Home Aminos sodium 1-[(E)-{[5-(4-nitrophenyl)furan-2-yl]methylidene}amino]-4-oxo-4,5-dihydro-1H-imidazol-2-olate hydrate

sodium 1-[(E)-{[5-(4-nitrophenyl)furan-2-yl]methylidene}amino]-4-oxo-4,5-dihydro-1H-imidazol-2-olate hydrate

CAS No.:
24868-20-0
Catalog Number:
AG002POP
Molecular Formula:
C28H34N8Na2O17
Molecular Weight:
800.5925
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%
In Stock USA
United States
$32
- +
5g
98%
In Stock USA
United States
$94
- +
25g
98%
In Stock USA
United States
$282
- +
100g
98%
In Stock USA
United States
$850
- +
Product Description
Catalog Number:
AG002POP
Chemical Name:
sodium 1-[(E)-{[5-(4-nitrophenyl)furan-2-yl]methylidene}amino]-4-oxo-4,5-dihydro-1H-imidazol-2-olate hydrate
CAS Number:
24868-20-0
Molecular Formula:
C28H34N8Na2O17
Molecular Weight:
800.5925
MDL Number:
MFCD00079130
IUPAC Name:
disodium;3-[(E)-[5-(4-nitrophenyl)furan-2-yl]methylideneamino]-2-oxo-4H-imidazol-5-olate;heptahydrate
InChI:
InChI=1S/2C14H10N4O5.2Na.7H2O/c2*19-13-8-17(14(20)16-13)15-7-11-5-6-12(23-11)9-1-3-10(4-2-9)18(21)22;;;;;;;;;/h2*1-7H,8H2,(H,16,19,20);;;7*1H2/q;;2*+1;;;;;;;/p-2/b2*15-7+;;;;;;;;;
InChI Key:
LTWQNYPDAUSXBC-CDJGKPBYSA-L
SMILES:
O=C1CN(C(=O)N1)N=Cc1ccc(o1)c1ccc(cc1)[N+](=O)[O-].O=C1CN(C(=O)N1)N=Cc1ccc(o1)c1ccc(cc1)[N+](=O)[O-].O.O.O.O.O.O.O.[Na].[Na]
UNII:
287M0347EV
Properties
Complexity:
536  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
11  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
2  
Exact Mass:
798.168g/mol
Formal Charge:
0
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
19  
Hydrogen Bond Donor Count:
7  
Isotope Atom Count:
0
Molecular Weight:
798.583g/mol
Monoisotopic Mass:
798.168g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
261A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Tributyltin-induced endoplasmic reticulum stress and its Ca(2+)-mediated mechanism. Toxicology and applied pharmacology 20131001
Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix. Journal of ethnopharmacology 20130109
The calcium signaling pathway regulates leydig cell steroidogenesis through a transcriptional cascade involving the nuclear receptor NR4A1 and the steroidogenic acute regulatory protein. Endocrinology 20130101
Mixing and using dantrolene for simulated malignant hyperthermia crisis. Acta anaesthesiologica Scandinavica 20121101
Implication of the ryanodine receptor in TRPV4-induced calcium response in pulmonary arterial smooth muscle cells from normoxic and chronically hypoxic rats. American journal of physiology. Lung cellular and molecular physiology 20121101
Small-molecular inhibitors of Ca²⁺-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene. Bioorganic & medicinal chemistry 20121101
Intra-arterial dantrolene for refractory cerebral vasospasm after aneurysmal subarachnoid hemorrhage. Neurocritical care 20121001
Dantrolene is neuroprotective in vitro, but does not affect survival in SOD1(G⁹³A) mice. Neuroscience 20120918
Ecstacy-induced delayed rhabdomyolysis and neuroleptic malignant syndrome in a patient with a novel variant in the ryanodine receptor type 1 gene. Anaesthesia 20120901
Ca²⁺-dependent regulation of Ca²⁺ currents in rat primary afferent neurons: role of CaMKII and the effect of injury. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120822
Calcium channel blockers are inadequate for malignant hyperthermia crisis. Journal of anesthesia 20120801
Early-phase occurrence of K+ and Cl- efflux in addition to Ca 2+ mobilization is a prerequisite to apoptosis in HeLa cells. Apoptosis : an international journal on programmed cell death 20120801
Dantrolene blockade of ryanodine receptor impairs ethanol-induced behavioral stimulation, ethanol intake and loss of righting reflex. Behavioural brain research 20120801
[Case of suspected malignant hyperthermia following local infiltration anesthesia]. Masui. The Japanese journal of anesthesiology 20120801
Ryanodine receptors contribute to bile acid-induced pathological calcium signaling and pancreatitis in mice. American journal of physiology. Gastrointestinal and liver physiology 20120615
Malignant hyperthermia: a crisis response plan. OR manager 20120601
Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice. Neuroscience letters 20120516
Involvement of ryanodine receptors in tetanic sciatic stimulation-induced long-term potentiation of spinal dorsal horn and persistent pain in rats. Journal of neuroscience research 20120501
Current state of malignant hyperthermia in China mainland: a less optimistic reality. Paediatric anaesthesia 20120501
Dantrolene sodium for the treatment of aldesleukin-induced rigors in a melanoma patient. The Annals of pharmacotherapy 20120501
Serotonin syndrome vs neuroleptic malignant syndrome: a contrast of causes, diagnoses, and management. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20120501
Cerebrospinal fluid can be used as a surrogate to assess brain exposures of breast cancer resistance protein and P-glycoprotein substrates. Drug metabolism and disposition: the biological fate of chemicals 20120401
[Pharmacological treatment of spasticity in multiple sclerosis]. Revue neurologique 20120401
Dantrolene for severe rhabdomyolysis in Staphylococcus aureus toxic shock syndrome. European journal of anaesthesiology 20120301
The severity of sevoflurane-induced malignant hyperthermia. Acta anaesthesiologica Scandinavica 20120301
Dantrolene rescues arrhythmogenic RYR2 defect in a patient-specific stem cell model of catecholaminergic polymorphic ventricular tachycardia. EMBO molecular medicine 20120301
Atypical clinically diagnosed stiff-person syndrome response to dantrolene--a refractory case. Muscle & nerve 20120301
Dantrolene prevents arrhythmogenic Ca2+ release in heart failure. American journal of physiology. Heart and circulatory physiology 20120215
HOCl causes necrotic cell death in human monocyte derived macrophages through calcium dependent calpain activation. Biochimica et biophysica acta 20120201
Special article: Creation of a guide for the transfer of care of the malignant hyperthermia patient from ambulatory surgery centers to receiving hospital facilities. Anesthesia and analgesia 20120101
Radiosynthesis of [13N]dantrolene, a positron emission tomography probe for breast cancer resistant protein, using no-carrier-added [13N]ammonia. Bioorganic & medicinal chemistry 20120101
[Malignant neuroleptic syndrome and Clostridium difficile: causal association or mere coincidence?]. Medicina intensiva 20120101
[Comatose patient with neuroleptic malignant syndrome brought by ambulance]. Masui. The Japanese journal of anesthesiology 20120101
[Dantrolene sodium may not be effective in the treatment of status epileptics]. Rinsho shinkeigaku = Clinical neurology 20120101
The ameliorating effect of dantrolene on the morphology of urinary bladder in spinal cord injured rats. Pathology, research and practice 20111215
Drug-induced eosinophilic pleural effusion. European respiratory review : an official journal of the European Respiratory Society 20111201
Calpain-mediated dystrophin disruption may be a potential structural culprit behind chronic doxorubicin-induced cardiomyopathy. European journal of pharmacology 20111130
Variation in expression of calcium-handling proteins is associated with inter-individual differences in mechanical performance of rat (Rattus norvegicus) skeletal muscle. The Journal of experimental biology 20111101
Dantrolene preparation. Anaesthesia and intensive care 20111101
[A case of status epilepticus with a possible therapeutic effect by dantrolene sodium]. Rinsho shinkeigaku = Clinical neurology 20111001
Malignant hyperthermia in the oral and maxillofacial surgery patient: an update. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20110901
Safety of low-dose oral dantrolene sodium on hepatic function. Archives of physical medicine and rehabilitation 20110901
Pattern of summation with fatigue and inhibition of calcium release in rat muscle. Muscle & nerve 20110901
Mutation-linked defective interdomain interactions within ryanodine receptor cause aberrant Ca²⁺release leading to catecholaminergic polymorphic ventricular tachycardia. Circulation 20110809
[Influence of tenotomy on posttetanic responses of the rat fast and slow muscle]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20110801
Hypomyelination with atrophy of the basal ganglia and cerebellum in an infant with Down syndrome. Clinical dysmorphology 20110701
