Nonsteroidal anti-inflammatory drug-activated gene-1 plays a role in the impairing effects of cyclooxygenase inhibitors on gastric ulcer healing.

The Journal of pharmacology and experimental therapeutics 20120701

Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.

Bioorganic & medicinal chemistry 20120501

Structure-activity relationship of nonacidic quinazolinone inhibitors of human microsomal prostaglandin synthase 1 (mPGES 1).

Journal of medicinal chemistry 20120426

Retinoic acid increases hypoxia-inducible factor-1α through intracrine prostaglandin E(2) signaling in human renal proximal tubular cells HK-2.

Biochimica et biophysica acta 20120401

Interaction between selective cyclooxygenase inhibitors and capsaicin-sensitive afferent sensory nerves in pathogenesis of stress-induced gastric lesions. Role of oxidative stress.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20120401

Prostaglandin E2-mediated attenuation of mesocortical dopaminergic pathway is critical for susceptibility to repeated social defeat stress in mice.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20120321

Cyclooxygenase-1-selective inhibitors based on the (E)-2'-des-methyl-sulindac sulfide scaffold.

Journal of medicinal chemistry 20120308

Relative contribution of cyclooxygenases, epoxyeicosatrienoic acids, and pH to the cerebral blood flow response to vibrissal stimulation.

American journal of physiology. Heart and circulatory physiology 20120301

Hemokinin-1 stimulates prostaglandin E₂ production in human colon through activation of cyclooxygenase-2 and inhibition of 15-hydroxyprostaglandin dehydrogenase.

The Journal of pharmacology and experimental therapeutics 20120101

Novel selective COX-1 inhibitors suppress neuroinflammatory mediators in LPS-stimulated N13 microglial cells.

Pharmacological research 20120101

Effects of cyclooxygenase inhibitors in combination with taxol on expression of cyclin D1 and Ki-67 in a xenograft model of ovarian carcinoma.

International journal of molecular sciences 20120101

Cyclooxygenase-2-derived prostacyclin protective role on endotoxin-induced mouse cardiomyocyte mortality.

Cardiovascular toxicology 20111201

SO(2)-induced neurotoxicity is mediated by cyclooxygenases-2-derived prostaglandin E(2) and its downstream signaling pathway in rat hippocampal neurons.

Toxicological sciences : an official journal of the Society of Toxicology 20111201

Nitric oxide-releasing aspirin but not conventional aspirin improves healing of experimental colitis.

World journal of gastroenterology 20110928

Balloon catheter injury abolishes phenylephrine-induced relaxation in the rat contralateral carotid.

British journal of pharmacology 20110601

Human prostaglandin H synthase (hPHS)-1 and hPHS-2 in amphetamine analog bioactivation, DNA oxidation, and cytotoxicity.

Toxicological sciences : an official journal of the Society of Toxicology 20110301

Progestogens reduce thromboxane production by cultured human endothelial cells.

Climacteric : the journal of the International Menopause Society 20110201

Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110201

Cyclooxygenase-2 protects germ cells against spermatogenesis disturbance in experimental cryptorchidism model mice.

Journal of andrology 20110101

Inhibition of cyclooxygenase-2 prevents adverse effects induced by phosphodiesterase type 4 inhibitors in rats.

British journal of pharmacology 20110101

Design, synthesis and pharmacobiological evaluation of novel acrylic acid derivatives acting as lipoxygenase and cyclooxygenase-1 inhibitors with antioxidant and anti-inflammatory activities.

European journal of medicinal chemistry 20110101

Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on ovarian carcinoma in vivo.

International journal of molecular sciences 20110101

[Regulatory interconnections of cyclooxigenase and inducible no-synthase in urinary bladder epithelial cells of the frog Rana temporaria under action of bacterial stimuli].

Zhurnal evoliutsionnoi biokhimii i fiziologii 20110101

Blockade of leukocyte haptokinesis and haptotaxis by ketoprofen, diclofenac and SC-560.

BMC immunology 20110101

Non-steroidal anti-inflammatory drugs inhibit calpain activity and membrane localization of calpain 2 protease.

The international journal of biochemistry & cell biology 20101201

Augmented cyclooxygenase-2 effects on renal function during varying states of angiotensin II.

