Home Aminos Phosphonic acid, P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-

Phosphonic acid, P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-

CAS No.:
261365-11-1
Catalog Number:
AG002RTK
Molecular Formula:
C11H15N2O4PS
Molecular Weight:
302.2866
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$390
- +
10mg
99%
1 week
United States
$557
- +
50mg
99%
1 week
United States
$1390
- +
100mg
99%
1 week
United States
$2390
- +
Product Description
Catalog Number:
AG002RTK
Chemical Name:
Phosphonic acid, P-[5-[2-amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]-
CAS Number:
261365-11-1
Molecular Formula:
C11H15N2O4PS
Molecular Weight:
302.2866
MDL Number:
MFCD14584901
IUPAC Name:
[5-[2-amino-5-(2-methylpropyl)-1,3-thiazol-4-yl]furan-2-yl]phosphonic acid
InChI:
InChI=1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16)
InChI Key:
XJMYIJPPDSZOPN-UHFFFAOYSA-N
SMILES:
CC(Cc1sc(nc1c1ccc(o1)P(=O)(O)O)N)C
Properties
Complexity:
365  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
302.049g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
302.285g/mol
Monoisotopic Mass:
302.049g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
138A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.4  
Literature
Title Journal
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase. Journal of medicinal chemistry 20110113
Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells. Endocrinology 20101001
Fructose-1,6-bisphosphatase Inhibitors. 2. Design, synthesis, and structure-activity relationship of a series of phosphonic acid containing benzimidazoles that function as 5'-adenosinemonophosphate (AMP) mimics. Journal of medicinal chemistry 20100114
A library of novel allosteric inhibitors against fructose 1,6-bisphosphatase. Bioorganic & medicinal chemistry 20090601
Discovery of phosphonic diamide prodrugs and their use for the oral delivery of a series of fructose 1,6-bisphosphatase inhibitors. Journal of medicinal chemistry 20080724
Properties