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Avosentan

CAS No.:
290815-26-8
Catalog Number:
AG002X8U
Molecular Formula:
C23H21N5O5S
Molecular Weight:
479.5083
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$240
- +
10mg
98%
1 week
United States
$307
- +
50mg
98%
1 week
United States
$1223
- +
Product Description
Catalog Number:
AG002X8U
Chemical Name:
Avosentan
CAS Number:
290815-26-8
Molecular Formula:
C23H21N5O5S
Molecular Weight:
479.5083
MDL Number:
MFCD23843806
IUPAC Name:
N-[6-methoxy-5-(2-methoxyphenoxy)-2-pyridin-4-ylpyrimidin-4-yl]-5-methylpyridine-2-sulfonamide
InChI:
InChI=1S/C23H21N5O5S/c1-15-8-9-19(25-14-15)34(29,30)28-22-20(33-18-7-5-4-6-17(18)31-2)23(32-3)27-21(26-22)16-10-12-24-13-11-16/h4-14H,1-3H3,(H,26,27,28)
InChI Key:
YBWLTKFZAOSWSM-UHFFFAOYSA-N
SMILES:
COc1nc(nc(c1Oc1ccccc1OC)NS(=O)(=O)c1ccc(cn1)C)c1ccncc1
UNII:
L94KSX715K
Properties
Complexity:
732  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
479.126g/mol
Formal Charge:
0
Heavy Atom Count:
34  
Hydrogen Bond Acceptor Count:
10  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
479.511g/mol
Monoisotopic Mass:
479.126g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
134A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.1  
Literature
Title Journal
2012 update on diabetic kidney disease: the expanding spectrum, novel pathogenic insights and recent clinical trials. Minerva medica 20120801
Antidiuretic effects of the endothelin receptor antagonist avosentan. Frontiers in physiology 20120101
Effect of avosentan (SPP-301) in porcine ciliary arteries. Current eye research 20110201
Effect of SPP 301, an endothelin antagonist, on intraocular pressure in glaucomatous monkey eyes. Current eye research 20110101
Diabetic nephropathy - Epidemiology in Asia and the current state of treatment. Indian journal of nephrology 20110101
Endothelin receptor blockade in patients with diabetic nephropathy. Contributions to nephrology 20110101
TRC120038, a Novel Dual AT(1)/ET(A) Receptor Blocker for Control of Hypertension, Diabetic Nephropathy, and Cardiomyopathy in ob-ZSF1 Rats. International journal of hypertension 20110101
Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse. Diabetes 20101201
Potential new therapeutic agents for diabetic kidney disease. American journal of kidney diseases : the official journal of the National Kidney Foundation 20100501
Avosentan for overt diabetic nephropathy. Journal of the American Society of Nephrology : JASN 20100301
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia 20100101
Channels and transporters. Mini-symposium of the Division of Medicinal Chemistry (DMC) of the Swiss Chemical Society (SCS) at the Department of Chemistry, University of Basel, May 27, 2010. Chimia 20100101
Unlike each drug alone, lisinopril if combined with avosentan promotes regression of renal lesions in experimental diabetes. American journal of physiology. Renal physiology 20091101
Absolute bioavailability and pharmacokinetics of avosentan in man. International journal of clinical pharmacology and therapeutics 20090901
Dose-dependent acute and sustained renal effects of the endothelin receptor antagonist avosentan in healthy subjects. Clinical pharmacology and therapeutics 20090601
Avosentan reduces albumin excretion in diabetics with macroalbuminuria. Journal of the American Society of Nephrology : JASN 20090301
Influence of food intake on the pharmacokinetics of avosentan in man. International journal of clinical pharmacology and therapeutics 20080901
Influence of avosentan (SPP3OI) on the pharmacokinetics of a second generation oral contraceptive containing ethinylestradiol and levonorgestrel in healthy female volunteers. International journal of clinical pharmacology and therapeutics 20061201
Pharmacokinetic interaction between ketoconazole and SPP301 in healthy volunteers. International journal of clinical pharmacology and therapeutics 20060701
Profile of past and current clinical trials involving endothelin receptor antagonists: the novel '-sentan' class of drug. Experimental biology and medicine (Maywood, N.J.) 20060601
Properties