1-Piperidineethanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-
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Why are most phospholipidosis inducers also hERG blockers? | Archives of toxicology 20171201 |
Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway. | PloS one 20140101 |
Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis. | Neurobiology of disease 20130101 |
Peri-infarct blood-brain barrier dysfunction facilitates induction of spreading depolarization associated with epileptiform discharges. | Neurobiology of disease 20121201 |
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. | British journal of pharmacology 20121101 |
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. | Neuropharmacology 20121101 |
Re-evaluation of in vivo selectivity of [(11)C]SA4503 to σ(1) receptors in the brain: contributions of emopamil binding protein. | Nuclear medicine and biology 20121001 |
Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice. | Neurobiology of disease 20121001 |
Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. | Aging cell 20121001 |
Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats. | Anesthesia and analgesia 20121001 |
Structural changes of regulatory domain heterodimer of N-methyl-D-aspartate receptor subunits GluN1 and GluN2B through the binding of spermine and ifenprodil. | The Journal of pharmacology and experimental therapeutics 20121001 |
Essential role of NR2B-containing NMDA receptor-ERK pathway in nucleus accumbens shell in morphine-associated contextual memory. | Brain research bulletin 20121001 |
Combination therapy of ifenprodil with piroxicam may be an effective therapeutic intervention in cerebral stroke: a hypothesis. | Medical hypotheses 20121001 |
Inflammatory activation enhances NMDA-triggered Ca2+ signalling and IL-1β secretion in primary cultures of rat astrocytes. | Brain research 20120914 |
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. | Neuropharmacology 20120901 |
Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures. | Current Alzheimer research 20120901 |
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway. | Brain research bulletin 20120901 |
Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. | Molecular pharmacology 20120801 |
Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor. | The Journal of biological chemistry 20120720 |
The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation. | Neurochemistry international 20120701 |
Amino-terminal ligands prolong NMDA Receptor-mediated EPSCs. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120606 |
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. | British journal of pharmacology 20120601 |
Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat. | British journal of pharmacology 20120601 |
N-methyl-D-aspartate (NMDA) receptor composition modulates dendritic spine morphology in striatal medium spiny neurons. | The Journal of biological chemistry 20120525 |
Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models. | Pain 20120501 |
The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. | PLoS computational biology 20120401 |
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321 |
Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus. | Journal of neuroscience research 20120301 |
Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels. | Journal of neurophysiology 20120301 |
Ifenprodil for the treatment of flashbacks in female posttraumatic stress disorder patients with a history of childhood sexual abuse. | Biological psychiatry 20120215 |
NMDA-induced ERK signalling is mediated by NR2B subunit in rat cortical neurons and switches from positive to negative depending on stage of development. | Neuropharmacology 20120201 |
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons. | Naunyn-Schmiedeberg's archives of pharmacology 20120201 |
Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures. | Cell calcium 20120201 |
Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. | Translational psychiatry 20120201 |
Confocal microscopy imaging of NR2B-containing NMDA receptors based on fluorescent ifenprodil-like conjugates. | Bioconjugate chemistry 20120118 |
GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine. | Neurochemistry international 20120101 |
Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity. | Cell death & disease 20120101 |
Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats. | Journal of biomedical science 20120101 |
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. | PloS one 20120101 |
Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection. | PloS one 20120101 |
Prion protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate receptor (NMDAR) activity. | PloS one 20120101 |
Dendritic hold and read: a gated mechanism for short term information storage and retrieval. | PloS one 20120101 |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors. | PloS one 20120101 |
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. | International journal of cell biology 20120101 |
An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease. | Parkinson's disease 20120101 |
Properties of doublecortin expressing neurons in the adult mouse dentate gyrus. | PloS one 20120101 |
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. | Journal of medicinal chemistry 20111222 |
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ₁ receptor ligands. | Bioorganic & medicinal chemistry 20111215 |
A critical role for GluN2B-containing NMDA receptors in cortical development and function. | Neuron 20111208 |
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. | Neurobiology of aging 20111201 |
Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors. | Neuropharmacology 20111201 |
NMDA receptors and fear extinction: implications for cognitive behavioral therapy. | Dialogues in clinical neuroscience 20111201 |
Involvement of NMDA receptors in ryanodine receptor expression in dopaminergic neurons in the ventral tegmental area of mice with intermittent methamphetamine treatment. | Synapse (New York, N.Y.) 20111101 |
Chronically saturating levels of endogenous glycine disrupt glutamatergic neurotransmission and enhance synaptogenesis in the CA1 region of mouse hippocampus. | Synapse (New York, N.Y.) 20111101 |
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice. | Journal of neuroscience research 20111101 |
Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20111101 |
Ifenprodil restores GDNF-evoked Ca(2+) signalling and Na(+)/K(+) -ATPase expression in inflammation-pretreated astrocytes. | Journal of neurochemistry 20111101 |
Histamine facilitates consolidation of fear extinction. | The international journal of neuropsychopharmacology 20111001 |
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain. | Brain, behavior, and immunity 20111001 |
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20111001 |
Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. | Neuroscience 20110929 |
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. | Neuron 20110922 |
Discriminative stimulus effects of NMDA, AMPA, and mGluR5 glutamate receptor ligands in methamphetamine-trained rats. | Behavioural pharmacology 20110901 |
Effects of intraoperative low dose ketamine on remifentanil-induced hyperalgesia in gynecologic surgery with sevoflurane anesthesia. | Korean journal of anesthesiology 20110901 |
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831 |
