Home Other Building Blocks 1-Piperidineethanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-

1-Piperidineethanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-

CAS No.:
23210-56-2
Catalog Number:
AG002MJD
Molecular Formula:
C21H27NO2
Molecular Weight:
325.4446
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Purity
Availability
Location
Price(USD)
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Product Description
Catalog Number:
AG002MJD
Chemical Name:
1-Piperidineethanol, α-(4-hydroxyphenyl)-β-methyl-4-(phenylmethyl)-
CAS Number:
23210-56-2
Molecular Formula:
C21H27NO2
Molecular Weight:
325.4446
MDL Number:
MFCD00209873
IUPAC Name:
4-[2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl]phenol
InChI:
InChI=1S/C21H27NO2/c1-16(21(24)19-7-9-20(23)10-8-19)22-13-11-18(12-14-22)15-17-5-3-2-4-6-17/h2-10,16,18,21,23-24H,11-15H2,1H3
InChI Key:
UYNVMODNBIQBMV-UHFFFAOYSA-N
SMILES:
Oc1ccc(cc1)C(C(N1CCC(CC1)Cc1ccccc1)C)O
UNII:
R8OE3P6O5S
Properties
Complexity:
353  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
325.204g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
325.452g/mol
Monoisotopic Mass:
325.204g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
43.7A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
XLogP3:
3.9  
Literature
Title Journal
Why are most phospholipidosis inducers also hERG blockers? Archives of toxicology 20171201
Efficacy of lovastatin on learning and memory deficits caused by chronic intermittent hypoxia-hypercapnia: through regulation of NR2B-containing NMDA receptor-ERK pathway. PloS one 20140101
Thiol oxidation and altered NR2B/NMDA receptor functions in in vitro and in vivo pilocarpine models: implications for epileptogenesis. Neurobiology of disease 20130101
Peri-infarct blood-brain barrier dysfunction facilitates induction of spreading depolarization associated with epileptiform discharges. Neurobiology of disease 20121201
K+ depolarization evokes ATP, adenosine and glutamate release from glia in rat hippocampus: a microelectrode biosensor study. British journal of pharmacology 20121101
Ifenprodil, a NR2B-selective antagonist of NMDA receptor, inhibits reverse Na+/Ca2+ exchanger in neurons. Neuropharmacology 20121101
Re-evaluation of in vivo selectivity of [(11)C]SA4503 to σ(1) receptors in the brain: contributions of emopamil binding protein. Nuclear medicine and biology 20121001
Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice. Neurobiology of disease 20121001
Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. Aging cell 20121001
Resveratrol regulates N-methyl-D-aspartate receptor expression and suppresses neuroinflammation in morphine-tolerant rats. Anesthesia and analgesia 20121001
Structural changes of regulatory domain heterodimer of N-methyl-D-aspartate receptor subunits GluN1 and GluN2B through the binding of spermine and ifenprodil. The Journal of pharmacology and experimental therapeutics 20121001
Essential role of NR2B-containing NMDA receptor-ERK pathway in nucleus accumbens shell in morphine-associated contextual memory. Brain research bulletin 20121001
Combination therapy of ifenprodil with piroxicam may be an effective therapeutic intervention in cerebral stroke: a hypothesis. Medical hypotheses 20121001
Inflammatory activation enhances NMDA-triggered Ca2+ signalling and IL-1β secretion in primary cultures of rat astrocytes. Brain research 20120914
TCN 201 selectively blocks GluN2A-containing NMDARs in a GluN1 co-agonist dependent but non-competitive manner. Neuropharmacology 20120901
Amyloid-beta peptide 1-42 causes microtubule deregulation through N-methyl-D-aspartate receptors in mature hippocampal cultures. Current Alzheimer research 20120901
Creatine increases hippocampal Na(+),K(+)-ATPase activity via NMDA-calcineurin pathway. Brain research bulletin 20120901
Mapping the binding of GluN2B-selective N-methyl-D-aspartate receptor negative allosteric modulators. Molecular pharmacology 20120801
Cleavage of the NR2B subunit amino terminus of N-methyl-D-aspartate (NMDA) receptor by tissue plasminogen activator: identification of the cleavage site and characterization of ifenprodil and glycine affinities on truncated NMDA receptor. The Journal of biological chemistry 20120720
The expression of NR2B subunit of NMDA receptor in the suprachiasmatic nucleus of Wistar rats and its role in glutamate-induced CREB and ERK1/2 phosphorylation. Neurochemistry international 20120701
Amino-terminal ligands prolong NMDA Receptor-mediated EPSCs. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120606
Direct pharmacological monitoring of the developmental switch in NMDA receptor subunit composition using TCN 213, a GluN2A-selective, glycine-dependent antagonist. British journal of pharmacology 20120601
Subtype selective NMDA receptor antagonists induce recovery of synapses lost following exposure to HIV-1 Tat. British journal of pharmacology 20120601
N-methyl-D-aspartate (NMDA) receptor composition modulates dendritic spine morphology in striatal medium spiny neurons. The Journal of biological chemistry 20120525
Effect of NMDA NR2B antagonist on neuropathic pain in two spinal cord injury models. Pain 20120501
The effects of NMDA subunit composition on calcium influx and spike timing-dependent plasticity in striatal medium spiny neurons. PLoS computational biology 20120401
Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321
Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus. Journal of neuroscience research 20120301
Ifenprodil reduces excitatory synaptic transmission by blocking presynaptic P/Q type calcium channels. Journal of neurophysiology 20120301
Ifenprodil for the treatment of flashbacks in female posttraumatic stress disorder patients with a history of childhood sexual abuse. Biological psychiatry 20120215
NMDA-induced ERK signalling is mediated by NR2B subunit in rat cortical neurons and switches from positive to negative depending on stage of development. Neuropharmacology 20120201
Role of GluN2A and GluN2B subunits in the formation of filopodia and secondary dendrites in cultured hippocampal neurons. Naunyn-Schmiedeberg's archives of pharmacology 20120201
Amyloid beta peptide 1-42 disturbs intracellular calcium homeostasis through activation of GluN2B-containing N-methyl-d-aspartate receptors in cortical cultures. Cell calcium 20120201
Forebrain glutamatergic neurons mediate leptin action on depression-like behaviors and synaptic depression. Translational psychiatry 20120201
Confocal microscopy imaging of NR2B-containing NMDA receptors based on fluorescent ifenprodil-like conjugates. Bioconjugate chemistry 20120118
GluN2B-containing NMDA receptors as possible targets for the neuroprotective and antidepressant effects of fluoxetine. Neurochemistry international 20120101
Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity. Cell death & disease 20120101
Dual regulation by ethanol of the inhibitory effects of ketamine on spinal NMDA-induced pressor responses in rats. Journal of biomedical science 20120101
Brain deletion of insulin receptor substrate 2 disrupts hippocampal synaptic plasticity and metaplasticity. PloS one 20120101
Selective regulation of NR2B by protein phosphatase-1 for the control of the NMDA receptor in neuroprotection. PloS one 20120101
Prion protein is a key determinant of alcohol sensitivity through the modulation of N-methyl-D-aspartate receptor (NMDAR) activity. PloS one 20120101
Dendritic hold and read: a gated mechanism for short term information storage and retrieval. PloS one 20120101
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by ifenprodil: the role of sigma-1 and IP3 receptors. PloS one 20120101
Mitochondrial- and endoplasmic reticulum-associated oxidative stress in Alzheimer's disease: from pathogenesis to biomarkers. International journal of cell biology 20120101
An NR2B-Dependent Decrease in the Expression of trkB Receptors Precedes the Disappearance of Dopaminergic Cells in Substantia Nigra in a Rat Model of Presymptomatic Parkinson's Disease. Parkinson's disease 20120101
Properties of doublecortin expressing neurons in the adult mouse dentate gyrus. PloS one 20120101
Synthesis and biological characterization of 3-substituted-1H-indoles as ligands of GluN2B-containing N-methyl-D-aspartate receptors. Journal of medicinal chemistry 20111222
Synthesis and binding assays of novel 3,3-dimethylpiperidine derivatives with various lipophilicities as σ₁ receptor ligands. Bioorganic & medicinal chemistry 20111215
A critical role for GluN2B-containing NMDA receptors in cortical development and function. Neuron 20111208
Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiology of aging 20111201
Chronic administration of the anabolic androgenic steroid nandrolone alters neurosteroid action at the sigma-1 receptor but not at the sigma-2 or NMDA receptors. Neuropharmacology 20111201
NMDA receptors and fear extinction: implications for cognitive behavioral therapy. Dialogues in clinical neuroscience 20111201
Involvement of NMDA receptors in ryanodine receptor expression in dopaminergic neurons in the ventral tegmental area of mice with intermittent methamphetamine treatment. Synapse (New York, N.Y.) 20111101
Chronically saturating levels of endogenous glycine disrupt glutamatergic neurotransmission and enhance synaptogenesis in the CA1 region of mouse hippocampus. Synapse (New York, N.Y.) 20111101
NR2B phosphorylation at tyrosine 1472 in spinal dorsal horn contributed to N-methyl-D-aspartate-induced pain hypersensitivity in mice. Journal of neuroscience research 20111101
Overexpression of Reelin prevents the manifestation of behavioral phenotypes related to schizophrenia and bipolar disorder. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20111101
Ifenprodil restores GDNF-evoked Ca(2+) signalling and Na(+)/K(+) -ATPase expression in inflammation-pretreated astrocytes. Journal of neurochemistry 20111101
