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6-Gingerol

CAS No.:
23513-14-6
Catalog Number:
AG002NIA
Molecular Formula:
C17H26O4
Molecular Weight:
294.3859
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$111
- +
5mg
99%
1 week
United States
$140
- +
10mg
99%
1 week
United States
$196
- +
25mg
99%
1 week
United States
$307
- +
50mg
99%
1 week
United States
$460
- +
100mg
99%
1 week
United States
$779
- +
Product Description
Catalog Number:
AG002NIA
Chemical Name:
6-Gingerol
CAS Number:
23513-14-6
Molecular Formula:
C17H26O4
Molecular Weight:
294.3859
MDL Number:
MFCD00210507
IUPAC Name:
(5S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)decan-3-one
InChI:
InChI=1S/C17H26O4/c1-3-4-5-6-14(18)12-15(19)9-7-13-8-10-16(20)17(11-13)21-2/h8,10-11,14,18,20H,3-7,9,12H2,1-2H3/t14-/m0/s1
InChI Key:
NLDDIKRKFXEWBK-AWEZNQCLSA-N
SMILES:
CCCCC[C@@H](CC(=O)CCc1ccc(c(c1)OC)O)O
UNII:
925QK2Z900
Properties
Complexity:
293  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
294.183g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
294.391g/mol
Monoisotopic Mass:
294.183g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
66.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.5  
Literature
Title Journal
Assessment of anti-cancerous potential of 6-gingerol (Tongling White Ginger) and its synergy with drugs on human cervical adenocarcinoma cells. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20171101
Protective properties of 6-gingerol-rich fraction from Zingiber officinale (Ginger) on chlorpyrifos-induced oxidative damage and inflammation in the brain, ovary and uterus of rats. Chemico-biological interactions 20170525
[6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na(+) channels. Pharmacological research 20170301
Revealing the effect of 6-gingerol, 6-shogaol and curcumin on mPGES-1, GSK-3β and β-catenin pathway in A549 cell line. Chemico-biological interactions 20161025
6-Gingerol induces autophagy to protect HUVECs survival from apoptosis. Chemico-biological interactions 20160825
Inhibitory effect 6-gingerol on adipogenesis through activation of the Wnt/β-catenin signaling pathway in 3T3-L1 adipocytes. Toxicology in vitro : an international journal published in association with BIBRA 20151225
Warfarin is an effective modifier of multiple UDP-glucuronosyltransferase enzymes: evaluation of its potential to alter the pharmacokinetics of zidovudine. Journal of pharmaceutical sciences 20150101
Gingerol sensitizes TRAIL-induced apoptotic cell death of glioblastoma cells. Toxicology and applied pharmacology 20140915
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine. Bioorganic & medicinal chemistry 20121115
[6]-Gingerol induces caspase 3 dependent apoptosis and autophagy in cancer cells: drug-DNA interaction and expression of certain signal genes in HeLa cells. European journal of pharmacology 20121105
6-Gingerol induces apoptosis through lysosomal-mitochondrial axis in human hepatoma G2 cells. Phytotherapy research : PTR 20121101
Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes. Planta medica 20120901
Molecular mechanism inhibiting human hepatocarcinoma cell invasion by 6-shogaol and 6-gingerol. Molecular nutrition & food research 20120801
Putative mycobacterial efflux inhibitors from the seeds of Aframomum melegueta. Journal of natural products 20120727
Zingiber officinale extract exhibits antidiabetic potential via modulating glucose uptake, protein glycation and inhibiting adipocyte differentiation: an in vitro study. Journal of the science of food and agriculture 20120701
Simultaneous determination of six active components in traditional herbal medicine 'Oyaksungisan' by HPLC-DAD. Journal of natural medicines 20120701
Administration of 6-gingerol greatly enhances the number of tumor-infiltrating lymphocytes in murine tumors. International journal of cancer 20120601
Effects of club soda and ginger brew on linguapalatal pressures in healthy swallowing. Dysphagia 20120601
α-Glucosylated 6-gingerol: chemoenzymatic synthesis using α-glucosidase from Halomonas sp. H11, and its physical properties. Carbohydrate research 20120601
Determination and pharmacokinetics of [6]-gingerol in mouse plasma by liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC 20120501