American journal of physiology. Renal physiology 20101101

Chronic treatment with the cannabinoid 1 antagonist rimonabant altered vasoactive cyclo-oxygenase-derived products on arteries from obese Zucker rats.

Journal of cardiovascular pharmacology 20101101

Therapeutic potential of sulindac hydroxamic acid against human pancreatic and colonic cancer cells.

European journal of medicinal chemistry 20101101

NS-398 (a selective cyclooxygenase-2 inhibitor) decreases agonist-induced contraction of the human ureter via calcium channel inhibition.

Journal of endourology 20101101

Role of COX-2 in nonsteroidal anti-inflammatory drug enteropathy in rodents.

Scandinavian journal of gastroenterology 20100801

Chronic inhibition of nitric-oxide synthase potentiates endothelium-dependent contractions in the rat aorta by augmenting the expression of cyclooxygenase-2.

The Journal of pharmacology and experimental therapeutics 20100801

Ghrelin signaling in human mesenteric arteries.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20100801

Triterpene saponins from Clematis chinensis and their potential anti-inflammatory activity.

Journal of natural products 20100723

Gastric acid is the key modulator in the pathogenesis of non-steroidal anti-inflammatory drug-induced ulceration in rats.

Clinical and experimental pharmacology & physiology 20100701

Paradoxical thrombotic effects of aspirin: experimental study on 1000 animals.

Cardiovascular & hematological disorders drug targets 20100601

Dithiolethione modified valproate and diclofenac increase E-cadherin expression and decrease proliferation of non-small cell lung cancer cells.

Lung cancer (Amsterdam, Netherlands) 20100501

Roles of COX inhibition in pathogenesis of NSAID-induced small intestinal damage.

Clinica chimica acta; international journal of clinical chemistry 20100402

Thromboxane A(2) promotes soluble CD40 ligand release from human platelets.

Atherosclerosis 20100401

Effects of a selective cyclooxygenase-1 inhibitor in SKOV-3 ovarian carcinoma xenograft-bearing mice.

Medical oncology (Northwood, London, England) 20100301

The effects of nepafenac and amfenac on retinal angiogenesis.

Brain research bulletin 20100215

Cyclooxygenase-1 mediates the immediate corticosterone response to peripheral immune challenge induced by lipopolysaccharide.

Neuroscience letters 20100205

Effects of cyclooxygenase inhibitor treatment on the renal toxicity of cisplatin in rats.

Cancer chemotherapy and pharmacology 20100201

Improvement in neurogenic detrusor overactivity by peripheral C fiber's suppression with cyclooxygenase inhibitors.

The Journal of urology 20100201

Synthesis and biological evaluation of nitrogen-containing chalcones as possible anti-inflammatory and antioxidant agents.

Bioorganic & medicinal chemistry letters 20100115

Spinal antinociceptive effects of cyclooxygenase inhibition during inflammation: Involvement of prostaglandins and endocannabinoids.

Pain 20100101

The influence of constitutive COX-2 in smooth muscle tissue on the contractile effect of phenylephrine in the rat abdominal aorta.

Frontiers in bioscience (Elite edition) 20100101

Pharmacologic inhibition of COX-1 and COX-2 in influenza A viral infection in mice.

PloS one 20100101

Roles of NADPH oxidase in occurrence of gastric damage and expression of cyclooxygenase-2 during ischemia/reperfusion in rat stomachs.

Journal of pharmacological sciences 20091201

Cerebrovascular cyclooxygenase-1 expression, regulation, and role in hypothalamic-pituitary-adrenal axis activation by inflammatory stimuli.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20091014

Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.

Nature chemical biology 20091001

Anti-bovine viral diarrhoea virus and hepatitis C virus activity of the cyclooxygenase inhibitor SC-560.

Antiviral chemistry & chemotherapy 20090925

Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.

Immunology 20090901

Cyclooxygenase-1 or -2--which one mediates lipopolysaccharide-induced hypothermia?

American journal of physiology. Regulatory, integrative and comparative physiology 20090801

Omega-3 Fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment.

PLoS biology 20090801

Protective effects of amifostine and cyclooxygenase-1 inhibitor against normal human epidermal keratinocyte toxicity induced by methotrexate and 5-fluorouracil.

