2H-Isoindole-2-butanoic acid, octahydro-γ-oxo-α-(phenylmethyl)-, calcium salt, hydrate (2:1:2), (αS,3aR,7aS)-
| Title | Journal |
|---|---|
| Tighter control of postprandial hyperglycemia with mitiglinide/voglibose fixed-dose combination in Japanese patients with type 2 diabetes mellitus. | Expert opinion on pharmacotherapy 20121101 |
| Hollow fiber liquid-phase microextraction combined with high performance liquid chromatography for the determination of trace mitiglinide in biological fluids. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501 |
| Comparison of the rapidity of onset of the therapeutic effect between nateglinide and mitiglinide by PK/PD analysis in rats. | European journal of drug metabolism and pharmacokinetics 20120301 |
| Pharmacogenomic analysis of ATP-sensitive potassium channels coexpressing the common type 2 diabetes risk variants E23K and S1369A. | Pharmacogenetics and genomics 20120301 |
| The effects of food on the pharmacokinetics of mitiglinide tablets in healthy volunteers and a novel mass-spectrometric (UPLC-MS/MS) method for such studies. | Journal of clinical pharmacy and therapeutics 20120201 |
| Efficacy and safety of mitiglinide versus nateglinide in newly diagnose patients with type 2 diabetes mellitus: a randomized double blind trial. | Diabetes, obesity & metabolism 20120201 |
| Variations in tissue selectivity amongst insulin secretagogues: a systematic review. | Diabetes, obesity & metabolism 20120201 |
| Mitiglinide treatment may decreases plasma fibroblast growth factor-21 levels in individuals with new-onset T2DM. | Cytokine 20120201 |
| Effect of gemfibrozil on the pharmacokinetics of mitiglinide in rats. | Arzneimittel-Forschung 20120101 |
| Mitiglinide: a novel agent for the treatment of type 2 diabetes mellitus. | The Annals of pharmacotherapy 20101001 |
| Combination therapy with mitiglinide and voglibose improves glycemic control in type 2 diabetic patients on hemodialysis. | Expert opinion on pharmacotherapy 20100201 |
| Efficacy and safety of mitiglinide in diabetic patients on maintenance hemodialysis. | Endocrine journal 20100101 |
| Effect of mitiglinide on Streptozotocin-induced experimental type 2 diabetic rats: a urinary metabonomics study based on ultra-performance liquid chromatography-tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101 |
| Treatment with glimepiride, but not mitiglinide and short-acting insulin, resists body weight and abdominal fat reduction under dietary energy restriction. | Journal of atherosclerosis and thrombosis 20090301 |
| Addition of mitiglinide to pioglitazone monotherapy improves overall glycemic control in Japanese patients with type 2 diabetes: a randomized double blind trial. | Endocrine journal 20090101 |
| Effect of mitiglinide on glycemic control over 52 weeks in Japanese type 2 diabetic patients insufficiently controlled with pioglitazone monotherapy. | Endocrine journal 20090101 |
| Multicentre, double-blind, randomized study of mitiglinide compared with nateglinide in type 2 diabetes mellitus patients in China. | The Journal of international medical research 20090101 |
| Pleiotropic effects of mitiglinide in type 2 diabetes mellitus. | The Journal of international medical research 20090101 |
| Mitiglinide: a rapid- and short-acting non-sulfonylurea insulinotropic agent for the treatment of type 2 diabetic patients. | Expert opinion on pharmacotherapy 20081001 |
| Liquid chromatography/electrospray ionization tandem mass spectrometry for the quantification of mitiglinide in human plasma: validation and its application to pharmacokinetic studies. | Biomedical chromatography : BMC 20080801 |
| Quantitative determination of mitiglinide in human plasma by ultra-performance liquid chromatography/electrospray ionization tandem mass spectrometry. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080601 |
| Nateglinide and mitiglinide, but not sulfonylureas, induce insulin secretion through a mechanism mediated by calcium release from endoplasmic reticulum. | The Journal of pharmacology and experimental therapeutics 20070701 |
| Carboxyl-glucuronidation of mitiglinide by human UDP-glucuronosyltransferases. | Biochemical pharmacology 20070601 |
| Mitiglinide, a novel oral hypoglycemic agent, preserves the cardioprotective effect of ischemic preconditioning in isolated perfused rat hearts. | International heart journal 20070501 |
| High-performance liquid chromatography-electrospray ionization mass spectrometry determination of mitiglinide in human plasma and its pharmacokinetics. | Journal of mass spectrometry : JMS 20070201 |
