Synthesis, hypoglycemic and hypolipidemic activities of novel thiazolidinedione derivatives containing thiazole/triazole/oxadiazole ring.

European journal of medicinal chemistry 20120701

Effect of phosphatidylinositol 3-kinase-γ inhibitor CAY10505 in hypertension, and its associated vascular endothelium dysfunction in rats.

Canadian journal of physiology and pharmacology 20120701

Thiazolidinedione-dependent activation of sphingosine kinase 1 causes an anti-fibrotic effect in renal mesangial cells.

British journal of pharmacology 20120601

5-benzylidenerhodanine and 5-benzylidene-2-4-thiazolidinedione based antibacterials.

Bioorganic & medicinal chemistry letters 20120415

Initiation of insulin among veterans with type 2 diabetes and sustained elevation of A1c.

Primary care diabetes 20120401

Peroxisome proliferator-activated receptors-α and -γ, and cAMP-mediated pathways, control retinol-binding protein-4 gene expression in brown adipose tissue.

Endocrinology 20120301

Effect of structural modifications on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione-induced hepatotoxicity in Fischer 344 rats.

Journal of applied toxicology : JAT 20120201

Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity.

Chemistry & biology 20120127

Privileged scaffolds or promiscuous binders: a comparative study on rhodanines and related heterocycles in medicinal chemistry.

Journal of medicinal chemistry 20120126

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease.

Neurobiology of disease 20120101

Synthesis and antihyperglycemic evaluation of new 2,4-thiazolidinediones having biodynamic aryl sulfonylurea moieties.

Bioorganic & medicinal chemistry letters 20120101

In vivo adipogenesis in rats measured by cell kinetics in adipocytes and plastic-adherent stroma-vascular cells in response to high-fat diet and thiazolidinedione.

Diabetes 20120101

New cholesterol esterase inhibitors based on rhodanine and thiazolidinedione scaffolds.

Bioorganic & medicinal chemistry 20111215

The role of PPARβ/δ in the management of metabolic syndrome and its associated cardiovascular complications.

Endocrine, metabolic & immune disorders drug targets 20111201

Comparison of the acute toxicities of novel algicides, thiazolidinedione derivatives TD49 and TD53, to various marine organisms.

Environmental toxicology and chemistry 20111201

Genetic predisposition and nongenetic risk factors of thiazolidinedione-related edema in patients with type 2 diabetes.

Pharmacogenetics and genomics 20111201

Effects of plane of nutrition and 2,4-thiazolidinedione on insulin responses and adipose tissue gene expression in dairy cattle during late gestation.

Journal of dairy science 20111201

Effects of prepartum 2,4-thiazolidinedione on insulin sensitivity, plasma concentrations of tumor necrosis factor-α and leptin, and adipose tissue gene expression.

Journal of dairy science 20111101

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation.

Nature 20110922

The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease.

Biochimica et biophysica acta 20110901

Structure-activity relationship and docking studies of thiazolidinedione-type compounds with monoamine oxidase B.

Bioorganic & medicinal chemistry letters 20110815

Profibrinolytic, antithrombotic, and antiinflammatory effects of an insulin-sensitizing strategy in patients in the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) trial.

Circulation 20110809

Synthesis of new chalcone derivatives bearing 2,4-thiazolidinedione and benzoic acid moieties as potential anti-bacterial agents.

European journal of medicinal chemistry 20110801

High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.

Chemistry & biology 20110729

Efficacy and safety of saxagliptin combination therapy in US patients with type 2 diabetes.

Postgraduate medicine 20110701

Synthesis of spirocyclic thiazolidinediones using ring-closing metathesis and one-pot sequential ring-closing/cross metathesis.

Organic & biomolecular chemistry 20110521

Peroxisome proliferator-activated receptor-γ stimulates 11β-hydroxysteroid dehydrogenase type 1 in rat vascular smooth muscle cells.

Steroids 20110501

Changes and predictors for change to thiazolidinedione prescribing in UK primary care following the rosiglitazone safety warning.

