3-Amino-3-((4-aminophenyl)thio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
| Title | Journal |
|---|---|
| Melatonin attenuates memory impairment induced by Klotho gene deficiency via interactive signaling between MT2 receptor, ERK, and Nrf2-related antioxidant potential. | The international journal of neuropsychopharmacology 20150401 |
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Proteinase-activated receptor 2 (PAR(2)) in cholangiocarcinoma (CCA) cells: effects on signaling and cellular level. | Histochemistry and cell biology 20121201 |
| Curcumin produces antidepressant effects via activating MAPK/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice. | Behavioural brain research 20121101 |
| Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase. | The Journal of pharmacology and experimental therapeutics 20120901 |
| Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome. | Journal of neurochemistry 20120501 |
| The effect of mTOR inhibition alone or combined with MEK inhibitors on brain metastasis: an in vivo analysis in triple-negative breast cancer models. | Breast cancer research and treatment 20120101 |
| Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning. | Neurobiology of learning and memory 20120101 |
| MEK-ERK signaling dictates DNA-repair gene MGMT expression and temozolomide resistance of stem-like glioblastoma cells via the MDM2-p53 axis. | Stem cells (Dayton, Ohio) 20111201 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| The MEK inhibitor SL327 blocks acquisition but not expression of lithium-induced conditioned place aversion: a behavioral and immunohistochemical study. | Psychopharmacology 20110701 |
| Naloxone-precipitated morphine withdrawal evokes phosphorylation of heat shock protein 27 in rat heart through extracellular signal-regulated kinase. | Journal of molecular and cellular cardiology 20110701 |
| Inhibition of extracellular signal-regulated kinase (ERK) activity with SL327 does not prevent acquisition, expression, and extinction of ethanol-seeking behavior in mice. | Behavioural brain research 20110301 |
| Molecular switch from L-type Ca v 1.3 to Ca v 1.2 Ca2+ channel signaling underlies long-term psychostimulant-induced behavioral and molecular plasticity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101215 |
| Crosstalk between the PI3K/mTOR and MEK/ERK pathways involved in the maintenance of self-renewal and tumorigenicity of glioblastoma stem-like cells. | Stem cells (Dayton, Ohio) 20101101 |
| Oral supplementation with Leu-Ile, a hydrophobic dipeptide, prevents the impairment of memory induced by amyloid beta in mice via restraining the hyperphosphorylation of extracellular signal-regulated kinase. | Behavioural brain research 20100711 |
| Intrastriatal inhibition of extracellular signal-regulated kinases impaired the consolidation phase of motor skill learning. | Neurobiology of learning and memory 20100701 |
| 5-HT1A receptors mediate detrimental effects of cocaine on long-term potentiation and expression of polysialylated neural cell adhesion molecule protein in rat dentate gyrus. | Neuroscience 20100310 |
| Resveratrol reduces glutamate-mediated monocyte chemotactic protein-1 expression via inhibition of extracellular signal-regulated kinase 1/2 pathway in rat hippocampal slice cultures. | Journal of neurochemistry 20100301 |
| Upregulation of early growth response factor-1 by bile acids requires mitogen-activated protein kinase signaling. | Toxicology and applied pharmacology 20100215 |
| Identification of plasticity-associated genes regulated by Pavlovian fear conditioning in the lateral amygdala. | Journal of neurochemistry 20100201 |
| The time course of unconditioned morphine-induced psychomotor sensitization mirrors the phosphorylation of FADD and MEK/ERK in rat striatum: role of PEA-15 as a FADD-ERK binding partner in striatal plasticity. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100101 |
| ERK1/2 activation in reactive astrocytes of mice with pilocarpine-induced status epilepticus. | Neurological research 20091201 |
| Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. | Journal of neuroscience research 20091201 |
| Synergistic interactions of dopamine D1 and glutamate NMDA receptors in rat hippocampus and prefrontal cortex: involvement of ERK1/2 signaling. | Neuroscience 20091110 |
| Differential involvement of D1 and D2 dopamine receptors in L-DOPA-induced angiogenic activity in a rat model of Parkinson's disease. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20091101 |
| Extracellular signal-regulated kinase activation is required for consolidation and reconsolidation of memory at an early stage of ontogenesis. | The European journal of neuroscience 20091101 |
| Extracellular signal-regulated kinase activation in the amygdala mediates elevated plus maze behavior during opioid withdrawal. | Behavioural pharmacology 20091001 |
| Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. | The Journal of pharmacology and experimental therapeutics 20090901 |
| Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. | Psychopharmacology 20090501 |
| Effects of the MEK inhibitor, SL-327, on rewarding, motor- and cellular-activating effects of D-amphetamine and SKF-82958, and their augmentation by food restriction in rat. | Psychopharmacology 20090101 |
| ERK signalling pathway is not involved in PSA-NCAM-dependent alterations of hippocampal plasticity evoked by CB1 receptor activation. | Pharmacological reports : PR 20090101 |
| IL-6 mediated alterations on immobile behavior of rats in the forced swim test via ERK1/2 activation in specific brain regions. | Behavioural brain research 20081121 |
| Changes in apical dendritic structure correlate with sustained ERK1/2 phosphorylation in medial prefrontal cortex of a rat model of dopamine D1 receptor agonist sensitization. | The Journal of comparative neurology 20081110 |
| Regulation of extracellular signal-regulated kinases (ERKs) by naloxone-induced morphine withdrawal in the brain stress system. | Naunyn-Schmiedeberg's archives of pharmacology 20081001 |
| The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. | British journal of pharmacology 20080901 |
| Estradiol-induced enhancement of object memory consolidation involves hippocampal extracellular signal-regulated kinase activation and membrane-bound estrogen receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080827 |