| Long-term effect of combination therapy with mitiglinide and once daily insulin glargine in patients who were successfully switched from intensive insulin therapy in short-term study. | Endocrine journal 20070201 |
| Effect of combination therapy of a rapid-acting insulin secretagogue (glinide) with premixed insulin in type 2 diabetes mellitus. | Internal medicine (Tokyo, Japan) 20070101 |
| [Glinide(s), sulfonylurea(s)]. | Nihon rinsho. Japanese journal of clinical medicine 20061101 |
| Imaging docking and fusion of insulin granules induced by antidiabetes agents: sulfonylurea and glinide drugs preferentially mediate the fusion of newcomer, but not previously docked, insulin granules. | Diabetes 20061001 |
| Determination of mitiglinide in rat plasma by high-performance liquid chromatography with UV detection. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060413 |
| Effects of mitiglinide on glucose-induced insulin release into the portal vein and fat-induced triglyceride elevation in prediabetic and diabetic OLETF rats. | Endocrine 20060401 |
| Effects of mitiglinide and sulfonylureas in isolated canine coronary arteries and perfused rat hearts. | European journal of pharmacology 20060215 |
| Therapeutic efficacy of mitiglinide combined with once daily insulin glargine after switching from multiple daily insulin regimen of aspart insulin and glargine in patients with type 2 diabetes mellitus. | Endocrine journal 20060201 |
| [Significance of insulin secretion pattern lectured by 'glinides' in the treatment of postprandial hyperglycemia]. | Nihon rinsho. Japanese journal of clinical medicine 20051201 |
| [Synthesis and insulinotropic activity of 2-benzylidenesuccinic acid derivatives]. | Yao xue xue bao = Acta pharmaceutica Sinica 20051201 |
| Characterization of the action of S 21403 (mitiglinide) on insulin secretion and biosynthesis in normal and diabetic beta-cells. | British journal of pharmacology 20051101 |
| Effects of S21403 (mitiglinide) on postprandial generation of oxidative stress and inflammation in type 2 diabetic patients. | Diabetologia 20050901 |
| [Selection of oral antidiabetic drugs]. | Nihon rinsho. Japanese journal of clinical medicine 20050201 |
| [Effects of mitiglinide in treatment of impaired glucose tolerance]. | Nihon rinsho. Japanese journal of clinical medicine 20050201 |
| [Pharmacological and clinical profile of mitiglinide calcium hydrate (Glufast), a new insulinotropic agent with rapid onset]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20041001 |
| [Achieving better control of blood sugar--understanding of oral hypoglycemic agents according to their characteristics in pharmacological action mechanism (discussion)]. | Nihon rinsho. Japanese journal of clinical medicine 20040401 |
| Mitiglinide: KAD 1229, S 21403. | Drugs in R&D 20040101 |
| [Nateglinide and mitiglinide]. | Nihon rinsho. Japanese journal of clinical medicine 20030701 |
| Effects of S 21403 on hormone secretion from isolated rat pancreas at different glucose concentrations. | European journal of pharmacology 20021205 |
| [Structures and mechanisms for non SU insulin secretagogues]. | Nihon rinsho. Japanese journal of clinical medicine 20020901 |
| [Mitiglinide (KAD-1229)]. | Nihon rinsho. Japanese journal of clinical medicine 20020901 |
| Effect of KAD-1229, a novel hypoglycaemic agent, on plasma glucose levels after meal load in type 2 diabetic rats. | Clinical and experimental pharmacology & physiology 20020101 |
| Study of the insulinotropic effect of the novel antihyperglycemic agent KAD-1229 using HIT T15 cells, a hamster's insulinoma cell line. | Arzneimittel-Forschung 20020101 |
| Absence of exacerbation of myocardial stunning in anesthetized dogs treated with KAD-1229, a novel hypoglycemic agent. | European journal of pharmacology 20011123 |
| The effects of mitiglinide (KAD-1229), a new anti-diabetic drug, on ATP-sensitive K+ channels and insulin secretion: comparison with the sulfonylureas and nateglinide. | European journal of pharmacology 20011109 |
| Rapid acting insulinotropic agents: restoration of early insulin secretion as a physiologic approach to improve glucose control. | Current pharmaceutical design 20010901 |
| Effects of mitiglinide (S 21403) on Kir6.2/SUR1, Kir6.2/SUR2A and Kir6.2/SUR2B types of ATP-sensitive potassium channel. | British journal of pharmacology 20010401 |
| Effect of KAD-1229, a nonsulfonylurea hypoglycemic agent, on plasma glucose and insulin in streptozotocin-induced diabetic dogs. | Pharmacology 20010201 |