Idebenone inhibition of glutamate release from rat cerebral cortex nerve endings by suppression of voltage-dependent calcium influx and protein kinase A. Naunyn-Schmiedeberg's archives of pharmacology 20110701
Chronic high cytosolic calcium decreases AICAR-induced AMPK activity via calcium/calmodulin activated protein kinase II signaling cascade. Cell calcium 20110701
Clinical utility gene card for: malignant hyperthermia. European journal of human genetics : EJHG 20110601
Pharmacokinetics and metabolism of dantrolene in horses. Journal of veterinary pharmacology and therapeutics 20110601
Is a formal statistical analysis always necessary? Anesthesia and analgesia 20110601
Malignant hyperthermia and charcoal absorbent: too hot to handle. Anesthesia and analgesia 20110601
Iatrogenic eosinophilic pleural effusion. European respiratory review : an official journal of the European Respiratory Society 20110601
[Case of fulminant-malignant hyperthermia occurring on sixth sevoflurane anesthesia]. Masui. The Japanese journal of anesthesiology 20110601
Complications associated with the administration of dantrolene 1987 to 2006: a report from the North American Malignant Hyperthermia Registry of the Malignant Hyperthermia Association of the United States. Anesthesia and analgesia 20110501
Effects of a single dose of dantrolene in patients with cerebral vasospasm after subarachnoid hemorrhage: a prospective pilot study. Stroke 20110501
Put out the fire (with apologies to Queen). Anesthesia and analgesia 20110501
Ethanol enhances carbachol-induced protease activation and accelerates Ca2+ waves in isolated rat pancreatic acini. The Journal of biological chemistry 20110422
Localization of the dantrolene-binding sequence near the FK506-binding protein-binding site in the three-dimensional structure of the ryanodine receptor. The Journal of biological chemistry 20110408
Pharmacobehavioural evidence for nitric oxide and noradrenaline interactions with ryanodine receptors during memory formation in the young chick. Behavioral neuroscience 20110401
Comparison of the therapeutic effectiveness of a dantrolene sodium solution and a novel nanocrystalline suspension of dantrolene sodium in malignant hyperthermia normal and susceptible pigs. European journal of anaesthesiology 20110401
Pharmacotherapy of spasticity in children with cerebral palsy. Journal of the Formosan Medical Association = Taiwan yi zhi 20110401
[Effect of dantrolene on energy metabolism in rats with myocardial ischemia-reperfusion]. Zhonghua yi xue za zhi 20110111
Malignant hyperthermia-part I. Plastic surgical nursing : official journal of the American Society of Plastic and Reconstructive Surgical Nurses 20110101
Speeding dantrolene preparation for treating malignant hyperthermia. Anaesthesia and intensive care 20110101
HTDP-2, a new synthetic compound, inhibits glutamate release through reduction of voltage-dependent Ca²⁺ influx in rat cerebral cortex nerve terminals. Pharmacology 20110101
Dopamine D(1) receptors participate in cocaine-induced place preference via regulation of ryanodine receptor expression. Journal of pharmacological sciences 20110101
Malignant hyperthermia during a laparoscopic operation. Journal of minimally invasive gynecology 20110101
Dantrolene is neuroprotective in Huntington's disease transgenic mouse model. Molecular neurodegeneration 20110101
Serotonin syndrome following Methylene Blue infusion: a rare complication of antidepressant therapy. Journal of neurology, neurosurgery, and psychiatry 20101201
Regulation of ryanodine receptors by dopamine D1 receptors during methamphetamine-induced place conditioning. Journal of neurochemistry 20101201
The cytoprotective effects of dantrolene: a ryanodine receptor antagonist. Anesthesia and analgesia 20101201
Effects of dantrolene on apoptosis and immunohistochemical expression of NeuN in the spinal cord after traumatic injury in rats. International journal of experimental pathology 20101201
Pharmacologic treatment of spasticity in children. Seminars in pediatric neurology 20101201
Impaired hippocampal Ca2+ homeostasis and concomitant K+ channel dysfunction in a mouse model of Rett syndrome during anoxia. Neuroscience 20101124
Dantrolene, a therapeutic agent for malignant hyperthermia, inhibits catecholaminergic polymorphic ventricular tachycardia in a RyR2(R2474S/+) knock-in mouse model. Circulation journal : official journal of the Japanese Circulation Society 20101101
Effect of feed restriction on plasma dantrolene concentrations in horses. Equine veterinary journal. Supplement 20101101
Effects of dantrolene on ischemia-reperfusion injury in animal models: a review of outcomes in heart, brain, liver, and kidney. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20101001
Caffeine and theophylline block insulin-stimulated glucose uptake and PKB phosphorylation in rat skeletal muscles. Acta physiologica (Oxford, England) 20100901
Dissociation of calmodulin from cardiac ryanodine receptor causes aberrant Ca(2+) release in heart failure. Cardiovascular research 20100901
Radiosynthesis of [2-(11)C-carbonyl]dantrolene using [(11)C]phosgene for PET. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 20100901
Malignant hyperthermia in the absence of triggering agents. Anesthesia and analgesia 20100901
Dantrolene in the treatment of MDMA-related hyperpyrexia: a systematic review. CJEM 20100901
Dantrolene for the treatment of MDMA toxicity. CJEM 20100901
'Fatal 2,4-dinitrophenol poisoning... coming to a hospital near you'. Emergency medicine journal : EMJ 20100801
Oral dantrolene and severe respiratory failure in a patient with chronic spinal cord injury. Anaesthesia 20100801
Assessment of the effect of the use of laser light or dantrolene on facial muscle under occlusal wear: a Raman spectroscopic study in a rodent model. Photomedicine and laser surgery 20100801
Screening of OATP1B1/3 and OCT1 inhibitors in cryopreserved hepatocytes in suspension. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100711
A report of fulminant malignant hyperthermia in a patient with a novel mutation of the CACNA1S gene. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20100701
Dantrolene mitigates caerulein-induced pancreatitis in vivo in mice. American journal of physiology. Gastrointestinal and liver physiology 20100701
Dantrolene inhibits the calcium plateau and prevents the development of spontaneous recurrent epileptiform discharges following in vitro status epilepticus. The European journal of neuroscience 20100701
[Intensive care treatment for neuroleptic malignant syndrome]. Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS 20100701
Role of presenilins in neuronal calcium homeostasis. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100623
Hydrostatic pressure-induced release of stored calcium in cultured rat optic nerve head astrocytes. Investigative ophthalmology & visual science 20100601
Gonadotropin-induced ovarian cancer cell migration and proliferation require extracellular signal-regulated kinase 1/2 activation regulated by calcium and protein kinase C{delta}. Endocrine-related cancer 20100601
Kinetic analysis of the cooperation of P-glycoprotein (P-gp/Abcb1) and breast cancer resistance protein (Bcrp/Abcg2) in limiting the brain and testis penetration of erlotinib, flavopiridol, and mitoxantrone. The Journal of pharmacology and experimental therapeutics 20100601
Recognizing and treating malignant hyperthermia. Simulation in healthcare : journal of the Society for Simulation in Healthcare 20100601
Levamisole and ryanodine receptors. I: A contraction study in Ascaris suum. Molecular and biochemical parasitology 20100501
[Treatment of childhood dystonia]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20100501
Low-dose dantrolene is effective in treating hyperthermia and hypercapnia, and seems not to affect recovery of the allograft after liver transplantation: case report. Transplantation proceedings 20100401
Clinical presentation, treatment, and complications of malignant hyperthermia in North America from 1987 to 2006. Anesthesia and analgesia 20100201
Characterization of spontaneous inhibitory postsynaptic currents in cultured rat retinal amacrine cells. Neuroscience 20100120
[Effect of neurogenic inactivity on posttetanic responses of rat fast muscle]. Zhurnal evoliutsionnoi biokhimii i fiziologii 20100101
Spasticity: revisiting the role and the individual value of several pharmacological treatments. NeuroRehabilitation 20100101