International journal of clinical practice 20110501

[Effects of drugs for lifestyle-related diseases on bone metabolism].

Clinical calcium 20110501

[Pharmacotherapy of osteoporosis accompanied by lifestyle-related diseases].

Clinical calcium 20110501

Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives for the treatment of inflammatory diseases.

Journal of medicinal chemistry 20110414

Thiazolidinedione use and ulcerative colitis-related flares: an exploratory analysis of administrative data.

Inflammatory bowel diseases 20110301

Interaction of phytochemicals with hypoglycemic drugs on glucose uptake in L6 myotubes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20110215

S-oxidation of thiazolidinedione with hydrogen peroxide, peroxynitrous acid, and C4a-hydroperoxyflavin: a theoretical study.

The journal of physical chemistry. A 20110210

Convenient synthesis of polyfunctional dihydrothiophenes with tandem reaction of 1,3-thiazolidinedione, aldehyde, arylamine and ethyl cyanoacetate.

Molecular diversity 20110201

Lipocalin 2 is a selective modulator of peroxisome proliferator-activated receptor-gamma activation and function in lipid homeostasis and energy expenditure.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110201

An arylidene-thiazolidinedione derivative, GPU-4, without PPARγ activation, reduces retinal neovascularization.

Current neurovascular research 20110201

Concomitant oral antihyperglycemic agent use and associated treatment outcomes after initiation of insulin therapy.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20110101

Thiazolidinedione therapy for managing metabolic syndrome.

American family physician 20101215

Thiazolidinediones as a novel class of algicides against red tide harmful algal species.

Applied biochemistry and biotechnology 20101201

Safety and tolerability of vildagliptin vs. thiazolidinedione as add-on to metformin in type 2 diabetic patients with and without mild renal impairment: a retrospective analysis of the GALIANT study.

Diabetes research and clinical practice 20101101

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma.

Human molecular genetics 20101015

Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients.

Diabetes care 20101001

Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Diabetes care 20101001

Synthesis and primary cytotoxicity evaluation of new 5-benzylidene-2,4-thiazolidinedione derivatives.

European journal of medicinal chemistry 20101001

Effects of in vitro insulin and 2,4-thiazolidinedione on the function of neutrophils harvested from blood of cows in different physiological states.

Journal of dairy science 20100901

Colon OCTN2 gene expression is up-regulated by peroxisome proliferator-activated receptor gamma in humans and mice and contributes to local and systemic carnitine homeostasis.

The Journal of biological chemistry 20100827

Modulation of pantothenate kinase 3 activity by small molecules that interact with the substrate/allosteric regulatory domain.

Chemistry & biology 20100827

MCC-555-induced NAG-1 expression is mediated in part by KLF4.

European journal of pharmacology 20100710

Distinct association of serum FGF21 or adiponectin levels with clinical parameters in patients with type 2 diabetes.

Diabetes research and clinical practice 20100701

Bone loss and fracture risk associated with thiazolidinedione therapy.

Pharmacotherapy 20100701

A perspective on the American Heart Association/American College of Cardiology science advisory on thiazolidinedione drugs and cardiovascular risks.

Circulation. Cardiovascular quality and outcomes 20100501

[Revascularization in patients with type 2 diabetes and coronary artery disease: BARI 2D (Bypass Angioplasty Revascularization Investigation 2 Diabetes) Study Group].

Der Internist 20100501

Adherence to a fixed-dose combination of rosiglitazone/glimepiride in subjects switching from monotherapy or dual therapy with a thiazolidinedione and/or a sulfonylurea.

The Annals of pharmacotherapy 20100501

Synthesis and biological evaluation of novel pyrazolyl-2,4-thiazolidinediones as anti-inflammatory and neuroprotective agents.

Bioorganic & medicinal chemistry 20100301

Lack of association between thiazolidinediones and macular edema in type 2 diabetes: the ACCORD eye substudy.

Archives of ophthalmology (Chicago, Ill. : 1960) 20100301

Binding of histidine in the (Cys)3(His)1-coordinated [2Fe-2S] cluster of human mitoNEET.