Histamine facilitates consolidation of fear extinction. The international journal of neuropsychopharmacology 20111001
Neuronal NR2B-containing NMDA receptor mediates spinal astrocytic c-Jun N-terminal kinase activation in a rat model of neuropathic pain. Brain, behavior, and immunity 20111001
Synthesis of a series of γ-amino alcohols comprising an N-methyl isoindoline moiety and their evaluation as NMDA receptor antagonists. Bioorganic & medicinal chemistry letters 20111001
Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors. Neuroscience 20110929
Distinct modes of AMPA receptor suppression at developing synapses by GluN2A and GluN2B: single-cell NMDA receptor subunit deletion in vivo. Neuron 20110922
Discriminative stimulus effects of NMDA, AMPA, and mGluR5 glutamate receptor ligands in methamphetamine-trained rats. Behavioural pharmacology 20110901
Effects of intraoperative low dose ketamine on remifentanil-induced hyperalgesia in gynecologic surgery with sevoflurane anesthesia. Korean journal of anesthesiology 20110901
Kalirin binds the NR2B subunit of the NMDA receptor, altering its synaptic localization and function. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110831
Opposing synaptic regulation of amyloid-β metabolism by NMDA receptors in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110803
CGX-1007 prevents excitotoxic cell death via actions at multiple types of NMDA receptors. Neurotoxicology 20110801
Misplaced NMDA receptors in epileptogenesis contribute to excitotoxicity. Neurobiology of disease 20110801
Subunit arrangement and phenylethanolamine binding in GluN1/GluN2B NMDA receptors. Nature 20110714
Effects of divalent cations on slow unblock of native NMDA receptors in mouse neocortical pyramidal neurons. The European journal of neuroscience 20110701
Role of P2X4 receptors in synaptic strengthening in mouse CA1 hippocampal neurons. The European journal of neuroscience 20110701
An N-methyl-D-aspartate-receptor dependent, late-phase long-term depression in middle-aged mice identifies no GluN2-subunit bias. Neuroscience 20110630
Involvement of synaptic NR2B-containing NMDA receptors in long-term depression induction in the young rat visual cortex in vitro. The Chinese journal of physiology 20110630
Effect of the selective NMDA NR2B antagonist, ifenprodil, on acute tolerance to ethanol-induced motor impairment in adolescent and adult rats. Alcoholism, clinical and experimental research 20110601
Synthesis, evaluation and metabolic studies of radiotracers containing a 4-(4-[18F]-fluorobenzyl)piperidin-1-yl moiety for the PET imaging of NR2B NMDA receptors. European journal of medicinal chemistry 20110601
2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity. Bioorganic & medicinal chemistry letters 20110601
New therapeutic targets in Alzheimer's disease: brain deregulation of calcium and zinc. Cell death & disease 20110601
Kynurenine metabolites and migraine: experimental studies and therapeutic perspectives. Current neuropharmacology 20110601
The neuroprotective effects of NMDAR antagonist, ifenprodil and ASIC1a inhibitor, flurbiprofen on post-ischemic cerebral injury. Brain research 20110510
Soluble Aβ oligomers inhibit long-term potentiation through a mechanism involving excessive activation of extrasynaptic NR2B-containing NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20110504
Pre-synaptic glycine GlyT1 transporter--NMDA receptor interaction: relevance to NMDA autoreceptor activation in the presence of Mg2+ ions. Journal of neurochemistry 20110501
mGluR5 and NMDA receptors drive the experience- and activity-dependent NMDA receptor NR2B to NR2A subunit switch. Neuron 20110428
Influence of GIRK channel inhibition on alcohol abstinence and relapse risk in Japanese alcohol-dependent outpatients. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20110401
Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-D-aspartate receptor channels. Neuroscience 20110317
Effects of ifenprodil on morphine-induced conditioned place preference and spatial learning and memory in rats. Neurochemical research 20110301
Lead exposure during synaptogenesis alters NMDA receptor targeting via NMDA receptor inhibition. Neurotoxicology 20110301
Amyloid β peptide oligomers directly activate NMDA receptors. Cell calcium 20110301
The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats. Acta physiologica Hungarica 20110301
The Selective Serotonin Reuptake Inhibitor Paroxetine, but not Fluvoxamine, Decreases Methamphetamine Conditioned Place Preference in Mice. Current neuropharmacology 20110301
NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters. Behavioural brain research 20110202
Peripheral N-methyl-d-aspartate receptors contribute to mechanical hypersensitivity in a rat model of inflammatory temporomandibular joint pain. European journal of pain (London, England) 20110201
Down-regulation of synaptic GluN2B subunit-containing N-methyl-D-aspartate receptors: a physiological brake on CA1 neuron α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid hyperexcitability during benzodiazepine withdrawal. The Journal of pharmacology and experimental therapeutics 20110101
Defining established and emerging microbial risks in the aquatic environment: current knowledge, implications, and outlooks. International journal of microbiology 20110101
Involvement of spinal NR2B-containing NMDA receptors in oxaliplatin-induced mechanical allodynia in rats. Molecular pain 20110101
Inhibition of spinal astrocytic c-Jun N-terminal kinase (JNK) activation correlates with the analgesic effects of ketamine in neuropathic pain. Journal of neuroinflammation 20110101
Endogenous nitric oxide generation linked to ryanodine receptors activates cyclic GMP / protein kinase G pathway for cell proliferation of neural stem/progenitor cells derived from embryonic hippocampus. Journal of pharmacological sciences 20110101
mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. Journal of biomedical science 20110101
Presynaptic NMDA receptors mediate IPSC potentiation at GABAergic synapses in developing rat neocortex. PloS one 20110101
Amino terminal domains of the NMDA receptor are organized as local heterodimers. PloS one 20110101
Dissecting the contribution of individual receptor subunits to the enhancement of N-methyl-d-aspartate currents by dopamine D1 receptor activation in striatum. Frontiers in systems neuroscience 20110101
Characterization of NMDAR-Independent Learning in the Hippocampus. Frontiers in behavioral neuroscience 20110101
Aberrant methylation of N-methyl-D-aspartate receptor type 2B (NMDAR2B) in non-small cell carcinoma. BMC cancer 20110101
Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. PloS one 20110101
Functional refinement in the projection from ventral cochlear nucleus to lateral superior olive precedes hearing onset in rat. PloS one 20110101
Neuronal and microglial mechanisms of neuropathic pain. Molecular brain 20110101
CDK5 is essential for soluble amyloid β-induced degradation of GKAP and remodeling of the synaptic actin cytoskeleton. PloS one 20110101
Activity dependent protein degradation is critical for the formation and stability of fear memory in the amygdala. PloS one 20110101
Huntington's Disease and Striatal Signaling. Frontiers in neuroanatomy 20110101
Modulation of synaptic plasticity by stress hormone associates with plastic alteration of synaptic NMDA receptor in the adult hippocampus. PloS one 20110101
Slice orientation and muscarinic acetylcholine receptor activation determine the involvement of N-methyl D-aspartate receptor subunit GluN2B in hippocampal area CA1 long-term depression. Molecular brain 20110101
Mechanisms of aminoglycoside ototoxicity and targets of hair cell protection. International journal of otolaryngology 20110101
Kalirin-7 is necessary for normal NMDA receptor-dependent synaptic plasticity. BMC neuroscience 20110101
Requirement of both NR3A and NR3B subunits for dominant negative properties on Ca2+ mobilization mediated by acquired N-methyl-D-aspartate receptor channels into mitochondria. Neurochemistry international 20101201
The biochemistry, ultrastructure, and subunit assembly mechanism of AMPA receptors. Molecular neurobiology 20101201
The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil. European journal of pharmacology 20101125
Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols. Bioorganic & medicinal chemistry 20101115
Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors. Journal of pharmaceutical and biomedical analysis 20101102
Synthesis and biological evaluation of radio-iodinated benzimidazoles as SPECT imaging agents for NR2B subtype of NMDA receptor. Bioorganic & medicinal chemistry 20101101
Purinergic P2X receptor regulates N-methyl-D-aspartate receptor expression and synaptic excitatory amino acid concentration in morphine-tolerant rats. Anesthesiology 20101101
Allosteric modulation of the NMDA receptor by neurosteroids in rat brain and the impact of long term morphine administration. Biochemical and biophysical research communications 20101029
Lack of efficacy of NMDA receptor-NR2B selective antagonists in the R6/2 model of Huntington disease. Experimental neurology 20101001
Casein kinase 2 regulates the NR2 subunit composition of synaptic NMDA receptors. Neuron 20100923
The basolateral amygdala is critical for the acquisition and extinction of associations between a neutral stimulus and a learned danger signal but not between two neutral stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100922
Identification of a novel NR2B-selective NMDA receptor antagonist using a virtual screening approach. Bioorganic & medicinal chemistry letters 20100915
Facilitation of corticostriatal plasticity by the amygdala requires Ca2+-induced Ca2+ release in the ventral striatum. Journal of neurophysiology 20100901
