Molecular imaging with 11C-PD153035 PET/CT predicts survival in non-small cell lung cancer treated with EGFR-TKI: a pilot study.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20111001

EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix.

Journal of cellular biochemistry 20110701

Impact of aryloxy-linked quinazolines: a novel series of selective VEGFR-2 receptor tyrosine kinase inhibitors.

Bioorganic & medicinal chemistry letters 20110401

A novel hybrid peptide targeting EGFR-expressing cancers.

European journal of cancer (Oxford, England : 1990) 20110301

Evaluation of radioiodinated quinazoline derivative as a new ligand for EGF receptor tyrosine kinase activity using SPECT.

Annals of nuclear medicine 20110201

Determining the binding mode and binding affinity constant of tyrosine kinase inhibitor PD153035 to DNA using optical tweezers.

Biochemical and biophysical research communications 20110107

Identification of the amyloid β-protein precursor and cystatin C as novel epidermal growth factor receptor regulated secretory proteins in nasopharyngeal carcinoma by proteomics.

Journal of proteome research 20101203

Design, synthesis, and DNA-binding of N-alkyl(anilino)quinazoline derivatives.

Journal of medicinal chemistry 20101125

Synthesis and initial tumor affinity testing of iodine-123 labelled EGFR-affine agents as potential imaging probes for hormone-refractory prostate cancer.

European journal of medicinal chemistry 20100901

Signaling through erbB receptors is a critical functional regulator in the mature cochlea.

The European journal of neuroscience 20100901

Epidermal growth factor receptor tyrosine kinase inhibitors induce CCL2 and CCL5 via reduction in IL-1R2 in keratinocytes.

Experimental dermatology 20100801

Gastrin-releasing peptide promotes the growth of HepG2 cells via EGFR-independent ERK1/2 activation.

Oncology reports 20100801

F84, a quinazoline derivative, exhibits high potent antitumor activity against human gynecologic malignancies.

Investigational new drugs 20100401

B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest.

Investigational new drugs 20100201

Potent cardioprotective effect of the 4-anilinoquinazoline derivative PD153035: involvement of mitochondrial K(ATP) channel activation.

PloS one 20100101

EGFR tyrosine kinase inhibitor (PD153035) improves glucose tolerance and insulin action in high-fat diet-fed mice.

Diabetes 20091201

EFEMP1 binds the EGF receptor and activates MAPK and Akt pathways in pancreatic carcinoma cells.

Biological chemistry 20091201

The unfolded protein response is activated in differentiating epidermal keratinocytes.

The Journal of investigative dermatology 20090901

Molecular imaging of EGFR: it's time to go beyond receptor expression.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090701

Lead acetate induces EGFR activation upstream of SFK and PKCalpha linkage to the Ras/Raf-1/ERK signaling.

Toxicology and applied pharmacology 20090301

Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo.

Investigational new drugs 20090201

Growth factors involved in aqueous humour-induced lens cell proliferation.

Growth factors (Chur, Switzerland) 20090201

PET-based biodistribution and radiation dosimetry of epidermal growth factor receptor-selective tracer 11C-PD153035 in humans.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20090201

Priming with EGFR tyrosine kinase inhibitor and EGF sensitizes ovarian cancer cells to respond to chemotherapeutical drugs.

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HTS assays using a disease-relevant cell model for interrogating the MAP kinase pathway initiated by multiple receptors.

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[Molecular imaging of epidermal growth factor receptor in glioma-bearing rats].

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Biochemical assay-based selectivity profiling of clinically relevant kinase inhibitors on mutant forms of EGF receptor.

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Leptin stimulates the proliferation of human oesophageal adenocarcinoma cells via HB-EGF and Tgfalpha mediated transactivation of the epidermal growth factor receptor.

British journal of biomedical science 20080101

The DNA-binding epidermal growth factor-receptor inhibitor PD153035 and other DNA-intercalating cytotoxic drugs reactivate the expression of the retinoic acid receptor-beta tumor-suppressor gene in breast cancer cells.

Differentiation; research in biological diversity 20071101

Assessment of 11C-labeled-4-N-(3-bromoanilino)-6,7-dimethoxyquinazoline as a positron emission tomography agent to monitor epidermal growth factor receptor expression.

Cancer science 20070901

Signaling pathway for 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced TNF-alpha production in differentiated THP-1 human macrophages.

Experimental & molecular medicine 20070831

Further characterization of the epidermal growth factor receptor ligand 11C-PD153035.

Chinese medical journal 20070605

Upregulation of retinoic acid receptor-beta by the epidermal growth factor-receptor inhibitor PD153035 is not mediated by blockade of ErbB pathways.

Journal of cellular physiology 20070601

Protein C is an autocrine growth factor for human skin keratinocytes.

The Journal of biological chemistry 20070504

[Expressions of epidermal growth factor receptor signaling substances in gastric mucosal cells influenced by serum derived from rats treated with electroacupuncture at stomach meridian acupoints].

Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20070501

Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma.

Cancer letters 20070408

EGF receptor clustering is induced by a 0.4 mT power frequency magnetic field and blocked by the EGF receptor tyrosine kinase inhibitor PD153035.

Bioelectromagnetics 20070401

Immortalization of human urothelial cells by human papillomavirus type 16 E6 and E7 genes in a defined serum-free system.

Cell proliferation 20070401

Control of tight junctional sealing: role of epidermal growth factor.

American journal of physiology. Renal physiology 20070201

Epidermal growth factor receptor inhibition sensitizes renal cell carcinoma cells to the cytotoxic effects of bortezomib.

Molecular cancer therapeutics 20070101

Signal pathways involved in the regulation of prostaglandin E synthase-1 in human gingival fibroblasts.

Cellular signalling 20061201

The tyrosine kinase inhibitor PD153035: implication of labeling position on radiometabolites formed in vitro.

Nuclear medicine and biology 20061101

UVB radiation induces expression of HIF-1alpha and VEGF through the EGFR/PI3K/DEC1 pathway.

International journal of molecular medicine 20061001

PPARgamma-regulated tight junction development during human urothelial cytodifferentiation.

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Inhibition of EGFR/PI3K/AKT cell survival pathway promotes TSA's effect on cell death and migration in human ovarian cancer cells.

International journal of oncology 20060701

Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells.

Cancer research 20060615

The epidermal growth factor receptor (EGFR)-S442F mutant displays increased affinity for neuregulin-2beta and agonist-independent coupling with downstream signalling events.

The Biochemical journal 20060515

Indole-3-carbinol-induced death in cancer cells involves EGFR downregulation and is exacerbated in a 3D environment.

Apoptosis : an international journal on programmed cell death 20060501

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Suppression of pro-metastasis phenotypes expression in malignant pleural mesothelioma by the PI3K inhibitor LY294002 or the MEK inhibitor UO126.

Anticancer research 20060101

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Experimental lung research 20060101

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Cells, tissues, organs 20060101

Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.

International journal of oncology 20050901

Mechanism of thymus- and activation-regulated chemokine (TARC)/CCL17 production and its modulation by roxithromycin.

The Journal of investigative dermatology 20050901

Up-regulation in endothelin-1 by Helicobacter pylori lipopolysaccharide interferes with gastric mucin synthesis via epidermal growth factor receptor transactivation.

Scandinavian journal of gastroenterology 20050801

Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.

American journal of physiology. Heart and circulatory physiology 20050601

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Experimental cell research 20050515

The selective epidermal growth factor receptor tyrosine kinase inhibitor PD153035 suppresses expression of prometastasis phenotypes in malignant pleural mesothelioma cells in vitro.

The Journal of thoracic and cardiovascular surgery 20050501

An EGF receptor inhibitor induces RAR-beta expression in breast and ovarian cancer cells.

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Inhibition of the epidermal growth factor receptor increases expression of genes that stimulate inflammation, apoptosis, and cell attachment.

Molecular cancer therapeutics 20050401

High performance liquid chromatography analysis of a 4-anilinoquinazoline derivative (PD153035), a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in rat plasma.

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Global kinase screening. Applications of frontal affinity chromatography coupled to mass spectrometry in drug discovery.

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Comparison of ELISA-based tyrosine kinase assays for screening EGFR inhibitors.

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[Role of PD153035 in the induction of apoptosis of XG-1 myeloma cell line].

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Porphyromonas gingivalis lipopolysaccharide-induced up-regulation in endothelin-1 interferes with salivary mucin synthesis via epidermal growth factor receptor transactivation.

IUBMB life 20041001

Co-inhibition of epidermal growth factor receptor and type 1 insulin-like growth factor receptor synergistically sensitizes human malignant glioma cells to CD95L-induced apoptosis.

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Salivary phospholipid secretion in response to beta-adrenergic stimulation is mediated by Src kinase-dependent epidermal growth factor receptor transactivation.

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Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501

Activation of peroxisome proliferator-activated receptor-gamma reverses squamous metaplasia and induces transitional differentiation in normal human urothelial cells.

The American journal of pathology 20040501

Role of PPARgamma and EGFR signalling in the urothelial terminal differentiation programme.

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Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation.

American journal of respiratory cell and molecular biology 20040401

Regulation of parathyroid hormone-related protein gene expression by epidermal growth factor-family ligands in primary human keratinocytes.

The Journal of endocrinology 20040401

EphB4 signaling is capable of mediating ephrinB2-induced inhibition of cell migration.

Biochemical and biophysical research communications 20040102

Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors.

Breast cancer research and treatment 20040101

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Cancer research 20031101

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Synergistic antiproliferative and apoptotic effects induced by epidermal growth factor receptor and protein kinase a inhibitors in human prostatic cancer cell lines.