Journal of the American Chemical Society 20100217

Investigation of the role of the thiazolidinedione ring of troglitazone in inducing hepatotoxicity.

Toxicology letters 20100201

Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.

Bioorganic & medicinal chemistry letters 20100201

Structure-based design of a thiazolidinedione which targets the mitochondrial protein mitoNEET.

Bioorganic & medicinal chemistry letters 20100201

Thiazolidinedione therapy for nonalcoholic steatohepatitis: go, stop, or proceed with caution?

Hepatology (Baltimore, Md.) 20100201

Thiazolidinedione attenuate proteinuria and glomerulosclerosis in Adriamycin-induced nephropathy rats via slit diaphragm protection.

Nephrology (Carlton, Vic.) 20100201

Managing highly insulin-resistant diabetes mellitus: weight loss approaches and medical management.

Postgraduate medicine 20100101

Biguanide, but not thiazolidinedione, improved insulin resistance in Werner syndrome.

Journal of the American Geriatrics Society 20100101

Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for type 2 diabetes.

Cardiology in review 20100101

Osteopontin is required for the early onset of high fat diet-induced insulin resistance in mice.

PloS one 20100101

Synergistic effect of phytochemicals in combination with hypoglycemic drugs on glucose uptake in myotubes.

Phytomedicine : international journal of phytotherapy and phytopharmacology 20091201

Importance of changes in adipose tissue insulin resistance to histological response during thiazolidinedione treatment of patients with nonalcoholic steatohepatitis.

Hepatology (Baltimore, Md.) 20091001

Synthesis and in vitro anticancer activity of 2,4-azolidinedione-acetic acids derivatives.

European journal of medicinal chemistry 20090901

A comparison between simplified and intensive dose-titration algorithms using AIR inhaled insulin for insulin-naive patients with type 2 diabetes in a randomized noninferiority trial.

Diabetes technology & therapeutics 20090901

CoMFA and CoMSIA analysis of 2,4-thiazolidinediones derivatives as aldose reductase inhibitors.

Journal of molecular modeling 20090701

A randomized trial of therapies for type 2 diabetes and coronary artery disease.

The New England journal of medicine 20090611

Proangiogenic contribution of adiponectin toward mammary tumor growth in vivo.

Clinical cancer research : an official journal of the American Association for Cancer Research 20090515

Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones.

European journal of medicinal chemistry 20090501

Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarials.

Bioorganic & medicinal chemistry letters 20090501

Translating science into clinical practice: focus on vildagliptin in combination with metformin.

Diabetes, obesity & metabolism 20090501

Thiazolidinedione use and the risk of fractures.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20090414

Thiazolidinedione use and the risk of fractures.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 20090414

Thiazolidinedione-induced fluid retention is independent of collecting duct alphaENaC activity.

Journal of the American Society of Nephrology : JASN 20090401

Quantitative structure-activity relationship models with receptor-dependent descriptors for predicting peroxisome proliferator-activated receptor activities of thiazolidinedione and oxazolidinedione derivatives.

Chemical biology & drug design 20090401

Synthesis and evaluation of novel inhibitors of Pim-1 and Pim-2 protein kinases.

Journal of medicinal chemistry 20090108

Impact of peripheral arterial disease in patients with diabetes--results from PROactive (PROactive 11).

Atherosclerosis 20090101

Factors associated with results and conclusions of trials of thiazolidinediones.

PloS one 20090101

Thiazolidinedione therapy is not associated with increased colonic neoplasia risk in patients with diabetes mellitus.

Gastroenterology 20081201

Thiazolidinedione associated volume overload and pulmonary hypertension.

Therapeutic advances in cardiovascular disease 20081201

Synthesis and aldose reductase inhibitory activity of some new chromonyl-2,4-thiazolidinediones.

European journal of medicinal chemistry 20081101

An assessment of the effect of thiazolidinedione exposure on the risk of myocardial infarction in type 2 diabetic patients.

Pharmacoepidemiology and drug safety 20081001

Glycaemic control among patients with type 2 diabetes mellitus in seven European countries: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) study.