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803 |
CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors. | Neurotoxicology 20110801 |
Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity. | Neurobiology of disease 20110801 |
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. | Nature 20110714 |
Effects of divalent cations on slow unblock of native NMDA receptors in mouse neocortical pyramidal neurons. | The European journal of neuroscience 20110701 |
Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons. | The European journal of neuroscience 20110701 |
An N-methyl-D-aspartate-receptor dependent, late-phase long-term depression in middle-aged mice identifies no GluN2-subunit bias. | Neuroscience 20110630 |
Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro. | The Chinese journal of physiology 20110630 |
Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats. | Alcoholism, clinical and experimental research 20110601 |
Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors. | European journal of medicinal chemistry 20110601 |
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity. | Bioorganic & medicinal chemistry letters 20110601 |
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc. | Cell death & disease 20110601 |
Kynurenine metabolites and migraine: experimental studies and therapeutic perspectives. | Current neuropharmacology 20110601 |
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury. | Brain research 20110510 |
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110504 |
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. | Journal of neurochemistry 20110501 |
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. | Neuron 20110428 |
Influence of GIRK channel inhibition on alcohol abstinence and relapse risk in Japanese alcohol-dependent outpatients. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20110401 |
Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-D-aspartate receptor channels. | Neuroscience 20110317 |
Effects of ifenprodil on morphine-induced conditioned place preference and spatial learning and memory in rats. | Neurochemical research 20110301 |
Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibition. | Neurotoxicology 20110301 |
Amyloid β peptide oligomers directly activate NMDA receptors. | Cell calcium 20110301 |
The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats. | Acta physiologica Hungarica 20110301 |
The Selective Serotonin Reuptake Inhibitor Paroxetine, but not Fluvoxamine, Decreases Methamphetamine Conditioned Place Preference in Mice. | Current neuropharmacology 20110301 |
NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters. | Behavioural brain research 20110202 |
Peripheral N-methyl-d-aspartate receptors contribute to mechanical hypersensitivity in a rat model of inflammatory temporomandibular joint pain. | European journal of pain (London, England) 20110201 |
Down-regulation of synaptic GluN2B subunit-containing N-methyl-D-aspartate receptors: a physiological brake on CA1 neuron α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyperexcitability during benzodiazepine withdrawal. | The Journal of pharmacology and experimental therapeutics 20110101 |
Defining established and emerging microbial risks in the aquatic environment: current knowledge, implications, and outlooks. | International journal of microbiology 20110101 |
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. | Molecular pain 20110101 |
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain. | Journal of neuroinflammation 20110101 |
Endogenous nitric oxide generation linked to ryanodine receptors activates cyclic GMP / protein kinase G pathway for cell proliferation of neural stem/progenitor cells derived from embryonic hippocampus. | Journal of pharmacological sciences 20110101 |
mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. | Journal of biomedical science 20110101 |
Presynaptic NMDA receptors mediate IPSC potentiation at GABAergic synapses in developing rat neocortex. | PloS one 20110101 |
Amino terminal domains of the NMDA receptor are organized as local heterodimers. | PloS one 20110101 |
Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum. | Frontiers in systems neuroscience 20110101 |
Characterization of NMDAR-Independent Learning in the Hippocampus. | Frontiers in behavioral neuroscience 20110101 |
Aberrant methylation of N-methyl-D-aspartate receptor type 2B (NMDAR2B) in non-small cell carcinoma. | BMC cancer 20110101 |
Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. | PloS one 20110101 |
Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat. | PloS one 20110101 |
Neuronal and microglial mechanisms of neuropathic pain. | Molecular brain 20110101 |
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. | PloS one 20110101 |
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala. | PloS one 20110101 |
Huntington's Disease and Striatal Signaling. | Frontiers in neuroanatomy 20110101 |
Modulation of synaptic plasticity by stress hormone associates with plastic alteration of synaptic NMDA receptor in the adult hippocampus. | PloS one 20110101 |
Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression. | Molecular brain 20110101 |
Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. | International journal of otolaryngology 20110101 |
Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. | BMC neuroscience 20110101 |
Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria. | Neurochemistry international 20101201 |
The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors. | Molecular neurobiology 20101201 |
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. | European journal of pharmacology 20101125 |
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. | Bioorganic & medicinal chemistry 20101115 |
Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors. | Journal of pharmaceutical and biomedical analysis 20101102 |
Synthesis and biological evaluation of radio-iodinated benzimidazoles as SPECT imaging agents for NR2B subtype of NMDA receptor. | Bioorganic & medicinal chemistry 20101101 |
Purinergic P2X receptor regulates N-methyl-D-aspartate receptor expression and synaptic excitatory amino acid concentration in morphine-tolerant rats. | Anesthesiology 20101101 |
Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration. | Biochemical and biophysical research communications 20101029 |
Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease. | Experimental neurology 20101001 |
Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. | Neuron 20100923 |
The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two neutral stimuli. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100922 |
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach. | Bioorganic & medicinal chemistry letters 20100915 |
Facilitation of corticostriatal plasticity by the amygdala requires Ca2+-induced Ca2+ release in the ventral striatum. | Journal of neurophysiology 20100901 |
Inhibition of NMDA receptor/NO signaling blocked tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice. | Epilepsy research 20100901 |
Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca(2+) influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly. | Journal of neuroscience research 20100815 |
NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling. | Journal of neurochemistry 20100801 |
Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones. | The European journal of neuroscience 20100801 |