Inhibition of NMDA receptor/NO signaling blocked tolerance to the anticonvulsant effect of morphine on pentylenetetrazole-induced seizures in mice. Epilepsy research 20100901
Preferential inhibition by antidiarrheic 2-methoxy-4-methylphenol of Ca(2+) influx across acquired N-methyl-D-aspartate receptor channels composed of NR1/NR2B subunit assembly. Journal of neuroscience research 20100815
NR2B-NMDA receptor-mediated increases in intracellular Ca2+ concentration regulate the tyrosine phosphatase, STEP, and ERK MAP kinase signaling. Journal of neurochemistry 20100801
Functional heterogeneity of NMDA receptors in rat substantia nigra pars compacta and reticulata neurones. The European journal of neuroscience 20100801
NMDA receptor contributions to visual contrast coding. Neuron 20100729
Rapid activation of dormant presynaptic terminals by phorbol esters. The Journal of neuroscience : the official journal of the Society for Neuroscience 20100728
d-Serine modulates neurogenic relaxation in rat corpus cavernosum. Biochemical pharmacology 20100615
Involvement of the spinal NMDA receptor/PKCγ signaling pathway in the development of bone cancer pain. Brain research 20100604
Implementation of a fluorescence-based screening assay identifies histamine H3 receptor antagonists clobenpropit and iodophenpropit as subunit-selective N-methyl-D-aspartate receptor antagonists. The Journal of pharmacology and experimental therapeutics 20100601
Stoichiometry of N-methyl-D-aspartate receptors within the suprachiasmatic nucleus. Journal of neurophysiology 20100601
Electrophysiological and morphological properties of Cajal-Retzius cells with different ontogenetic origins. Neuroscience 20100519
Design, Synthesis, and Biological Evaluation of 3-Benzazepin-1-ols as NR2B-Selective NMDA Receptor Antagonists. ChemMedChem 20100503
Distinct trafficking and expression mechanisms underlie LTP and LTD of NMDA receptor-mediated synaptic responses. Hippocampus 20100501
The role of N-methyl-D-aspartate receptor subunit NR2B in spinal cord in cancer pain. European journal of pain (London, England) 20100501
Polyaminergic agents modulate contextual fear extinction in rats. Neurobiology of learning and memory 20100501
The effects of polyamine agonists and antagonists on N-methyl-D-aspartate-induced depolarizations of amphibian motoneurons in situ. Brain research 20100414
NMDA receptor antagonists augment antidepressant-like effects of lithium in the mouse forced swimming test. Journal of psychopharmacology (Oxford, England) 20100401
Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures. Nature medicine 20100401
Synaptic plasticity and NO-cGMP-PKG signaling coordinately regulate ERK-driven gene expression in the lateral amygdala and in the auditory thalamus following Pavlovian fear conditioning. Learning & memory (Cold Spring Harbor, N.Y.) 20100401
CXCL12 inhibits expression of the NMDA receptor's NR2B subunit through a histone deacetylase-dependent pathway contributing to neuronal survival. Cell death & disease 20100401
NMDA receptors in primary afferents require phosphorylation by Src family kinases to induce substance P release in the rat spinal cord. Neuroscience 20100331
Differential NR2B subunit expression at dorsal root and ventrolateral funiculus synapses on lumbar motoneurons of neonatal rat. Neuroscience 20100317
Copper-catalyzed amination of (bromophenyl)ethanolamine for a concise synthesis of aniline-containing analogues of NMDA NR2B antagonist ifenprodil. Organic & biomolecular chemistry 20100307
Histamine potentiates N-methyl-D-aspartate receptors by interacting with an allosteric site distinct from the polyamine binding site. The Journal of pharmacology and experimental therapeutics 20100301
NMDA NR2B subtype-selective receptor antagonists fail to antagonize electrically-precipitated seizures and elicit popping in mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20100301
Temperature dependence of N-methyl-D-aspartate receptor channels and N-methyl-D-aspartate receptor excitatory postsynaptic currents. Neuroscience 20100203
NMDAR-mediated EPSCs are maintained and accelerate in time course during maturation of mouse and rat auditory brainstem in vitro. The Journal of physiology 20100201
Effect of hydrogen sulfide on intracellular calcium homeostasis in neuronal cells. Neurochemistry international 20100201
Selective vulnerability of hippocampal cornu ammonis 1 pyramidal cells to excitotoxic insult is associated with the expression of polyamine-sensitive N-methyl-D-asparate-type glutamate receptors. Neuroscience 20100120
Hippocampal NMDA receptors and anxiety: at the interface between cognition and emotion. European journal of pharmacology 20100110
The dorsal periaqueductal gray modulates the increased fear-like behavior exhibited by experienced rats in the elevated plus-maze. Behavioural brain research 20100105
Mapping the high-affinity binding domain of 5-substituted benzimidazoles to the proximal N-terminus of the GluN2B subunit of the NMDA receptor. British journal of pharmacology 20100101
The site specific demethylation in the 5'-regulatory area of NMDA receptor 2B subunit gene associated with CIE-induced up-regulation of transcription. PloS one 20100101
A role for nitric oxide-driven retrograde signaling in the consolidation of a fear memory. Frontiers in behavioral neuroscience 20100101
Inhibition by 2-methoxy-4-ethylphenol of Ca2+ influx through acquired and native N-methyl-D-aspartate-receptor channels. Journal of pharmacological sciences 20100101
DREAM (downstream regulatory element antagonist modulator) contributes to synaptic depression and contextual fear memory. Molecular brain 20100101
NR2 subunits and NMDA receptors on lamina II inhibitory and excitatory interneurons of the mouse dorsal horn. Molecular pain 20100101
Molecular structure of ionotropic glutamate receptors. Current medicinal chemistry 20100101
Selective Vulnerabilities of N-methyl-D-aspartate (NMDA) Receptors During Brain Aging. Frontiers in aging neuroscience 20100101
Synaptic plasticity and NO-cGMP-PKG signaling regulate pre- and postsynaptic alterations at rat lateral amygdala synapses following fear conditioning. PloS one 20100101
Amyloid-β induces caspase-dependent loss of PSD-95 and synaptophysin through NMDA receptors. Journal of Alzheimer's disease : JAD 20100101
Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine. PloS one 20100101
Synaptic neurotransmission depression in ventral tegmental dopamine neurons and cannabinoid-associated addictive learning. PloS one 20100101
Glycine transport inhibitors for the treatment of schizophrenia. The open medicinal chemistry journal 20100101
STDP in the Developing Sensory Neocortex. Frontiers in synaptic neuroscience 20100101
The NO-cGMP-PKG signaling pathway coordinately regulates ERK and ERK-driven gene expression at pre- and postsynaptic sites following LTP-inducing stimulation of thalamo-amygdala synapses. Neural plasticity 20100101
NMDA receptors are expressed by small-cell lung cancer and are potential targets for effective treatment. Clinical pharmacology : advances and applications 20100101
Selective effects of neonatal handling on rat brain N-methyl-D-aspartate receptors. Neuroscience 20091229
Exploring the importance of piperazine N-atoms for sigma(2) receptor affinity and activity in a series of analogs of 1-cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28). Journal of medicinal chemistry 20091210
Double dissociation of spike timing-dependent potentiation and depression by subunit-preferring NMDA receptor antagonists in mouse barrel cortex. Cerebral cortex (New York, N.Y. : 1991) 20091201
Locus coeruleus activation facilitates memory encoding and induces hippocampal LTD that depends on beta-adrenergic receptor activation. Cerebral cortex (New York, N.Y. : 1991) 20091201
Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience 20091110
Spinal ERK activation via NO-cGMP pathway contributes to nociceptive behavior induced by morphine-3-glucuronide. Biochemical pharmacology 20091015
NMDA receptor/nitrergic system blockage augments antidepressant-like effects of paroxetine in the mouse forced swimming test. Psychopharmacology 20091001
Glutamate receptor properties of human mesencephalic neural progenitor cells: NMDA enhances dopaminergic neurogenesis in vitro. Journal of neurochemistry 20091001
N-methyl-D-aspartate-evoked adenosine and inosine release from neurons requires extracellular calcium. Canadian journal of physiology and pharmacology 20091001
NR2A/B-containing NMDA receptors mediate cocaine-induced synaptic plasticity in the VTA and cocaine psychomotor sensitization. Neuroscience letters 20090918
Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives. Journal of medicinal chemistry 20090910
Synthesis, structural activity-relationships, and biological evaluation of novel amide-based allosteric binding site antagonists in NR1A/NR2B N-methyl-D-aspartate receptors. Bioorganic & medicinal chemistry 20090901
The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B. Neuropharmacology 20090801
Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. British journal of pharmacology 20090801
NR2B subunit-dependent long-term potentiation enhancement in the rat cortical auditory system in vivo following masking of patterned auditory input by white noise exposure during early postnatal life. The European journal of neuroscience 20090801
NR2A-containing NMDA receptors are required for LTP induction in rat dorsolateral striatum in vitro. Brain research 20090605
The novel NMDA receptor antagonist, 2-hydroxy-5-(2,3,5,6-tetrafluoro-4-trifluoromethyl-benzylamino)-benzoic acid, is a gating modifier in cultured mouse cortical neurons. Journal of neurochemistry 20090601
Electrophysiological Characterization of AMPA and NMDA Receptors in Rat Dorsal Striatum. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20090601