Diabetes, obesity & metabolism 20080601

Hypoglycaemic symptoms, treatment satisfaction, adherence and their associations with glycaemic goal in patients with type 2 diabetes mellitus: findings from the Real-Life Effectiveness and Care Patterns of Diabetes Management (RECAP-DM) Study.

Diabetes, obesity & metabolism 20080601

Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.

Bioorganic & medicinal chemistry 20080601

Thiazolidinedione addition reduces the serum retinol-binding protein 4 in type 2 diabetic patients treated with metformin and sulfonylurea.

Translational research : the journal of laboratory and clinical medicine 20080601

[Do thiazolidinediones harm skeletal integrity?].

Clinical calcium 20080501

[Relationship between lipid and glucose metabolism and bone mineral metabolism : pleiotropic effects of therapeutic agents for diabetes and hyperlipidemia].

Clinical calcium 20080501

Differing pharmacological activities of thiazolidinone analogs at the FSH receptor.

Biochemical and biophysical research communications 20080411

T2384, a novel antidiabetic agent with unique peroxisome proliferator-activated receptor gamma binding properties.

The Journal of biological chemistry 20080404

Effect of gender, dose, and time on 3-(3,5-dichlorophenyl)-2,4-thiazolidinedione (DCPT)-induced hepatotoxicity in Fischer 344 rats.

Xenobiotica; the fate of foreign compounds in biological systems 20080401

Electrophilic alpha-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones.

Bioorganic & medicinal chemistry letters 20080315

Sitagliptin: a novel agent for the management of type 2 diabetes mellitus.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20080315

Antiproteinuric and anti-inflammatory effects of thiazolidinedione.

Nephrology (Carlton, Vic.) 20080201

Oral antidiabetic medication adherence and glycemic control in managed care.

The American journal of managed care 20080201

Efficacy and tolerability of vildagliptin vs. pioglitazone when added to metformin: a 24-week, randomized, double-blind study.

Diabetes, obesity & metabolism 20080101

Fat and beyond: the diverse biology of PPARgamma.

Annual review of biochemistry 20080101

Statins but not thiazolidinediones attenuate albumin-mediated chemokine production by proximal tubular cells independently of endocytosis.

American journal of nephrology 20080101

Performing meta-analysis with incomplete statistical information in clinical trials.

BMC medical research methodology 20080101

Outcomes of adding second hypoglycemic drug after metformin monotherapy failure among type 2 diabetes in Hungary.

Health and quality of life outcomes 20080101

Thiazolidinedione use and post-operative atrial fibrillation: a US nested case-control study.

Current medical research and opinion 20071101

Adipose tissue integrity as a prerequisite for systemic energy balance: a critical role for peroxisome proliferator-activated receptor gamma.

The Journal of biological chemistry 20071012

Synthesis and three-dimensional qualitative structure selectivity relationship of 3,5-disubstituted-2,4-thiazolidinedione derivatives as COX2 inhibitors.

Archives of pharmacal research 20071001

Cytosolic aspartate aminotransferase, a new partner in adipocyte glyceroneogenesis and an atypical target of thiazolidinedione.

The Journal of biological chemistry 20070810

Prepartum 2,4-thiazolidinedione alters metabolic dynamics and dry matter intake of dairy cows.

Journal of dairy science 20070801

Secondary failure of glycemic control for patients adding thiazolidinedione or sulfonylurea therapy to a metformin regimen.

The American journal of managed care 20070801

Pharmacogenetics of thiazolidinedione therapy.

Pharmacogenomics 20070801

Heregulin-mediated ErbB2-ERK signaling activates hyaluronan synthases leading to CD44-dependent ovarian tumor cell growth and migration.

The Journal of biological chemistry 20070706

The impact of thiazolidinedione use on outcomes in ambulatory patients with diabetes mellitus and heart failure.

Journal of the American College of Cardiology 20070703

Effect of thiazolidinedione therapy on restenosis after coronary stent implantation: a meta-analysis of randomized controlled trials.

