2-((4-(2-(3-Cyclohexyl-1-(4-cyclohexylbutyl)ureido)ethyl)phenyl)thio)-2-methylpropanoic acid
| Title | Journal |
|---|---|
| The urinary metabolites of DINCH(®) have an impact on the activities of the human nuclear receptors ERα, ERβ, AR, PPARα and PPARγ. | Toxicology letters 20180501 |
| Agonistic and antagonistic effects of phthalates and their urinary metabolites on the steroid hormone receptors ERα, ERβ, and AR. | Toxicology letters 20170805 |
| Hepatic Aryl Hydrocarbon Receptor Attenuates Fibroblast Growth Factor 21 Expression. | The Journal of biological chemistry 20160715 |
| Model steatogenic compounds (amiodarone, valproic acid, and tetracycline) alter lipid metabolism by different mechanisms in mouse liver slices. | PloS one 20140101 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| In vitro toxicological characterization of perfluorinated carboxylic acids with different carbon chain lengths. | Toxicology letters 20130412 |
| Long-term stability of primary rat hepatocytes in micropatterned cocultures. | Journal of biochemical and molecular toxicology 20130301 |
| Adenosine A2A receptor modulates vascular response in soluble epoxide hydrolase-null mice through CYP-epoxygenases and PPARγ. | American journal of physiology. Regulatory, integrative and comparative physiology 20130101 |
| Induction of the fatty acid 2-hydroxylase (FA2H) gene by Δ(9)-tetrahydrocannabinol in human breast cancer cells. | The Journal of toxicological sciences 20130101 |
| Rodent thyroid, liver, and fetal testis toxicity of the monoester metabolite of bis-(2-ethylhexyl) tetrabromophthalate (tbph), a novel brominated flame retardant present in indoor dust. | Environmental health perspectives 20121201 |
| Roles of α-linolenic acid on IGF-I secretion and GH/IGF system gene expression in porcine primary hepatocytes. | Molecular biology reports 20121201 |
| Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors. | Bioorganic & medicinal chemistry letters 20121001 |
| Integrated virtual screening for the identification of novel and selective peroxisome proliferator-activated receptor (PPAR) scaffolds. | Journal of medicinal chemistry 20120614 |
| Transcription of genes involved in fat metabolism in chicken embryos exposed to the peroxisome proliferator-activated receptor alpha (PPARα) agonist GW7647 or to perfluorooctane sulfonate (PFOS) or perfluorooctanoic acid (PFOA). | Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20120601 |
| A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ. | PloS one 20120101 |
| Selective and cell-active inhibitors of the USP1/ UAF1 deubiquitinase complex reverse cisplatin resistance in non-small cell lung cancer cells. | Chemistry & biology 20111123 |
| Effect of synthetic ligands of PPAR α, β/δ, γ, RAR, RXR and LXR on the fatty acid composition of phospholipids in mice. | Lipids 20111101 |
| Discovery of gemfibrozil analogues that activate PPARα and enhance the expression of gene CPT1A involved in fatty acids catabolism. | European journal of medicinal chemistry 20111001 |
| Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. | Journal of natural products 20110826 |
| Benzothiazole-based N-(phenylsulfonyl)amides as a novel family of PPARα antagonists. | Bioorganic & medicinal chemistry letters 20110815 |
| Peroxisome proliferator-activated receptor-α activation promotes macrophage reverse cholesterol transport through a liver X receptor-dependent pathway. | Arteriosclerosis, thrombosis, and vascular biology 20110601 |
| Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. | Journal of lipid research 20110501 |
| Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes. | Biochemical and biophysical research communications 20110422 |
| Identification of diaryl ether-based ligands for estrogen-related receptor α as potential antidiabetic agents. | Journal of medicinal chemistry 20110210 |
| Molecular mechanisms underlying the inhibition of IFN-γ-induced, STAT1-mediated gene transcription in human macrophages by simvastatin and agonists of PPARs and LXRs. | Journal of cellular biochemistry 20110201 |
| PPAR activation has dichotomous control on the expression levels of cytosolic and secretory phospholipase A2 in astrocytes; inhibition in naïve, untreated cells and enhancement in LPS-stimulated cells. | Journal of neurochemistry 20101001 |
| Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787. | Molecular pharmacology 20100901 |
| Peroxisome proliferator-activated receptors gamma and alpha agonists stimulate cardiac glucose uptake via activation of AMP-activated protein kinase. | The Journal of nutritional biochemistry 20100701 |
| Rational design of a pirinixic acid derivative that acts as subtype-selective PPARgamma modulator. | Bioorganic & medicinal chemistry letters 20100415 |
| Ligand-enhanced expression and in-cell assay of human peroxisome proliferator-activated receptor alpha ligand binding domain. | Protein expression and purification 20100401 |
| Impact of environmental chemicals on key transcription regulators and correlation to toxicity end points within EPA's ToxCast program. | Chemical research in toxicology 20100315 |
| Peroxisome proliferator-activated receptor-alpha control of lipid and glucose metabolism in human white adipocytes. | Endocrinology 20100101 |
| Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation. | Proceedings of the National Academy of Sciences of the United States of America 20091208 |
| Synthesis and biological evaluation of 2-heteroarylthioalkanoic acid analogues of clofibric acid as peroxisome proliferator-activated receptor alpha agonists. | Journal of medicinal chemistry 20091022 |
