Androst-5-en-17-one, 3-[2-(diethylamino)ethoxy]-, hydrochloride (1:1), (3β)-
| Title | Journal |
|---|---|
| Increased copper levels in in vitro and in vivo models of Niemann-Pick C disease. | Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120801 |
| Cholesterol-depletion corrects APP and BACE1 misstrafficking in NPC1-deficient cells. | Biochimica et biophysica acta 20120801 |
| Arachidonic acid metabolism via cytosolic phospholipase A2 α induces cytotoxicity in niemann-pick disease type C cells. | Journal of cellular physiology 20120701 |
| Characterization of the Niemann-Pick C pathway in alveolar type II cells and lamellar bodies of the lung. | American journal of physiology. Lung cellular and molecular physiology 20120501 |
| Subversion of NPC1 pathway of cholesterol transport by Anaplasma phagocytophilum. | Cellular microbiology 20120401 |
| 3β-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species. | Journal of bone and mineral metabolism 20120301 |
| U18666A, an intra-cellular cholesterol transport inhibitor, inhibits dengue virus entry and replication. | Antiviral research 20120101 |
| Activation mobilizes the cholesterol in the late endosomes-lysosomes of Niemann Pick type C cells. | PloS one 20120101 |
| Amiodarone impairs trafficking through late endosomes inducing a Niemann-Pick C-like phenotype. | Biochemical pharmacology 20111101 |
| Augmentation of DHCR24 expression by hepatitis C virus infection facilitates viral replication in hepatocytes. | Journal of hepatology 20110901 |
| Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation. | The Journal of biological chemistry 20110805 |
| Proteome-wide dysregulation by PRA1 depletion delineates a role of PRA1 in lipid transport and cell migration. | Molecular & cellular proteomics : MCP 20110301 |
| Role for LAMP-2 in endosomal cholesterol transport. | Journal of cellular and molecular medicine 20110201 |
| Synthetic LXR agonist suppresses endogenous cholesterol biosynthesis and efficiently lowers plasma cholesterol. | Current pharmaceutical biotechnology 20110201 |
| Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation. | The American journal of pathology 20110201 |
| Nonesterified cholesterol content of lysosomes modulates susceptibility to oxidant-induced permeabilization. | Free radical biology & medicine 20110115 |
| The dynamin chemical inhibitor dynasore impairs cholesterol trafficking and sterol-sensitive genes transcription in human HeLa cells and macrophages. | PloS one 20110101 |
| Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease. | The Journal of biological chemistry 20100820 |
| Inhibition of DHCR24/seladin-1 impairs cellular homeostasis in prostate cancer. | The Prostate 20100615 |
| Modulation of cholesterol, farnesylpyrophosphate, and geranylgeranylpyrophosphate in neuroblastoma SH-SY5Y-APP695 cells: impact on amyloid beta-protein production. | Molecular neurobiology 20100601 |
| Endocytosis of beta-cyclodextrins is responsible for cholesterol reduction in Niemann-Pick type C mutant cells. | Proceedings of the National Academy of Sciences of the United States of America 20100323 |
| Inhibition of cholesterol recycling impairs cellular PrP(Sc) propagation. | Cellular and molecular life sciences : CMLS 20091201 |
| Variations in the effects on synthesis of amyloid beta protein in modulated autophagic conditions. | Neurological research 20091101 |
| Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol. | Journal of lipid research 20090901 |
| 24-dehydrocholesterol reductase/seladin-1: a key protein differentially involved in adrenocorticotropin effects observed in human and rat adrenal cortex. | Endocrinology 20090901 |
| Association of autophagy with cholesterol-accumulated compartments in Niemann-Pick disease type C cells. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20090701 |
| Cholesterol synthesis inhibitor U18666A and the role of sterol metabolism and trafficking in numerous pathophysiological processes. | Lipids 20090601 |
| Identification of an intracellular site of prion conversion. | PLoS pathogens 20090501 |
| U18666A, a cholesterol-inhibition agent, modulates human neuronal nicotinic acetylcholine receptors heterologously expressed in SH-EP1 cell line. | Journal of neurochemistry 20090301 |
| Novel mechanism of U18666A-induced tumour necrosis factor-alpha production in RAW 264.7 macrophage cells. | Clinical and experimental immunology 20090301 |