American heart journal 20070701

Mechanism of thiazolidinedione-dependent cell death in Jurkat T cells.

Molecular pharmacology 20070601

Thiazolidinedione treatment decreases bone mineral density in type 2 diabetic men.

Diabetes care 20070601

Pioglitazone and rosiglitazone decrease prostaglandin E2 in non-small-cell lung cancer cells by up-regulating 15-hydroxyprostaglandin dehydrogenase.

Molecular pharmacology 20070601

Thiazolidinedione therapy gets complicated: is bone loss the price of improved insulin resistance?

Diabetes care 20070601

Inhaled insulin for diabetes mellitus.

The New England journal of medicine 20070517

Novel thyroid hormone receptor antagonists with an N-alkylated diphenylamine skeleton.

Bioorganic & medicinal chemistry 20070501

Hepatocyte growth factor induces glucose uptake in 3T3-L1 adipocytes through A Gab1/phosphatidylinositol 3-kinase/Glut4 pathway.

The Journal of biological chemistry 20070406

Summaries for patients. Exenatide therapy for type 2 diabetes.

Annals of internal medicine 20070403

The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial.

Annals of internal medicine 20070403

Exenatide in combination therapy: small study, big market, and many unanswered questions.

Annals of internal medicine 20070403

Thiazolidinedione ameliorates renal injury in experimental diabetic rats through anti-inflammatory effects mediated by inhibition of NF-kappaB activation.

American journal of physiology. Renal physiology 20070401

Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study.

Diabetes, obesity & metabolism 20070301

Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment.

Nature medicine 20070301

Human visfatin expression: relationship to insulin sensitivity, intramyocellular lipids, and inflammation.

The Journal of clinical endocrinology and metabolism 20070201

The ASP receptor C5L2 is regulated by metabolic hormones associated with insulin resistance.

Biochemistry and cell biology = Biochimie et biologie cellulaire 20070201

Effect of thiazolidinedione on the proliferation of bovine retinal endothelial cells stimulated by vascular endothelial cell growth factor.

Japanese journal of ophthalmology 20070101

Thiazolidinedione induced thyroid associated orbitopathy.

BMC ophthalmology 20070101

The lipogenic enzymes DGAT1, FAS, and LPL in adipose tissue: effects of obesity, insulin resistance, and TZD treatment.

Journal of lipid research 20061101

Surface-specific effects of a PPARgamma agonist, darglitazone, on bone in mice.

Bone 20061001

Thiazolidinedione use and bone loss in older diabetic adults.

The Journal of clinical endocrinology and metabolism 20060901

Plasma concentrations of vascular endothelial growth factor are associated with peripheral oedema in patients treated with thiazolidinedione.

Diabetologia 20060901

Endothelial dysfunction and its role in diabetic vascular disease.

Endocrinology and metabolism clinics of North America 20060901

Thailand diabetes registry project: glycemic control in Thai type 2 diabetes and its relation to hypoglycemic agent usage.

Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20060801

Amelioration of age-related inflammation and oxidative stress by PPARgamma activator: suppression of NF-kappaB by 2,4-thiazolidinedione.

Experimental gerontology 20060601

Can thiazolidinediones delay disease progression in type 2 diabetes?

Current medical research and opinion 20060601

Etiology of insulin resistance.

The American journal of medicine 20060501

Insulin sensitizing pharmacotherapy for prevention of myocardial infarction in patients with diabetes mellitus.

The American journal of cardiology 20060301

Outcomes associated with introduction of thiazolidinedione therapy in Medicaid enrolled patients with type 2 diabetes: an updated and expanded retrospective analysis.

Current medical research and opinion 20060301

Quantitative structure-activity analysis of 5-arylidene-2,4-thiazolidinediones as aldose reductase inhibitors.

Bioorganic & medicinal chemistry letters 20060201

Attenuation of experimental colonic injury by thiazolidinedione agents.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060101

Treatment of type 2 diabetes. Use of fixed-dose oral combinations.

Postgraduate medicine 20060101

Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring.

