
Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation. | Oncogene 20031211 |
Overexpression of the immediate early gene fra-1 inhibits proliferation, induces apoptosis, and reduces tumourigenicity of c6 glioma cells. | Experimental cell research 20031115 |
[Effects of hexamethylene bisacetamide on cell cycle and expression of its regulatory proteins in HL-60 cells]. | Zhongguo shi yan xue ye xue za zhi 20031001 |
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA. | Molecular cell 20031001 |
Identification of a novel inhibitor of breast cell growth that is down-regulated by estrogens and decreased in breast tumors. | Cancer research 20030815 |
A porphobilinogen deaminase (PBGD) Ran-binding protein interaction is implicated in nuclear trafficking of PBGD in differentiating glioma cells. | Oncogene 20030814 |
Differential expression of Ran GTPase during HMBA-induced differentiation in murine erythroleukemia cells. | Leukemia research 20030701 |
The cleavage product deltaPML-RARalpha contributes to all-trans retinoic acid-mediated differentiation in acute promyelocytic leukemia cells. | Oncogene 20030626 |
Modulation of SOX2 and SOX3 gene expression during differentiation of human neuronal precursor cell line NTERA2. | Molecular biology reports 20030601 |
Clinical and laboratory studies of expression of cyclin A in leukemia cells. | Zhongguo shi yan xue ye xue za zhi 20030401 |
Suppression of NF-kappaB-dependent gene expression by a hexamethylene bisacetamide-inducible protein HEXIM1 in human vascular smooth muscle cells. | Genes to cells : devoted to molecular & cellular mechanisms 20030201 |
Leukemia-related transcription factor TEL accelerates differentiation of Friend erythroleukemia cells. | Oncogene 20030109 |
Induction of apoptosis by combined treatment with differentiation-inducing agents and interferon-alpha in human lung cancer cells. | Anticancer research 20030101 |
[Effects of HMBA on the expression of cell-cycle-associated genes in human hepatocarcinoma SMMC-7721 cells]. | Shi yan sheng wu xue bao 20020901 |
Targeted removal of PML-RARalpha protein is required prior to inhibition of histone deacetylase for overcoming all-trans retinoic acid differentiation resistance in acute promyelocytic leukemia. | Blood 20020801 |
Structure, expression, and functional characterization of the mouse CLP-1 gene. | Gene 20020612 |
Specific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cells. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020501 |
[Effect of hexamethylene bisacetamine on proliferation and apoptosis of human leukemia cells in vitro and relevant mechanisms]. | Zhonghua yi xue za zhi 20020425 |
Membrane phospholipid reorganization differentially regulates metallothionein and heme oxygenase by heme-hemopexin. | DNA and cell biology 20020401 |
A Myb dependent pathway maintains Friend murine erythroleukemia cells in an immature and proliferating state. | Oncogene 20020314 |
Surface antigens of human embryonic stem cells: changes upon differentiation in culture. | Journal of anatomy 20020301 |
[Effects of hexamethylene bisacetamide on related genes expression of apoptosis and cell proliferating in human mucoepidermoid carcinoma cell line MEC-1]. | Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology 20020301 |
New designed HMBA agents as inducers of erythroleukemia cell differentiation. | Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih 20020301 |
[Differentiation of human hepatocarcinoma SMMC-7721 cells induced by HMBA]. | Shi yan sheng wu xue bao 20011201 |
[Regulation of Chinese medicine bailong and hexamethylene bisacetamide on cyclin dependent kinase inhibitor P16 genes in human cancer cell]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20011001 |
Hexamethylene bisacetamide protects peritoneal mesothelial cells from glucose. | Kidney international 20010901 |
Calretinin and calretinin-22k increase resistance toward sodium butyrate-induced differentiation in CaCo-2 colon adenocarcinoma cells. | Experimental cell research 20010801 |
Establishment of a consistent L929 bioassay system for TNF-alpha quantitation to evaluate the effect of lipopolysaccharide, phytomitogens and cytodifferentiation agents on cytotoxicity of TNF-alpha secreted by adherent human mononuclear cells. | Mediators of inflammation 20010801 |
Induction of telomerase activity during development of human mast cells from peripheral blood CD34+ cells: comparisons with tumor mast-cell lines. | Journal of immunology (Baltimore, Md. : 1950) 20010601 |
Expression of microtubule-associated protein 2 in benign and malignant melanocytes: implications for differentiation and progression of cutaneous melanoma. | The American journal of pathology 20010601 |
Structural characterization of erythroid and megakaryocytic differentiation in Friend erythroleukemia cells. | Experimental hematology 20010501 |
[Regulative effects of bailong and Hexamethylene bisacetamide on growth and phenotype of human gastric cancer cells in cell cycle]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010501 |
Regulation of tyrosinase-related protein-2 (TYRP2) in human melanocytes: relationship to growth and morphology. | Pigment cell research 20010401 |
[Study on common character of regulative molecular mechanism of Chinese drug bailong and hexamethylen bisacetamide in human cancer cell cycle and their oncogene and tumor suppressor gene expression]. | Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20010401 |
Growth inhibition and differentiation of C6 glioma cells on treatment with hmba. | Cell biology international 20010101 |
A novel system to identify Myb target promoters in friend murine erythroleukemia cells. | Blood cells, molecules & diseases 20010101 |
Induction of apoptosis in U937 human leukemia cells by suberoylanilide hydroxamic acid (SAHA) proceeds through pathways that are regulated by Bcl-2/Bcl-XL, c-Jun, and p21CIP1, but independent of p53. | Oncogene 19991125 |
Effects of oxygen radical scavengers on connexins 32 and 26 expression in primary cultures of adult rat hepatocytes. | Carcinogenesis 19960301 |
All-trans retinoic acid induces monocyte growth factor receptor (c-fms) gene expression in HL-60 leukemia cells. | Leukemia 19930301 |