A retrospective study of 34 catatonic patients: analysis of clinical care and treatment. General hospital psychiatry 20100101
Functional role of neuroendocrine-specific protein-like 1 in membrane translocation of GLUT4. Diabetes 20091201
Hyperthermia in the pediatric intensive care unit--is it malignant hyperthermia? Paediatric anaesthesia 20091101
Malignant hyperthermia: a pharmacogenetic disorder. Orthopedics 20091101
Development and validation of a stability-indicating RP-HPLC method for the determination of paracetamol with dantrolene or/and cetirizine and pseudoephedrine in two pharmaceutical dosage forms. Talanta 20091015
Dantrolene can reduce secondary damage after spinal cord injury. European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20091001
GIF-0173 protects against cerebral infarction through DP1 receptor activation. Experimental neurology 20091001
Abused inhalants enhance GABA-mediated synaptic inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090901
Parkin deficiency disrupts calcium homeostasis by modulating phospholipase C signalling. The FEBS journal 20090901
Depletion of calcium stores in injured sensory neurons: anatomic and functional correlates. Anesthesiology 20090801
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 2. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090722
Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20090601
Excitatory and inhibitory synaptic transmission is differentially influenced by two ortho-substituted polychlorinated biphenyls in the hippocampal slice preparation. Toxicology and applied pharmacology 20090601
Effects of small molecule modulators on ATP binding to skeletal ryanodine receptor. The protein journal 20090601
Dantrolene, a therapeutic agent for malignant hyperthermia, markedly improves the function of failing cardiomyocytes by stabilizing interdomain interactions within the ryanodine receptor. Journal of the American College of Cardiology 20090526
Diastolic release of calcium from the sarcoplasmic reticulum: a potential target for treating triggered arrhythmias and heart failure. Journal of the American College of Cardiology 20090526
Fenvalerate-induced Ca2+ transients via both intracellular and extracellular way in mouse GC-2spd (ts) cells. Toxicology 20090517
Inhibition of stored Ca2+ release disrupts convergence-related cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos. Development, growth & differentiation 20090501
Severe acneiform eruption exacerbated by dantrolene sodium. Clinical and experimental dermatology 20090301
[A 17-year-old woman with acute abdomen]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20090115
Dantrolene: mechanisms of neuroprotection and possible clinical applications in the neurointensive care unit. Neurocritical care 20090101
Dantrolene mediates vasorelaxation in cerebral vasoconstriction: a case series. Neurocritical care 20090101
Uniaxial cyclic stretch increases glucose uptake into C2C12 myotubes through a signaling pathway independent of insulin-like growth factor I. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090101
Inhibition of cerebral vasoconstriction by dantrolene and nimodipine. Neurocritical care 20090101
[Management of spasticity in children with cerebral palsy]. Acta orthopaedica et traumatologica turcica 20090101
Dantrolene exerts protective activity in double and triple combination with nimodipine, ruthenium red and basilene blue in bilirubin-induced neurotoxicity in cell culture of rats. The International journal of neuroscience 20090101
Stretch reduces central core lesions and calcium build-up in tenotomized soleus. Muscle & nerve 20081201
Dantrolene: new indication. Cerebral palsy in children: uncertain clinical benefit. Prescrire international 20081201
Deranged calcium signaling and neurodegeneration in spinocerebellar ataxia type 3. The Journal of neuroscience : the official journal of the Society for Neuroscience 20081126
Dantrolene inhibits human erythrocyte glutathione reductase. Biological & pharmaceutical bulletin 20081101
Increased intracellular Ca2+ and SR Ca2+ load contribute to arrhythmias after acidosis in rat heart. Role of Ca2+/calmodulin-dependent protein kinase II. American journal of physiology. Heart and circulatory physiology 20081001
Can dantrolene protect spinal cord against ischemia/reperfusion injury? An experimental study. The Thoracic and cardiovascular surgeon 20081001
Rhabdomyolysis after liver transplantation: a case report. Transplantation proceedings 20081001
Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction. Critical care medicine 20080901
A case of malignant hyperthermia in a child encountered during a humanitarian assistance mission to the Philippines. Military medicine 20080801
Reduced threshold for luminal Ca2+ activation of RyR1 underlies a causal mechanism of porcine malignant hyperthermia. The Journal of biological chemistry 20080725
A requirement for calcium in the caspase-independent killing of Burkitt lymphoma cell lines by Rituximab. British journal of haematology 20080701
Successful management of malignant hyperthermia during orthognathic surgery: a case report. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20080701
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 4: in patients with classic heat stroke does adding treatment with dantrolene improve outcome? Emergency medicine journal : EMJ 20080701
Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. Bet 5: is dantrolene the best way to treat hyperthermia in patients with cocaine abuse? Emergency medicine journal : EMJ 20080701
Quantitative investigation of the role of breast cancer resistance protein (Bcrp/Abcg2) in limiting brain and testis penetration of xenobiotic compounds. Drug metabolism and disposition: the biological fate of chemicals 20080601
Be prepared: malignant hyperthermia. OR manager 20080601
Store-operated Ca2+ influx causes Ca2+ release from the intracellular Ca2+ channels that is required for T cell activation. The Journal of biological chemistry 20080502
Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene. Molecular pharmacology 20080401
Halothane modulation of skeletal muscle ryanodine receptors: dependence on Ca2+, Mg2+, and ATP. American journal of physiology. Cell physiology 20080401
Molecular characterization of Helicobacter pylori VacA induction of IL-8 in U937 cells reveals a prominent role for p38MAPK in activating transcription factor-2, cAMP response element binding protein, and NF-kappaB activation. Journal of immunology (Baltimore, Md. : 1950) 20080401
Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle. Basic & clinical pharmacology & toxicology 20080301
Dantrolene antagonizes the glycineB site of the NMDA receptor. Neuroscience letters 20080220
The effects of dantrolene on hypoxic-ischemic injury in the neonatal rat brain. Anesthesia and analgesia 20080101
Ischemia/reperfusion induce renal tubule apoptosis by inositol 1,4,5-trisphosphate receptor and L-type Ca2+ channel opening. American journal of nephrology 20080101
Electroconvulsive therapy in drug resistant neuroleptic malignant syndrome. The Journal of the Association of Physicians of India 20080101
[Pathogenetic therapy of spasticity]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20080101
[Malignant hyperthermia: pharmacogenetically caused acute massive rhabdomyolysis]. Anesteziologiia i reanimatologiia 20080101
Malignant hyperthermia developing during esophageal resection in an 82-year-old man. Journal of anesthesia 20080101
[A comparative analysis of contractile responses induced by acetylcholine and choline in twich and tonic frog skeletal muscle fibres]. Biofizika 20080101
Malignant hyperthermia in a liver transplant patient: a case report. Transplantation proceedings 20071201
A novel compound heterozygous dysferlin mutation in Miyoshi myopathy siblings responding to dantrolene. European journal of neurology 20071101
Transitional cell carcinoma in the paediatric population: be aware of unusual aetiologies. Journal of paediatrics and child health 20071101
[Recurrent fever related to dantrolene sodium in a girl with sequelae of acute encephalopathy]. No to hattatsu = Brain and development 20071101
[Drug-induced malignant hyperthermia]. Nihon rinsho. Japanese journal of clinical medicine 20071028
[Drug-induced neuroleptic malignant syndrome]. Nihon rinsho. Japanese journal of clinical medicine 20071028
Identification of functional type 1 ryanodine receptors in human dendritic cells. Biochemical and biophysical research communications 20071019