International journal of cancer 20030810

Regulation of TGF-alpha-induced activation of AP-1 in the aging gastric mucosa.

American journal of physiology. Gastrointestinal and liver physiology 20030801

Epidermal growth factor inhibition of c-Myc-mediated apoptosis through Akt and Erk involves Bcl-xL upregulation in mammary epithelial cells.

Experimental cell research 20030715

Mutation of threonine 766 in the epidermal growth factor receptor reveals a hotspot for resistance formation against selective tyrosine kinase inhibitors.

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Quantitative image analysis of cellular protein translocation induced by magnetic microspheres: application to the EGF receptor.

Cytometry. Part A : the journal of the International Society for Analytical Cytology 20030301

Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20030201

PET screening of anticancer drugs. A faster route to drug/target evaluations in vivo.

Methods in molecular medicine 20030101

Enhanced antiangiogenic therapy of squamous cell carcinoma by combined endostatin and epidermal growth factor receptor-antisense therapy.

Clinical cancer research : an official journal of the American Association for Cancer Research 20021101

Heparin-binding EGF-like growth factor gene transcription regulated by Cdx2 in the intestinal epithelium.

American journal of physiology. Gastrointestinal and liver physiology 20021001

Activation of proteinase-activated receptor 1 stimulates epithelial chloride secretion through a unique MAP kinase- and cyclo-oxygenase-dependent pathway.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20021001

4-anilino-3-quinolinecarbonitriles: an emerging class of kinase inhibitors.

Current topics in medicinal chemistry 20020901

Regulation of Akt by EGF-R inhibitors, a possible mechanism of EGF-R inhibitor-enhanced TRAIL-induced apoptosis.

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Okadaic acid-induced EGF receptor and MAP kinase activation does not require reactive oxygen species in primary keratinocytes.

Archives of dermatological research 20020701

EBV-expressing AGS gastric carcinoma cell sublines present increased motility and invasiveness.

International journal of cancer 20020610

Establishment and characterization of acquired resistance to the farnesyl protein transferase inhibitor R115777 in a human colon cancer cell line.

Clinical cancer research : an official journal of the American Association for Cancer Research 20020601

Autocrine-mediated activation of STAT3 correlates with cell proliferation in breast carcinoma lines.

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Role of Ras in metal-induced EGF receptor signaling and NF-kappaB activation in human airway epithelial cells.

American journal of physiology. Lung cellular and molecular physiology 20020501

Regulation of cultured rat hepatocyte proliferation by stellate cells.

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Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.

Nature medicine 20020301

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Experimental lung research 20020101

Transactivation of the epidermal growth factor receptor is involved in 12-O-tetradecanoylphorbol-13-acetate-induced signal transduction.

The Journal of biological chemistry 20011214

Lymnaea epidermal growth factor promotes axonal regeneration in CNS organ culture.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20011201

Induction of EGFR-dependent and EGFR-independent signaling pathways by ultraviolet A irradiation.

DNA and cell biology 20011201

1,4-dioxane-fused 4-anilinoquinazoline as inhibitors of epidermal growth factor receptor kinase.

Archiv der Pharmazie 20011101

Epidermal growth factor receptor signaling and the invasive phenotype of ovarian carcinoma cells.

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Signaling-inactive epidermal growth factor receptor/ligand complexes in intact carcinoma cells by quinazoline tyrosine kinase inhibitors.

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Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes.

Neoplasia (New York, N.Y.) 20010701

Epidermal growth factor induction of apolipoprotein A-I is mediated by the Ras-MAP kinase cascade and Sp1.

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DNA interaction of the tyrosine protein kinase inhibitor PD153035 and its N-methyl analogue.

Biochemistry 20010417

Transmodulation of epidermal growth factor receptor mediates IL-1 beta-induced MMP-1 expression in cultured human keratinocytes.

International journal of molecular medicine 20010301

BIBX1382BS, but not AG1478 or PD153035, inhibits the ErbB kinases at different concentrations in intact cells.

Biochemical and biophysical research communications 20010216

Role of transforming growth factor-alpha in von Hippel--Lindau (VHL)(-/-) clear cell renal carcinoma cell proliferation: a possible mechanism coupling VHL tumor suppressor inactivation and tumorigenesis.

Proceedings of the National Academy of Sciences of the United States of America 20010213

A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells.

Journal of cellular physiology 20010201

EGF receptor crosstalks with cytokine receptors leading to the activation of c-Jun kinase in response to UV irradiation in human keratinocytes.

Cellular signalling 20010201

Tyrosine kinase inhibitors. 8. An unusually steep structure-activity relationship for analogues of 4-(3-bromoanilino)-6,7-dimethoxyquinazoline (PD 153035), a potent inhibitor of the epidermal growth factor receptor.

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Identification of cariogenic bacteria by fluorescent antibody and other techniques: an international symposium. New York City, April 3-4, 1975. Concluding remarks: the current status of the National Caries Program.

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