Basic & clinical pharmacology & toxicology 20090701

Inhibition of cyclooxygenase-1 lowers proliferation and induces macroautophagy in colon cancer cells.

Biochemical and biophysical research communications 20090424

Cyclooxygenase 2 inhibition suppresses tubuloglomerular feedback: roles of thromboxane receptors and nitric oxide.

American journal of physiology. Renal physiology 20090401

Reactions of functionalized sulfonamides: application to lowering the lipophilicity of cytosolic phospholipase A2alpha inhibitors.

Journal of medicinal chemistry 20090226

Effects of nonselective and selective cyclooxygenase inhibitors on small intestinal motility in the horse.

Research in veterinary science 20090201

COX-1 vs. COX-2 as a determinant of basal tone in the internal anal sphincter.

American journal of physiology. Gastrointestinal and liver physiology 20090201

Cyclo-oxygenase-1-selective inhibitor SC-560.

Acta crystallographica. Section E, Structure reports online 20090201

Effects of a cyclooxygenase-1-selective inhibitor in a mouse model of ovarian cancer, administered alone or in combination with ibuprofen, a nonselective cyclooxygenase inhibitor.

Medical oncology (Northwood, London, England) 20090101

Delayed neonatal closure of the ductus arteriosus following early in utero exposure to indomethacin in the rat.

Neonatology 20090101

Resveratrol inhibits prostaglandin formation in IL-1beta-stimulated SK-N-SH neuronal cells.

Journal of neuroinflammation 20090101

Differential involvement of cyclooxygenase isoforms in neutrophil migration in vivo and in vitro.

European journal of pharmacology 20081119

Role of cyclooxygenase isoforms in prostacyclin biosynthesis and murine prehepatic portal hypertension.

American journal of physiology. Gastrointestinal and liver physiology 20081101

Cyclooxygenase-dependent vasoconstricting factor(s) in remodelled rat femoral arteries.

Cardiovascular research 20080701

Histone deacetylase inhibitors and aspirin interact synergistically to induce cell death in ovarian cancer cells.

Oncology reports 20080701

Indole cytosolic phospholipase A2 alpha inhibitors: discovery and in vitro and in vivo characterization of 4-{3-[5-chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic acid, efipladib.

Journal of medicinal chemistry 20080626

Cyclooxygenase-2 derived PGE2 and PGI2 play an important role via EP2 and PPARdelta receptors in early steps of oil induced decidualization in mice.

Placenta 20080601

Expression of cyclooxygenase genes and production of prostaglandins during ovulation in the ovarian follicles of Xenopus laevis.

General and comparative endocrinology 20080601

Genetic deletion or pharmacological inhibition of cyclooxygenase-1 attenuate lipopolysaccharide-induced inflammatory response and brain injury.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080501

Drug-induced alterations to gene and protein expression in intestinal epithelial cell 6 cells suggest a role for calpains in the gastrointestinal toxicity of nonsteroidal anti-inflammatory agents.

The Journal of pharmacology and experimental therapeutics 20080501

Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release.

American journal of physiology. Lung cellular and molecular physiology 20080501

The effects of intrathecal cyclooxygenase-1, cyclooxygenase-2, or nonselective inhibitors on pain behavior and spinal Fos-like immunoreactivity.

Anesthesia and analgesia 20080301

Cyclooxygenase-1 suppresses lipopolysaccharide-induced changes in rat gastric inducible nitric oxide synthase.

Critical care medicine 20080201

Evidence that PAR2-triggered prostaglandin E2 (PGE2) formation involves the ERK-cytosolic phospholipase A2-COX-1-microsomal PGE synthase-1 cascade in human lung epithelial cells.

Cell biochemistry and function 20080101

Effects of cyclooxygenase inhibition on canine coronary artery blood flow and thrombosis.

American journal of physiology. Heart and circulatory physiology 20080101

Effects of aspirin, nimesulide, and SC-560 on vasopressin-induced contraction of human gastroepiploic artery and saphenous vein.

Critical care medicine 20080101

Cyclooxygenase-2-derived endogenous prostacyclin reduces apoptosis and enhances embryo viability in mouse.

Prostaglandins, leukotrienes, and essential fatty acids 20080101

Involvement of COX-1 in A3 adenosine receptor-mediated contraction through endothelium in mice aorta.