Src and Pyk2 mediate angiotensin II effects in cultured rat astrocytes. Regulatory peptides 20071004
Intramuscular injection of sevoflurane detects malignant hyperthermia predisposition in susceptible pigs. Anesthesiology 20071001
Electroreduction of the muscle relaxant drug dantrolene sodium at the mercury electrode and its determination in bulk form and pharmaceutical formulation. Chemical & pharmaceutical bulletin 20071001
Malignant hyperthermia: hot stuff! Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20071001
Hemichannels in cardiomyocytes open transiently during ischemia and contribute to reperfusion injury following brief ischemia. American journal of physiology. Heart and circulatory physiology 20070901
Role of InsP3 and ryanodine receptors in the activation of capacitative Ca2+ entry by store depletion or hypoxia in canine pulmonary arterial smooth muscle cells. British journal of pharmacology 20070901
Pharmacological blockade of sarcoplasmic reticulum induces a negative lusitropic effect. General physiology and biophysics 20070901
[Drug-induced neuroleptic malignant syndrome]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine 20070810
Delayed onset of malignant hyperthermia without creatine kinase elevation in a geriatric, ryanodine receptor type 1 gene compound heterozygous patient. Anesthesiology 20070801
Ryanodine receptor Ca2+-release channels are an output pathway for the circadian clock in the rat suprachiasmatic nuclei. The European journal of neuroscience 20070801
Role of dantrolene in the management of the acute toxic effects of Ecstasy (MDMA). British journal of anaesthesia 20070701
Antidotes to anesthetic catastrophe: lipid emulsion and dantrolene. Anesthesia and analgesia 20070701
[Case of malignant hyperthermia in which treatment was carried out smoothly]. Masui. The Japanese journal of anesthesiology 20070701
Ryanodine receptor antagonism protects the ischemic liver and modulates TNF-alpha and IL-10. The Journal of surgical research 20070601
Neuroleptic malignant syndrome. The American journal of psychiatry 20070601
Catatonia and neuroleptic malignant syndrome: two sides of a coin? Acta neurologica Belgica 20070601
Muscle contraction accelerates IL-6 mRNA expression in the rat masseter muscle. Archives of oral biology 20070501
Arsenic trioxide (As2O3) induced calcium signals and cytotoxicity in two human cell lines: SY-5Y neuroblastoma and 293 embryonic kidney (HEK). Toxicology and applied pharmacology 20070501
Analysis of the clinical variables associated with recrudescence after malignant hyperthermia reactions. Anesthesiology 20070501
Electrophysiological studies of malaria parasite-infected erythrocytes: current status. International journal for parasitology 20070401
Differential contribution of extracellular and intracellular calcium sources to basal transmission and long-term potentiation in the sympathetic ganglion of the rat. Developmental neurobiology 20070401
The Icarus effect: the influence of diluent warming on dantrolene sodium mixing time. AANA journal 20070401
Postoperative neuroleptic malignant syndrome that occurred repeatedly in a patient with cerebral palsy. Paediatric anaesthesia 20070301
Dantrolene, like fatigue, has a length-dependent effect on submaximal force-length relationships of rat gastrocnemius muscle. Acta physiologica (Oxford, England) 20070301
Role of dantrolene in treatment of heat stroke associated with Ecstasy ingestion. British journal of anaesthesia 20070101
Cerebral salt-wasting syndrome in a patient with neuroleptic malignant syndrome. Archives of neurology 20070101
Managing an effective treatment for neuroleptic malignant syndrome. Critical care (London, England) 20070101
Fulminant-type malignant hyperthermia in Japan: cumulative analysis of 383 cases. Journal of anesthesia 20070101
Conclusions regarding the efficacy of treatments for neuroleptic malignant syndrome should be tempered given poor quality data, regardless of the analysis conducted. Critical care (London, England) 20070101
Cooling and hemodynamic management in heatstroke: practical recommendations. Critical care (London, England) 20070101
Video of dantrolene effectiveness on neuroleptic malignant syndrome associated muscular rigidity and tremor. Critical care (London, England) 20070101
Uniaxial cyclic stretch-stimulated glucose transport is mediated by a ca-dependent mechanism in cultured skeletal muscle cells. Pathobiology : journal of immunopathology, molecular and cellular biology 20070101
The pharmacological management of spasticity. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20061201
Ryanodine receptors in liver. The Journal of biological chemistry 20061110
Specific inhibition of the plasmodial surface anion channel by dantrolene. Eukaryotic cell 20061101
Can dantrolene contribute to methotrexate toxicity? The Annals of pharmacotherapy 20060901
Use of cognitive aids in a simulated anesthetic crisis. Anesthesia and analgesia 20060901
Calcium and reactive oxygen species mediated Zn2+ -induced apoptosis in PC12 cells. Journal of pharmacological sciences 20060901
Regulation of kindling epileptogenesis by hippocampal galanin type 1 and type 2 receptors: The effects of subtype-selective agonists and the role of G-protein-mediated signaling. The Journal of pharmacology and experimental therapeutics 20060801
Dantrolene, a calcium-induced calcium release inhibitor, prevents the acquisition of amygdaloid kindling in rats, a model of experimental epilepsy. The Tohoku journal of experimental medicine 20060801
First phase of glucose-stimulated insulin secretion from MIN 6 cells does not always require extracellular calcium influx. Journal of pharmacological sciences 20060801
Dantrolene reconstitution: can warmed diluent make a difference? Journal of clinical anesthesia 20060801
Pharmaco-behavioural evidence indicating a complex role for ryanodine receptor calcium release channels in memory processing for a passive avoidance task. Neurobiology of learning and memory 20060701
Depletion of intracellular Ca2+ store itself may be a major factor in thapsigargin-induced ER stress and apoptosis in PC12 cells. Neurochemistry international 20060601
Malignant hyperthermia: successful management in a private surgery centre. The Journal of otolaryngology 20060601
Transient recovery of synaptic transmission is related to rapid energy depletion during hypoxia. Neuroscience letters 20060529
Importance of ryanodine receptors in effects of cyclic GMP is reduced in thyroxine-induced cardiac hypertrophy. European journal of pharmacology 20060510
Extracellular ATP stimulates exocytosis via localized Ca(2+) release from acidic stores in rat pancreatic beta cells. Traffic (Copenhagen, Denmark) 20060401
Suspected malignant hyperthermia in a child with laminin alpha2 (merosin) deficiency in the absence of a triggering agent. Paediatric anaesthesia 20060401
Pharmacologic modulation of skeletal muscle metabolism: a microdialysis study. Basic & clinical pharmacology & toxicology 20060401
Early bicarbonate loading and dantroline for ziprasidone/haloperidol-induced neuroleptic malignant syndrome. The Journal of clinical psychiatry 20060401
The effect of sevoflurane on intracellular calcium concentration from cholinergic cells. Brain research bulletin 20060331
Approach to management of malignant hyperthermia-like syndrome in pediatric diabetes mellitus. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies 20060301
Pharmacological interventions for spasticity following spinal cord injury: results of a Cochrane systematic review. Europa medicophysica 20060301
Secretion of brain-derived neurotrophic factor from PC12 cells in response to oxidative stress requires autocrine dopamine signaling. Journal of neurochemistry 20060201
Voltage-gated potassium channel Kv1.3 regulates GLUT4 trafficking to the plasma membrane via a Ca2+-dependent mechanism. American journal of physiology. Cell physiology 20060201
Calcium release from ryanodine receptors in the nucleoplasmic reticulum. Cell calcium 20060101
PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101
[Pleural effusion associated with long-term dantrolene administration in three patients with severe motor and intellectual disabilities]. No to hattatsu = Brain and development 20060101
Successful treatment of six patients with neuroleptic malignant syndrome associated with myoglobulinemic acute renal failure. Renal failure 20060101
Malignant hyperthermia--the perioperative nurse's role. AORN journal 20060101