NMDA receptor contributions to visual contrast coding. | Neuron 20100729 |
Rapid activation of dormant presynaptic terminals by phorbol esters. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100728 |
d-Serine modulates neurogenic relaxation in rat corpus cavernosum. | Biochemical pharmacology 20100615 |
Involvement of the spinal NMDA receptor/PKCγ signaling pathway in the development of bone cancer pain. | Brain research 20100604 |
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. | The Journal of pharmacology and experimental therapeutics 20100601 |
Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus. | Journal of neurophysiology 20100601 |
Electrophysiological and morphological properties of Cajal-Retzius cells with different ontogenetic origins. | Neuroscience 20100519 |
Design, Synthesis, and Biological Evaluation of 3-Benzazepin-1-ols as NR2B-Selective NMDA Receptor Antagonists. | ChemMedChem 20100503 |
Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor-mediated synaptic responses. | Hippocampus 20100501 |
The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain. | European journal of pain (London, England) 20100501 |
Polyaminergic agents modulate contextual fear extinction in rats. | Neurobiology of learning and memory 20100501 |
The effects of polyamine agonists and antagonists on N-methyl-D-aspartate-induced depolarizations of amphibian motoneurons in situ. | Brain research 20100414 |
NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test. | Journal of psychopharmacology (Oxford, England) 20100401 |
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. | Nature medicine 20100401 |
Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. | Learning & memory (Cold Spring Harbor, N.Y.) 20100401 |
CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival. | Cell death & disease 20100401 |
NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord. | Neuroscience 20100331 |
Differential NR2B subunit expression at dorsal root and ventrolateral funiculus synapses on lumbar motoneurons of neonatal rat. | Neuroscience 20100317 |
Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil. | Organic & biomolecular chemistry 20100307 |
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site. | The Journal of pharmacology and experimental therapeutics 20100301 |
NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100301 |
Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents. | Neuroscience 20100203 |
NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstem in vitro. | The Journal of physiology 20100201 |
Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells. | Neurochemistry international 20100201 |
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. | Neuroscience 20100120 |
Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. | European journal of pharmacology 20100110 |
The dorsal periaqueductal gray modulates the increased fear-like behavior exhibited by experienced rats in the elevated plus-maze. | Behavioural brain research 20100105 |
Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor. | British journal of pharmacology 20100101 |
The site specific demethylation in the 5'-regulatory area of NMDA receptor 2B subunit gene associated with CIE-induced up-regulation of transcription. | PloS one 20100101 |
A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory. | Frontiers in behavioral neuroscience 20100101 |
Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. | Journal of pharmacological sciences 20100101 |
DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory. | Molecular brain 20100101 |
NR2 subunits and NMDA receptors on lamina II inhibitory and excitatory interneurons of the mouse dorsal horn. | Molecular pain 20100101 |
Molecular structure of ionotropic glutamate receptors. | Current medicinal chemistry 20100101 |
Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging. | Frontiers in aging neuroscience 20100101 |
Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. | PloS one 20100101 |
Amyloid-β induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors. | Journal of Alzheimer's disease : JAD 20100101 |
Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine. | PloS one 20100101 |
Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. | PloS one 20100101 |
Glycine transport inhibitors for the treatment of schizophrenia. | The open medicinal chemistry journal 20100101 |
STDP in the Developing Sensory Neocortex. | Frontiers in synaptic neuroscience 20100101 |
The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. | Neural plasticity 20100101 |
NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment. | Clinical pharmacology : advances and applications 20100101 |
Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors. | Neuroscience 20091229 |
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28). | Journal of medicinal chemistry 20091210 |
Double dissociation of spike timing-dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex. | Cerebral cortex (New York, N.Y. : 1991) 20091201 |
Locus coeruleus activation facilitates memory encoding and induces hippocampal LTD that depends on beta-adrenergic receptor activation. | Cerebral cortex (New York, N.Y. : 1991) 20091201 |
Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. | Neuroscience 20091110 |
Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide. | Biochemical pharmacology 20091015 |
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test. | Psychopharmacology 20091001 |
Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro. | Journal of neurochemistry 20091001 |
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium. | Canadian journal of physiology and pharmacology 20091001 |
NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization. | Neuroscience letters 20090918 |
Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives. | Journal of medicinal chemistry 20090910 |
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. | Bioorganic & medicinal chemistry 20090901 |
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. | Neuropharmacology 20090801 |
Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. | British journal of pharmacology 20090801 |
NR2B subunit-dependent long-term potentiation enhancement in the rat cortical auditory system in vivo following masking of patterned auditory input by white noise exposure during early postnatal life. | The European journal of neuroscience 20090801 |
NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro. | Brain research 20090605 |
The novel NMDA receptor antagonist, 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid, is a gating modifier in cultured mouse cortical neurons. | Journal of neurochemistry 20090601 |
Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum. | The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20090601 |
Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527 |
Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices. | Brain research 20090507 |
Maturation of excitatory synaptic transmission of the rat nucleus accumbens from juvenile to adult. | Journal of neurophysiology 20090501 |
Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. | Journal of neurochemistry 20090401 |
Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes). | The Journal of toxicological sciences 20090401 |
Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat. | Brain research 20090331 |
Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis. | Neuroreport 20090325 |
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus. | Neuroscience 20090303 |
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity. | Neurochemical research 20090301 |
Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression. | Neuropharmacology 20090301 |
Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats. | Anesthesia and analgesia 20090301 |
Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists. | Bioorganic & medicinal chemistry 20090215 |
Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution. | Cerebral cortex (New York, N.Y. : 1991) 20090201 |
Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: laboratory photolysis, biodegradation, and sorption experiments. | Water research 20090201 |
Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. | Experimental neurology 20090201 |
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. | PLoS biology 20090201 |
In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. | Neuroscience 20090112 |
Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats. | Epilepsy & behavior : E&B 20090101 |
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors. | Molecular pharmacology 20090101 |
Complementary roles for amygdala and periaqueductal gray in temporal-difference fear learning. | Learning & memory (Cold Spring Harbor, N.Y.) 20090101 |
Plasticity of NMDA receptor NR2B subunit in memory and chronic pain. | Molecular brain 20090101 |
Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress. | BMC neuroscience 20090101 |
Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors. | BMC neuroscience 20090101 |
NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. | PloS one 20090101 |
Molecular determinants of multiple effects of nickel on NMDA receptor channels. | Neurotoxicity research 20090101 |
Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis. | PloS one 20090101 |
Influence of NR2B-selective NMDA antagonist on lindane-induced seizures in rats. | Pharmacology 20090101 |
Cloning and Phylogenetic Analysis of NMDA Receptor Subunits NR1, NR2A and NR2B in Xenopus laevis Tadpoles. | Frontiers in molecular neuroscience 20090101 |
Migraine: an overview. | The open neurology journal 20090101 |
Synaptic NR2A- but not NR2B-Containing NMDA Receptors Increase with Blockade of Ionotropic Glutamate Receptors. | Frontiers in molecular neuroscience 20090101 |
Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. | Journal of biomedical science 20090101 |
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. | Journal of medicinal chemistry 20081211 |
A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. | Neuropharmacology 20081201 |
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. | Brain : a journal of neurology 20081201 |
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor. | Journal of neurochemistry 20081201 |
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance. | Stroke 20081101 |
The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine. | The Journal of pharmacology and experimental therapeutics 20081001 |
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity. | Journal of neurophysiology 20081001 |
Dopamine D1 receptor inhibition of NMDA receptor currents mediated by tyrosine kinase-dependent receptor trafficking in neonatal rat striatum. | The Journal of physiology 20081001 |
The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation. | PLoS computational biology 20081001 |
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. | Journal of medicinal chemistry 20080925 |
Enhanced expression of RNase L as a novel intracellular signal generated by NMDA receptors in mouse cortical neurons. | Neurochemistry international 20080901 |
Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear. | Learning & memory (Cold Spring Harbor, N.Y.) 20080901 |
A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation. | Experimental cell research 20080815 |
NR2A-containing NMDA receptors depress glutamatergic synaptic transmission and evoked-dopamine release in the mouse striatum. | Journal of neurochemistry 20080801 |
Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory. | Neuropharmacology 20080801 |
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A. | Biochemical and biophysical research communications 20080725 |
GABAA and strychnine-sensitive glycine receptors modulate N-methyl-D-aspartate-evoked acetylcholine release from rat spinal motoneurons: a possible role in neuroprotection. | Neuroscience 20080717 |
Pathway-specificity in N-methyl-D-aspartate receptor-mediated synaptic inputs onto subplate neurons. | Neuroscience 20080602 |
Sustained saturating level of glycine induces changes in NR2B-containing-NMDA receptor localization in the CA1 region of the hippocampus. | Journal of neurochemistry 20080601 |
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. | Alcoholism, clinical and experimental research 20080601 |
Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS. | The Journal of physiology 20080515 |
Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors. | Bioorganic & medicinal chemistry letters 20080501 |
The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear. | Learning & memory (Cold Spring Harbor, N.Y.) 20080501 |
[Determination of ifenprodil in human plasma using liquid chromatography with electrospray tandem mass spectrometry]. | Se pu = Chinese journal of chromatography 20080501 |
Role for the NR2B subunit of the N-methyl-D-aspartate receptor in mediating light input to the circadian system. | The European journal of neuroscience 20080401 |
Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors. | The European journal of neuroscience 20080401 |
Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex. | Cerebral cortex (New York, N.Y. : 1991) 20080301 |
Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N-methyl-D-aspartate receptor activation. | Journal of neuroscience research 20080301 |
Alcohol related changes in regulation of NMDA receptor functions. | Current neuropharmacology 20080301 |
Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors. | European journal of pharmacology 20080226 |
Molecular mechanisms for nanomolar concentrations of neurosteroids at NR1/NR2B receptors. | The Journal of pharmacology and experimental therapeutics 20080201 |
NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. | The Journal of physiology 20080201 |
Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. | PLoS biology 20080201 |
Molecular determinants of Pb2+ interaction with NMDA receptor channels. | Neurochemistry international 20080101 |
The effects of glutamate receptor antagonists on cerebellar granule cell survival and development. | Neurotoxicology 20080101 |
NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol. | Neuroendocrinology 20080101 |
Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. | PloS one 20080101 |
Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function. | PloS one 20080101 |
Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance. | Molecular brain 20080101 |
Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats. | Molecular brain 20080101 |
Assessment of neuroprotection in the retina with DARC. | Progress in brain research 20080101 |
The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex. | Neural plasticity 20080101 |
Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. | Molecular brain 20080101 |