| Niemann-Pick C1 protein transports copper to the secretory compartment from late endosomes where ATP7B resides. | Experimental cell research 20090115 |
| ARF6-mediated endosome recycling reverses lipid accumulation defects in Niemann-Pick Type C disease. | PloS one 20090101 |
| Cholesterol accumulation by macrophages impairs phagosome maturation. | The Journal of biological chemistry 20081219 |
| The cholesterol transport inhibitor U18666a regulates amyloid precursor protein metabolism and trafficking in N2aAPP 'Swedish' cells. | Current Alzheimer research 20081001 |
| Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts. | Histochemistry and cell biology 20080501 |
| Bax activation and stress-induced apoptosis delayed by the accumulation of cholesterol in mitochondrial membranes. | Cell death and differentiation 20080301 |
| Regulation of the V-ATPase along the endocytic pathway occurs through reversible subunit association and membrane localization. | PloS one 20080101 |
| Different kinetics of cholesterol delivery to components of the cholesterol homeostatic machinery: implications for cholesterol trafficking to the endoplasmic reticulum. | Biochimica et biophysica acta 20080101 |
| Cholesterol efflux via HDL resecretion occurs when cholesterol transport out of the lysosome is impaired. | Journal of lipid research 20071001 |
| Neuronal apoptosis mediated by inhibition of intracellular cholesterol transport: microarray and proteomics analyses in cultured murine cortical neurons. | Journal of cellular physiology 20070401 |
| Prevention of prion propagation by dehydrocholesterol reductase inhibitors in cultured cells and a therapeutic trial in mice. | Biological & pharmaceutical bulletin 20070401 |
| Resistance to alkyl-lysophospholipid-induced apoptosis due to downregulated sphingomyelin synthase 1 expression with consequent sphingomyelin- and cholesterol-deficiency in lipid rafts. | The Biochemical journal 20070115 |
| Seladin-1 expression in rat adrenal gland: effect of adrenocorticotropic hormone treatment. | The Journal of endocrinology 20070101 |
| The luminal domain participates in the endosomal trafficking of the cation-independent mannose 6-phosphate receptor. | Experimental cell research 20061210 |
| Constitutive and vitamin C-induced, NO-catalyzed release of heparan sulfate from recycling glypican-1 in late endosomes. | Glycobiology 20061201 |
| Investigating cytoskeletal alterations as a potential marker of retinal and lens drug-related toxicity. | Assay and drug development technologies 20061201 |
| Cellular mechanism of U18666A-mediated apoptosis in cultured murine cortical neurons: bridging Niemann-Pick disease type C and Alzheimer's disease. | Cellular signalling 20061101 |
| U18666A-mediated apoptosis in cultured murine cortical neurons: role of caspases, calpains and kinases. | Cellular signalling 20061001 |
| Defective nitric oxide-dependent, deaminative cleavage of glypican-1 heparan sulfate in Niemann-Pick C1 fibroblasts. | Glycobiology 20060801 |
| Tricyclic antidepressants, quinacrine and a novel, synthetic chimera thereof clear prions by destabilizing detergent-resistant membrane compartments. | Journal of neurochemistry 20060801 |
| Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons. | Journal of neurochemistry 20060801 |
| Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism. | Cellular microbiology 20060301 |
| Pharmacological sequestration of intracellular cholesterol in late endosomes disrupts ruffled border formation in osteoclasts. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060301 |
| Automated microscopy screening for compounds that partially revert cholesterol accumulation in Niemann-Pick C cells. | Journal of lipid research 20060201 |
| Identification of N-arachidonylglycine, U18666A, and 4-androstene-3,17-dione as novel insulin Secretagogues. | Biochemical and biophysical research communications 20050805 |
| DHCR24 gene expression is upregulated in melanoma metastases and associated to resistance to oxidative stress-induced apoptosis. | International journal of cancer 20050610 |
| Comparison of effects of U18666A and enantiomeric U18666A on sterol synthesis and induction of apoptosis. | Lipids 20050601 |
| The lipid composition of autophagic vacuoles regulates expression of multilamellar bodies. | Journal of cell science 20050501 |
| The regulation of beta-secretase by cholesterol and statins in Alzheimer's disease. | Journal of the neurological sciences 20050315 |