American journal of physiology. Heart and circulatory physiology 20071201

Roles of platelet and endothelial cell COX-1 in hypercholesterolemia-induced microvascular dysfunction.

American journal of physiology. Heart and circulatory physiology 20071201

Characterization of the vasorelaxant mechanisms of the endocannabinoid anandamide in rat aorta.

British journal of pharmacology 20071101

Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension.

World journal of gastroenterology 20071014

Aggravation by selective COX-1 and COX-2 inhibitors of dextran sulfate sodium (DSS)-induced colon lesions in rats.

Digestive diseases and sciences 20070901

Involvement of prostaglandin E receptor EP3 subtype and prostacyclin IP receptor in decreased acid response in damaged stomach.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20070901

Abnormalities of prostaglandins and cyclooxygenase enzymes in female patients with slow-transit constipation.

Gastroenterology 20070801

Bradykinin-induced nociceptor sensitisation to heat depends on cox-1 and cox-2 in isolated rat skin.

Pain 20070701

Dexamethasone damages the rat stomach but not small intestine during inhibition of COX-1.

Digestive diseases and sciences 20070601

Cyclooxygenase-1 inhibition delays recovery of the cutaneous barrier disruption caused by mechanical scratching in mice.

The British journal of dermatology 20070601

Interactive actions of prostaglandin and epidermal growth factor to enhance proliferation of granulosa cells from chicken prehierarchical follicles.

Prostaglandins & other lipid mediators 20070601

Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer.

Cancer research 20070601

Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries.

The Journal of pharmacology and experimental therapeutics 20070501

Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells.

Biochemical pharmacology 20070501

Escherichia coli lipopolysaccharides produce serotype-specific hypothermic response in biotelemetered rats.

American journal of physiology. Regulatory, integrative and comparative physiology 20070501

Aspirin and COX-2 inhibitor nimesulide potentiate adrenergic contractions of human gastroepiploic artery.

American journal of hypertension 20070501

Thromboxane receptor blockade improves the antiatherogenic effect of thromboxane A2 suppression in LDLR KO mice.

Blood 20070415

Spinal prostaglandins facilitate exaggerated A- and C-fiber-mediated reflex responses and are critical to the development of allodynia early after L5-L6 spinal nerve ligation.

Anesthesiology 20070401

Evaluation of cyclooxygenase 2 derived endogenous prostacyclin in mouse preimplantation embryo development in vitro.

Life sciences 20070327

Screening method for nonsteroidal antiinflammatory drugs based on the cyclooxygenase 2 pathway activated by serum-free stimulation in A549 cells.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070301

[Effects of cyclooxygenase-1 inhibitor on spinal ERK expression in rats with postoperative pain].

Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20070201

Intrathecally administered COX-2 but not COX-1 or COX-3 inhibitors attenuate streptozotocin-induced mechanical hyperalgesia in rats.

European journal of pharmacology 20070105

Effect of cyclooxygenase inhibition on cholesterol efflux proteins and atheromatous foam cell transformation in THP-1 human macrophages: a possible mechanism for increased cardiovascular risk.

Arthritis research & therapy 20070101

Acetaminophen, phenacetin and dipyrone do not modulate pressor responses to arachidonic Acid or to pressor agents.

Pharmacology 20070101

Effect of cyclooxygenase on 'window of implantation' in mouse.

Prostaglandins, leukotrienes, and essential fatty acids 20070101

Reverse effect of aspirin: is the prothrombotic effect after aspirin discontinuation mediated by cyclooxygenase 2 inhibition?

Pathophysiology of haemostasis and thrombosis 20070101

Roles of stretch-activated cation channel and Rho-kinase in the spontaneous contraction of airway smooth muscle.

European journal of pharmacology 20061215

Intestinal effects of nonselective and selective cyclooxygenase inhibitors in the rat.

European journal of pharmacology 20061215

Endogenous prostaglandins regulate spontaneous contractile activity of uterine strips isolated from non-pregnant pigs.

Prostaglandins & other lipid mediators 20061201

Effects of selective PGE2 receptor antagonists in esophageal adenocarcinoma cells derived from Barrett's esophagus.

Prostaglandins & other lipid mediators 20061201

Prostaglandin E2 release in gastric antral mucosa of guinea-pigs: basal PGE2 release by cyclo-oxygenase 2 and ACh-stimulated PGE2 release by cyclo-oxygenase 1.