Arzneimittel-Forschung 20060101

Oral agents in managing diabetes mellitus in children and adolescents.

Pediatric clinics of North America 20051201

SAR and 3D-QSAR studies on thiadiazolidinone derivatives: exploration of structural requirements for glycogen synthase kinase 3 inhibitors.

Journal of medicinal chemistry 20051117

[Insulin resistance: the adipose tissue in the focus].

Orvosi hetilap 20051023

[The effects of thiazolidinedione from the cardiologic viewpoint].

Medizinische Monatsschrift fur Pharmazeuten 20051001

Impact of thiazolidinedione therapy on atherogenesis.

Current atherosclerosis reports 20050901

Thiazolidinedione treatment inhibits bile duct proliferation and fibrosis in a rat model of chronic cholestasis.

World journal of gastroenterology 20050828

Peroxisome proliferator-activated receptor gamma ligands induce cell cycle arrest and apoptosis in human renal carcinoma cell lines.

Acta pharmacologica Sinica 20050601

The nonthiazolidinedione tyrosine-based peroxisome proliferator-activated receptor gamma ligand GW7845 induces apoptosis and limits migration and invasion of rat and human glioma cells.

The Journal of pharmacology and experimental therapeutics 20050501

Dietary (n-3) polyunsaturated fatty acids inhibit HER-2/neu-induced breast cancer in mice independently of the PPARgamma ligand rosiglitazone.

The Journal of nutrition 20050501

[Polycystic ovary syndrome].

Nihon rinsho. Japanese journal of clinical medicine 20050401

Thiazolidinedione treatment attenuates diffuse neointimal hyperplasia in restenotic lesions after coronary stent implantation in type 2 diabetic patients: an intravascular ultrasound study.

Journal of cardiology 20050401

Peroxisome proliferator-activated receptor gamma-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress.

The Journal of biological chemistry 20050318

PPAR-gamma activation fails to provide myocardial protection in ischemia and reperfusion in pigs.

American journal of physiology. Heart and circulatory physiology 20050301

Peroxisome proliferator-activated receptor gamma agonists promote TRAIL-induced apoptosis by reducing survivin levels via cyclin D3 repression and cell cycle arrest.

The Journal of biological chemistry 20050225

Corepressors selectively control the transcriptional activity of PPARgamma in adipocytes.

Genes & development 20050215

[Selection of oral antidiabetic drugs].

Nihon rinsho. Japanese journal of clinical medicine 20050201

The utility of oral diabetes medications in type 2 diabetes of the young.

Current diabetes reviews 20050201

Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide.

The Journal of pharmacology and experimental therapeutics 20050101

Potential role of oral thiazolidinedione therapy in preserving beta-cell function in type 2 diabetes mellitus.

Drugs 20050101

Efficacy and safety of ezetimibe co-administered with simvastatin in thiazolidinedione-treated type 2 diabetic patients.

Diabetes, obesity & metabolism 20050101

Thiazolidinediones improve insulin sensitivity in adipose tissue and reduce the hyperlipidaemia without affecting the hyperglycaemia in a transgenic model of type 2 diabetes.

Diabetologia 20041201

Thiazolidinediones: a review of their mechanisms of insulin sensitization, therapeutic potential, clinical efficacy, and tolerability.

Diabetes technology & therapeutics 20041201

Variance-modeled posterior inference of microarray data: detecting gene-expression changes in 3T3-L1 adipocytes.

Bioinformatics (Oxford, England) 20041122

Peroxisome proliferator-activated receptor gamma-dependent and -independent growth inhibition of gastrointestinal tumour cells.

Genes to cells : devoted to molecular & cellular mechanisms 20041101

Evidence for a new human CYP1A1 regulation pathway involving PPAR-alpha and 2 PPRE sites.

Gastroenterology 20041101

Synthesis and biological activity of benzoxazole containing thiazolidinedione derivatives.

Archives of pharmacal research 20041101

Application of liquid chromatography/mass spectrometry and nuclear magnetic resonance to the identification of degradates of a novel insulin sensitizer in aqueous solutions.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041025

Integrated genomic and proteomic analyses of gene expression in Mammalian cells.

