Home Sulfos 2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-

2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-

CAS No.:
211311-95-4
Catalog Number:
AG002LAB
Molecular Formula:
C19H22N2O2S
Molecular Weight:
342.4552
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Product Description
Catalog Number:
AG002LAB
Chemical Name:
2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-
CAS Number:
211311-95-4
Molecular Formula:
C19H22N2O2S
Molecular Weight:
342.4552
MDL Number:
MFCD07364003
IUPAC Name:
N-[2-[4-(4-cyanophenyl)phenyl]propyl]propane-2-sulfonamide
InChI:
InChI=1S/C19H22N2O2S/c1-14(2)24(22,23)21-13-15(3)17-8-10-19(11-9-17)18-6-4-16(12-20)5-7-18/h4-11,14-15,21H,13H2,1-3H3
InChI Key:
HOQAVGZLYRYHSO-UHFFFAOYSA-N
SMILES:
N#Cc1ccc(cc1)c1ccc(cc1)C(CNS(=O)(=O)C(C)C)C
Properties
Complexity:
527  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
342.14g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
342.457g/mol
Monoisotopic Mass:
342.14g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
78.3A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8  
Literature
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A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives. Bioorganic & medicinal chemistry letters 20061001
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The AMPA receptor potentiator LY404187 increases cerebral glucose utilization and c-fos expression in the rat. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20041001
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Design and synthesis of a novel series of 1,2-disubstituted cyclopentanes as small, potent potentiators of 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl)propanoic acid (AMPA) receptors. Journal of medicinal chemistry 20020509
Positive modulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors in prefrontal cortical pyramidal neurons by a novel allosteric potentiator. The Journal of pharmacology and experimental therapeutics 20010701
Novel AMPA receptor potentiators LY392098 and LY404187: effects on recombinant human AMPA receptors in vitro. Neuropharmacology 20010601
Pharmacological effects of AMPA receptor potentiators LY392098 and LY404187 on rat neuronal AMPA receptors in vitro. Neuropharmacology 20010601
Potentiation of responses to AMPA on central neurones by LY392098 and LY404187 in vivo. Neuropharmacology 20010601
Properties