Experimental physiology 20061101

Cis-unsaturated fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa.

The Journal of clinical endocrinology and metabolism 20061001

Prostacyclin production in tryptase and thrombin stimulated human bladder endothelial cells: effect of pretreatment with phospholipase A2 and cyclooxygenase inhibitors.

The Journal of urology 20061001

Effects of selective inhibition of cyclooxygenase and lipooxygenase pathways in follicle rupture and ovulation in the rat.

Reproduction (Cambridge, England) 20061001

Therapeutic levels of aspirin and salicylate directly inhibit a model of angiogenesis through a Cox-independent mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20061001

Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct.

The Journal of endocrinology 20061001

Kinase-dependent, retinoic acid receptor-independent up-regulation of cyclooxygenase-2 by all-trans retinoic acid in human mesangial cells.

British journal of pharmacology 20060901

Intrathecal administration of a cylcooxygenase-1, but not a cyclooxygenase-2 inhibitor, reverses the effects of laparotomy on exploratory activity in rats.

Anesthesia and analgesia 20060901

Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats.

The Journal of pharmacology and experimental therapeutics 20060801

Endogenous opioids mediate the hypoalgesia induced by selective inhibitors of cyclo-oxygenase 2 in rat paws treated with carrageenan.

Neuropharmacology 20060701

Inhibition of prostaglandin E2 synthesis by SC-560 is independent of cyclooxygenase 1 inhibition.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060701

Factors involved in upregulation of inducible nitric oxide synthase in rat small intestine following administration of nonsteroidal anti-inflammatory drugs.

Digestive diseases and sciences 20060701

Role of p21CIP1 as a determinant of SC-560 response in human HCT116 colon carcinoma cells.

Experimental & molecular medicine 20060630

Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.

Bioorganic & medicinal chemistry letters 20060601

Lipopolysaccharide induces epithelium- and prostaglandin E(2)-dependent relaxation of mouse isolated trachea through activation of cyclooxygenase (COX)-1 and COX-2.

The Journal of pharmacology and experimental therapeutics 20060501

Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice.

Arteriosclerosis, thrombosis, and vascular biology 20060501

Cyclooxygenase inhibitors not inhibit resting lung cancer A549 cell proliferation.

Prostaglandins, leukotrienes, and essential fatty acids 20060501

5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-trifluoromethylpyrazole acts in a reactive oxygen species-dependent manner to suppress human lung cancer growth.

Journal of cancer research and clinical oncology 20060401

Products of cyclooxygenase-2 depress duodenal function in rats subjected to abdominal surgery.

Acta physiologica (Oxford, England) 20060401

Influence of plasma protein on the potencies of inhibitors of cyclooxygenase-1 and -2.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060301

Roles of cyclooxygenase-2 and prostacyclin/IP receptors in mucosal defense against ischemia/reperfusion injury in mouse stomach.

The Journal of pharmacology and experimental therapeutics 20060201

The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells.

International journal of molecular medicine 20060201

Effects of cyclooxygenase-1 and -2 inhibition on gastric acid secretion and cardiovascular functions in rats.

Pharmacology 20060101

Dexamethasone impairs the gastric mucosal integrity in rats treated with a cyclooxygenase-1 but not with a cyclooxygenase-2 inhibitor.

Pharmacology 20060101

Differential effects of COX inhibitors against beta-amyloid-induced neurotoxicity in human neuroblastoma cells.

Neurochemistry international 20051201

Cyclooxygenase 2 (COX-2) inhibition increases the inflammatory response in the brain during systemic immune stimuli.

Journal of neurochemistry 20051201

Cyclo-oxygenase-2 contributes to constitutive prostanoid production in rat kidney and brain.

The Biochemical journal 20051101

Synthesis and antiinflammatory activity of coumarin derivatives.

Journal of medicinal chemistry 20051006

Radiosynthesis and in vivo evaluation of 11C-labeled 1,5-diarylpyrazole derivatives for mapping cyclooxygenases.

Annals of nuclear medicine 20051001

Central cyclooxygenase inhibitors reduced IL-1beta-induced hyperalgesia in temporomandibular joint of freely moving rats.