Optical and electrophysiological recordings of corticospinal synaptic activity and its developmental change in in vitro rat slice co-cultures. | Neuroscience 20071219 |
The NR2B subunit in NMDA receptors is functionally important during cerebellar granule cell migration. | Neuroscience letters 20071218 |
The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors. | Molecular pharmacology 20071201 |
A role for polyamines in retinal ganglion cell excitotoxic death. | Journal of neurochemistry 20071101 |
Improving solubility of NR2B amino-terminal domain of N-methyl-d-aspartate receptor expressed in Escherichia coli. | Biochemical and biophysical research communications 20071012 |
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20071003 |
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding. | ChemMedChem 20071001 |
Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies. | Journal of medicinal chemistry 20070920 |
Retinal influences induce bidirectional changes in the kinetics of N-methyl-D-aspartate receptor-mediated responses in striate cortex cells during postnatal development. | Neuroscience 20070907 |
Rapid bidirectional switching of synaptic NMDA receptors. | Neuron 20070906 |
Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070901 |
Effects of ifenprodil on voltage-gated tetrodotoxin-resistant Na+ channels in rat sensory neurons. | European journal of anaesthesiology 20070901 |
PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling. | Journal of neurophysiology 20070901 |
Allosteric theory: taking therapeutic advantage of the malleable nature of GPCRs. | Current neuropharmacology 20070901 |
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. | The Journal of pharmacology and experimental therapeutics 20070801 |
Differential roles of NR2A and NR2B subtypes in NMDA receptor-dependent protein synthesis in dendrites. | Neuropharmacology 20070801 |
Leptin promotes rapid dynamic changes in hippocampal dendritic morphology. | Molecular and cellular neurosciences 20070801 |
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia. | The Journal of pharmacology and experimental therapeutics 20070701 |
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart. | The Journal of pharmacology and experimental therapeutics 20070701 |
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. | Neuropharmacology 20070701 |
Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures. | Brain research 20070529 |
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. | Neuron 20070524 |
Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity. | Neuroscience 20070511 |
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. | Pain 20070501 |
Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. | Neurochemistry international 20070501 |
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site. | Journal of pharmacological sciences 20070501 |
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells. | The Journal of steroid biochemistry and molecular biology 20070501 |
[Developmental changes in synaptic and extrasynaptic N-methyl-D-aspartate receptors in cultured rat hippocampal neurons]. | Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070501 |
Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal. | Alcoholism, clinical and experimental research 20070401 |
NMDA receptor 2B subunit-mediated synaptic transmission in the superficial dorsal horn of peripheral nerve-injured neuropathic mice. | Brain research 20070302 |
Glutamate exocytosis from astrocytes controls synaptic strength. | Nature neuroscience 20070301 |
The role of physiological afferent nerve activity during in vivo maturation of the calyx of Held synapse. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20070214 |
Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption. | Life sciences 20070206 |
NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. | Experimental neurology 20070201 |
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. | Molecular and cellular neurosciences 20070201 |
Effects of ifenprodil on the discriminative stimulus effects of cocaine in rhesus monkeys. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070201 |
Role of tyrosine kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in morphine reward. | Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20070201 |
[NR2B-pERK1/2-pElk-1 signaling contributes to the avoidance learning and memory of rats]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201 |
Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists. | Bioorganic & medicinal chemistry letters 20070115 |
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. | Neuropharmacology 20070101 |
Persistent (>24h) long-term depression in the dentate gyrus of freely moving rats is not dependent on activation of NMDA receptors, L-type voltage-gated calcium channels or protein synthesis. | Neuropharmacology 20070101 |
Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. | Molecular pain 20070101 |
Age-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice. | BMC neuroscience 20070101 |
Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia. | Current medicinal chemistry 20070101 |
Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. | BMC neuroscience 20070101 |
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus. | Hippocampus 20070101 |
Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma. | Neural plasticity 20070101 |
NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia. | Epilepsy research 20061201 |
Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons. | The European journal of neuroscience 20061201 |
[Treatment by medicine which improves cerebral circulation and metabolism]. | Nihon rinsho. Japanese journal of clinical medicine 20061128 |
Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death. | The Journal of biological chemistry 20061117 |
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons. | Journal of neuroscience research 20061115 |
Coordination of presynaptic and postsynaptic maturation in a zebra finch forebrain motor control nucleus during song learning. | The European journal of neuroscience 20061101 |
[Nicergoline, ibudilast, ifenprodil tartrate]. | Nihon rinsho. Japanese journal of clinical medicine 20061028 |
Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors. | The Journal of biological chemistry 20061006 |
Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice. | Neuroscience letters 20060911 |
An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons. | Neuroscience 20060901 |
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor. | Molecular and cellular neurosciences 20060901 |
N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. | Journal of neurochemistry 20060901 |
Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060801 |
Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons. | American journal of physiology. Gastrointestinal and liver physiology 20060801 |
The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats. | Experimental neurology 20060801 |
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060705 |
Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism. | Neurobiology of learning and memory 20060701 |
NR2B subunit exerts a critical role in postischemic synaptic plasticity. | Stroke 20060701 |
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons. | The European journal of neuroscience 20060701 |
Activity-dependent synaptic plasticity in the supraoptic nucleus of the rat hypothalamus. | The Journal of physiology 20060615 |