| Formation of multivesicular endosomes in Dictyostelium. | Journal of cell science 20041201 |
| Early-phase redistribution of the cation-independent mannose 6-phosphate receptor by U18666A treatment in HeLa cells. | Cell and tissue research 20040901 |
| Abnormal benzodiazepine and zinc modulation of GABAA receptors in an acquired absence epilepsy model. | Brain research 20040709 |
| Human ATP-binding cassette transporter-2 (ABCA2) positively regulates low-density lipoprotein receptor expression and negatively regulates cholesterol esterification in Chinese hamster ovary cells. | Biochimica et biophysica acta 20040705 |
| Direct perturbation of lens membrane structure may contribute to cataracts caused by U18666A, an oxidosqualene cyclase inhibitor. | Journal of lipid research 20040701 |
| Accumulation of glycosphingolipids in Niemann-Pick C disease disrupts endosomal transport. | The Journal of biological chemistry 20040618 |
| Up-regulation of low-density lipoprotein receptor in human hepatocytes is induced by sequestration of free cholesterol in the endosomal/lysosomal compartment. | Biochemical pharmacology 20040615 |
| The ABCA1 transporter modulates late endocytic trafficking: insights from the correction of the genetic defect in Tangier disease. | The Journal of biological chemistry 20040409 |
| Chronic exposure to U18666A induces apoptosis in cultured murine cortical neurons. | Biochemical and biophysical research communications 20040305 |
| Intracellular accumulation of amyloidogenic fragments of amyloid-beta precursor protein in neurons with Niemann-Pick type C defects is associated with endosomal abnormalities. | The American journal of pathology 20040301 |
| Suppression of macrophage eicosanoid synthesis by atherogenic lipoproteins is profoundly affected by cholesterol-fatty acyl esterification and the Niemann-Pick C pathway of lipid trafficking. | The Journal of biological chemistry 20040227 |
| Analysis of post-lysosomal compartments. | Biochemical and biophysical research communications 20040206 |
| The steroidal analog GW707 activates the SREBP pathway through disruption of intracellular cholesterol trafficking. | Journal of lipid research 20040201 |
| Proteolytic cascade in the amyloidogenesis of Alzheimer's disease. | Biochemical Society transactions 20040201 |
| Distribution and trafficking of MPR300 is normal in cells with cholesterol accumulated in late endocytic compartments: evidence for early endosome-to-TGN trafficking of MPR300. | Journal of lipid research 20031001 |
| Accumulation of tyrosinase in the endolysosomal compartment is induced by U18666A. | Pigment cell research 20030401 |
| Trafficking of cholesterol from cell bodies to distal axons in Niemann Pick C1-deficient neurons. | The Journal of biological chemistry 20030207 |
| ABCA1-mediated cholesterol efflux is defective in free cholesterol-loaded macrophages. Mechanism involves enhanced ABCA1 degradation in a process requiring full NPC1 activity. | The Journal of biological chemistry 20021108 |
| Cholesterol modulates the membrane binding and intracellular distribution of annexin 6. | The Journal of biological chemistry 20020830 |
| Selective uptake from LDL is stimulated by unsaturated fatty acids and modulated by cholesterol content in the plasma membrane: role of plasma membrane composition in regulating non-SR-BI-mediated selective lipid transfer. | Biochemistry 20020625 |
| Late endosome motility depends on lipids via the small GTPase Rab7. | The EMBO journal 20020315 |
| Dynamics of lysosomal cholesterol in Niemann-Pick type C and normal human fibroblasts. | Journal of lipid research 20020201 |
| Selective effect of cholesterylphosphoserine on intracellular cholesterol transport. | Lipids 20020101 |
| Golgi localization and phosphorylation of oxysterol binding protein in Niemann-Pick C and U18666A-treated cells. | Journal of lipid research 20010701 |
| Depletion of rafts in late endocytic membranes is controlled by NPC1-dependent recycling of cholesterol to the plasma membrane. | Journal of cell science 20010501 |
| Accumulation and aggregation of amyloid beta-protein in late endosomes of Niemann-pick type C cells. | The Journal of biological chemistry 20010209 |
| A novel sequence element is involved in the transcriptional regulation of expression of the ERG1 (squalene epoxidase) gene in Saccharomyces cerevisiae. | European journal of biochemistry 20010201 |