Molecular & cellular proteomics : MCP 20041001

Healthcare costs and prescription adherence with introduction of thiazolidinedione therapy in Medicaid type 2 diabetic patients: a retrospective data analysis.

Current medical research and opinion 20041001

Thiazolidinedione, a peroxisome proliferator-activated receptor-gamma ligand, inhibits growth and metastasis of HT-29 human colon cancer cells through differentiation-promoting effects.

International journal of oncology 20040901

Retinoid X receptor-gamma and peroxisome proliferator-activated receptor-gamma expression predicts thyroid carcinoma cell response to retinoid and thiazolidinedione treatment.

Molecular cancer therapeutics 20040801

Continuation of thiazolidinedione therapy in patients without left ventricular dysfunction who developed edema and congestive-heart-failure symptoms.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040801

Limited tumor growth (HT29) in vivo under RO205-2349 is due to increased apoptosis and reduced cell volume but not to decreased proliferation rate.

Cancer letters 20040708

Peroxisome proliferator activated receptors alpha and gamma require zinc for their anti-inflammatory properties in porcine vascular endothelial cells.

The Journal of nutrition 20040701

Increased adipose tissue expression of Grb14 in several models of insulin resistance.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040601

Quantitative determination of a novel insulin sensitizer and its para-hydroxylated metabolite in human plasma by LC-MS/MS.

Journal of pharmaceutical and biomedical analysis 20040528

Transactivation of the PPAR-responsive enhancer module in chemopreventive glutathione S-transferase gene by the peroxisome proliferator-activated receptor-gamma and retinoid X receptor heterodimer.

Cancer research 20040515

Coronary vasomotor abnormalities in insulin-resistant individuals.

Annals of internal medicine 20040504

Interaction of tumor necrosis factor-alpha- and thiazolidinedione-regulated pathways in obesity.

Endocrinology 20040501

Thiazolidinedione-induced congestive heart failure.

The Annals of pharmacotherapy 20040501

Thiazolidinediones reduce the LDL binding affinity of non-human primate vascular cell proteoglycans.

Diabetologia 20040501

Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione.

European journal of medicinal chemistry 20040501

Cinnamic acid based thiazolidinediones inhibit human P450c17 and 3beta-hydroxysteroid dehydrogenase and improve insulin sensitivity independent of PPARgamma agonist activity.

Journal of molecular endocrinology 20040401

[Achieving better control of blood sugar--understanding of oral hypoglycemic agents according to their characteristics in pharmacological action mechanism (discussion)].

Nihon rinsho. Japanese journal of clinical medicine 20040401

Complex distribution, not absolute amount of adiponectin, correlates with thiazolidinedione-mediated improvement in insulin sensitivity.

The Journal of biological chemistry 20040326

Type 2 diabetes mellitus: what is the optimal treatment regimen?

The American journal of medicine 20040308

Increased CD36 protein as a response to defective insulin signaling in macrophages.

The Journal of clinical investigation 20040301

Prevalence of edema in patients receiving combination therapy with insulin and thiazolidinedione.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20040215

Antiproliferative effect of fluvastatin and thiazolidinedione in mesangial cells of diabetic rats.

Pediatric nephrology (Berlin, Germany) 20040101

Antitumor effects of peroxisome proliferator activate receptor gamma ligands on anaplastic thyroid carcinoma.

International journal of oncology 20040101

Thiazolidinedione use, fluid retention, and congestive heart failure: a consensus statement from the American Heart Association and American Diabetes Association.

Diabetes care 20040101

Cardiovascular implications of thiazolidinedione therapy.

Progress in cardiovascular nursing 20040101

Cbl PYXXM motifs activate the P85 subunit of phosphatidylinositol 3-kinase, Crk, atypical protein kinase C, and glucose transport during thiazolidinedione action in 3T3/L1 and human adipocytes.

Biochemistry 20031209

The roles of insulin resistance, hyperinsulinemia, and thiazolidinediones in cardiovascular disease.