Zingiber officinale (ginger) as an anti-emetic in cancer chemotherapy: a review. Journal of alternative and complementary medicine (New York, N.Y.) 20120501
[6]-Gingerol isolated from ginger attenuates sodium arsenite induced oxidative stress and plays a corrective role in improving insulin signaling in mice. Toxicology letters 20120405
Metabolism of [6]-shogaol in mice and in cancer cells. Drug metabolism and disposition: the biological fate of chemicals 20120401
Cytotoxic, cytoprotective and antioxidant effects of isolated phenolic compounds from fresh ginger. Fitoterapia 20120401
Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger. Biochemical and biophysical research communications 20120323
Antiinflammatory effects of ginger and some of its components in human bronchial epithelial (BEAS-2B) cells. Phytotherapy research : PTR 20120301
[Simultaneous determination of four components in sini tang by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120301
Synthesis and biological evaluation of [6]-gingerol analogues as transient receptor potential channel TRPV1 and TRPA1 modulators. Bioorganic & medicinal chemistry letters 20120215
Synbiotic (probiotic and ginger extract) loaded floating beads: a novel therapeutic option in an experimental paradigm of gastric ulcer. The Journal of pharmacy and pharmacology 20120201
The tibetan uterotonic zhi byed 11: mechanisms of action, efficacy, and historical use for postpartum hemorrhage. Evidence-based complementary and alternative medicine : eCAM 20120101
Cancer cell signaling pathways targeted by spice-derived nutraceuticals. Nutrition and cancer 20120101
Zingiber officinale Improves Cognitive Function of the Middle-Aged Healthy Women. Evidence-based complementary and alternative medicine : eCAM 20120101
A nonimmunosuppressant approach on Asia psoriasis subjects: 5-year followup and 11-year data analysis. Dermatology research and practice 20120101
Protective effect of [6]-gingerol on the ethanol-induced teratogenesis of cultured mouse embryos. Archives of pharmacal research 20120101
Effect of [6]-gingerol on myofibroblast differentiation in transforming growth factor beta 1-induced nasal polyp-derived fibroblasts. American journal of rhinology & allergy 20120101
Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells. Journal of biomedicine & biotechnology 20120101
An impression on current developments in the technology, chemistry, and biological activities of ginger (Zingiber officinale Roscoe). Critical reviews in food science and nutrition 20120101
Scientific evidence and rationale for the development of curcumin and resveratrol as nutraceutricals for joint health. International journal of molecular sciences 20120101
Plants' metabolites as potential antiobesity agents. TheScientificWorldJournal 20120101
Protective Action of Flavonoids Genistein and Gingerol against Cisplatin Toxicity In Vitro. Journal of young pharmacists : JYP 20120101
Ginger stimulates hematopoiesis via Bmp pathway in zebrafish. PloS one 20120101
[Analysis of gingerol-related compounds in fresh ginger by HPLC-ESI-Q-TOF-MS/MS]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20111201
Chemical constituents and their bioactivities of 'Tongling White Ginger' (Zingiber officinale). Journal of agricultural and food chemistry 20111109
6-gingerol, an active ingredient of ginger, protects acetaminophen-induced hepatotoxicity in mice. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111101
Characterization of [6]-gingerol metabolism in rat by liquid chromatography electrospray tandem mass spectrometry. Biomedical chromatography : BMC 20111001
6-gingerol prevents patulin-induced genotoxicity in HepG2 cells. Phytotherapy research : PTR 20111001
Study on the hypochlolesterolemic and antioxidative effects of tyramine derivatives from the root bark of Lycium chenese Miller. Nutrition research and practice 20111001
Orosensory stimulation effects on human saliva proteome. Journal of agricultural and food chemistry 20110928
Synthesis of a new [6]-gingerol analogue and its protective effect with respect to the development of metabolic syndrome in mice fed a high-fat diet. Journal of medicinal chemistry 20110922