Prolonged withdrawal from repeated noncontingent cocaine exposure increases NMDA receptor expression and ERK activity in the nucleus accumbens. The Journal of neuroscience : the official journal of the Society for Neuroscience 20090527
Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices. Brain research 20090507
Maturation of excitatory synaptic transmission of the rat nucleus accumbens from juvenile to adult. Journal of neurophysiology 20090501
Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. Journal of neurochemistry 20090401
Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes). The Journal of toxicological sciences 20090401
Impaired axonal transport and neurofilament compaction occur in separate populations of injured axons following diffuse brain injury in the immature rat. Brain research 20090331
Amygdala depotentiation ex vivo requires mitogen-activated protein kinases and protein synthesis. Neuroreport 20090325
Late phase of long-term potentiation induced by co-application of N-methyl-d-aspartic acid and the antagonist of NR2B-containing N-methyl-d-aspartic acid receptors in rat hippocampus. Neuroscience 20090303
N-methyl-D-aspartate receptor antagonists have variable affect in 3-nitropropionic acid toxicity. Neurochemical research 20090301
Isoflurane anaesthesia reversibly improves cognitive function and long-term potentiation (LTP) via an up-regulation in NMDA receptor 2B subunit expression. Neuropharmacology 20090301
Ifenprodil induced antinociception and decreased the expression of NR2B subunits in the dorsal horn after chronic dorsal root ganglia compression in rats. Anesthesia and analgesia 20090301
Development of 3-substituted-1H-indole derivatives as NR2B/NMDA receptor antagonists. Bioorganic & medicinal chemistry 20090215
Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution. Cerebral cortex (New York, N.Y. : 1991) 20090201
Persistence and partitioning of eight selected pharmaceuticals in the aquatic environment: laboratory photolysis, biodegradation, and sorption experiments. Water research 20090201
Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain. Experimental neurology 20090201
Neto1 is a novel CUB-domain NMDA receptor-interacting protein required for synaptic plasticity and learning. PLoS biology 20090201
In developing hippocampal neurons, NR2B-containing N-methyl-D-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death. Neuroscience 20090112
Different effects of two N-methyl-D-aspartate receptor antagonists on seizures, spontaneous behavior, and motor performance in immature rats. Epilepsy & behavior : E&B 20090101
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors. Molecular pharmacology 20090101
Complementary roles for amygdala and periaqueductal gray in temporal-difference fear learning. Learning & memory (Cold Spring Harbor, N.Y.) 20090101
Plasticity of NMDA receptor NR2B subunit in memory and chronic pain. Molecular brain 20090101
Genomic and biochemical approaches in the discovery of mechanisms for selective neuronal vulnerability to oxidative stress. BMC neuroscience 20090101
Effects of NR1 splicing on NR1/NR3B-type excitatory glycine receptors. BMC neuroscience 20090101
NMDA receptor stimulation induces reversible fission of the neuronal endoplasmic reticulum. PloS one 20090101
Molecular determinants of multiple effects of nickel on NMDA receptor channels. Neurotoxicity research 20090101
Reelin secreted by GABAergic neurons regulates glutamate receptor homeostasis. PloS one 20090101
Influence of NR2B-selective NMDA antagonist on lindane-induced seizures in rats. Pharmacology 20090101
Cloning and Phylogenetic Analysis of NMDA Receptor Subunits NR1, NR2A and NR2B in Xenopus laevis Tadpoles. Frontiers in molecular neuroscience 20090101
Migraine: an overview. The open neurology journal 20090101
Synaptic NR2A- but not NR2B-Containing NMDA Receptors Increase with Blockade of Ionotropic Glutamate Receptors. Frontiers in molecular neuroscience 20090101
Attenuation by dextromethorphan on the higher liability to morphine-induced reward, caused by prenatal exposure of morphine in rat offspring. Journal of biomedical science 20090101
Novel 4-(4-aryl)cyclohexyl-1-(2-pyridyl)piperazines as Delta(8)-Delta(7) sterol isomerase (emopamil binding protein) selective ligands with antiproliferative activity. Journal of medicinal chemistry 20081211
A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. Neuropharmacology 20081201
A novel non-transcriptional pathway mediates the proconvulsive effects of interleukin-1beta. Brain : a journal of neurology 20081201
Binding of spermine and ifenprodil to a purified, soluble regulatory domain of the N-methyl-D-aspartate receptor. Journal of neurochemistry 20081201
Differential roles of NMDA receptor subtypes in ischemic neuronal cell death and ischemic tolerance. Stroke 20081101
The pore region of N-methyl-D-aspartate receptors differentially influences stimulation and block by spermine. The Journal of pharmacology and experimental therapeutics 20081001
NMDA receptor antagonists reveal age-dependent differences in the properties of visual cortical plasticity. Journal of neurophysiology 20081001
Dopamine D1 receptor inhibition of NMDA receptor currents mediated by tyrosine kinase-dependent receptor trafficking in neonatal rat striatum. The Journal of physiology 20081001
The effects of NR2 subunit-dependent NMDA receptor kinetics on synaptic transmission and CaMKII activation. PLoS computational biology 20081001
Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists. Journal of medicinal chemistry 20080925
Enhanced expression of RNase L as a novel intracellular signal generated by NMDA receptors in mouse cortical neurons. Neurochemistry international 20080901
Distinct contributions of the basolateral amygdala and the medial prefrontal cortex to learning and relearning extinction of context conditioned fear. Learning & memory (Cold Spring Harbor, N.Y.) 20080901
A critical importance of polyamine site in NMDA receptors for neurite outgrowth and fasciculation at early stages of P19 neuronal differentiation. Experimental cell research 20080815
NR2A-containing NMDA receptors depress glutamatergic synaptic transmission and evoked-dopamine release in the mouse striatum. Journal of neurochemistry 20080801
Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory. Neuropharmacology 20080801
Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A. Biochemical and biophysical research communications 20080725
GABAA and strychnine-sensitive glycine receptors modulate N-methyl-D-aspartate-evoked acetylcholine release from rat spinal motoneurons: a possible role in neuroprotection. Neuroscience 20080717
Pathway-specificity in N-methyl-D-aspartate receptor-mediated synaptic inputs onto subplate neurons. Neuroscience 20080602
Sustained saturating level of glycine induces changes in NR2B-containing-NMDA receptor localization in the CA1 region of the hippocampus. Journal of neurochemistry 20080601
Age and gender differences in response to neonatal ethanol withdrawal and polyamine challenge in organotypic hippocampal cultures. Alcoholism, clinical and experimental research 20080601
Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS. The Journal of physiology 20080515
Reactive derivatives for affinity labeling in the ifenprodil site of NMDA receptors. Bioorganic & medicinal chemistry letters 20080501
The basolateral amygdala is necessary for learning but not relearning extinction of context conditioned fear. Learning & memory (Cold Spring Harbor, N.Y.) 20080501
[Determination of ifenprodil in human plasma using liquid chromatography with electrospray tandem mass spectrometry]. Se pu = Chinese journal of chromatography 20080501
Role for the NR2B subunit of the N-methyl-D-aspartate receptor in mediating light input to the circadian system. The European journal of neuroscience 20080401
Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors. The European journal of neuroscience 20080401
Functional maturation of excitatory synapses in layer 3 pyramidal neurons during postnatal development of the primate prefrontal cortex. Cerebral cortex (New York, N.Y. : 1991) 20080301
Spermine induces cell death in cultured human embryonic cerebral cortical neurons through N-methyl-D-aspartate receptor activation. Journal of neuroscience research 20080301
Alcohol related changes in regulation of NMDA receptor functions. Current neuropharmacology 20080301
Intrathecal high-dose histamine induces spinally-mediated nociceptive behavioral responses through a polyamine site of NMDA receptors. European journal of pharmacology 20080226
Molecular mechanisms for nanomolar concentrations of neurosteroids at NR1/NR2B receptors. The Journal of pharmacology and experimental therapeutics 20080201
NR2B- and NR2D-containing synaptic NMDA receptors in developing rat substantia nigra pars compacta dopaminergic neurones. The Journal of physiology 20080201
Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. PLoS biology 20080201
Molecular determinants of Pb2+ interaction with NMDA receptor channels. Neurochemistry international 20080101
The effects of glutamate receptor antagonists on cerebellar granule cell survival and development. Neurotoxicology 20080101
NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol. Neuroendocrinology 20080101
Expression of NR2B in cerebellar granule cells specifically facilitates effect of motor training on motor learning. PloS one 20080101
Prenatal activation of microglia induces delayed impairment of glutamatergic synaptic function. PloS one 20080101
Cingulate NMDA NR2B receptors contribute to morphine-induced analgesic tolerance. Molecular brain 20080101
Induction- and conditioning-protocol dependent involvement of NR2B-containing NMDA receptors in synaptic potentiation and contextual fear memory in the hippocampal CA1 region of rats. Molecular brain 20080101