Pain 20050901

COX-1 and COX-2 conversely promote and suppress ischemia-reperfusion gastric injury in mice.

Scandinavian journal of gastroenterology 20050801

Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats.

The Journal of pharmacology and experimental therapeutics 20050701

Selective cyclooxygenase (COX) inhibition causes damage to portal hypertensive gastric mucosa: roles of nitric oxide and NF-kappaB.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050701

Progestogens stimulate prostacyclin production by human endothelial cells.

Human reproduction (Oxford, England) 20050601

Selective inhibitors differentially affect cyclooxygenase-dependent pial arteriolar responses in newborn pigs.

Pediatric research 20050601

Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus.

Journal of neurochemistry 20050601

Cyclooxygenase-1 mediates the final stage of morphine-induced delayed cardioprotection in concert with cyclooxygenase-2.

Journal of the American College of Cardiology 20050517

Cyclooxygenase-2 is an obligatory factor in methamphetamine-induced neurotoxicity.

The Journal of pharmacology and experimental therapeutics 20050501

Preoperative inhibition of cyclooxygenase-1 in the spinal cord reduces postoperative pain.

Anesthesia and analgesia 20050501

Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer.

Cancer research 20050501

The anti-invasive activity of cyclooxygenase inhibitors is regulated by the transcription factor ATF3 (activating transcription factor 3).

Molecular cancer therapeutics 20050501

Translational studies on aromatase, cyclooxygenases, and enzyme inhibitors in breast cancer.

The Journal of steroid biochemistry and molecular biology 20050501

Preemptive analgesia by zaltoprofen that inhibits bradykinin action and cyclooxygenase in a post-operative pain model.

Neuroscience research 20050401

Development of in vitro assays for the evaluation of cyclooxygenase inhibitors and predicting selectivity of nonsteroidal anti-inflammatory drugs in cats.

American journal of veterinary research 20050401

Cyclooxygenase-2 inhibition improves vascular endothelial dysfunction in a rat model of endotoxic shock: role of inducible nitric-oxide synthase and oxidative stress.

The Journal of pharmacology and experimental therapeutics 20050301

Induced microsomal PGE synthase-1 is involved in cyclooxygenase-2-dependent PGE2 production in gastric fibroblasts.

American journal of physiology. Gastrointestinal and liver physiology 20050201

Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antitumorigenic protein.

Molecular pharmacology 20050201

In vivo endothelial interaction between ACE and COX inhibitors.

Prostaglandins, leukotrienes, and essential fatty acids 20050201

The cyclooxygenase inhibitor indomethacin modulates gene expression and represses the extracellular matrix protein laminin gamma1 in human glioblastoma cells.

Experimental cell research 20050115

Functional mechanism underlying cyclooxygenase-2 expression in rat small intestine following administration of indomethacin: relation to intestinal hypermotility.

Journal of gastroenterology and hepatology 20050101

Development of intestinal, but not gastric damage caused by a low dose of indomethacin in the presence of rofecoxib.

Inflammopharmacology 20050101

Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells.

The Journal of pharmacology and experimental therapeutics 20041201

Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells.

Journal of the National Cancer Institute 20041201

Acute regulation of OAT3-mediated estrone sulfate transport in isolated rabbit renal proximal tubules.

American journal of physiology. Renal physiology 20041101

Role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion.

Muscle & nerve 20041001

Dose-dependent immunomodulatory effects of acetylsalicylic acid and indomethacin in human whole blood: potential role of cyclooxygenase-2 inhibition.

Scandinavian journal of immunology 20041001

Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves.

European journal of pharmacology 20040919

Sensitization of vanilloid receptor 1 induced by bradykinin via the activation of second messenger signaling cascades in rat primary afferent neurons.

European journal of pharmacology 20040913

Inhibition of cyclooxygenase-2, but not cyclooxygenase-1, reduces prostaglandin E2 secretion from diabetic rat retinas.

European journal of pharmacology 20040913

Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone.

Circulation 20040907

High-performance liquid chromatographic analysis of a selective cyclooxygenase-1 inhibitor SC-560 in rat serum: application to pharmacokinetic studies.

Journal of pharmaceutical and biomedical analysis 20040903

Antitussive effect of NS-398, a selective cyclooxygenase-2 inhibitor, in guinea pigs.