Preparation of the monomers of gingerols and 6-shogaol by flash high speed counter-current chromatography. Journal of chromatography. A 20110909
10-Gingerol, a component of rikkunshito, improves cisplatin-induced anorexia by inhibiting acylated ghrelin degradation. Biochemical and biophysical research communications 20110902
Examination of the pharmacokinetics of active ingredients of ginger in humans. The AAPS journal 20110901
Ginger phytochemicals mitigate the obesogenic effects of a high-fat diet in mice: a proteomic and biomarker network analysis. Molecular nutrition & food research 20110901
Pressurized liquid extraction of ginger (Zingiber officinale Roscoe) with bioethanol: an efficient and sustainable approach. Journal of chromatography. A 20110826
Characterization of constituents in Sini decoction and rat plasma by high-performance liquid chromatography with diode array detection coupled to time-of-flight mass spectrometry. Biomedical chromatography : BMC 20110801
Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. Planta medica 20110701
Transient receptor potential (TRP) channels as drug targets for diseases of the digestive system. Pharmacology & therapeutics 20110701
Update on the chemopreventive effects of ginger and its phytochemicals. Critical reviews in food science and nutrition 20110701
[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20110601
Emodin and [6]-gingerol lessen hypoxia-induced embryotoxicities in cultured mouse whole embryos via upregulation of hypoxia-inducible factor 1α and intracellular superoxide dismutases. Reproductive toxicology (Elmsford, N.Y.) 20110501
Anti-invasive activity of α-tocopherol against hepatoma cells in culture via protein kinase C inhibition. Journal of clinical biochemistry and nutrition 20110501
Ginger suppresses phthalate ester-induced airway remodeling. Journal of agricultural and food chemistry 20110413
Inhibitors of microglial neurotoxicity: focus on natural products. Molecules (Basel, Switzerland) 20110125
Gastroprotective Effect of Ginger Rhizome (Zingiber officinale) Extract: Role of Gallic Acid and Cinnamic Acid in H(+), K(+)-ATPase/H. pylori Inhibition and Anti-Oxidative Mechanism. Evidence-based complementary and alternative medicine : eCAM 20110101
Cyclooxygenase-2 inhibitors in ginger (Zingiber officinale). Fitoterapia 20110101
Potential of Complementary and Alternative Medicine in Preventive Management of Novel H1N1 Flu (Swine Flu) Pandemic: Thwarting Potential Disasters in the Bud. Evidence-based complementary and alternative medicine : eCAM 20110101
Zingiber officinale Mitigates Brain Damage and Improves Memory Impairment in Focal Cerebral Ischemic Rat. Evidence-based complementary and alternative medicine : eCAM 20110101
Antibacterial activity of natural spices on multiple drug resistant Escherichia coli isolated from drinking water, Bangladesh. Annals of clinical microbiology and antimicrobials 20110101
Physiological and therapeutical roles of ginger and turmeric on endocrine functions. The American journal of Chinese medicine 20110101
Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. PloS one 20110101
High throughput ratio imaging to profile caspase activity: potential application in multiparameter high content apoptosis analysis and drug screening. PloS one 20110101
Inhibitory effect of [6]-gingerol on melanogenesis in B16F10 melanoma cells and a possible mechanism of action. Bioscience, biotechnology, and biochemistry 20110101
An efficient approach to finding Siraitia grosvenorii triterpene biosynthetic genes by RNA-seq and digital gene expression analysis. BMC genomics 20110101
The role of the p38 MAPK signaling pathway in high glucose-induced epithelial-mesenchymal transition of cultured human renal tubular epithelial cells. PloS one 20110101
Role of phenolic compounds in peptic ulcer: An overview. Journal of pharmacy & bioallied sciences 20110101
Generation of autotetraploid plant of ginger (Zingiber officinale Rosc.) and its quality evaluation. Pharmacognosy magazine 20110101
Standardization of sulaharan yoga: an ayurvedic tablet formulation. Indian journal of pharmaceutical sciences 20110101
Effect of Turkish propolis extracts on proteome of prostate cancer cell line. Proteome science 20110101