Neuroleptic malignant syndrome associated with metoclopramide in a burn patient. Journal of burn care & research : official publication of the American Burn Association 20060101
Adrenergic and cholinergic activation of calcium signals in cultured postnatal skeletal myocytes of the rat. Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20060101
Comment on 'Pediatric fatality following ingestion of Dinitrophenol: postmortem identification of a 'dietary supplement''. Clinical toxicology (Philadelphia, Pa.) 20060101
Neuroleptic malignant syndrome and serotonin syndrome in the critical care setting: case analysis. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 20060101
[A cocaine-induced variant of the neuroleptic malignant syndrome. A case study]. Tijdschrift voor psychiatrie 20060101
[Effects of agonists and antagonists of rhyanodine receptors on potassium contractures in twitch and tonic frog skeletal muscle fibers]. Biofizika 20060101
Fatigue and damage to the masseter muscle by prolonged low-frequency stimulation in the rat. Archives of oral biology 20051201
IP3-mediated Ca2+ increases do not involve the ryanodine receptor, but ryanodine receptor antagonists reduce IP3-mediated Ca2+ increases in guinea-pig colonic smooth muscle cells. The Journal of physiology 20051201
The effect of dantrolene sodium in Very Long Chain Acyl-CoA Dehydrogenase Deficiency. Neuromuscular disorders : NMD 20051201
Compartmental pharmacokinetics of dantrolene in adults: do malignant hyperthermia association dosing guidelines work? Anesthesia and analgesia 20051201
Mannitol but not dantrolene prevents myocardial dysfunction following intra-cranial hypertension in rats. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20051201
Redox activation of intracellular calcium release channels (ryanodine receptors) in the sustained phase of hypoxia-induced pulmonary vasoconstriction. Chest 20051201
Ryanodine receptor-mediated interference of neuronal cell differentiation by presenilin 2 mutation. Journal of neuroscience research 20051115
An unusual case of Dantrolene sodium-induced urinary retention in post-traumatic minimally responsive state. Brain injury 20051101
Effect of dantrolene on lipid peroxidation, lutathione and glutathione-dependent enzyme activities in experimental otitis media with effusion in guinea pigs. Human & experimental toxicology 20051101
[Changes in the electromechanical activity in the course of tetanic contraction]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20051101
[Malignant hyperthermia--a hereditary and potentially life-threatening condition]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke 20051020
The ryanodine receptor mediates early zymogen activation in pancreatitis. Proceedings of the National Academy of Sciences of the United States of America 20051004
Nickel compound-induced DNA single-strand breaks in chromosomal and nuclear chromatin in human blood lymphocytes in vitro: role of oxidative stress and intracellular calcium. Mutation research 20051003
Exacerbating factors in neuroleptic malignant syndrome: comparisons between cases with death, sequelae, and full recovery. Journal of clinical psychopharmacology 20051001
Pharmacologic interventions for reducing spasticity in cerebral palsy. Indian journal of pediatrics 20051001
Parkinsonism-hyperpyrexia syndrome not related to antiparkinsonian treatment withdrawal during the 2003 summer heat wave. Journal of neurology 20050901
Eosinophilic pleurisy induced by dantrolene. The Tokai journal of experimental and clinical medicine 20050901
Inositol triphosphate and ryanodine receptors in the control of the cholinosensitivity of common snail neurons by the Na,K pump during habituation. Neuroscience and behavioral physiology 20050901
The effects of ruthenium red, dantrolene and nimodipine, alone or in combination, in NMDA induced neurotoxicity of cerebellar granular cell culture of rats. Toxicology in vitro : an international journal published in association with BIBRA 20050801
Cooling methods used in the treatment of exertional heat illness. British journal of sports medicine 20050801
Heatstroke--predictable, preventable, treatable. JAAPA : official journal of the American Academy of Physician Assistants 20050801
Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction. The Journal of biological chemistry 20050715
Netrin-1 induces axon branching in developing cortical neurons by frequency-dependent calcium signaling pathways. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050713
Malaria parasites are rapidly killed by dantrolene derivatives specific for the plasmodial surface anion channel. Molecular pharmacology 20050701
The protective effect of dantrolene on ischemic neuronal cell death is associated with reduced expression of endoplasmic reticulum stress markers. Brain research 20050628
Contraction- and hypoxia-stimulated glucose transport is mediated by a Ca2+-dependent mechanism in slow-twitch rat soleus muscle. American journal of physiology. Endocrinology and metabolism 20050601
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores. Neuropharmacology 20050601
Intracellular calcium involvement in pituitary adenylate cyclase-activating polypeptide stimulation of growth hormone and gonadotrophin secretion in goldfish pituitary cells. Journal of neuroendocrinology 20050601
Malignant hyperthermia. Nursing 20050601
Neuroleptic malignant syndrome in a patient with Parkinson's disease: a case study. The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses 20050601
[Mechanism of Ca2+ on the hyperthermia-induced apoptosis of rat hippocampal neurons in vitro]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases 20050601
Probing a putative dantrolene-binding site on the cardiac ryanodine receptor. The Biochemical journal 20050501
Carbamazepine toxicity following Oxybutynin and Dantrolene administration: a case report. Spinal cord 20050401
Isoflurane and sevoflurane affect cell survival and BCL-2/BAX ratio differently. Brain research 20050310
Interplay between ryanodine and IP3 receptors in ATP-stimulated mouse luteinized-granulosa cells. Cell calcium 20050301
Involvement of phospholipase C in Yersinia enterocolitica heat stable enterotoxin (Y-STa) mediated rise in intracellular calcium level in rat intestinal epithelial cells. Toxicon : official journal of the International Society on Toxinology 20050301
Design of dantrolene-derived probes for radioisotope-free photoaffinity labeling of proteins involved in the physiological Ca2+ release from sarcoplasmic reticulum of skeletal muscle. Bioorganic & medicinal chemistry letters 20050301
Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: A multicenter study. Archives of physical medicine and rehabilitation 20050301
Protective effects of dantrolene against myocardial injury induced by isoproterenol in rats: biochemical and histological findings. International journal of cardiology 20050227
Dantrolene stabilizes domain interactions within the ryanodine receptor. The Journal of biological chemistry 20050225
Reactive blue prevented caffeine-induced neurotoxicity by an independent mechanism from intracellular calcium currents in cell culture from auditory cortex of rats. The International journal of neuroscience 20050201
Dantrolene and heatstroke: a good molecule applied in an unsuitable situation. Critical care (London, England) 20050101
Clinical review: Treatment of heat stroke: should dantrolene be considered? Critical care (London, England) 20050101
[Central hyperthermia suspected of malignant hyperthermia in a patient undergoing radical neck clipping for cerebral aneurysm]. Masui. The Japanese journal of anesthesiology 20050101
Postoperative hyperthermia of unknown origin treated with dantrolene sodium. Anesthesia progress 20050101
A case report of malignant hyperthermia in a dental clinic operating room. Anesthesia progress 20050101
A malignant hyperthermia-like reaction in a six-month-old female with a 5q chromosomal deletion. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20050101
Accumulation of BCL10 at the perinuclear region is required for the BCL10-mediated nuclear factor-kappa B activation. Pathobiology : journal of immunopathology, molecular and cellular biology 20050101
Malignant hyperthermia with excellent response to small dose of dantrolene. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20041201
Oral dantrolene. Anaesthesia 20041101