Assessment of neuroprotection in the retina with DARC. Progress in brain research 20080101
The role of NMDA receptor subtypes in short-term plasticity in the rat entorhinal cortex. Neural plasticity 20080101
Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Molecular brain 20080101
Optical and electrophysiological recordings of corticospinal synaptic activity and its developmental change in in vitro rat slice co-cultures. Neuroscience 20071219
The NR2B subunit in NMDA receptors is functionally important during cerebellar granule cell migration. Neuroscience letters 20071218
The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors. Molecular pharmacology 20071201
A role for polyamines in retinal ganglion cell excitotoxic death. Journal of neurochemistry 20071101
Improving solubility of NR2B amino-terminal domain of N-methyl-d-aspartate receptor expressed in Escherichia coli. Biochemical and biophysical research communications 20071012
Enhanced astrocytic Ca2+ signals contribute to neuronal excitotoxicity after status epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience 20071003
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding. ChemMedChem 20071001
Design and evaluation of naphthol- and carbazole-containing fluorescent sigma ligands as potential probes for receptor binding studies. Journal of medicinal chemistry 20070920
Retinal influences induce bidirectional changes in the kinetics of N-methyl-D-aspartate receptor-mediated responses in striate cortex cells during postnatal development. Neuroscience 20070907
Rapid bidirectional switching of synaptic NMDA receptors. Neuron 20070906
Acquisition of fear extinction requires activation of NR2B-containing NMDA receptors in the lateral amygdala. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20070901
Effects of ifenprodil on voltage-gated tetrodotoxin-resistant Na+ channels in rat sensory neurons. European journal of anaesthesiology 20070901
PREGS induces LTP in the hippocampal dentate gyrus of adult rats via the tyrosine phosphorylation of NR2B coupled to ERK/CREB [corrected] signaling. Journal of neurophysiology 20070901
Allosteric theory: taking therapeutic advantage of the malleable nature of GPCRs. Current neuropharmacology 20070901
Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits. The Journal of pharmacology and experimental therapeutics 20070801
Differential roles of NR2A and NR2B subtypes in NMDA receptor-dependent protein synthesis in dendrites. Neuropharmacology 20070801
Leptin promotes rapid dynamic changes in hippocampal dendritic morphology. Molecular and cellular neurosciences 20070801
Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia. The Journal of pharmacology and experimental therapeutics 20070701
sigma(2)-receptor ligand-mediated inhibition of inwardly rectifying K(+) channels in the heart. The Journal of pharmacology and experimental therapeutics 20070701
Excitotoxicity in vitro by NR2A- and NR2B-containing NMDA receptors. Neuropharmacology 20070701
Changes in NMDA receptor-induced cyclic nucleotide synthesis regulate the age-dependent increase in PDE4A expression in primary cortical cultures. Brain research 20070529
A critical period for enhanced synaptic plasticity in newly generated neurons of the adult brain. Neuron 20070524
Sex-related differences in NMDA-evoked rat masseter muscle afferent discharge result from estrogen-mediated modulation of peripheral NMDA receptor activity. Neuroscience 20070511
Prolonged maintenance of capsaicin-induced hyperalgesia by brief daily vibration stimuli. Pain 20070501
Dextromethorphan attenuates trimethyltin-induced neurotoxicity via sigma1 receptor activation in rats. Neurochemistry international 20070501
Intrathecally administered D-cycloserine produces nociceptive behavior through the activation of N-methyl-D-aspartate receptor ion-channel complex acting on the glycine recognition site. Journal of pharmacological sciences 20070501
Neurosteroids alter glutamate-induced changes in neurite morphology of NG108-15 cells. The Journal of steroid biochemistry and molecular biology 20070501
[Developmental changes in synaptic and extrasynaptic N-methyl-D-aspartate receptors in cultured rat hippocampal neurons]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20070501
Baclofen blocks expression and sensitization of anxiety-like behavior in an animal model of repeated stress and ethanol withdrawal. Alcoholism, clinical and experimental research 20070401
NMDA receptor 2B subunit-mediated synaptic transmission in the superficial dorsal horn of peripheral nerve-injured neuropathic mice. Brain research 20070302
Glutamate exocytosis from astrocytes controls synaptic strength. Nature neuroscience 20070301
The role of physiological afferent nerve activity during in vivo maturation of the calyx of Held synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience 20070214
Changes in function of NMDA receptor NR2B subunit in spinal cord of rats with neuropathy following chronic ethanol consumption. Life sciences 20070206
NR2B-containing NMDA receptor is required for morphine-but not stress-induced reinstatement. Experimental neurology 20070201
Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Molecular and cellular neurosciences 20070201
Effects of ifenprodil on the discriminative stimulus effects of cocaine in rhesus monkeys. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070201
Role of tyrosine kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in morphine reward. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20070201
[NR2B-pERK1/2-pElk-1 signaling contributes to the avoidance learning and memory of rats]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201
Kynurenic acid amides as novel NR2B selective NMDA receptor antagonists. Bioorganic & medicinal chemistry letters 20070115
Activation of NR2B-containing NMDA receptors is not required for NMDA receptor-dependent long-term depression. Neuropharmacology 20070101
Persistent (>24h) long-term depression in the dentate gyrus of freely moving rats is not dependent on activation of NMDA receptors, L-type voltage-gated calcium channels or protein synthesis. Neuropharmacology 20070101
Pharmacological isolation of postsynaptic currents mediated by NR2A- and NR2B-containing NMDA receptors in the anterior cingulate cortex. Molecular pain 20070101
Age-related declines in a two-day reference memory task are associated with changes in NMDA receptor subunits in mice. BMC neuroscience 20070101
Polyamines in the brain: distribution, biological interactions, and their potential therapeutic role in brain ischaemia. Current medicinal chemistry 20070101
Role of NMDA receptor subtypes in different forms of NMDA-dependent synaptic plasticity. BMC neuroscience 20070101
Effects of exercise on NMDA receptor subunit contributions to bidirectional synaptic plasticity in the mouse dentate gyrus. Hippocampus 20070101
Blockade of cochlear NMDA receptors prevents long-term tinnitus during a brief consolidation window after acoustic trauma. Neural plasticity 20070101
NR2B antagonists restrict spatiotemporal spread of activity in a rat model of cortical dysplasia. Epilepsy research 20061201
Postnatal switching of NMDA receptor subunits from NR2B to NR2A in rat facial motor neurons. The European journal of neuroscience 20061201
[Treatment by medicine which improves cerebral circulation and metabolism]. Nihon rinsho. Japanese journal of clinical medicine 20061128
Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death. The Journal of biological chemistry 20061117
Brain-derived neurotrophic factor regulation of N-methyl-D-aspartate receptor-mediated synaptic currents in suprachiasmatic nucleus neurons. Journal of neuroscience research 20061115
Coordination of presynaptic and postsynaptic maturation in a zebra finch forebrain motor control nucleus during song learning. The European journal of neuroscience 20061101
[Nicergoline, ibudilast, ifenprodil tartrate]. Nihon rinsho. Japanese journal of clinical medicine 20061028
Interleukin-1 beta released by gp120 drives neural death through tyrosine phosphorylation and trafficking of NMDA receptors. The Journal of biological chemistry 20061006
Conantokins and variants derived from cone snail venom inhibit naloxone-induced withdrawal jumping in morphine-dependent mice. Neuroscience letters 20060911
An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons. Neuroscience 20060901
A genetically modified mouse model probing the selective action of ifenprodil at the N-methyl-D-aspartate type 2B receptor. Molecular and cellular neurosciences 20060901
N-methyl-D-aspartate receptor antagonists enhance histamine neuron activity in rodent brain. Journal of neurochemistry 20060901
Hallucinogen-induced UP states in the brain slice of rat prefrontal cortex: role of glutamate spillover and NR2B-NMDA receptors. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060801
Experimental colitis modulates the functional properties of NMDA receptors in dorsal root ganglia neurons. American journal of physiology. Gastrointestinal and liver physiology 20060801
The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats. Experimental neurology 20060801
Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060705
Histamine enhances inhibitory avoidance memory consolidation through a H2 receptor-dependent mechanism. Neurobiology of learning and memory 20060701
NR2B subunit exerts a critical role in postischemic synaptic plasticity. Stroke 20060701
Taurine potentiates presynaptic NMDA receptors in hippocampal Schaffer collateral axons. The European journal of neuroscience 20060701
Activity-dependent synaptic plasticity in the supraoptic nucleus of the rat hypothalamus. The Journal of physiology 20060615
Implication of Src family kinase-dependent phosphorylation of NR2B subunit-containing NMDA receptor in the rewarding effect of morphine. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20060601