Quantitative analysis of ginger components in commercial products using liquid chromatography with electrochemical array detection. Journal of agricultural and food chemistry 20101222
Zingiber officinale (ginger) compounds have tetracycline-resistance modifying effects against clinical extensively drug-resistant Acinetobacter baumannii. Phytotherapy research : PTR 20101201
Ginger extract inhibits human telomerase reverse transcriptase and c-Myc expression in A549 lung cancer cells. Journal of medicinal food 20101201
Anti-invasion effects of 6-shogaol and 6-gingerol, two active components in ginger, on human hepatocarcinoma cells. Molecular nutrition & food research 20101101
Larvicidal constituents of Zingiber officinale (ginger) against Anisakis simplex. Planta medica 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Indian spices for healthy heart - an overview. Current cardiology reviews 20101101
Production of dehydrogingerdione derivatives in Escherichia coli by exploiting a curcuminoid synthase from Oryza sativa and a β-oxidation pathway from Saccharomyces cerevisiae. Chembiochem : a European journal of chemical biology 20100924
6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. Molecular nutrition & food research 20100901
Effect of [6]-shogaol on cytosolic Ca2+ levels and proliferation in human oral cancer cells (OC2). Journal of natural products 20100827
Zingiber officinale protects HaCaT cells and C57BL/6 mice from ultraviolet B-induced inflammation. Journal of medicinal food 20100601
Identification of serotonin 5-HT1A receptor partial agonists in ginger. Bioorganic & medicinal chemistry 20100501
[Comparative protein analysis of K562 cell apoptosis induced by 6-gingerol]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100501
Genotoxic effect of 6-gingerol on human hepatoma G2 cells. Chemico-biological interactions 20100415
[Reactive oxygen species and mitochondrial membrane potential changes in leukemia cells during 6-gingerol induced apoptosis]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20100401
Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis. Cancer chemotherapy and pharmacology 20100301
RP-thin layer chromatographic method for the quantification of three gingerol homologs of ultrasonic-assisted fresh rhizome extracts of Zingiber officinale collected from North Western Himalayas. Journal of separation science 20100301
Effect of gingerol on substance P and NK1 receptor expression in a vomiting model of mink. Chinese medical journal 20100220
Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. Journal of ethnopharmacology 20100203
TRPA1 modulation of spontaneous and mechanically evoked firing of spinal neurons in uninjured, osteoarthritic, and inflamed rats. Molecular pain 20100101
Molecular targets of [6]-gingerol: Its potential roles in cancer chemoprevention. BioFactors (Oxford, England) 20100101
Dietary polyphenols affect MUC5AC expression and ciliary movement in respiratory cells and nasal mucosa. American journal of rhinology & allergy 20100101
Subacute thyroiditis following ginger (Zingiber officinale) consumption. International journal of Ayurveda research 20100101
Effects of ATRA combined with citrus and ginger-derived compounds in human SCC xenografts. BMC cancer 20100101
Phytoconstituents from Alpinia purpurata and their in vitro inhibitory activity against Mycobacterium tuberculosis. Pharmacognosy magazine 20100101
De novo assembly and characterization of root transcriptome using Illumina paired-end sequencing and development of cSSR markers in sweet potato (Ipomoea batatas). BMC genomics 20100101
Management of Amavata with 'Amrita Ghrita': A clinical study. Ayu 20100101
Differential growth suppression of human melanoma cells by tea (Camellia sinensis) epicatechins (ECG, EGC and EGCG). Evidence-based complementary and alternative medicine : eCAM 20091201
Modification of pharmacokinetics of norfloxacin following oral administration of curcumin in rabbits. Journal of veterinary science 20091201
Increased growth inhibitory effects on human cancer cells and anti-inflammatory potency of shogaols from Zingiber officinale relative to gingerols. Journal of agricultural and food chemistry 20091125