Antispasticity medications: uses and limitations of enteral therapy. American journal of physical medicine & rehabilitation 20041001
[Pharmacology and upper limb poststroke spasticity: a review. International Society of Prosthetics and Orthotics]. Annales de readaptation et de medecine physique : revue scientifique de la Societe francaise de reeducation fonctionnelle de readaptation et de medecine physique 20041001
Is there a link between malignant hyperthermia and exertional heat illness? Exercise and sport sciences reviews 20041001
Exploring the pharmacology of the leukotriene B4 receptor BLT1, without the confounding effects of BLT2. European journal of pharmacology 20040919
Sevoflurane-induced malignant hyperthermia during cardiopulmonary bypass and moderate hypothermia. Acta anaesthesiologica Scandinavica 20040901
When economy meets medicine--malignant hyperthermia in Taiwan. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20040901
A survey for prevention and treatment of malignant hyperthermia in Taiwan. Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists 20040901
Subthalamic deep brain stimulation masking possible malignant syndrome in Parkinson disease. Neurology 20040810
Dantrolene protects hippocampal cells from damage induced by TsTX, an alpha-scorpion toxin from Tityus serrulatus. Toxicon : official journal of the International Society on Toxinology 20040801
Neuroleptic malignant syndrome. Geriatrics 20040801
GRP94 reduces cell death in SH-SY5Y cells perturbated calcium homeostasis. Apoptosis : an international journal on programmed cell death 20040701
Dantrolene use in 3,4-methylenedioxymethamphetamine (ecstasy)-mediated hyperthermia. Anesthesiology 20040701
Atypical neuroleptic malignant syndrome caused by clozapine and venlafaxine: early brief treatment with dantrolene. Canadian journal of psychiatry. Revue canadienne de psychiatrie 20040701
RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. The Journal of biological chemistry 20040604
Non-cross-bridge calcium-dependent stiffness in frog muscle fibers. American journal of physiology. Cell physiology 20040601
Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501
Dantrolene reduces the threshold and gain for shivering. Anesthesia and analgesia 20040501
Dantrolene and pleural effusion: case report and review of literature. Spinal cord 20040501
In vitro and in vivo effects of dantrolene on carbonic anhydrase enzyme activities. Biological & pharmaceutical bulletin 20040501
Prevention of acute adriamycin cardiotoxicity by dantrolene in rats. Human & experimental toxicology 20040501
Influence of intracellular Ca2+ release modulating drugs on bupivacaine infiltration anesthesia in mice. European journal of pain (London, England) 20040401
Dantrolene--a review of its pharmacology, therapeutic use and new developments. Anaesthesia 20040401
Neuroleptic malignant syndrome and atypical antipsychotic drugs. The Journal of clinical psychiatry 20040401
[Masseter muscle rigidity after suxamethonium during induction and postoperative abortive malignant hyperthermia in a patient with esophageal achalasia]. Masui. The Japanese journal of anesthesiology 20040301
Heat stroke in schizophrenia during clozapine treatment: rapid recognition and management. Journal of psychopharmacology (Oxford, England) 20040301
[Functioning of the electromechanical connection in the course of the contracture contraction]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20040301
Gamma-secretase activity of presenilin 1 regulates acetylcholine muscarinic receptor-mediated signal transduction. The Journal of biological chemistry 20040220
Involvement of the ryanodine receptor in morphologic modification of Hermissenda type B photoreceptors after in vitro conditioning. Journal of neurophysiology 20040201
Effects of modulators of sarcoplasmic Ca2+ release on the development of skeletal muscle fatigue. Journal of applied physiology (Bethesda, Md. : 1985) 20040201
Effects of alpha-scorpion toxin, tityustoxin on the release of [3H] dopamine of rat brain prefrontal cortical slices. Neurochemistry international 20040101
Ryanodine receptors in peritoneal mast cells: possible role in the modulation of exocytotic activity. Pflugers Archiv : European journal of physiology 20040101
Effect of oral administration of dantrolene sodium on serum creatine kinase activity after exercise in horses with recurrent exertional rhabdomyolysis. American journal of veterinary research 20040101
Heat stroke : a review of cooling methods. Sports medicine (Auckland, N.Z.) 20040101
Na(+) and Ca(2+) homeostasis pathways, cell death and protection after oxygen-glucose-deprivation in organotypic hippocampal slice cultures. Neuroscience 20040101
[Inositoltriphosphate receptors and ryanodine receptors in regulation of cholinosensitivity of Helix lucorum neurones by Na,K-pump during habituation]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova 20040101
Malignant hyperthermia. Best practice & research. Clinical anaesthesiology 20031201
Induction of malignant hyperthermia in susceptible swine by 3,4-methylenedioxymethamphetamine ('ecstasy'). Anesthesiology 20031101
The efficacy of dantrolene sodium in controlling exertional rhabdomyolysis in the Thoroughbred racehorse. Equine veterinary journal 20031101
Acute akinesia or akinetic crisis in Parkinson's disease. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology 20031001
Increased cAMP as a positive inotropic factor for mammalian skeletal muscle in vitro. Canadian journal of physiology and pharmacology 20031001
Involvement of transient receptor potential-like channels in responses to mGluR-I activation in midbrain dopamine neurons. The European journal of neuroscience 20031001
[Malignant hyperthermia]. Wiener klinische Wochenschrift 20030915
Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling. Cell calcium 20030901
Neuroleptic malignant syndrome following cardiac surgery: successful treatment with dantrolene. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 20030901
Malignant hyperthermia. The Journal of craniofacial surgery 20030901
Myoclonus after prolonged infusion of etomidate treated with dantrolene. Journal of clinical anesthesia 20030901
Dantrolene: effects on abnormal intracellular Ca(2+) handling and inotropy in postinfarcted rat myocardium. European journal of pharmacology 20030613
Dantrolene protects erythrocytes against oxidative stress during whole-body irradiation in rats. Cell biochemistry and function 20030601
Fatal malignant hyperthermia-like syndrome with rhabdomyolysis complicating the presentation of diabetes mellitus in adolescent males. Pediatrics 20030601
Malignant hyperthermia: clinical features and management. Nursing times 20030601
[Head retraction reflex-like movements with severe bulbar symptoms in a patient with stiff-person syndrome]. Rinsho shinkeigaku = Clinical neurology 20030601
Changes in [Ca2+]i induced by several glucose transport-enhancing stimuli in rat epitrochlearis muscle. Journal of applied physiology (Bethesda, Md. : 1985) 20030501
Calcium antagonists in N-methyl d-aspartate-induced retinal injury. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20030501
A fatal case of malignant hyperthermia complicated by generalized compartment syndrome and rhabdomyolysis. Acta anaesthesiologica Scandinavica 20030501
Hemodynamic interactions of propofol and dantrolene in chronically instrumented dogs. Anesthesia and analgesia 20030501
[Malignant hyperthermia]. Ugeskrift for laeger 20030421
The role of the presenilin-1 homologue gene sel-12 of Caenorhabditis elegans in apoptotic activities. The Journal of biological chemistry 20030404
Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030401
A case of malignant syndrome associated with a parkinsonism patient. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20030401
Dantrolene analogues revisited: general synthesis and specific functions capable of discriminating two kinds of Ca2+ release from sarcoplasmic reticulum of mouse skeletal muscle. Bioorganic & medicinal chemistry 20030306
Incremental responses of compound muscle action potentials in normal rats produced by repeated electrical stimulation. Electromyography and clinical neurophysiology 20030301
[Dantrolene. Pharmacological and therapeutic aspects]. Der Anaesthesist 20030301
Cellular mechanisms of the acute increase of glutamate release induced by nerve growth factor in rat cerebral cortex. Neuropharmacology 20030301
Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells. Hepatology (Baltimore, Md.) 20030201