Implication of Src family kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in the rewarding effect of morphine. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20060601 |
Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse. | The Journal of physiology 20060515 |
Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. | Synapse (New York, N.Y.) 20060501 |
Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias. | Psychopharmacology 20060401 |
Nickel differentially affects NMDA receptor channels in developing cultured rat neurons. | Brain research 20060317 |
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315 |
Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060301 |
Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. | Journal of neurophysiology 20060301 |
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. | Nature 20060223 |
Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. | Brain research 20060216 |
Glutamate-based therapeutic approaches: NR2B receptor antagonists. | Current opinion in pharmacology 20060201 |
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. | Investigative ophthalmology & visual science 20060201 |
Generalization of NMDA-receptor antagonists to the discriminative stimulus effects of kappa-opioid receptor agonists U-50,488H, but not TRK-820 in rats. | Journal of pharmacological sciences 20060201 |
Role of neuronal NR2B subunit-containing NMDA receptor-mediated Ca2+ influx and astrocytic activation in cultured mouse cortical neurons and astrocytes. | Synapse (New York, N.Y.) 20060101 |
NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore. | Current topics in medicinal chemistry 20060101 |
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor. | Journal of medicinal chemistry 20051229 |
Modulation of striatal dopamine release in vitro by agonists of the glycineB site of NMDA receptors; interaction with antipsychotics. | European journal of pharmacology 20051219 |
Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones. | The Journal of physiology 20051115 |
Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex. | British journal of pharmacology 20051101 |
NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. | Neuron 20051020 |
Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia. | The Journal of biological chemistry 20051014 |
Treatment for psychological dependence on morphine: usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens. | Life sciences 20050916 |
Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor. | Protein science : a publication of the Protein Society 20050901 |
Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence. | The European journal of neuroscience 20050901 |
Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons. | The Journal of biological chemistry 20050819 |
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats. | Journal of neurophysiology 20050701 |
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice. | The journal of pain : official journal of the American Pain Society 20050701 |
The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. | Brain research 20050607 |
Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. | The Journal of pharmacology and experimental therapeutics 20050601 |
Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil. | Neuroscience letters 20050513 |
NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives. | Bioorganic & medicinal chemistry letters 20050502 |
Allosteric modulation of 5-HT3 serotonin receptors. | European journal of pharmacology 20050502 |
Neonatal toluene exposure alters agonist and antagonist sensitivity and NR2B subunit expression of NMDA receptors in cultured cerebellar granule neurons. | Toxicological sciences : an official journal of the Society of Toxicology 20050501 |
In vitro characterization of novel NR2B selective NMDA receptor antagonists. | Neurochemistry international 20050501 |
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. | Neuropharmacology 20050501 |
Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. | Neuron 20050421 |
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420 |
Hearing loss raises excitability in the auditory cortex. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413 |
Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat. | Psychopharmacology 20050401 |
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. | Current drug targets. CNS and neurological disorders 20050401 |
AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells. | Brain research. Developmental brain research 20050322 |
Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice. | The Journal of physiology 20050315 |
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302 |
Impairment of conditioned freezing to tone, but not to context, in Fyn-transgenic mice: relationship to NMDA receptor subunit 2B function. | The European journal of neuroscience 20050301 |
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation. | Pain 20050201 |
The effect of dehydroepiandrosterone sulfate and allopregnanolone sulfate on the binding of [(3)H]ifenprodil to the N-methyl-d-aspartate receptor in rat frontal cortex membrane. | The Journal of steroid biochemistry and molecular biology 20050201 |
The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112 |
Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. | Neuroscience 20050101 |
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals. | Neuroscience 20050101 |
The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor. | Neuroscience 20050101 |
The function of the amino terminal domain in NMDA receptor modulation. | Journal of molecular graphics & modelling 20050101 |
The lateral amygdala processes the value of conditioned and unconditioned aversive stimuli. | Neuroscience 20050101 |
Are unconventional NMDA receptors involved in slowly adapting type I mechanoreceptor responses? | Neuroscience 20050101 |
Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation. | Molecular pain 20050101 |
A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity. | Neuroscience 20050101 |
Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms. | Neuroscience 20050101 |
Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats. | Acta neurochirurgica. Supplement 20050101 |
Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041215 |
Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly. | Epilepsia 20041201 |
Brain-derived neurotrophic factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms. | Brain research. Molecular brain research 20041104 |
Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex. | Journal of neurophysiology 20041001 |
Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. | The Journal of pharmacology and experimental therapeutics 20041001 |
Amino terminal domain regulation of NMDA receptor function. | European journal of pharmacology 20041001 |
Lesion-induced enhancement of LTP in rat visual cortex is mediated by NMDA receptors containing the NR2B subunit. | The Journal of physiology 20040915 |
NMDA receptor 2B-selective antagonist ifenprodil-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical neurons. | Brain research 20040910 |
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908 |
Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux. | Journal of neuroscience methods 20040830 |
The role of NMDA receptor binding sites in ethanol place conditioning. | Behavioral neuroscience 20040801 |