Identification and quantification of gingerols and related compounds in ginger dietary supplements using high-performance liquid chromatography-tandem mass spectrometry. Journal of agricultural and food chemistry 20091111
Visualization of volatile substances in different organelles with an atmospheric-pressure mass microscope. Analytical chemistry 20091101
[6]-Gingerol induces reactive oxygen species regulated mitochondrial cell death pathway in human epidermoid carcinoma A431 cells. Chemico-biological interactions 20090914
An enantioselective synthesis of (+)-(S)-[n]-gingerols via the L-proline-catalyzed aldol reaction. Bioorganic & medicinal chemistry letters 20090715
[6]-Gingerol suppresses colon cancer growth by targeting leukotriene A4 hydrolase. Cancer research 20090701
Ginger's (Zingiber officinale Roscoe) inhibition of rat colonic adenocarcinoma cells proliferation and angiogenesis in vitro. Phytotherapy research : PTR 20090501
Plasma pharmacokinetics, tissue distribution and excretion study of 6-gingerol in rat by liquid chromatography-electrospray ionization time-of-flight mass spectrometry. Journal of pharmaceutical and biomedical analysis 20090501
6-Gingerol inhibits ROS and iNOS through the suppression of PKC-alpha and NF-kappaB pathways in lipopolysaccharide-stimulated mouse macrophages. Biochemical and biophysical research communications 20090424
Gingerol inhibits cisplatin-induced vomiting by down regulating 5-hydroxytryptamine, dopamine and substance P expression in minks. Archives of pharmacal research 20090401
Comparative effects of two gingerol-containing Zingiber officinale extracts on experimental rheumatoid arthritis. Journal of natural products 20090327
Simultaneous determination of 6-gingerol, 8-gingerol, 10-gingerol and 6-shogaol in rat plasma by liquid chromatography-mass spectrometry: Application to pharmacokinetics. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090315
Effect of [10]-gingerol on [ca2+]i and cell death in human colorectal cancer cells. Molecules (Basel, Switzerland) 20090302
[Quality analysis of processing products of dried ginger]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20090301
Modulation of macrophage functions by compounds isolated from Zingiber officinale. Planta medica 20090201
[6]-Gingerol suppresses interleukin-1 beta-induced MUC5AC gene expression in human airway epithelial cells. American journal of rhinology & allergy 20090101
Protective Effect of Ginger oil on Aspirin and Pylorus Ligation-Induced Gastric Ulcer model in Rats. Indian journal of pharmaceutical sciences 20090101
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults. Bioorganic & medicinal chemistry 20081215
6-Shogaol suppressed lipopolysaccharide-induced up-expression of iNOS and COX-2 in murine macrophages. Molecular nutrition & food research 20081201
Plasma pharmacokinetics and tissue distribution of [6]-gingerol in rats. Biopharmaceutics & drug disposition 20081201
Antibacterial activity of [10]-gingerol and [12]-gingerol isolated from ginger rhizome against periodontal bacteria. Phytotherapy research : PTR 20081101
Specific reaction of alpha,beta-unsaturated carbonyl compounds such as 6-shogaol with sulfhydryl groups in tubulin leading to microtubule damage. FEBS letters 20081015
Muscarinic, Ca(++) antagonist and specific butyrylcholinesterase inhibitory activity of dried ginger extract might explain its use in dementia. The Journal of pharmacy and pharmacology 20081001
Cancer is a preventable disease that requires major lifestyle changes. Pharmaceutical research 20080901
6-Shogaol and 6-gingerol, the pungent of ginger, inhibit TNF-alpha mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes. Biochemical and biophysical research communications 20080829
Pharmacokinetics of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol and conjugate metabolites in healthy human subjects. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20080801
Changes in the contents of oleoresin and pungent bioactive principles of Jamaican ginger (Zingiber officinale Roscoe.) during maturation. Journal of agricultural and food chemistry 20080723
Analysis of anti-platelet aggregation components of Rhizoma Zingiberis using chicken thrombocyte extract and high performance liquid chromatography. Chinese medical journal 20080705