Developmental remodelling of the lemniscal synapse in the ventral basal thalamus of the mouse. The Journal of physiology 20060515
Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse (New York, N.Y.) 20060501
Effects of N-methyl-D-aspartate receptor antagonism on neuroleptic-induced orofacial dyskinesias. Psychopharmacology 20060401
Nickel differentially affects NMDA receptor channels in developing cultured rat neurons. Brain research 20060317
Developmental changes in NMDA neurotoxicity reflect developmental changes in subunit composition of NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20060315
Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060301
Synaptic and extrasynaptic NMDA receptor NR2 subunits in cultured hippocampal neurons. Journal of neurophysiology 20060301
NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia. Nature 20060223
Early chronic blockade of NR2B subunits and transient activation of NMDA receptors modulate LTP in mouse auditory cortex. Brain research 20060216
Glutamate-based therapeutic approaches: NR2B receptor antagonists. Current opinion in pharmacology 20060201
Assessment of neuroprotective effects of glutamate modulation on glaucoma-related retinal ganglion cell apoptosis in vivo. Investigative ophthalmology & visual science 20060201
Generalization of NMDA-receptor antagonists to the discriminative stimulus effects of kappa-opioid receptor agonists U-50,488H, but not TRK-820 in rats. Journal of pharmacological sciences 20060201
Role of neuronal NR2B subunit-containing NMDA receptor-mediated Ca2+ influx and astrocytic activation in cultured mouse cortical neurons and astrocytes. Synapse (New York, N.Y.) 20060101
NR2B selective NMDA antagonists: the evolution of the ifenprodil-type pharmacophore. Current topics in medicinal chemistry 20060101
Methyl substitution on the piperidine ring of N-[omega-(6-methoxynaphthalen-1-yl)alkyl] derivatives as a probe for selective binding and activity at the sigma(1) receptor. Journal of medicinal chemistry 20051229
Modulation of striatal dopamine release in vitro by agonists of the glycineB site of NMDA receptors; interaction with antipsychotics. European journal of pharmacology 20051219
Functional NR2B- and NR2D-containing NMDA receptor channels in rat substantia nigra dopaminergic neurones. The Journal of physiology 20051115
Low concentrations of neuroactive steroids alter kinetics of [3H]ifenprodil binding to the NMDA receptor in rat frontal cortex. British journal of pharmacology 20051101
NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII. Neuron 20051020
Transcription of the NR1 subunit of the N-methyl-D-aspartate receptor is down-regulated by excitotoxic stimulation and cerebral ischemia. The Journal of biological chemistry 20051014
Treatment for psychological dependence on morphine: usefulness of inhibiting NMDA receptor and its associated protein kinase in the nucleus accumbens. Life sciences 20050916
Expression and characterization of soluble amino-terminal domain of NR2B subunit of N-methyl-D-aspartate receptor. Protein science : a publication of the Protein Society 20050901
Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence. The European journal of neuroscience 20050901
Microtubule regulation of N-methyl-D-aspartate receptor channels in neurons. The Journal of biological chemistry 20050819
Prolonged NMDA-mediated responses, altered ifenprodil sensitivity, and epileptiform-like events in the malformed hippocampus of methylazoxymethanol exposed rats. Journal of neurophysiology 20050701
Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice. The journal of pain : official journal of the American Pain Society 20050701
The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. Brain research 20050607
Effects of the N-methyl-D-aspartate receptor antagonist perzinfotel [EAA-090; [2-(8,9-dioxo-2,6-diazabicyclo[5.2.0]non-1(7)-en-2-yl)-ethyl]phosphonic acid] on chemically induced thermal hypersensitivity. The Journal of pharmacology and experimental therapeutics 20050601
Production of NGF, BDNF and GDNF in mouse astrocyte cultures is strongly enhanced by a cerebral vasodilator, ifenprodil. Neuroscience letters 20050513
NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives. Bioorganic & medicinal chemistry letters 20050502
Allosteric modulation of 5-HT3 serotonin receptors. European journal of pharmacology 20050502
Neonatal toluene exposure alters agonist and antagonist sensitivity and NR2B subunit expression of NMDA receptors in cultured cerebellar granule neurons. Toxicological sciences : an official journal of the Society of Toxicology 20050501
In vitro characterization of novel NR2B selective NMDA receptor antagonists. Neurochemistry international 20050501
The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology 20050501
Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron 20050421
Diminished neuronal activity increases neuron-neuron connectivity underlying silent synapse formation and the rapid conversion of silent to functional synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050420
Hearing loss raises excitability in the auditory cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050413
Evidence for improved performance in cognitive tasks following selective NR2B NMDA receptor antagonist pre-treatment in the rat. Psychopharmacology 20050401
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. Current drug targets. CNS and neurological disorders 20050401
AMPA and NMDA receptor-mediated currents in developing dentate gyrus granule cells. Brain research. Developmental brain research 20050322
Reduced glycine transporter type 1 expression leads to major changes in glutamatergic neurotransmission of CA1 hippocampal neurones in mice. The Journal of physiology 20050315
Neurosteroid-induced plasticity of immature synapses via retrograde modulation of presynaptic NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050302
Impairment of conditioned freezing to tone, but not to context, in Fyn-transgenic mice: relationship to NMDA receptor subunit 2B function. The European journal of neuroscience 20050301
Pronociceptive role of dynorphins in uninjured animals: N-ethylmaleimide-induced nociceptive behavior mediated through inhibition of dynorphin degradation. Pain 20050201
The effect of dehydroepiandrosterone sulfate and allopregnanolone sulfate on the binding of [(3)H]ifenprodil to the N-methyl-d-aspartate receptor in rat frontal cortex membrane. The Journal of steroid biochemistry and molecular biology 20050201
The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. The Journal of neuroscience : the official journal of the Society for Neuroscience 20050112
Alterations in glutamatergic and gabaergic ion channel activity in hippocampal neurons following exposure to the abused inhalant toluene. Neuroscience 20050101
The non-peptidic delta opioid receptor agonist TAN-67 enhances dopamine efflux in the nucleus accumbens of freely moving rats via a mechanism that involves both glutamate and free radicals. Neuroscience 20050101
The effects of alanine-substituted conantokin-G and ifenprodil on the human spermine-activated N-methyl-D-aspartate receptor. Neuroscience 20050101
The function of the amino terminal domain in NMDA receptor modulation. Journal of molecular graphics & modelling 20050101
The lateral amygdala processes the value of conditioned and unconditioned aversive stimuli. Neuroscience 20050101
Are unconventional NMDA receptors involved in slowly adapting type I mechanoreceptor responses? Neuroscience 20050101
Spinal cord NR1 serine phosphorylation and NR2B subunit suppression following peripheral inflammation. Molecular pain 20050101
A single day of ethanol exposure during development has persistent effects on bi-directional plasticity, N-methyl-D-aspartate receptor function and ethanol sensitivity. Neuroscience 20050101
Acute effects of ethanol on hippocampal long-term potentiation and long-term depression are mediated by different mechanisms. Neuroscience 20050101
Ifenprodil treatment is associated with a down-regulation of brain aquaporin 4 following cardiac arrest in rats. Acta neurochirurgica. Supplement 20050101
Impaired synaptic function in the microglial KARAP/DAP12-deficient mouse. The Journal of neuroscience : the official journal of the Society for Neuroscience 20041215
Altered expression of neurotransmitter-receptor subunit and uptake site mRNAs in hemimegalencephaly. Epilepsia 20041201
Brain-derived neurotrophic factor acutely enhances tyrosine phosphorylation of the AMPA receptor subunit GluR1 via NMDA receptor-dependent mechanisms. Brain research. Molecular brain research 20041104
Protective effect of ifenprodil against spreading depression in the mouse entorhinal cortex. Journal of neurophysiology 20041001
Chronic morphine treatment alters N-methyl-D-aspartate receptors in freshly isolated neurons from nucleus accumbens. The Journal of pharmacology and experimental therapeutics 20041001
Amino terminal domain regulation of NMDA receptor function. European journal of pharmacology 20041001
Lesion-induced enhancement of LTP in rat visual cortex is mediated by NMDA receptors containing the NR2B subunit. The Journal of physiology 20040915
NMDA receptor 2B-selective antagonist ifenprodil-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in cultured rat cortical neurons. Brain research 20040910
Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040908
Kinetic characterization of novel NR2B antagonists using fluorescence detection of calcium flux. Journal of neuroscience methods 20040830
The role of NMDA receptor binding sites in ethanol place conditioning. Behavioral neuroscience 20040801
Extrasynaptic NR2B and NR2D subunits of NMDA receptors shape 'superslow' afterburst EPSC in rat hippocampus. The Journal of physiology 20040715