Rapid intervention for an episode of malignant hyperthermia. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030201
Warmed diluent speeds dantrolene reconstitution. Canadian journal of anaesthesia = Journal canadien d'anesthesie 20030201
Dosage of dantrolene--'empiric' please! Anaesthesia and intensive care 20030201
Delayed onset of malignant hyperthermia in desflurane anesthesia. Anesthesia and analgesia 20030101
Dantrolene inhibits NMDA-induced 45Ca uptake in cultured cerebellar granule neurons. Neurochemistry international 20030101
[Neuroleptic malignant syndrome]. Ryoikibetsu shokogun shirizu 20030101
FK506 attenuates 1-methyl-4-phenylpyridinium- and 3-nitropropionic acid-evoked inhibition of kynurenic acid synthesis in rat cortical slices. Acta neurobiologiae experimentalis 20030101
Glucose 6-phosphate dehydrogenase: in vitro and in vivo effects of dantrolene sodium. Polish journal of pharmacology 20030101
Force response to stretches in activated frog muscle fibres at low tension. Advances in experimental medicine and biology 20030101
Effects of immunosuppressants, calcineurin inhibition, and blockade of endoplasmic reticulum calcium channels on free fatty acid efflux from the ischemic/reperfused rat cerebral cortex. Brain research 20021206
Cellular mechanisms regulating activity-dependent release of native brain-derived neurotrophic factor from hippocampal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20021201
In vitro effects of oxytocin, acepromazine, detomidine, xylazine, butorphanol, terbutaline, isoproterenol, and dantrolene on smooth and skeletal muscles of the equine esophagus. American journal of veterinary research 20021201
[(125)I]-N-[(3-azido-5-iodo)benzyl]dantrolene and [(125)I]-N-[[3-iodo-5-(3-trifluoromethyl-3H-diazirin-3-yl)]benzyl]dantrolene: photoaffinity probes specific for the physiological Ca(2+) release from sarcoplasmic reticulum of skeletal muscle. Bioorganic & medicinal chemistry letters 20021118
Dantrolene diminishes forelimb force-related tremor at doses that do not decrease operant behavior in the rat. Experimental and clinical psychopharmacology 20021101
Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021001
Malignant hyperthermia: considerations for the general surgeon. Canadian journal of surgery. Journal canadien de chirurgie 20021001
Nitric oxide donor sodium nitroprusside induces neurotoxicity in cerebellar granular cell culture in rats by an independent mechanism from L-type or dantrolene-sensitive calcium channels. Biological & pharmaceutical bulletin 20021001
The presenilin 1 deltaE9 mutation gives enhanced basal phospholipase C activity and a resultant increase in intracellular calcium concentrations. The Journal of biological chemistry 20020927
Identification of a dantrolene-binding sequence on the skeletal muscle ryanodine receptor. The Journal of biological chemistry 20020920
[A case of Satoyoshi syndrome complicating marginal gingivitis of the mandible and dislocation of the temporomandibular joint]. Rinsho shinkeigaku = Clinical neurology 20020901
Tumor necrosis factor induces apoptosis in hepatoma cells by increasing Ca(2+) release from the endoplasmic reticulum and suppressing Bcl-2 expression. The Journal of biological chemistry 20020830
Reduction in intracellular calcium levels inhibits myoblast differentiation. The Journal of biological chemistry 20020809
Influence of agents affecting voltage-dependent calcium channels and dantrolene on the anticonvulsant action of the AMPA/kainate receptor antagonist LY 300164 in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020801
Distinct intracellular calcium transients in neurites and somata integrate neuronal signals. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020701
Successful treatment of a complicated case of neuroleptic malignant syndrome. Intensive care medicine 20020701
Malignant hyperthermia: how to spot it early. RN 20020701
[Malignant hyperthermia]. La Tunisie medicale 20020701
Anti-inflammatory and antinociceptive properties of dantrolene sodium in rats and mice. Pharmacological research 20020601
[Eosinophilic pleural effusion associated with dantrolene administration]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20020601
Dantrolene downregulates the gene expression and activity of the ubiquitin-proteasome proteolytic pathway in septic skeletal muscle. The Journal of surgical research 20020515
Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020501
Translocation of protein kinase C by halothane in cholinergic cells. Brain research bulletin 20020501
Mechanism of the beneficial effects of dantrolene sodium on ethanol-induced acute gastric mucosal injury in rats. Pharmacological research 20020501
Neuroleptic malignant syndrome presenting as pulmonary edema and severe bronchorrhea. Journal of the National Medical Association 20020401
Aluminum neurotoxicity is reduced by dantrolene and dimethyl sulfoxide in cultured rat hippocampal neurons. Biological trace element research 20020401
Sorbitol activates atypical protein kinase C and GLUT4 glucose transporter translocation/glucose transport through proline-rich tyrosine kinase-2, the extracellular signal-regulated kinase pathway and phospholipase D. The Biochemical journal 20020315
Caffeine-stimulated GTH-II release involves Ca(2+) stores with novel properties. American journal of physiology. Cell physiology 20020301
Effects of dantrolene on extracellular glutamate concentration and neuronal death in the rat hippocampal CA1 region subjected to transient ischemia. Anesthesiology 20020301
Role of RyRs and IP3 receptors after traumatic injury to spinal cord white matter. Journal of neurotrauma 20020301
Role of intracellular calcium stores in cell death from oxygen-glucose deprivation in a neuronal cell line. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20020201
Dual mechanisms of Ca(2+) increases elicited by N-methyl-D-aspartate in immature and mature cultured cortical neurons. Journal of neuroscience research 20020115
Depletion of intracellular calcium stores is toxic to SH-SY5Y neuronal cells. Brain research 20020111
[Malignant hyperthermia]. Nihon rinsho. Japanese journal of clinical medicine 20020101
Cardiomyocyte intracellular calcium and cardiac dysfunction after burn trauma. Critical care medicine 20020101
Effects of moderate and deep hypothermia on Ca2+ signaling in rat ventricular myocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20020101
Determinants of ictal epileptiform patterns in the hippocampal slice. Epilepsia 20020101
The inhibitory effects of dantrolene on action potential-induced calcium transients in cultured rat dorsal root ganglion neurons. Physiological research 20020101
[Neuroleptic malignant syndrome]. Medicina (Kaunas, Lithuania) 20020101
Dantrolene protects neurons against kainic acid induced apoptosis in vitro and in vivo. Journal of cellular and molecular medicine 20020101
In vitro effects of dantrolene sodium and verapamil on noradrenaline-induced contractions of rabbit aorta and their interactions. Journal of basic and clinical physiology and pharmacology 20020101
Calcium-induced calcium release and calcium buffering in retinal horizontal cells. Visual neuroscience 20020101
Halothane-induced intracellular calcium release in cholinergic cells. Brain research 20011207
In vitro antioxidant properties of dantrolene sodium. Pharmacological research 20011201
Principles of pharmaceutical management of spastic hypertonia. Physical medicine and rehabilitation clinics of North America 20011101
[Two pediatric cases of malignant hyperthermia caused by sevoflurane]. Masui. The Japanese journal of anesthesiology 20011101
Dantrolene counteracts the masseter muscle damage induced by artificial occlusal wear: studies in a rat model. Journal of dental research 20011101
[Effects of dantrolene and ryanodine on the evoked activity of neuromuscular synapses in mice]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011101
Effects of dantrolene and its derivatives on Ca(2+) release from the sarcoplasmic reticulum of mouse skeletal muscle fibres. British journal of pharmacology 20011001
Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation. The Journal of biological chemistry 20010921
Platelet-activating factor evokes Ca2+ transients after the blockade of ryanodine receptor by dantrolene in RAW 264.7 macrophages. Neurochemical research 20010901
