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Zm 336372

CAS No.:
208260-29-1
Catalog Number:
AG002JMC
Molecular Formula:
C23H23N3O3
Molecular Weight:
389.4470
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
96%
1 week
United States
$154
- +
10mg
96%
1 week
United States
$232
- +
50mg
96%
1 week
United States
$657
- +
Product Description
Catalog Number:
AG002JMC
Chemical Name:
Zm 336372
CAS Number:
208260-29-1
Molecular Formula:
C23H23N3O3
Molecular Weight:
389.4470
MDL Number:
MFCD02683971
IUPAC Name:
3-(dimethylamino)-N-[3-[(4-hydroxybenzoyl)amino]-4-methylphenyl]benzamide
InChI:
InChI=1S/C23H23N3O3/c1-15-7-10-18(24-23(29)17-5-4-6-19(13-17)26(2)3)14-21(15)25-22(28)16-8-11-20(27)12-9-16/h4-14,27H,1-3H3,(H,24,29)(H,25,28)
InChI Key:
PYEFPDQFAZNXLI-UHFFFAOYSA-N
SMILES:
Oc1ccc(cc1)C(=O)Nc1cc(ccc1C)NC(=O)c1cccc(c1)N(C)C
Properties
Complexity:
560  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
389.174g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
389.455g/mol
Monoisotopic Mass:
389.174g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
81.7A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.7  
Literature
Title Journal
Mechanisms of the inhibition of nuclear factor-κB by morphine in neuronal cells. Molecular pharmacology 20120401
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
ZM336372 induces apoptosis associated with phosphorylation of GSK-3beta in pancreatic adenocarcinoma cell lines. The Journal of surgical research 20100601
ZM336372, a Raf-1 activator, causes suppression of proliferation in a human hepatocellular carcinoma cell line. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract 20080501
Pharmacophore identification of Raf-1 kinase inhibitors. Bioorganic & medicinal chemistry letters 20080401
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proceedings of the National Academy of Sciences of the United States of America 20071218
The selectivity of protein kinase inhibitors: a further update. The Biochemical journal 20071215
Neuroendocrine tumor cell growth inhibition by ZM336372 through alterations in multiple signaling pathways. Surgery 20071201
Bifunctional modulating effects of an indigo dimer (bisindigotin) to CYP1A1 induction in H4IIE cells. Toxicology 20060921
Rational design of inhibitors that bind to inactive kinase conformations. Nature chemical biology 20060701
ZM336372, a Raf-1 activator, inhibits growth of pheochromocytoma cells. The Journal of surgical research 20060601
Reactive oxygen species modulate independent protein phosphorylation pathways during human sperm capacitation. Free radical biology & medicine 20060315
ZM336372, a Raf-1 activator, suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells. Molecular cancer therapeutics 20050601
A novel series of p38 MAP kinase inhibitors for the potential treatment of rheumatoid arthritis. Bioorganic & medicinal chemistry letters 20041101
The specificities of protein kinase inhibitors: an update. The Biochemical journal 20030401
Properties