| Involvement of extracellular signal-regulated protein kinase in acute cocaine-induced c-fos in nucleus accumbens. | Neuroscience letters 20080620 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| Extracellular signal-regulated kinase (ERK) inhibition does not prevent the development or expression of tolerance to and dependence on morphine in the mouse. | Pharmacology, biochemistry, and behavior 20071101 |
| Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation. | Journal of neurochemistry 20071001 |
| Extracellular signal-regulated kinase 1/2 involvement in the enhancement of contextual fear conditioning by nicotine. | Behavioral neuroscience 20071001 |
| Broad-spectrum efficacy across cognitive domains by alpha7 nicotinic acetylcholine receptor agonism correlates with activation of ERK1/2 and CREB phosphorylation pathways. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070926 |
| Cellular mechanisms underlying the anxiolytic effect of low doses of peripheral Delta9-tetrahydrocannabinol in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070901 |
| Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal. | British journal of pharmacology 20070701 |
| Critical involvement of cAMP/DARPP-32 and extracellular signal-regulated protein kinase signaling in L-DOPA-induced dyskinesia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070627 |
| The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala. | Biological psychiatry 20070501 |
| A role for MAP kinase signaling in behavioral models of depression and antidepressant treatment. | Biological psychiatry 20070301 |
| Rnd family genes are differentially regulated by 3,4-methylenedioxymethamphetamine and cocaine acute treatment in mice brain. | Brain research 20070223 |
| A role for ERK2 in reconsolidation of fear memories in mice. | Neurobiology of learning and memory 20060901 |
| Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation. | Neuropharmacology 20060401 |
| Inhibition of ERK pathway or protein synthesis during reexposure to drugs of abuse erases previously learned place preference. | Proceedings of the National Academy of Sciences of the United States of America 20060221 |
| Regulation of cocaine-induced activator protein 1 transcription factors by the extracellular signal-regulated kinase pathway. | Neuroscience 20060101 |
| Extracellular signal-regulated mitogen-activated protein kinase inhibitors decrease amphetamine-induced behavior and neuropeptide gene expression in the striatum. | Neuroscience 20060101 |
| Role of the ERK pathway in psychostimulant-induced locomotor sensitization. | BMC neuroscience 20060101 |
| Parsing molecular and behavioral effects of cocaine in mitogen- and stress-activated protein kinase-1-deficient mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20051207 |
| Extracellular signal-regulated kinases (ERKs) modulate cocaine-induced gene expression in the mouse amygdala. | The European journal of neuroscience 20050801 |
| Odorant-induced activation of extracellular signal-regulated kinase/mitogen-activated protein kinase in the olfactory bulb promotes survival of newly formed granule cells. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050601 |
| Ras/ERK signalling in cannabinoid tolerance: from behaviour to cellular aspects. | Journal of neurochemistry 20050501 |
| ERK kinase inhibition stabilizes the aryl hydrocarbon receptor: implications for transcriptional activation and protein degradation. | The Journal of biological chemistry 20050211 |
| Food restriction increases NMDA receptor-mediated calcium-calmodulin kinase II and NMDA receptor/extracellular signal-regulated kinase 1/2-mediated cyclic amp response element-binding protein phosphorylation in nucleus accumbens upon D-1 dopamine receptor stimulation in rats. | Neuroscience 20050101 |
| Inhibition of mitogen-activated protein kinase-extracellular signal-regulated kinase disrupts latent inhibition of cued fear conditioning in C57BL/6 mice. | Behavioral neuroscience 20041201 |
| Amphetamine-evoked gene expression in striatopallidal neurons: regulation by corticostriatal afferents and the ERK/MAPK signaling cascade. | Journal of neurochemistry 20041001 |
| Sustained extracellular signal-regulated kinase 1/2 phosphorylation in neonate 6-hydroxydopamine-lesioned rats after repeated D1-dopamine receptor agonist administration: implications for NMDA receptor involvement. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040630 |
| Cocaine-induced intracellular signaling and gene expression are oppositely regulated by the dopamine D1 and D3 receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331 |
| The role of the extracellular signal-regulated kinase signaling pathway in mood modulation. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030813 |
| Opposite regulation by typical and atypical anti-psychotics of ERK1/2, CREB and Elk-1 phosphorylation in mouse dorsal striatum. | Journal of neurochemistry 20030701 |
| Regulation of extracellular signal-regulated kinase by cannabinoids in hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030315 |
| Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. | The Journal of pharmacology and experimental therapeutics 20030101 |
| A role for ERK MAP kinase in physiologic temporal integration in hippocampal area CA1. | Learning & memory (Cold Spring Harbor, N.Y.) 20030101 |
| Alcohol-induced c-Fos expression in the Edinger-Westphal nucleus: pharmacological and signal transduction mechanisms. | The Journal of pharmacology and experimental therapeutics 20020801 |
| The role of muscarinic acetylcholine receptor-mediated activation of extracellular signal-regulated kinase 1/2 in pilocarpine-induced seizures. | Journal of neurochemistry 20020701 |
| Bidirectional changes in synapsin I phosphorylation at MAP kinase-dependent sites by acute neuronal excitation in vivo. | Journal of neurochemistry 20020301 |
| Differential regulation of IL-1beta and TNF-alpha RNA expression by MEK1 inhibitor after focal cerebral ischemia in mice. | Biochemical and biophysical research communications 20010907 |
| Delta 9-tetrahydrocannabinol-induced MAPK/ERK and Elk-1 activation in vivo depends on dopaminergic transmission. | The European journal of neuroscience 20010701 |
| Synergistic induction of apoptosis in human leukemia cells (U937) exposed to bryostatin 1 and the proteasome inhibitor lactacystin involves dysregulation of the PKC/MAPK cascade. | Blood 20010401 |