Ca2+ signaling in the transformation of promastigotes to axenic amastigotes of Leishmania donovani. Molecular and cellular biochemistry 20010801
Functional overlap of IP(3)- and cADP-ribose-sensitive calcium stores in guinea pig myenteric neurons. American journal of physiology. Gastrointestinal and liver physiology 20010701
Characterization of action potential waveform-evoked L-type calcium currents in pituitary GH3 cells. Pflugers Archiv : European journal of physiology 20010701
Dantrolene ameliorates delayed cell death and concomitant DNA fragmentation in the rat hippocampal CA1 neurons subjected to mild ischemia. Resuscitation 20010701
Long-term memory formation in the chick requires mobilization of ryanodine-sensitive intracellular calcium stores. Neurobiology of learning and memory 20010501
Eosinophilic pleural effusion due to dantrolene: resolution with steroid therapy. Southern medical journal 20010501
[Malignant neuroleptic syndrome after haloperidol administration]. Der Anaesthesist 20010501
Management of spasticity, pain, and paroxysmal phenomena in multiple sclerosis. Current neurology and neuroscience reports 20010501
Dantrolene inhibition of ryanodine receptor Ca2+ release channels. Molecular mechanism and isoform selectivity. The Journal of biological chemistry 20010427
Comment: 'Dantrolene modulates the influence of steady magnetic fields on hippocampal evoked potentials in vitro'. Bioelectromagnetics 20010401
A3 adenosine receptor stimulation modulates sarcoplasmic reticulum Ca(2+) release in rat heart. Cardiovascular research 20010401
Malignant hyperthermia in a patient with Graves' disease during subtotal thyroidectomy. Endocrine journal 20010401
Malignant hyperthermia: an inherited disorder of skeletal muscle Ca+ regulation. Bioscience reports 20010401
Dantrolene reduces serum TNFalpha and corticosterone levels and muscle calcium, calpain gene expression, and protein breakdown in septic rats. Shock (Augusta, Ga.) 20010301
Evidence of calcium influx across the plasma membrane depends upon the initial rise of cytosolic calcium with activation of IP(3) in rat enterocytes by heat-stable enterotoxin of Vibrio cholerae non-O1. FEMS microbiology letters 20010301
Effects of dantrolene on rat diaphragm muscle during postnatal maturation. Anesthesiology 20010301
The effects of dantrolene alone or in combination with nimodipine in glutamate-induced neurotoxicity in cerebellar granular cell cultures of rat pups. Pharmacological research 20010301
Dantrolene: opening the anesthesiologist-proof packaging. Anesthesiology 20010201
Treating neuroleptic malignant syndrome as catatonia. Journal of clinical psychopharmacology 20010201
Persistent fever in a case of typhoid--an unusual cause of neuroleptic malignant syndrome. The Journal of the Association of Physicians of India 20010201
Product review: refrigerated malignant hyperthermia cart. Journal of perianesthesia nursing : official journal of the American Society of PeriAnesthesia Nurses 20010201
Potent serotonin (5-HT)(2A) receptor antagonists completely prevent the development of hyperthermia in an animal model of the 5-HT syndrome. Brain research 20010126
The skeletal muscle ryanodine receptor identified as a molecular target of [3H]azidodantrolene by photoaffinity labeling. Biochemistry 20010116
Effects of MK-801, dantrolene, and FK506 on convulsive seizures and brain nitric oxide production in seizure-susceptible EL mice. Brain research 20010112
Pharmacotherapy of spasticity: oral medications and intrathecal baclofen. Journal of child neurology 20010101
Prediction of accelerated Ca-induced Ca release rate by clinical findings in malignant hyperthermia susceptible subjects. In vivo (Athens, Greece) 20010101
Effects of the calcium release inhibitor dantrolene and the Ca2+-ATPase inhibitor thapsigargin on spinal nociception in rats. Pharmacology 20010101
[Satoyoshi syndrome (disease)]. Ryoikibetsu shokogun shirizu 20010101
Ping-pong gaze in combined intoxication with tranylcypromine, thioridazine, and clomipramine. Neuropsychiatry, neuropsychology, and behavioral neurology 20010101
Hippocampal mossy fiber activity evokes Ca2+ release in CA3 pyramidal neurons via a metabotropic glutamate receptor pathway. Neuroscience 20010101
Neuroleptic malignant syndrome associated with olanzapine therapy: a case report. The Journal of emergency medicine 20001101
Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression. Journal of neurochemistry 20000701
[A case of malignant syndrome triggered by the use of haloperidol and chrorpromazine]. Masui. The Japanese journal of anesthesiology 19970401
Development of an animal model for neuroleptic malignant syndrome: heat-exposed rabbits with haloperidol and atropine administration exhibit increased muscle activity, hyperthermia, and high serum creatine phosphokinase level. Brain research 19961216
Dantrolene treatment of opioid-induced myoclonus. Anesthesia and analgesia 19951201
Clinical effects of intravenously administered dantrolene. Mayo Clinic proceedings 19950301
Neuroleptic malignant syndrome and clozapine. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists 19930301
Management of neuroleptic malignant syndrome--a series of eight cases. The Journal of the Association of Physicians of India 19930201
Successful treatment of an episode of malignant hyperthermia using a large dose of dantrolene. Journal of clinical anesthesia 19930101
Successful treatment of levodopa-induced neuroleptic malignant syndrome (NMS) and disseminated intravascular coagulation (DIC) in a patient with Parkinson's disease. Internal medicine (Tokyo, Japan) 19921101
Neuroleptic malignant syndrome induced by domperidone. Digestive diseases and sciences 19920601
A case of clozapine-induced neuroleptic malignant syndrome. The Journal of clinical psychiatry 19910301
Effects of insulin and phospholipase C in control and denervated rat skeletal muscle. The American journal of physiology 19910201
[Successful treatment of levodopa-induced neuroleptic malignant syndrome (NMS) with disseminated intravascular coagulation (DIC) in a patient with Parkinson's disease]. Rinsho shinkeigaku = Clinical neurology 19910101
Treatment of lethal catatonia with electroconvulsive therapy and dantrolene sodium: a case report. Acta psychiatrica Scandinavica 19900701
Mortality from neuroleptic malignant syndrome. The Journal of clinical psychiatry 19890101
[Calcium inhibitors and anesthesia]. Annales francaises d'anesthesie et de reanimation 19880101
Sudden bilateral sensorineural hearing loss during treatment with dantrolene sodium (dantrium). The Journal of laryngology and otology 19880101
Prevention of amphotericin B-induced rigors by dantrolene. Archives of internal medicine 19860801
[Cardiac failure caused by an overdose of dantrolene]. Annales francaises d'anesthesie et de reanimation 19860101
[Extrapyramidal reactions and neuroleptic malignant syndrome]. Acta psiquiatrica y psicologica de America latina 19841201
Hyperkalemia and cardiovascular collapse after verapamil and dantrolene administration in swine. Anesthesia and analgesia 19840501
Pneumonitis, pleural effusion and pericarditis following treatment with dantrolene. Journal of neurology, neurosurgery, and psychiatry 19840501
Neuroleptic malignant syndrome: successful treatment with dantrolene and bromocriptine. Annals of neurology 19830701
Beneficial effects of dantrolene in the treatment of neuroleptic malignant syndrome: a report of two cases. Neurology 19830401
Neuroleptic malignant syndrome: response to dantrolene sodium. Annals of internal medicine 19830201
Treatment of neuroleptic malignant syndrome with dantrolene. Lancet (London, England) 19820703
[Neuroleptic malignant syndrome. Beneficial effects of dantrolene on hyperthermia and hypertonia (author's transl)]. La Nouvelle presse medicale 19820327
Dantrolene and lymphocytic lymphoma. Postgraduate medical journal 19800401
Pleuropericardial reaction to treatment with dantrolene. JAMA 19791221
Dantrolene and suxamethonium. The effect of pre-operative dantrolene on the action of suxamethonium. Anaesthesia 19790201
Hepatitis from dantrolene sodium. Gut 19790101
Dantrolene-associated hepatic injury. Incidence and character. Gastroenterology 19770401
Dantrolene hepatitis. JAMA 19760412
Treatment of spastic cerebral-palsied children with sodium dantrolene. Developmental medicine and child neurology 19751201
Letter: Hallucinations associated with dantrolene sodium therapy. Canadian Medical Association journal 19750125
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