| Synergistic acceleration of thyroid hormone degradation by phenobarbital and the PPAR alpha agonist WY14643 in rat hepatocytes. | Toxicology and applied pharmacology 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| Peroxisome proliferator-activated receptor (PPAR)-gamma positively controls and PPARalpha negatively controls cyclooxygenase-2 expression in rat brain astrocytes through a convergence on PPARbeta/delta via mutual control of PPAR expression levels. | Molecular pharmacology 20090801 |
| Central administration of palmitoylethanolamide reduces hyperalgesia in mice via inhibition of NF-kappaB nuclear signalling in dorsal root ganglia. | European journal of pharmacology 20090624 |
| Differentiated CaCo-2 cells as an in-vitro model to evaluate de-novo apolipoprotein A-I production in the small intestine. | European journal of gastroenterology & hepatology 20090601 |
| Type 2 deiodinase expression is induced by peroxisomal proliferator-activated receptor-gamma agonists in skeletal myocytes. | Endocrinology 20090401 |
| Rapid non-genomic regulation of Ca2+ signals and insulin secretion by PPAR alpha ligands in mouse pancreatic islets of Langerhans. | The Journal of endocrinology 20090201 |
| Thioredoxin-1 and its natural inhibitor, vitamin D3 up-regulated protein 1, are differentially regulated by PPARalpha in human macrophages. | Journal of molecular biology 20081219 |
| PPARalpha ligands inhibit radiation-induced microglial inflammatory responses by negatively regulating NF-kappaB and AP-1 pathways. | Free radical biology & medicine 20081215 |
| Antiobesity designed multiple ligands: Synthesis of pyrazole fatty acid amides and evaluation as hypophagic agents. | Bioorganic & medicinal chemistry 20081201 |
| 15-deoxy-delta 12,14-prostaglandin J(2) inhibits the synthesis of the acute phase protein SIP24 in cartilage: Involvement of COX-2 in resolution of inflammation. | Journal of cellular physiology 20081101 |
| Sulindac derivatives that activate the peroxisome proliferator-activated receptor gamma but lack cyclooxygenase inhibition. | Journal of medicinal chemistry 20080828 |
| Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. | Journal of agricultural and food chemistry 20080514 |
| PPARalpha and PPARbeta are differentially affected by ethanol and the ethanol metabolite acetaldehyde in the MCF-7 breast cancer cell line. | Toxicological sciences : an official journal of the Society of Toxicology 20080301 |
| SAR-oriented discovery of peroxisome proliferator-activated receptor pan agonist with a 4-adamantylphenyl group as a hydrophobic tail. | Bioorganic & medicinal chemistry letters 20080201 |
| Peroxisome proliferator-activated receptor alpha agonists enhance cardiomyogenesis of mouse ES cells by utilization of a reactive oxygen species-dependent mechanism. | Stem cells (Dayton, Ohio) 20080101 |
| PPARalpha agonists inhibit nitric oxide production by enhancing iNOS degradation in LPS-treated macrophages. | British journal of pharmacology 20071201 |
| Peroxisome proliferator-activated receptor-alpha is required for the neurotrophic effect of oleic acid in neurons. | Journal of neurochemistry 20071101 |
| Macrophage expression of peroxisome proliferator-activated receptor-alpha reduces atherosclerosis in low-density lipoprotein receptor-deficient mice. | Circulation 20070918 |
| Synergistic antinociception by the cannabinoid receptor agonist anandamide and the PPAR-alpha receptor agonist GW7647. | European journal of pharmacology 20070702 |
| Identification of apolipoprotein A-I as a 'STOP' signal for myopia. | Molecular & cellular proteomics : MCP 20061101 |
| A facile one-pot preparation of alkyl aminoaryl sulfides for the synthesis of GW7647 as an agonist of peroxisome proliferator-activated receptor alpha. | The Journal of organic chemistry 20060721 |
| Mono(2-ethylhexyl)phthalate and mono-n-butyl phthalate activation of peroxisome proliferator activated-receptors alpha and gamma in breast. | Toxicology letters 20060601 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Differential responses of PPARalpha, PPARdelta, and PPARgamma reporter cell lines to selective PPAR synthetic ligands. | Analytical biochemistry 20050901 |
| Activation of peroxisome proliferator-activated receptor alpha by substituted urea-derived soluble epoxide hydrolase inhibitors. | The Journal of pharmacology and experimental therapeutics 20050701 |
| Oleoylethanolamide, an endogenous PPAR-alpha agonist, lowers body weight and hyperlipidemia in obese rats. | Neuropharmacology 20050601 |
| Diverging regulation of pyruvate dehydrogenase kinase isoform gene expression in cultured human muscle cells. | The FEBS journal 20050601 |
| Peroxisome proliferator activated receptor delta (PPARdelta) agonist but not PPARalpha corrects carnitine palmitoyl transferase 2 deficiency in human muscle cells. | The Journal of clinical endocrinology and metabolism 20050301 |
| Evaluation of the therapeutic potential of PPARalpha agonists for X-linked adrenoleukodystrophy. | Molecular genetics and metabolism 20031201 |
| Activation of peroxisome proliferator-activated receptor-alpha protects the heart from ischemia/reperfusion injury. | Circulation 20031111 |
| Peroxisome proliferator-activated receptor alpha negatively regulates T-bet transcription through suppression of p38 mitogen-activated protein kinase activation. | Journal of immunology (Baltimore, Md. : 1950) 20030701 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. | Diabetes 20020401 |
| Identification of a subtype selective human PPARalpha agonist through parallel-array synthesis. | Bioorganic & medicinal chemistry letters 20010507 |
| A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat. | Diabetes 19990701 |