4-({4-[(2,4,6-trimethylphenyl)amino]pyrimidin-2-yl}amino)benzonitrile
| Title | Journal |
|---|---|
| Optimization of diarylazines as anti-HIV agents with dramatically enhanced solubility. | Bioorganic & medicinal chemistry letters 20130915 |
| Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents. | Bioorganic & medicinal chemistry letters 20121201 |
| Interactions of microbicide nanoparticles with a simulated vaginal fluid. | Molecular pharmaceutics 20121105 |
| Current status of topical antiretroviral chemoprophylaxis. | Current opinion in HIV and AIDS 20121101 |
| Polymeric nanoparticles affect the intracellular delivery, antiretroviral activity and cytotoxicity of the microbicide drug candidate dapivirine. | Pharmaceutical research 20120601 |
| Testing of viscous anti-HIV microbicides using Lactobacillus. | Journal of microbiological methods 20120201 |
| Novel diarylpyridinones, diarylpyridazinones and diarylphthalazinones as potential HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs). | Bioorganic & medicinal chemistry 20111015 |
| Synergy against drug-resistant HIV-1 with the microbicide antiretrovirals, dapivirine and tenofovir, in combination. | AIDS (London, England) 20110824 |
| Diarylpyrimidine-dihydrobenzyloxopyrimidine hybrids: new, wide-spectrum anti-HIV-1 agents active at (sub)-nanomolar level. | Journal of medicinal chemistry 20110428 |
| Complete inactivation of HIV-1 using photo-labeled non-nucleoside reverse transcriptase inhibitors. | Virus research 20110101 |
| Update on microbicide research and development - seeking new HIV prevention tools for women. | European journal of medical research 20110101 |
| Inhibition of HIV-1 by non-nucleoside reverse transcriptase inhibitors via an induced fit mechanism-Importance of slow dissociation and relaxation rates for antiviral efficacy. | Biochemical pharmacology 20101015 |
| Pharmacokinetics of 2 dapivirine vaginal microbicide gels and their safety vs. Hydroxyethyl cellulose-based universal placebo gel. | Journal of acquired immune deficiency syndromes (1999) 20101001 |
| Development and validation of a rapid reversed-phase HPLC method for the determination of the non-nucleoside reverse transcriptase inhibitor dapivirine from polymeric nanoparticles. | Journal of pharmaceutical and biomedical analysis 20100605 |
| Segmented polyurethane intravaginal rings for the sustained combined delivery of antiretroviral agents dapivirine and tenofovir. | European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20100219 |
| Selective killing of human immunodeficiency virus infected cells by non-nucleoside reverse transcriptase inhibitor-induced activation of HIV protease. | Retrovirology 20100101 |
| Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. | Bioorganic & medicinal chemistry letters 20090915 |
| Inhibition of human immunodeficiency virus type 1 infection by the candidate microbicide dapivirine, a nonnucleoside reverse transcriptase inhibitor. | Antimicrobial agents and chemotherapy 20090201 |
| Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide. | International journal of pharmaceutics 20061115 |
| Potent nonnucleoside reverse transcriptase inhibitors target HIV-1 Gag-Pol. | PLoS pathogens 20061101 |
| From 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk](1,4)benzodiazepin-2(1H)-one (TIBO) to etravirine (TMC125): fifteen years of research on non-nucleoside inhibitors of HIV-1 reverse transcriptase. | Journal of medicinal chemistry 20050324 |
| In search of a novel anti-HIV drug: multidisciplinary coordination in the discovery of 4-[[4-[[4-[(1E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2- pyrimidinyl]amino]benzonitrile (R278474, rilpivirine). | Journal of medicinal chemistry 20050324 |
| TMC125, a novel next-generation nonnucleoside reverse transcriptase inhibitor active against nonnucleoside reverse transcriptase inhibitor-resistant human immunodeficiency virus type 1. | Antimicrobial agents and chemotherapy 20041201 |
| A series of diaryltriazines and diarylpyrimidines are highly potent nonnucleoside reverse transcriptase inhibitors with possible applications as microbicides. | Antimicrobial agents and chemotherapy 20041001 |
| Roles of conformational and positional adaptability in structure-based design of TMC125-R165335 (etravirine) and related non-nucleoside reverse transcriptase inhibitors that are highly potent and effective against wild-type and drug-resistant HIV-1 variants. | Journal of medicinal chemistry 20040506 |
| In vitro evaluation of nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 as human immunodeficiency virus microbicides. | Antimicrobial agents and chemotherapy 20040101 |
| Recent advances in the development of next generation non-nucleoside reverse transcriptase inhibitors. | Current topics in medicinal chemistry 20040101 |
| Correlations between factors determining the pharmacokinetics and antiviral activity of HIV-1 non-nucleoside reverse transcriptase inhibitors of the diaryltriazine and diarylpyrimidine classes of compounds. | Drugs in R&D 20040101 |
| Evolution of anti-HIV drug candidates. Part 3: Diarylpyrimidine (DAPY) analogues. | Bioorganic & medicinal chemistry letters 20010903 |