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. | The Journal of physiology 20040715 |
Radiosynthesis and pharmacological evaluation of [11C]EMD-95885: a high affinity ligand for NR2B-containing NMDA receptors. | Bioorganic & medicinal chemistry 20040615 |
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia. | Brain research 20040611 |
Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol. | Brain research 20040611 |
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. | Cerebral cortex (New York, N.Y. : 1991) 20040601 |
Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons. | Pain 20040601 |
Nociceptive behavior induced by poly-L-lysine and other basic compounds involves the spinal NMDA receptors. | Brain research 20040515 |
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. | Science (New York, N.Y.) 20040514 |
Pharmacological characterization of the chronic constriction injury model of neuropathic pain. | European journal of pharmacology 20040503 |
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. | Resuscitation 20040501 |
Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cell. | British journal of pharmacology 20040501 |
Re-expression of NR2B-containing NMDA receptors in vitro by suppression of neuronal activity. | International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20040401 |
Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains. | Biological & pharmaceutical bulletin 20040401 |
The effect of endogenous modulator endobain E on NMDA receptor is interfered by Zn2+ but is independent of modulation by spermidine. | Neurochemical research 20040401 |
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice. | Methods and findings in experimental and clinical pharmacology 20040301 |
A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus. | Epilepsy research 20040301 |
Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218 |
The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. | Current medicinal chemistry 20040201 |
SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats. | Alcohol (Fayetteville, N.Y.) 20040201 |
Injury-induced alterations in N-methyl-D-aspartate receptor subunit composition contribute to prolonged 45calcium accumulation following lateral fluid percussion. | Neuroscience 20040101 |
Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding to N-terminal domains. | Doklady. Biochemistry and biophysics 20040101 |
Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons. | The Journal of pharmacology and experimental therapeutics 20031201 |
Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[(11)C]one, as a potent NR(1A)/2B subtype selective NMDA PET radiotracer. | Bioorganic & medicinal chemistry 20031201 |
Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil. | Alcoholism, clinical and experimental research 20031201 |
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201 |
NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20031112 |
Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. | Alcoholism, clinical and experimental research 20031101 |
Glutamatergic transmission in opiate and alcohol dependence. | Annals of the New York Academy of Sciences 20031101 |
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging. | Journal of neuroscience methods 20031015 |
Effect of the NR3 subunit on ethanol inhibition of recombinant NMDA receptors. | Brain research 20031010 |
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice. | Experimental neurology 20031001 |
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo. | The European journal of neuroscience 20031001 |
Effects of NMDA receptor antagonists on acute mu-opioid analgesia in the rat. | Pharmacology, biochemistry, and behavior 20030901 |
The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze. | European journal of pharmacology 20030829 |
Polyamines in a genetic animal model of paroxysmal dyskinesia. | Brain research 20030815 |
Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. | Journal of neurophysiology 20030801 |
Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B synapses in the adult central amygdala. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030730 |
Enhanced GABA(A) receptor-mediated activity following activation of NMDA receptors in Cajal-Retzius cells in the developing mouse neocortex. | The Journal of physiology 20030701 |
Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context. | Journal of neurochemistry 20030701 |
Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor. | Alcoholism, clinical and experimental research 20030701 |
Therapeutic N-methyl-D-aspartate receptor antagonists: will reality meet expectation? | Current opinion in investigational drugs (London, England : 2000) 20030701 |
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. | European journal of pharmacology 20030620 |
NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615 |
ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons and attenuates NMDA-mediated neurotoxicity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615 |
Synthesis of chiral 1-[omega-(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at sigma1, sigma2, and sterol delta8-delta7 isomerase sites. | Journal of medicinal chemistry 20030522 |
Expression of behavioral sensitization to ethanol by DBA/2J mice: the role of NMDA and non-NMDA glutamate receptors. | Psychopharmacology 20030501 |
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins. | Kidney international 20030501 |
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures. | Neuroscience letters 20030501 |
Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine. | Behavioural pharmacology 20030501 |
NMDA-receptor antagonism via dextromethorphan and ifenprodil modulates graded anxiety test performance of C57BL/6 mice. | Behavioural pharmacology 20030501 |
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415 |
PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat. | The Journal of physiology 20030401 |
Contribution of NR2B subunits to synaptic transmission in amygdaloid interneurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030401 |
Excitatory synaptic transmission in the lateral and central amygdala. | Annals of the New York Academy of Sciences 20030401 |
Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity. | FEBS letters 20030313 |
Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor. | Journal of neurophysiology 20030201 |
Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies. | Neurobiology of disease 20030201 |
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. | Neurochemistry international 20030101 |
Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol. | The Journal of pharmacology and experimental therapeutics 20030101 |
Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. | Journal of neurophysiology 20030101 |
Lack of ifenprodil anxiolytic activity after its multiple treatment in chronically ethanol-treated rats. | Alcohol and alcoholism (Oxford, Oxfordshire) 20030101 |
Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists. | Neurotoxicity research 20030101 |
Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl-D-aspartate receptors. | Neuroscience 20030101 |
Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. | Brain research. Developmental brain research 20021215 |
Ethanol sensitivity of NMDA receptors. | Neurochemistry international 20021201 |
Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line. | The European journal of neuroscience 20021201 |
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism. | Brain research 20021011 |
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. | Brain research 20021011 |
Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity. | Anesthesiology 20021001 |
Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. | Alcoholism, clinical and experimental research 20021001 |
Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil. | Brain research. Molecular brain research 20020930 |
Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis. | European journal of pharmacology 20020927 |
Differential regulation of synaptic and extra-synaptic NMDA receptors. | Nature neuroscience 20020901 |
Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations. | Neurobiology of learning and memory 20020901 |
Axonal projection, input and output synapses, and synaptic physiology of Cajal-Retzius cells in the developing rat neocortex. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020815 |
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity. | Naunyn-Schmiedeberg's archives of pharmacology 20020801 |
Increase in glutamate-induced neurotoxicity by activated astrocytes involves stimulation of protein kinase C. | Journal of neurochemistry 20020801 |
Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020715 |
Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors. | Nuclear medicine and biology 20020701 |
NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615 |
Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression. | The Journal of pharmacology and experimental therapeutics 20020601 |
Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats. | European journal of pharmacology 20020524 |
Subtypes of NMDA receptors in new-born rat hippocampal granule cells. | The Journal of physiology 20020515 |
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. | Nature neuroscience 20020501 |
Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem. | The Journal of physiology 20020501 |
Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat. | Alcoholism, clinical and experimental research 20020501 |
Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses. | Journal of neuroscience research 20020501 |
Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat. | Movement disorders : official journal of the Movement Disorder Society 20020501 |
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
NMDA receptor-mediated currents in rat cerebellar granule and unipolar brush cells. | Journal of neurophysiology 20020401 |
Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes. | British journal of pharmacology 20020401 |
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses. | Neuron 20020314 |
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. | Brain research. Molecular brain research 20020131 |
A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. | Journal of neuroscience methods 20020115 |
An MCASE approach to the search of a cure for Parkinson's Disease. | BMC pharmacology 20020101 |
NR2B selective NMDA receptor antagonists. | Current pharmaceutical design 20020101 |
Effect of multiple ifenprodil or spermidine treatment on social recognition in rats. | Journal of basic and clinical physiology and pharmacology 20020101 |
Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. | Neuron 20011120 |
Distinct NMDA and AMPA receptor-mediated responses in mouse and human Cajal-Retzius cells. | Journal of neurophysiology 20011101 |
[A case of eosinophilic pneumonia possibly due to ifenprodil]. | Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20011101 |
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord. | The European journal of neuroscience 20011101 |
Hypoxia-induced [(3)H]D-aspartate release from isolated bovine retina: modulation by calcium-channel blockers and glutamatergic agonists and antagonists. | Current eye research 20011101 |
Lead inhibition of NMDA channels in native and recombinant receptors. | Neuroreport 20011008 |
Establishment of CHO cell lines expressing four N-methyl-D-aspartate receptor subtypes and characterization of a novel antagonist PPDC. | FEBS letters 20011005 |
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. | Journal of neurophysiology 20011001 |
Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus. | Journal of neuroendocrinology 20011001 |
Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010901 |
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. | Nature neuroscience 20010901 |
NMDA receptor pharmacology: perspectives from molecular biology. | Current drug targets 20010901 |
Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action. | Current drug targets 20010901 |
The NMDA receptor complex: a promising target for novel antiepileptic strategies. | Current medicinal chemistry 20010901 |
Developmental depression of glutamate neurotransmission by chronic low-level activation of NMDA receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815 |
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine. | European journal of pharmacology 20010629 |
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. | Journal of neurophysiology 20010601 |
Polyamine and redox modulation of [3H]MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex. | Pharmacology & toxicology 20010601 |
Ontogeny of ionotropic glutamate receptor expression in human fetal brain. | Brain research. Developmental brain research 20010430 |
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. | European journal of pharmacology 20010330 |
Dynamic modulation of NMDA-induced responses by ifenprodil in rat prefrontal cortex. | Synapse (New York, N.Y.) 20010315 |
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons. | Journal of neurochemistry 20010301 |
A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke. | Brain research 20010223 |
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. | Neuropharmacology 20010101 |
Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits. | The Journal of pharmacology and experimental therapeutics 20010101 |
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition. | Journal of neurochemistry 20010101 |
Expression of ionotropic glutamate receptors in the retina of the rdta transgenic mouse. | BMC neuroscience 20010101 |
Effects of centrally-acting glutamatergic modulators on cardiovascular responses to stress in humans. | Journal of cardiology 20010101 |
Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. | Neuroscience 20010101 |
Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. | Pediatric research 20000401 |
Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex. | Neuropharmacology 20000128 |
Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema. | Archives of toxicology 20000101 |
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. | The Journal of physiology 19981001 |
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. | European journal of pharmacology 19970411 |
N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. | Nature medicine 19961201 |
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice. | Brain research 19950206 |
Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine. | European journal of pharmacology 19901106 |
[Effects of 2-(4-benzyl-piperidino)-1-(4-hydroxyphenyl)-1-propanol (ifenprodil) on the cardiovascular system in vivo]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19750901 |