5-(2,6-Dichlorophenyl)-2-((2,4-difluorophenyl)thio)-6h-pyrimido[1,6-b]pyridazin-6-one
| Title | Journal |
|---|---|
| Neflamapimod: Clinical Phase 2b-Ready Oral Small Molecule Inhibitor of p38α to Reverse Synaptic Dysfunction in Early Alzheimer's Disease. | The journal of prevention of Alzheimer's disease 20170101 |
| Selective Brain-Targeted Antagonism of p38 MAPKα Reduces Hippocampal IL-1β Levels and Improves Morris Water Maze Performance in Aged Rats. | Journal of Alzheimer's disease : JAD 20150101 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Identification, synthesis, and biological evaluation of 6-[(6R)-2-(4-fluorophenyl)-6-(hydroxymethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidin-3-yl]-2-(2-methylphenyl)pyridazin-3(2H)-one (AS1940477), a potent p38 MAP kinase inhibitor. | Journal of medicinal chemistry 20120913 |
| 1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. | Journal of medicinal chemistry 20111124 |
| Comprehensive analysis of kinase inhibitor selectivity. | Nature biotechnology 20111030 |
| The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor. | ACS medicinal chemistry letters 20111013 |
| Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. | Journal of medicinal chemistry 20110714 |
| Design, synthesis and activity of a potent, selective series of N-aryl pyridinone inhibitors of p38 kinase. | Bioorganic & medicinal chemistry letters 20110701 |
| Discovery, synthesis, and investigation of the antitumor activity of novel piperazinylpyrimidine derivatives. | European journal of medicinal chemistry 20110601 |
| Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. | Chemistry & biology 20101124 |
| Gram-scale synthesis of the p38α MAPK-inhibitor VX-745 for preclinical studies into Werner syndrome. | Future medicinal chemistry 20100901 |
| Selective p38alpha inhibitors clinically evaluated for the treatment of chronic inflammatory disorders. | Journal of medicinal chemistry 20100325 |
| Microwave-assisted Ullmann C-S bond formation: synthesis of the P38alpha MAPK clinical candidate VX-745. | The Journal of organic chemistry 20091106 |
| Inhibition of p38: has the fat lady sung? | Arthritis and rheumatism 20090201 |
| Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. | Bioorganic & medicinal chemistry letters 20080315 |
| The design and synthesis of novel alpha-ketoamide-based p38 MAP kinase inhibitors. | Bioorganic & medicinal chemistry letters 20080315 |
| A quantitative analysis of kinase inhibitor selectivity. | Nature biotechnology 20080101 |
| A novel p38 alpha MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model. | Journal of neuroinflammation 20070101 |
| p38 MAP kinase inhibitors. Part 6: 2-arylpyridazin-3-ones as templates for inhibitor design. | Bioorganic & medicinal chemistry letters 20061115 |
| The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production. | Bioorganic & medicinal chemistry letters 20060815 |
| p38 MAP kinase inhibitors. Part 3: SAR on 3,4-dihydropyrimido[4,5-d]pyrimidin-2-ones and 3,4-dihydropyrido[4,3-d]pyrimidin-2-ones. | Bioorganic & medicinal chemistry letters 20060815 |
| Small molecular anti-cytokine agents. | Medicinal research reviews 20060101 |
| A small molecule-kinase interaction map for clinical kinase inhibitors. | Nature biotechnology 20050301 |
| P38 MAP kinase inhibitors: evolution of imidazole-based and pyrido-pyrimidin-2-one lead classes. | Current topics in medicinal chemistry 20050101 |
| Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. | Journal of medicinal chemistry 20031218 |
| Structural basis for p38alpha MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. | Nature structural biology 20030901 |
| Targeting p38 MAPK inhibits multiple myeloma cell growth in the bone marrow milieu. | Blood 20030115 |