Effects of spice constituents on P-glycoprotein-mediated transport and CYP3A4-mediated metabolism in vitro. Drug metabolism and disposition: the biological fate of chemicals 20080701
Inhibitory effect of gingerol on the proliferation and invasion of hepatoma cells in culture. Cytotechnology 20080601
[6]-Gingerol inhibits metastasis of MDA-MB-231 human breast cancer cells. The Journal of nutritional biochemistry 20080501
6-Shogaol induces apoptosis in human colorectal carcinoma cells via ROS production, caspase activation, and GADD 153 expression. Molecular nutrition & food research 20080501
[RP-HPLC fingerprint evaluating different ginger juice as processing material]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080501
Screening of biochemical modulator by tumor cell permeability of doxorubicin. International journal of pharmaceutics 20080416
Systemic administration of [6]-gingerol, a pungent constituent of ginger, induces hypothermia in rats via an inhibitory effect on metabolic rate. European journal of pharmacology 20080414
Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe. Archives of pharmacal research 20080401
Multiple mechanisms are involved in 6-gingerol-induced cell growth arrest and apoptosis in human colorectal cancer cells. Molecular carcinogenesis 20080301
ThermoTRP channels in nociceptors: taking a lead from capsaicin receptor TRPV1. Current neuropharmacology 20080301
Herbal compounds and toxins modulating TRP channels. Current neuropharmacology 20080301
[6]-gingerol induces Ca2+ mobilization in Madin-Darby canine kidney cells. Journal of natural products 20080101
Herb-drug interaction: a case study of effect of ginger on the pharmacokinetic of metronidazole in rabbit. Indian journal of pharmaceutical sciences 20080101
In vitro synthesis of curcuminoids by type III polyketide synthase from Oryza sativa. The Journal of biological chemistry 20071228
Induction of multiple antibiotic resistance in Bacteroides fragilis by benzene and benzene-derived active compounds of commonly used analgesics, antiseptics and cleaning agents. The Journal of antimicrobial chemotherapy 20071201
In vitro and in vivo modulation of testosterone mediated alterations in apoptosis related proteins by [6]-gingerol. Molecular nutrition & food research 20071201
Evaluation of the topical anti-inflammatory activity of ginger dry extracts from solutions and plasters. Planta medica 20071201
Stability of [6]-gingerol and [6]-shogaol in simulated gastric and intestinal fluids. Journal of pharmaceutical and biomedical analysis 20071130
Ginger ingredients reduce viability of gastric cancer cells via distinct mechanisms. Biochemical and biophysical research communications 20071012
High-performance liquid chromatographic analysis of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol in ginger-containing dietary supplements, spices, teas, and beverages. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070901
Evaluation of Ginger (Zingiber officinale Roscoe) Bioactive Compounds in Increasing the Ratio of T-cell Surface Molecules of CD3+CD4+:CD3+CD8+ In-Vitro. Malaysian journal of nutrition 20070901
TRP channels and pain. Biochimica et biophysica acta 20070801
Indian herbal medicines: possible potent therapeutic agents for rheumatoid arthritis. Journal of clinical biochemistry and nutrition 20070701
Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells. Carcinogenesis 20070601
Antioxidant actions of phenolic compounds found in dietary plants on low-density lipoprotein and erythrocytes in vitro. Journal of the American College of Nutrition 20070601
Cancer preventive properties of ginger: a brief review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20070501
Activation of TRPA1 channels by the fatty acid amide hydrolase inhibitor 3'-carbamoylbiphenyl-3-yl cyclohexylcarbamate (URB597). Molecular pharmacology 20070501
[6]-Gingerol prevents UVB-induced ROS production and COX-2 expression in vitro and in vivo. Free radical research 20070501
Effect of 6-gingerol on pro-inflammatory cytokine production and costimulatory molecule expression in murine peritoneal macrophages. The Journal of surgical research 20070401
