Sulfamic acid, 6,7,8,9,10,11-hexahydro-6-oxobenzo[b]cyclohepta[d]pyran-3-yl ester
| Title | Journal |
|---|---|
| Synthesis, structure-activity relationship of iodinated-4-aryloxymethyl-coumarins as potential anti-cancer and anti-mycobacterial agents. | European journal of medicinal chemistry 20140303 |
| Naturally occurring steroids in Xenopus oocyte during meiotic maturation. Unexpected presence and role of steroid sulfates. | Molecular and cellular endocrinology 20121015 |
| Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions. | Biochemical pharmacology 20121015 |
| In vitro evaluation of the interaction potential of irosustat with drug-metabolizing enzymes. | Drug metabolism and disposition: the biological fate of chemicals 20120701 |
| Proton-in-flight mechanism for the spontaneous hydrolysis of N-methyl O-phenyl sulfamate: implications for the design of steroid sulfatase inhibitors. | The Journal of organic chemistry 20120504 |
| 17β-Arylsulfonamides of 17β-aminoestra-1,3,5(10)-trien-3-ol as highly potent inhibitors of steroid sulfatase. | Bioorganic & medicinal chemistry 20120215 |
| Structure-activity relationship for the first-in-class clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495). | ChemMedChem 20111104 |
| Inhibition of steroid sulfatase with 4-substituted estrone and estradiol derivatives. | Bioorganic & medicinal chemistry 20111015 |
| In vitro metabolism of irosustat, a novel steroid sulfatase inhibitor: interspecies comparison, metabolite identification, and metabolic enzyme identification. | Drug metabolism and disposition: the biological fate of chemicals 20110701 |
| Irosustat: a first-generation steroid sulfatase inhibitor in breast cancer. | Expert review of anticancer therapy 20110201 |
| Highly potent first examples of dual aromatase-steroid sulfatase inhibitors based on a biphenyl template. | Journal of medicinal chemistry 20100311 |
| The use of steroid sulfatase inhibitors as a novel therapeutic strategy against hormone-dependent endometrial cancer. | Endocrinology 20080801 |
| Chiral aromatase and dual aromatase-steroid sulfatase inhibitors from the letrozole template: synthesis, absolute configuration, and in vitro activity. | Journal of medicinal chemistry 20080724 |
| Inactivation of recombinant human steroid sulfatase by KW-2581. | The Journal of steroid biochemistry and molecular biology 20080101 |
| Inhibition of steroid sulphatase activity via the percutaneous route: a new option for breast cancer therapy. | Anticancer research 20080101 |
| A novel steroidal selective steroid sulfatase inhibitor KW-2581 inhibits sulfated-estrogen dependent growth of breast cancer cells in vitro and in animal models. | Breast cancer research and treatment 20071201 |
| Inhibition of steroid sulfatase activity and cell proliferation in ZR-75-1 and BT-474 human breast cancer cells by KW-2581 in vitro and in vivo. | Breast cancer research and treatment 20070801 |
| Thiosemicarbazones of formyl benzoic acids as novel potent inhibitors of estrone sulfatase. | Journal of medicinal chemistry 20070726 |
| Dual aromatase-steroid sulfatase inhibitors. | Journal of medicinal chemistry 20070726 |
| Steroid sulfatase: a new target for the endocrine therapy of breast cancer. | The oncologist 20070401 |
| Measurement of estrone sulfate in postmenopausal women: comparison of direct RIA and GC-MS/MS methods for monitoring response to endocrine therapy in women with breast cancer. | Anticancer research 20070101 |
| Hormonal therapy: still much to learn. | Clinical breast cancer 20060601 |
| Phase I study of STX 64 (667 Coumate) in breast cancer patients: the first study of a steroid sulfatase inhibitor. | Clinical cancer research : an official journal of the American Association for Cancer Research 20060301 |
| Steroid sulfatase: molecular biology, regulation, and inhibition. | Endocrine reviews 20050401 |
| Crystal structure of human carbonic anhydrase II at 1.95 A resolution in complex with 667-coumate, a novel anti-cancer agent. | The Biochemical journal 20050201 |
| Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats. | British journal of cancer 20041004 |
| The role of steroid sulphatase in regulating the oestrogenicity of oestrogen sulphamates. | Biochemical and biophysical research communications 20040910 |
| Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acid. | Bioorganic & medicinal chemistry letters 20040209 |
| Steroid sulphatase inhibitors for breast cancer therapy. | The Journal of steroid biochemistry and molecular biology 20030901 |
| First dual aromatase-steroid sulfatase inhibitors. | Journal of medicinal chemistry 20030717 |
| Docking studies of sulphamate inhibitors of estrone sulphatase in human carbonic anhydrase II. | Bioorganic & medicinal chemistry letters 20030310 |
| In vitro and in vivo models for the evaluation of new inhibitors of human steroid sulfatase, devoid of residual estrogenic activity. | The Journal of steroid biochemistry and molecular biology 20030201 |
| Development of a sensitive high-performance liquid chromatography method for the detection of 667 COUMATE in vivo. | The Journal of steroid biochemistry and molecular biology 20030201 |
| Inhibition of MCF-7 breast cancer cell proliferation and in vivo steroid sulphatase activity by 2-methoxyoestradiol-bis-sulphamate. | The Journal of steroid biochemistry and molecular biology 20030201 |
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). | The Journal of steroid biochemistry and molecular biology 20021101 |
| Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES). | Bioorganic & medicinal chemistry letters 20020520 |
| Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanism. | Bioorganic & medicinal chemistry letters 20011203 |
| Non-steroidal and steroidal sulfamates: new drugs for cancer therapy. | Molecular and cellular endocrinology 20010122 |