1H-Pyrrole-2,5-dione, 3-[(3-chloro-4-hydroxyphenyl)amino]-4-(2-nitrophenyl)-
| Title | Journal |
|---|---|
| PI3K/Akt/GSK3β induced CREB activation ameliorates arsenic mediated alterations in NMDA receptors and associated signaling in rat hippocampus: Neuroprotective role of curcumin. | Neurotoxicology 20180701 |
| Inhibitory Effects of Bisphenol-A on Neural Stem Cells Proliferation and Differentiation in the Rat Brain Are Dependent on Wnt/β-Catenin Pathway. | Molecular neurobiology 20151201 |
| Activation of β-catenin by inhibitors of glycogen synthase kinase-3 ameliorates cisplatin-induced cytotoxicity and pro-inflammatory cytokine expression in HEI-OC1 cells. | Toxicology 20140605 |
| Phosphorylation of amyloid precursor protein at threonine 668 is essential for its copper-responsive trafficking in SH-SY5Y neuroblastoma cells. | The Journal of biological chemistry 20140418 |
| Sirt1 inhibits the transcription factor CREB to regulate pituitary growth hormone synthesis. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20130401 |
| Roles of glycogen synthase kinase 3 in Alzheimer's disease. | Current Alzheimer research 20120901 |
| Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822 |
| Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120523 |
| A pharmacologically-based array to identify targets of cyclosporine A-induced toxicity in cultured renal proximal tubule cells. | Toxicology and applied pharmacology 20120115 |
| Canonical WNT signaling enhances stem cell expression in the developing heart without a corresponding inhibition of cardiogenic differentiation. | Stem cells and development 20111101 |
| GSK3-mediated instability of tubulin polymers is responsible for the failure of immature CD4+CD8+ thymocytes to polarize their MTOC in response to TCR stimulation. | International immunology 20111101 |
| Development of a cellular tau enzyme-linked immunosorbent assay method for screening GSK-3β inhibitors. | Assay and drug development technologies 20111001 |
| GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line. | Journal of neuro-oncology 20110801 |
| GSK-3β: a signaling pathway node modulating neural stem cell and endothelial cell interactions. | Angiogenesis 20110501 |
| Deletion of glycogen synthase kinase-3β in cartilage results in up-regulation of glycogen synthase kinase-3α protein expression. | Endocrinology 20110501 |
| Eutypoids B-E produced by a Penicillium sp. strain from the North Sea. | Journal of natural products 20110128 |
| P27(Kip1), regulated by glycogen synthase kinase-3β, results in HMBA-induced differentiation of human gastric cancer cells. | BMC cancer 20110101 |
| Lithium promotes neural precursor cell proliferation: evidence for the involvement of the non-canonical GSK-3β-NF-AT signaling. | Cell & bioscience 20110101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Regulation of GSK-3beta by calpain in the 3-nitropropionic acid model. | Hippocampus 20100801 |
| Role of glycogen synthase kinase 3 (GSK-3) in innate immune response of human immature dendritic cells to Aspergillus fumigatus. | Medical mycology 20100601 |
| Neurites regrowth of cortical neurons by GSK3beta inhibition independently of Nogo receptor 1. | Journal of neurochemistry 20100601 |
| GSK3 beta regulates myelin-dependent axon outgrowth inhibition through CRMP4. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100421 |
| A new class of molecular targeted radioprotectors: GSK-3beta inhibitors. | International journal of radiation oncology, biology, physics 20100201 |
| Dependence of EGF-induced increases in corneal epithelial proliferation and migration on GSK-3 inactivation. | Investigative ophthalmology & visual science 20091001 |
| Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. | Nature chemical biology 20091001 |
| A molecular study of pathways involved in the inhibition of cell proliferation in neuroblastoma B65 cells by the GSK-3 inhibitors lithium and SB-415286. | Journal of cellular and molecular medicine 20090901 |
| Chronic lithium treatment up-regulates cell surface Na(V)1.7 sodium channels via inhibition of glycogen synthase kinase-3 in adrenal chromaffin cells: enhancement of Na(+) influx, Ca(2+) influx and catecholamine secretion after lithium withdrawal. | Neuropharmacology 20090901 |
| Fragment and knowledge-based design of selective GSK-3beta inhibitors using virtual screening models. | European journal of medicinal chemistry 20090601 |
| Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium. | Cellular signalling 20090401 |
| Glucocorticoids and lithium reciprocally regulate the proliferation of adult dentate gyrus-derived neural precursor cells through GSK-3beta and beta-catenin/TCF pathway. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201 |
| Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells. | Biochemical pharmacology 20090101 |
| Mechanical strain inhibits adipogenesis in mesenchymal stem cells by stimulating a durable beta-catenin signal. | Endocrinology 20081201 |
| Enhanced glycogenesis is involved in cellular senescence via GSK3/GS modulation. | Aging cell 20081201 |
| Glycogen synthase kinase 3 inhibition slows mitochondrial adenine nucleotide transport and regulates voltage-dependent anion channel phosphorylation. | Circulation research 20081024 |
| Inactivation of glycogen synthase kinase 3 promotes axonal growth and recovery in the CNS. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080903 |
| GSK-3 beta inhibition and prevention of mitochondrial apoptosis inducing factor release are not involved in the antioxidant properties of SB-415286. | European journal of pharmacology 20080707 |
