Home Aminos Propanoic acid, 2-methyl-, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1)

Propanoic acid, 2-methyl-, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1)

CAS No.:
286930-03-8
Catalog Number:
AG002W3S
Molecular Formula:
C30H41NO7
Molecular Weight:
527.6490
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
95%
In Stock USA
United States
$107
- +
10mg
95%
In Stock USA
United States
$151
- +
25mg
95%
In Stock USA
United States
$248
- +
50mg
95%
In Stock USA
United States
$453
- +
100mg
95%
In Stock USA
United States
$619
- +
500mg
95%
In Stock USA
United States
$1286
- +
Product Description
Catalog Number:
AG002W3S
Chemical Name:
Propanoic acid, 2-methyl-, 2-[(1R)-3-[bis(1-methylethyl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl ester, (2E)-2-butenedioate (1:1)
CAS Number:
286930-03-8
Molecular Formula:
C30H41NO7
Molecular Weight:
527.6490
MDL Number:
MFCD12756004
IUPAC Name:
(E)-but-2-enedioic acid;[2-[(1R)-3-[di(propan-2-yl)amino]-1-phenylpropyl]-4-(hydroxymethyl)phenyl] 2-methylpropanoate
InChI:
InChI=1S/C26H37NO3.C4H4O4/c1-18(2)26(29)30-25-13-12-21(17-28)16-24(25)23(22-10-8-7-9-11-22)14-15-27(19(3)4)20(5)6;5-3(6)1-2-4(7)8/h7-13,16,18-20,23,28H,14-15,17H2,1-6H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t23-;/m1./s1
InChI Key:
MWHXMIASLKXGBU-RNCYCKTQSA-N
SMILES:
OC(=O)/C=C/C(=O)O.OCc1ccc(c(c1)[C@@H](c1ccccc1)CCN(C(C)C)C(C)C)OC(=O)C(C)C
UNII:
EOS72165S7
Properties
Complexity:
610  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
1  
Exact Mass:
527.288g/mol
Formal Charge:
0
Heavy Atom Count:
38  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
527.658g/mol
Monoisotopic Mass:
527.288g/mol
Rotatable Bond Count:
13  
Topological Polar Surface Area:
124A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Safety and efficacy of flexible-dose fesoterodine in British subjects with overactive bladder: insights into factors associated with dose escalation. International urogynecology journal 20121101
Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females. Expert opinion on drug metabolism & toxicology 20121101
Efficacy and tolerability of fesoterodine versus tolterodine in older and younger subjects with overactive bladder: a post hoc, pooled analysis from two placebo-controlled trials. Neurourology and urodynamics 20121101
Fesoterodine in randomised clinical trials: an updated systematic clinical review of efficacy and safety. International urogynecology journal 20121001
Multiple-dose pharmacokinetics of fesoterodine sustained-release in healthy Korean volunteers. International journal of clinical pharmacology and therapeutics 20121001
Sustained improvement in patient-reported outcomes during long-term fesoterodine treatment for overactive bladder symptoms: pooled analysis of two open-label extension studies. BJU international 20120801
Dose-escalating study of the pharmacokinetics and tolerability of fesoterodine in children with overactive bladder. Journal of pediatric urology 20120801
Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review. Annals of internal medicine 20120619
Add-on fesoterodine for residual storage symptoms suggestive of overactive bladder in men receiving α-blocker treatment for lower urinary tract symptoms. BJU international 20120601
Pharmacologic treatment for urgency-predominant urinary incontinence in women diagnosed using a simplified algorithm: a randomized trial. American journal of obstetrics and gynecology 20120501
Evaluation of cognitive function in healthy older subjects treated with fesoterodine. Postgraduate medicine 20120501
Long-term safety, tolerability and efficacy of fesoterodine in subjects with overactive bladder symptoms stratified by age: pooled analysis of two open-label extension studies. Drugs & aging 20120201
The psychometric validation of a 1-week recall period for the OAB-q. International urogynecology journal 20111201
Effects of voluntary dose escalation in a placebo-controlled, flexible-dose trial of fesoterodine in subjects with overactive bladder. Neurourology and urodynamics 20111101
Review of fesoterodine. Expert opinion on drug safety 20110901
Comparison of pharmacokinetic variability of fesoterodine vs. tolterodine extended release in cytochrome P450 2D6 extensive and poor metabolizers. British journal of clinical pharmacology 20110801
A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder. British journal of clinical pharmacology 20110801
Effects of fesoterodine on the pharmacokinetics and pharmacodynamics of warfarin in healthy volunteers. British journal of clinical pharmacology 20110801
Effects of the moderate CYP3A4 inhibitor, fluconazole, on the pharmacokinetics of fesoterodine in healthy subjects. British journal of clinical pharmacology 20110801
Fesoterodine stress degradation behavior by liquid chromatography coupled to ultraviolet detection and electrospray ionization mass spectrometry. Talanta 20110530
Superior efficacy of fesoterodine over tolterodine extended release with rapid onset: a prospective, head-to-head, placebo-controlled trial. BJU international 20110501
Long-term safety, tolerability, and efficacy of fesoterodine treatment in men and women with overactive bladder symptoms. Current medical research and opinion 20110501
Effect of fesoterodine 4 mg on bladder diary and patient-reported outcomes during the first week of treatment in subjects with overactive bladder. Current medical research and opinion 20110501
Effects of hepatic dysfunction on the single-dose pharmacokinetics of fesoterodine. Journal of clinical pharmacology 20110301
Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay. Journal of the American Geriatrics Society 20110301
Patient-optimized doses of fesoterodine improve bladder symptoms in an open-label, flexible-dose study. BJU international 20110201