Radiosynthesis and pharmacological evaluation of [11C]EMD-95885: a high affinity ligand for NR2B-containing NMDA receptors. Bioorganic & medicinal chemistry 20040615
The neuroprotective effects of N1-dansyl-spermine in the gerbil model of cerebral ischaemia. Brain research 20040611
Role of NMDA receptor subtypes in the induction of catalepsy and increase in Fos protein expression after administration of haloperidol. Brain research 20040611
NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cerebral cortex (New York, N.Y. : 1991) 20040601
Electrophysiological characterization of N-methyl-D-aspartate receptors in rat dorsal root ganglia neurons. Pain 20040601
Nociceptive behavior induced by poly-L-lysine and other basic compounds involves the spinal NMDA receptors. Brain research 20040515
Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science (New York, N.Y.) 20040514
Pharmacological characterization of the chronic constriction injury model of neuropathic pain. European journal of pharmacology 20040503
Effect of ifenprodil, a polyamine site NMDA receptor antagonist, on brain edema formation following asphyxial cardiac arrest in rats. Resuscitation 20040501
Schaffer collateral and perforant path inputs activate different subtypes of NMDA receptors on the same CA1 pyramidal cell. British journal of pharmacology 20040501
Re-expression of NR2B-containing NMDA receptors in vitro by suppression of neuronal activity. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 20040401
Synthesis of 11C-labelled bis(phenylalkyl)amines and their in vitro and in vivo binding properties in rodent and monkey brains. Biological & pharmaceutical bulletin 20040401
The effect of endogenous modulator endobain E on NMDA receptor is interfered by Zn2+ but is independent of modulation by spermidine. Neurochemical research 20040401
Effects of NMDA receptor-related agonists on learning and memory impairment in olfactory bulbectomized mice. Methods and findings in experimental and clinical pharmacology 20040301
A comparison of three NMDA receptor antagonists in the treatment of prolonged status epilepticus. Epilepsy research 20040301
Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis. The Journal of neuroscience : the official journal of the Society for Neuroscience 20040218
The NMDA receptor NR2B subunit: a valid therapeutic target for multiple CNS pathologies. Current medicinal chemistry 20040201
SB242084, flumazenil, and CRA1000 block ethanol withdrawal-induced anxiety in rats. Alcohol (Fayetteville, N.Y.) 20040201
Injury-induced alterations in N-methyl-D-aspartate receptor subunit composition contribute to prolonged 45calcium accumulation following lateral fluid percussion. Neuroscience 20040101
Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding to N-terminal domains. Doklady. Biochemistry and biophysics 20040101
Chronic ethanol ingestion facilitates N-methyl-D-aspartate receptor function and expression in rat lateral/basolateral amygdala neurons. The Journal of pharmacology and experimental therapeutics 20031201
Synthesis, radiosynthesis and in vivo evaluation of 5-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]-1,3-dihydrobenzoimidazol-2-[(11)C]one, as a potent NR(1A)/2B subtype selective NMDA PET radiotracer. Bioorganic & medicinal chemistry 20031201
Prenatal ethanol exposure modifies [3H]MK-801 binding to NMDA receptors: spermidine and ifenprodil. Alcoholism, clinical and experimental research 20031201
Glucose-deprivation-induced [3H]D-aspartate release from isolated bovine and human retinae. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201
NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory. The Journal of neuroscience : the official journal of the Society for Neuroscience 20031112
Fyn kinase and NR2B-containing NMDA receptors regulate acute ethanol sensitivity but not ethanol intake or conditioned reward. Alcoholism, clinical and experimental research 20031101
Glutamatergic transmission in opiate and alcohol dependence. Annals of the New York Academy of Sciences 20031101
Acute dissociation for analyses of NMDA receptor function in cortical neurons during aging. Journal of neuroscience methods 20031015
Effect of the NR3 subunit on ethanol inhibition of recombinant NMDA receptors. Brain research 20031010
Overexpression of spermidine/spermine N1-acetyltransferase elevates the threshold to pentylenetetrazol-induced seizure activity in transgenic mice. Experimental neurology 20031001
Postsynaptic contributions to hippocampal network hyperexcitability induced by chronic activity blockade in vivo. The European journal of neuroscience 20031001
Effects of NMDA receptor antagonists on acute mu-opioid analgesia in the rat. Pharmacology, biochemistry, and behavior 20030901
The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze. European journal of pharmacology 20030829
Polyamines in a genetic animal model of paroxysmal dyskinesia. Brain research 20030815
Activation of NMDA receptors in rat dentate gyrus granule cells by spontaneous and evoked transmitter release. Journal of neurophysiology 20030801
Development and subunit composition of synaptic NMDA receptors in the amygdala: NR2B synapses in the adult central amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030730
Enhanced GABA(A) receptor-mediated activity following activation of NMDA receptors in Cajal-Retzius cells in the developing mouse neocortex. The Journal of physiology 20030701
Amphetamine-evoked c-fos mRNA expression in the caudate-putamen: the effects of DA and NMDA receptor antagonists vary as a function of neuronal phenotype and environmental context. Journal of neurochemistry 20030701
Polyamines contribute to ethanol withdrawal-induced neurotoxicity in rat hippocampal slice cultures through interactions with the NMDA receptor. Alcoholism, clinical and experimental research 20030701
Therapeutic N-methyl-D-aspartate receptor antagonists: will reality meet expectation? Current opinion in investigational drugs (London, England : 2000) 20030701
Behavioral effects of NMDA receptor agonists and antagonists in combination with nitric oxide-related compounds. European journal of pharmacology 20030620
NR2B and NR2D subunits coassemble in cerebellar Golgi cells to form a distinct NMDA receptor subtype restricted to extrasynaptic sites. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615
ATP inhibits NMDA receptors after heterologous expression and in cultured hippocampal neurons and attenuates NMDA-mediated neurotoxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030615
Synthesis of chiral 1-[omega-(4-chlorophenoxy)alkyl]-4-methylpiperidines and their biological evaluation at sigma1, sigma2, and sterol delta8-delta7 isomerase sites. Journal of medicinal chemistry 20030522
Expression of behavioral sensitization to ethanol by DBA/2J mice: the role of NMDA and non-NMDA glutamate receptors. Psychopharmacology 20030501
Involvement of voltage- and ligand-gated Ca2+ channels in the neuroexcitatory and synergistic effects of putative uremic neurotoxins. Kidney international 20030501
N-Methyl-D-aspartate receptors contribute to the maintenance of dopaminergic neurons in rat midbrain slice cultures. Neuroscience letters 20030501
Role of the NMDA receptor NR2B subunit in the discriminative stimulus effects of ketamine. Behavioural pharmacology 20030501
NMDA-receptor antagonism via dextromethorphan and ifenprodil modulates graded anxiety test performance of C57BL/6 mice. Behavioural pharmacology 20030501
Functional NMDA receptor subtype 2B is expressed in astrocytes after ischemia in vivo and anoxia in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030415
PSD-95 regulates NMDA receptors in developing cerebellar granule neurons of the rat. The Journal of physiology 20030401
Contribution of NR2B subunits to synaptic transmission in amygdaloid interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience 20030401
Excitatory synaptic transmission in the lateral and central amygdala. Annals of the New York Academy of Sciences 20030401
Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity. FEBS letters 20030313
Excitatory amino acid receptors of the electrosensory system: the NR1/NR2B N-methyl-D-aspartate receptor. Journal of neurophysiology 20030201
Ionotropic glutamate receptors: still a target for neuroprotection in brain ischemia? Insights from in vitro studies. Neurobiology of disease 20030201
Differential alterations in the expression of NMDA receptor subunits following chronic ethanol treatment in primary cultures of rat cortical and hippocampal neurones. Neurochemistry international 20030101
Comparison of effect of ethanol on N-methyl-D-aspartate- and GABA-gated currents from acutely dissociated neurons: absence of regional differences in sensitivity to ethanol. The Journal of pharmacology and experimental therapeutics 20030101
Evidence for functionally distinct synaptic NMDA receptors in ventromedial versus dorsolateral striatum. Journal of neurophysiology 20030101
Lack of ifenprodil anxiolytic activity after its multiple treatment in chronically ethanol-treated rats. Alcohol and alcoholism (Oxford, Oxfordshire) 20030101
Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists. Neurotoxicity research 20030101
Ionotropic and metabotropic glutamate receptor mediation of glucocorticoid-induced apoptosis in hippocampal cells and the neuroprotective role of synaptic N-methyl-D-aspartate receptors. Neuroscience 20030101
Developmental Pb2+ exposure alters NMDAR subtypes and reduces CREB phosphorylation in the rat brain. Brain research. Developmental brain research 20021215
Ethanol sensitivity of NMDA receptors. Neurochemistry international 20021201
Expression of functional NR1/NR2B-type NMDA receptors in neuronally differentiated SK-N-SH human cell line. The European journal of neuroscience 20021201