| Pharmacophore modeling, quantitative structure-activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3beta inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin. | Journal of medicinal chemistry 20080410 |
| Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20080101 |
| The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
| Glycogen synthase kinase 3 activity during development of bone marrow-derived dendritic cells (DCs) essential for the DC function to induce T helper 2 polarization. | Immunology 20071001 |
| Lithium desensitizes brain mitochondria to calcium, antagonizes permeability transition, and diminishes cytochrome C release. | The Journal of biological chemistry 20070622 |
| LTP inhibits LTD in the hippocampus via regulation of GSK3beta. | Neuron 20070301 |
| Inhibiting glycogen synthase kinase 3beta in sepsis. | Novartis Foundation symposium 20070101 |
| HaCaT keratinocyte migration is dependent on epidermal growth factor receptor signaling and glycogen synthase kinase-3alpha. | Experimental cell research 20060910 |
| A cellular assay for measuring the inhibition of glycogen synthase kinase-3 via the accumulation of beta-catenin in Chinese hamster ovary clone K1 cells. | Assay and drug development technologies 20060801 |
| Glycogen synthase kinase-3 acts upstream of ADP-ribosylation factor 6 and Rac1 to regulate epithelial cell migration. | Experimental cell research 20060515 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Mechanical and chemical regulation of endothelial cell polarity. | Circulation research 20060414 |
| Reduction of experimental colitis in the rat by inhibitors of glycogen synthase kinase-3beta. | British journal of pharmacology 20060301 |
| Expression of cyclooxygenase-2 is regulated by glycogen synthase kinase-3beta in gastric cancer cells. | The Journal of biological chemistry 20060224 |
| Pharmacologic modulation of glycogen synthase kinase-3beta promotes p53-dependent apoptosis through a direct Bax-mediated mitochondrial pathway in colorectal cancer cells. | Cancer research 20051001 |
| GSK-3beta inhibitors attenuate the organ injury/dysfunction caused by endotoxemia in the rat. | Critical care medicine 20050901 |
| GSK-3beta reactivation with LY294002 sensitizes hepatoma cells to chemotherapy-induced apoptosis. | International journal of oncology 20050701 |
| Inhibition of GSK3beta is a common event in neuroprotection by different survival factors. | Brain research. Molecular brain research 20050613 |
| Glycogen synthase kinase 3 activity mediates neuronal pentraxin 1 expression and cell death induced by potassium deprivation in cerebellar granule cells. | Molecular pharmacology 20050401 |
| Constitutive activation of GSK3 down-regulates glycogen synthase abundance and glycogen deposition in rat skeletal muscle cells. | The Journal of biological chemistry 20050311 |
| Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. | Cancer research 20050301 |
| Implication of cyclin-dependent kinase 5 in the neuroprotective properties of lithium. | Neuroscience 20050101 |
| Examining the correlations between GSK-3 inhibitory properties and anti-convulsant efficacy of valproate and valproate-related compounds. | Bioorganic & medicinal chemistry letters 20041115 |
| GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression. | Experimental cell research 20041101 |
| Inhibition of glycogen synthase kinase-3 represses androgen receptor activity and prostate cancer cell growth. | Oncogene 20041014 |
| Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat hearts. | Circulation research 20040416 |
| Glycogen synthase kinase-3 regulates cytoskeleton and translocation of Rac1 in long cellular extensions of human keratinocytes. | Experimental cell research 20040201 |
| Glycogen synthase kinase-3 regulates formation of long lamellipodia in human keratinocytes. | Journal of cell science 20030915 |
| Use of lithium and SB-415286 to explore the role of glycogen synthase kinase-3 in the regulation of glucose transport and glycogen synthase. | European journal of biochemistry 20030901 |
| Glycogen synthase kinase-3 inhibitors protect central neurons against excitotoxicity. | Neuroreport 20030806 |
| PI3-kinase-induced hyperreactivity in DOCA-salt hypertension is independent of GSK-3 activity. | Hypertension (Dallas, Tex. : 1979) 20030401 |
| Evidence that the dephosphorylation of Ser(535) in the epsilon-subunit of eukaryotic initiation factor (eIF) 2B is insufficient for the activation of eIF2B by insulin. | The Biochemical journal 20021015 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| GSK-3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and beta-catenin stabilisation without elevation of glycogen synthase activity. | FEBS letters 20011102 |
| Inhibition of GSK-3 selectively reduces glucose-6-phosphatase and phosphatase and phosphoenolypyruvate carboxykinase gene expression. | Diabetes 20010501 |
| Selective small-molecule inhibitors of glycogen synthase kinase-3 activity protect primary neurones from death. | Journal of neurochemistry 20010401 |
| 3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3). | Bioorganic & medicinal chemistry letters 20010312 |
| Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription. | Chemistry & biology 20001001 |
| Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes. | Diabetes 20000201 |
| Increased glycogen synthase kinase-3 activity in diabetes- and obesity-prone C57BL/6J mice. | Diabetes 19990801 |
| Tau protein kinase I is essential for amyloid beta-protein-induced neurotoxicity. | Proceedings of the National Academy of Sciences of the United States of America 19930815 |