Early onset of fesoterodine efficacy in subjects with overactive bladder. BJU international 20110201
Overactive bladder drugs and constipation: a meta-analysis of randomized, placebo-controlled trials. Digestive diseases and sciences 20110101
Efficacy and tolerability of fesoterodine in older and younger subjects with overactive bladder. Urology 20101201
Fesoterodine in patients with overactive bladder syndrome: can the severity of baseline urgency urinary incontinence predict dosing requirement? BJU international 20100901
The cost-effectiveness of solifenacin vs fesoterodine, oxybutynin immediate-release, propiverine, tolterodine extended-release and tolterodine immediate-release in the treatment of patients with overactive bladder in the UK National Health Service. BJU international 20100801
Spinal effects of the fesoterodine metabolite 5-hydroxymethyl tolterodine and/or doxazosin in rats with or without partial urethral obstruction. The Journal of urology 20100801
Urodynamic evaluation of fesoterodine metabolite, doxazosin and their combination in a rat model of partial urethral obstruction. BJU international 20100701
Response to fesoterodine in patients with an overactive bladder and urgency urinary incontinence is independent of the urodynamic finding of detrusor overactivity. BJU international 20100501
Efficacy and tolerability of fesoterodine in men with overactive bladder: a pooled analysis of 2 phase III studies. Urology 20100501
Thorough QT study of the effect of fesoterodine on cardiac repolarization. International journal of clinical pharmacology and therapeutics 20100501
Efficacy of fesoterodine over 24 hours in subjects with overactive bladder. Current medical research and opinion 20100401
Long-term safety, tolerability and efficacy of fesoterodine treatment in subjects with overactive bladder symptoms. International journal of clinical practice 20100401
Durability of treatments for overactive bladder. International journal of clinical practice 20100401
The pharmacokinetic profile of fesoterodine 8 mg with daytime or nighttime dosing. European journal of clinical pharmacology 20100201
New Drugs2010, PART 1. Nursing 20100201
Fesoterodine fumarate. Drugs of today (Barcelona, Spain : 1998) 20100201
Randomized, double-blind, placebo-controlled trial of flexible-dose fesoterodine in subjects with overactive bladder. Urology 20100101
Comparison of fesoterodine and tolterodine extended release for the treatment of overactive bladder: a head-to-head placebo-controlled trial. BJU international 20100101
Modeling dose-response relationships of the effects of fesoterodine in patients with overactive bladder. BMC urology 20100101
Determination of fesoterodine in pharmaceutical formulations by using liquid chromatography-tandem mass spectrometry. European journal of mass spectrometry (Chichester, England) 20100101
Fesoterodine for the treatment of overactive bladder. The Annals of pharmacotherapy 20091201
Tolterodine extended-release for overactive bladder. Expert opinion on pharmacotherapy 20090901
Influence of age, gender, and race on pharmacokinetics, pharmacodynamics, and safety of fesoterodine. International journal of clinical pharmacology and therapeutics 20090901
Fesoterodine for the treatment of overactive bladder. The Nurse practitioner 20090801
Efficacy and tolerability of fesoterodine in women with overactive bladder. International urogynecology journal and pelvic floor dysfunction 20090701
Evaluation of drug-drug interactions with fesoterodine. European journal of clinical pharmacology 20090601
Influence of food on the pharmacokinetic profile of fesoterodine. International journal of clinical pharmacology and therapeutics 20090601
New drug information: Toviaz. JAAPA : official journal of the American Academy of Physician Assistants 20090601
Fesoterodine (toviaz) for overactive bladder. The Medical letter on drugs and therapeutics 20090504
Assessment of the effects of renal impairment on the pharmacokinetic profile of fesoterodine. Journal of clinical pharmacology 20090401
Effects of flexible-dose fesoterodine on overactive bladder symptoms and treatment satisfaction: an open-label study. International journal of clinical practice 20090401
The pharmacokinetic profile of fesoterodine: similarities and differences to tolterodine. Swiss medical weekly 20090307
Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa. The Journal of pharmacology and experimental therapeutics 20090301
Fesoterodine: a new agent for treating overactive bladder. The American journal of managed care 20090301
New drugs: milnacipran hydrochloride, fesoterodine fumarate, and silodosin. Journal of the American Pharmacists Association : JAPhA 20090101
Fesoterodine. Drugs 20090101
The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Current medicinal chemistry 20090101
Toviaz approved for overactive bladder. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20081201
Comparison of fesoterodine and tolterodine in patients with overactive bladder. BJU international 20081101
Pharmacokinetic profile of fesoterodine. International journal of clinical pharmacology and therapeutics 20081101
Impact of fesoterodine on quality of life: pooled data from two randomized trials. BJU international 20080701
Fesoterodine: a novel muscarinic receptor antagonist for the treatment of overactive bladder syndrome. Expert opinion on pharmacotherapy 20080701
Fesoterodine dose response in subjects with overactive bladder syndrome. Urology 20080501
Pharmacological characterization of a novel investigational antimuscarinic drug, fesoterodine, in vitro and in vivo. BJU international 20080401
Clinical efficacy, safety, and tolerability of once-daily fesoterodine in subjects with overactive bladder. European urology 20071001
Properties