Intrathecally administered big dynorphin, a prodynorphin-derived peptide, produces nociceptive behavior through an N-methyl-D-aspartate receptor mechanism. Brain research 20021011
Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil. Brain research 20021011
Changes in the effect of isoflurane on N-methyl-D-aspartic acid-gated currents in cultured cerebral cortical neurons with time in culture: evidence for subunit specificity. Anesthesiology 20021001
Acamprosate, MK-801, and ifenprodil inhibit neurotoxicity and calcium entry induced by ethanol withdrawal in organotypic slice cultures from neonatal rat hippocampus. Alcoholism, clinical and experimental research 20021001
Resistance to alcohol withdrawal-induced behaviour in Fyn transgenic mice and its reversal by ifenprodil. Brain research. Molecular brain research 20020930
Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis. European journal of pharmacology 20020927
Differential regulation of synaptic and extra-synaptic NMDA receptors. Nature neuroscience 20020901
Site-selective N-methyl-D-aspartate and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate antagonists produce distinct effects in rats performing complex discriminations. Neurobiology of learning and memory 20020901
Axonal projection, input and output synapses, and synaptic physiology of Cajal-Retzius cells in the developing rat neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020815
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity. Naunyn-Schmiedeberg's archives of pharmacology 20020801
Increase in glutamate-induced neurotoxicity by activated astrocytes involves stimulation of protein kinase C. Journal of neurochemistry 20020801
Mapping the binding site of the neuroprotectant ifenprodil on NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020715
Synthesis, in vitro and in vivo pharmacology of a C-11 labeled analog of CP-101,606, (+/-)threo-1-(4-hydroxyphenyl)-2-[4-hydroxy-4-(p-[11C]methoxyphenyl)piperidino]-1-propanol, as a PET tracer for NR2B subunit-containing NMDA receptors. Nuclear medicine and biology 20020701
NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615
Ifenprodil and ethanol enhance NMDA receptor-dependent long-term depression. The Journal of pharmacology and experimental therapeutics 20020601
Effects of acamprosate and some polyamine site ligands of NMDA receptor on short-term memory in rats. European journal of pharmacology 20020524
Subtypes of NMDA receptors in new-born rat hippocampal granule cells. The Journal of physiology 20020515
Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nature neuroscience 20020501
Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory brainstem. The Journal of physiology 20020501
Acamprosate has no effect on NMDA-induced toxicity but reduces toxicity induced by spermidine or by changing the medium in organotypic hippocampal slice cultures from rat. Alcoholism, clinical and experimental research 20020501
Deletion of the C-terminal domain of the NR2B subunit alters channel properties and synaptic targeting of N-methyl-D-aspartate receptors in nascent neocortical synapses. Journal of neuroscience research 20020501
Characterisation of striatal NMDA receptors involved in the generation of parkinsonian symptoms: intrastriatal microinjection studies in the 6-OHDA-lesioned rat. Movement disorders : official journal of the Movement Disorder Society 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
NMDA receptor-mediated currents in rat cerebellar granule and unipolar brush cells. Journal of neurophysiology 20020401
Evidence for sigma-1-like receptors in isolated rat liver mitochondrial membranes. British journal of pharmacology 20020401
Distinct NMDA receptors provide differential modes of transmission at mossy fiber-interneuron synapses. Neuron 20020314
Intrathecal high-dose morphine induces spinally-mediated behavioral responses through NMDA receptors. Brain research. Molecular brain research 20020131
A simple cell line based in vitro test system for N-methyl-D-aspartate (NMDA) receptor ligands. Journal of neuroscience methods 20020115
An MCASE approach to the search of a cure for Parkinson's Disease. BMC pharmacology 20020101
NR2B selective NMDA receptor antagonists. Current pharmaceutical design 20020101
Effect of multiple ifenprodil or spermidine treatment on social recognition in rats. Journal of basic and clinical physiology and pharmacology 20020101
Barrel cortex critical period plasticity is independent of changes in NMDA receptor subunit composition. Neuron 20011120
Distinct NMDA and AMPA receptor-mediated responses in mouse and human Cajal-Retzius cells. Journal of neurophysiology 20011101
[A case of eosinophilic pneumonia possibly due to ifenprodil]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20011101
Characterization of the single-channel properties of NMDA receptors in laminae I and II of the dorsal horn of neonatal rat spinal cord. The European journal of neuroscience 20011101
Hypoxia-induced [(3)H]D-aspartate release from isolated bovine retina: modulation by calcium-channel blockers and glutamatergic agonists and antagonists. Current eye research 20011101
Lead inhibition of NMDA channels in native and recombinant receptors. Neuroreport 20011008
Establishment of CHO cell lines expressing four N-methyl-D-aspartate receptor subtypes and characterization of a novel antagonist PPDC. FEBS letters 20011005
NR2B-containing NMDA autoreceptors at synapses on entorhinal cortical neurons. Journal of neurophysiology 20011001
Facilitation of Ca2+ store-dependent noradrenaline release after an N-methyl-D-aspartate receptor antagonist in the rat supraoptic nucleus. Journal of neuroendocrinology 20011001
Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience 20010901
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nature neuroscience 20010901
NMDA receptor pharmacology: perspectives from molecular biology. Current drug targets 20010901
Ifenprodil, a novel NMDA receptor antagonist: site and mechanism of action. Current drug targets 20010901
The NMDA receptor complex: a promising target for novel antiepileptic strategies. Current medicinal chemistry 20010901
Developmental depression of glutamate neurotransmission by chronic low-level activation of NMDA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815
Role of the NMDA receptor subunit in the expression of the discriminative stimulus effect induced by ketamine. European journal of pharmacology 20010629
Effects of adult neurogenesis on synaptic plasticity in the rat dentate gyrus. Journal of neurophysiology 20010601
Polyamine and redox modulation of [3H]MK-801 binding to N-methyl-D-aspartate receptors in the spinal cord and cerebral cortex. Pharmacology & toxicology 20010601
Ontogeny of ionotropic glutamate receptor expression in human fetal brain. Brain research. Developmental brain research 20010430
Pharmacological characterization of interactions of RO 25-6981 with the NR2B (epsilon2) subunit. European journal of pharmacology 20010330
Dynamic modulation of NMDA-induced responses by ifenprodil in rat prefrontal cortex. Synapse (New York, N.Y.) 20010315
Increased expression of NR2A subunit does not alter NMDA-evoked responses in cultured fetal trisomy 16 mouse hippocampal neurons. Journal of neurochemistry 20010301
A comparative assessment of the efficacy and side-effect liability of neuroprotective compounds in experimental stroke. Brain research 20010223
Supraspinal vs spinal sites of the antinociceptive action of the subtype-selective NMDA antagonist ifenprodil. Neuropharmacology 20010101
Use of trifluoroperazine isolates a [(3)H]Ifenprodil binding site in rat brain membranes with the pharmacology of the voltage-independent ifenprodil site on N-methyl-D-aspartate receptors containing NR2B subunits. The Journal of pharmacology and experimental therapeutics 20010101
N-methyl-D-aspartate receptors mediating hippocampal noradrenaline and striatal dopamine release display differential sensitivity to quinolinic acid, the HIV-1 envelope protein gp120, external pH and protein kinase C inhibition. Journal of neurochemistry 20010101
Expression of ionotropic glutamate receptors in the retina of the rdta transgenic mouse. BMC neuroscience 20010101
Effects of centrally-acting glutamatergic modulators on cardiovascular responses to stress in humans. Journal of cardiology 20010101
Altered effects of ethanol in NR2A(DeltaC/DeltaC) mice expressing C-terminally truncated NR2A subunit of NMDA receptor. Neuroscience 20010101
Maturation-dependent neurotoxicity of 3-hydroxyglutaric and glutaric acids in vitro: a new pathophysiologic approach to glutaryl-CoA dehydrogenase deficiency. Pediatric research 20000401
Prevention of cocaine-induced convulsions and lethality in mice: effectiveness of targeting different sites on the NMDA receptor complex. Neuropharmacology 20000128
Non-N-methyl-D-aspartate (NMDA) receptor antagonist 1,2,3, 4-tetrahydro-6-nitro-2,3-dioxo-benzo(f)quinoxaline-7-sulphonamide (NBQX) decreases functional disorders in cytotoxic brain oedema. Archives of toxicology 20000101
An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. The Journal of physiology 19981001
Recovery of decreased seizure threshold for pentylenetetrazole during diazepam withdrawal by NMDA receptor antagonists. European journal of pharmacology 19970411
N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss. Nature medicine 19961201
Effects of some excitatory amino acid antagonists on imipenem-induced seizures in DBA/2 mice. Brain research 19950206
Selective dysfunction of the vagal component of the baroreflex following cerebral ischemia: protection by ifenprodil and flunarizine. European journal of pharmacology 19901106
[Effects of 2-(4-benzyl-piperidino)-1-(4-hydroxyphenyl)-1-propanol (ifenprodil) on the cardiovascular system in vivo]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19750901
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