Liquid chromatographic determination of 6-, 8-, 10-gingerol, and 6-shogaol in ginger (Zingiber officinale) as the raw herb and dried aqueous extract. Journal of AOAC International 20070101
Ginger inhibits cell growth and modulates angiogenic factors in ovarian cancer cells. BMC complementary and alternative medicine 20070101
Microsomal hydroxylation and glucuronidation of [6]-gingerol. Journal of agricultural and food chemistry 20061115
[6]-Gingerol induces cell cycle arrest and cell death of mutant p53-expressing pancreatic cancer cells. Yonsei medical journal 20061031
Determination of 6-gingerol in ginger (Zingiber officinale) using high-performance thin-layer chromatography. Journal of separation science 20061001
Biosynthesis of curcuminoids and gingerols in turmeric (Curcuma longa) and ginger (Zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-CoA thioesterases. Phytochemistry 20060901
Gingerol metabolite and a synthetic analogue Capsarol inhibit macrophage NF-kappaB-mediated iNOS gene expression and enzyme activity. Planta medica 20060601
Variation in concentration and labeling of ginger root dietary supplements. Obstetrics and gynecology 20060601
[Effect of gingerol on endotoxemia mouse model induced by heatstroke]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20060601
Synergistic effect of [10]-gingerol and aminoglycosides against vancomycin-resistant enterococci (VRE). Biological & pharmaceutical bulletin 20060301
Mode of action of gingerols and shogaols on 5-HT3 receptors: binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. European journal of pharmacology 20060113
6-Gingerol prevents cisplatin-induced acute renal failure in rats. BioFactors (Oxford, England) 20060101
Instrument dependence of electrospray ionization and tandem mass spectrometric fragmentation of the gingerols. Rapid communications in mass spectrometry : RCM 20060101
Beneficial effects of Zingiber officinale Roscoe on fructose induced hyperlipidemia and hyperinsulinemia in rats. Indian journal of experimental biology 20051201
Cytotoxic and apoptotic activities of diarylheptanoids and gingerol-related compounds from the rhizome of Chinese ginger. Journal of ethnopharmacology 20051114
Prokinetic effect of a Kampo medicine, Hange-koboku-to (Banxia-houpo-tang), on patients with functional dyspepsia. Phytomedicine : international journal of phytotherapy and phytopharmacology 20051101
Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways. Vascular pharmacology 20051001
[Studies of commonly used traditional medicine-ginger]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20051001
[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo. Biochemical and biophysical research communications 20050923
Biological basis for the use of botanicals in osteoarthritis and rheumatoid arthritis: a review. Evidence-based complementary and alternative medicine : eCAM 20050901
Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways. Journal of cellular biochemistry 20050801
Gingerol content of diploid and tetraploid clones of ginger (Zingiber officinale Roscoe). Journal of agricultural and food chemistry 20050713
Commercially processed dry ginger (Zingiber officinale): composition and effects on LPS-stimulated PGE2 production. Phytochemistry 20050701
Mechanism of inhibition of peroxynitrite-induced oxidation and nitration by [6]-gingerol. Planta medica 20050601
Nutraceuticals and cancer management. Frontiers in bioscience : a journal and virtual library 20050501
[Study on quality standard of extracts from Rhizoma Zingiberis by supercritical fluid extraction]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20050501
[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin. Oncogene 20050407
Effects of dietary chemopreventive phytochemicals on P-glycoprotein function. Biochemical and biophysical research communications 20050218
Analgesic and anti-inflammatory activities of [6]-gingerol. Journal of ethnopharmacology 20050104
Cancer preventive role of selected dietary factors. Indian journal of cancer 20050101
Characterization of gingerol-related compounds in ginger rhizome (Zingiber officinale Rosc.) by high-performance liquid chromatography/electrospray ionization mass spectrometry. Rapid communications in mass spectrometry : RCM 20050101
Suppressive effects of mioga ginger and ginger constituents on reactive oxygen and nitrogen species generation, and the expression of inducible pro-inflammatory genes in macrophages. Antioxidants & redox signaling 20050101
Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Annals of the New York Academy of Sciences 20041201
Fresh organically grown ginger (Zingiber officinale): composition and effects on LPS-induced PGE2 production. Phytochemistry 20040701
Diarylheptanoids from the rhizomes of Zingiber officinale. Phytochemistry 20040401
Protective role of vanilloid receptor type 1 in HCl-induced gastric mucosal lesions in rats. Scandinavian journal of gastroenterology 20040401
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 20040325
Inhibitory effects of [6]-gingerol on PMA-induced COX-2 expression and activation of NF-kappaB and p38 MAPK in mouse skin. BioFactors (Oxford, England) 20040101
Antioxidant properties of gingerol related compounds from ginger. BioFactors (Oxford, England) 20040101
Enhancement of insulin sensitivity in adipocytes by ginger. BioFactors (Oxford, England) 20040101
Kinetic studies on Zingiber officinale. Pakistan journal of pharmaceutical sciences 20040101
Chemoprevention: eat ginger, rub on pomegranate. The Lancet. Oncology 20031201
[6]-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite-induced oxidation and nitration reactions. Life sciences 20031114
Dietary ginger constituents, galanals A and B, are potent apoptosis inducers in Human T lymphoma Jurkat cells. Cancer letters 20030925
Bioassay-guided isolation and identification of antifungal compounds from ginger. Phytotherapy research : PTR 20030901
Extraction of chili, black pepper, and ginger with near-critical CO2, propane, and dimethyl ether: analysis of the extracts by quantitative nuclear magnetic resonance. Journal of agricultural and food chemistry 20030813
Modifications of capsaicin-sensitive neurons in isolated guinea pig ileum by [6]-gingerol and lafutidine. Journal of pharmacological sciences 20030801
Analysis of a ginger extract by high-performance liquid chromatography coupled to nuclear magnetic resonance spectroscopy using superheated deuterium oxide as the mobile phase. Journal of chromatography. A 20030328
Ginger (Zingiber officinale Roscoe) and the gingerols inhibit the growth of Cag A+ strains of Helicobacter pylori. Anticancer research 20030101
Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger. Thrombosis research 20030101
Effects of 6-gingerol, an antioxidant from ginger, on inducing apoptosis in human leukemic HL-60 cells. In vivo (Athens, Greece) 20030101
Regulation of the phosphotyrosine content of human sperm proteins by intracellular Ca2+: role of Ca2+-adenosine triphosphatases. Biology of reproduction 20021101
Gingerols: a novel class of vanilloid receptor (VR1) agonists. British journal of pharmacology 20021101
Use of a fluorescent imaging plate reader--based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. Journal of biomolecular screening 20021001
Anti-tumor promoting potential of selected spice ingredients with antioxidative and anti-inflammatory activities: a short review. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20020801
[HPLC determination of 6-gingerol in Rhizoma Zingiberis Recens]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20020501
Metabolism of [6]-gingerol in rats. Life sciences 20020322
Structure-antiemetic-activity of some diarylheptanoids and their analogues. Phytomedicine : international journal of phytotherapy and phytopharmacology 20020301
The stability of gingerol and shogaol in aqueous solutions. Journal of pharmaceutical sciences 20011001
Gingerols and related analogues inhibit arachidonic acid-induced human platelet serotonin release and aggregation. Thrombosis research 20010901
Effect of ginger constituents and synthetic analogues on cyclooxygenase-2 enzyme in intact cells. Bioorganic chemistry 20010601
Insect growth inhibition, antifeedant and antifungal activity of compounds isolated/derived from Zingiber officinale Roscoe (ginger) rhizomes. Pest management science 20010301
Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol. Cancer research 20010201
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