European journal of pharmacology 20040823

Induction of small intestinal damage in rats following combined treatment with cyclooxygenase-2 and nitric-oxide synthase inhibitors.

The Journal of pharmacology and experimental therapeutics 20040801

Prostaglandin E2 is a product of induced prostaglandin-endoperoxide synthase 2 and microsomal-type prostaglandin E synthase at the implantation site of the hamster.

The Journal of biological chemistry 20040716

Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium.

Circulation research 20040611

Formation and antiproliferative effect of prostaglandin E(3) from eicosapentaenoic acid in human lung cancer cells.

Journal of lipid research 20040601

TNF-alpha hyperpolarizes membrane potential and potentiates the response to nicotinic receptor stimulation in cultured rat myenteric neurones.

Acta physiologica Scandinavica 20040501

Cyclooxygenase 1-dependent production of F2-isoprostane and changes in redox status during warm renal ischemia-reperfusion.

Free radical biology & medicine 20040415

Inhibition of IL-6, TNF-alpha, and cyclooxygenase-2 protein expression by prostaglandin E2-induced IL-10 in bone marrow-derived dendritic cells.

Cellular immunology 20040401

Gene modulation by Cox-1 and Cox-2 specific inhibitors in human colorectal carcinoma cancer cells.

Carcinogenesis 20040301

Roles of endogenous prostaglandins and cyclooxygenase izoenzymes in mucosal defense of inflamed rat stomach.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040301

Functional mechanism underlying COX-2 expression following administration of indomethacin in rat stomachs: importance of gastric hypermotility.

Digestive diseases and sciences 20040201

Unexpected nanomolar inhibition of carbonic anhydrase by COX-2-selective celecoxib: new pharmacological opportunities due to related binding site recognition.

Journal of medicinal chemistry 20040129

Genetic deficiency or pharmacological inhibition of cyclooxygenase-1 or -2 induces mouse keratinocyte differentiation in vitro and in vivo.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040101

Modulation of beta-amyloid metabolism by non-steroidal anti-inflammatory drugs in neuronal cell cultures.

Journal of neurochemistry 20040101

Raloxifene increases the capacity of serum to promote prostacyclin release in human endothelial cells: implication of COX-1 and COX-2.

Menopause (New York, N.Y.) 20040101

Role of COX-1 and -2 in prostanoid generation and modulation of angiotensin II responses.

American journal of physiology. Heart and circulatory physiology 20031201

Inhibition of spinal prostaglandin synthesis early after L5/L6 nerve ligation prevents the development of prostaglandin-dependent and prostaglandin-independent allodynia in the rat.

Anesthesiology 20031101

Specific roles of cyclooxygenase-1 and cyclooxygenase-2 in lipopolysaccharide-induced fever and Fos expression in rat brain.

The Journal of comparative neurology 20030811

Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats.

Thrombosis research 20030615

Mechanotransduction in bone cells proceeds via activation of COX-2, but not COX-1.

Biochemical and biophysical research communications 20030606

Cyclooxygenase-1-coupled prostaglandin biosynthesis constitutes an essential prerequisite for skin repair.

The Journal of investigative dermatology 20030501

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) sequentially upregulates nitric oxide and prostanoid production in primary human endothelial cells.

Circulation research 20030418

Induction of cyclooxygenase-1 and -2 modulates angiogenic responses to engagement of alphavbeta3.

British journal of haematology 20030401

Spinal nerve injury activates prostaglandin synthesis in the spinal cord that contributes to early maintenance of tactile allodynia.

Pain 20030101

Physiological apoptotic agents have different effects upon human amnion epithelial and mesenchymal cells.

Placenta 20030101

The influence of a cyclooxygenase-1 inhibitor on injured and uninjured ligaments in the rat.

The American journal of sports medicine 20030101

Both selective COX-1 and COX-2 inhibitors aggravate gastric damage induced in rats by 2-deoxy-D-glucose. relation to gastric hypermotility and COX-2 expression.

Digestion 20030101

COX-2-derived prostacyclin mediates opioid-induced late phase of preconditioning in isolated rat hearts.

American journal of physiology. Heart and circulatory physiology 20021201

The effects of cyclooxygenase isozyme inhibition on incisional wound healing in mouse skin.

The Journal of investigative dermatology 20021101

Diesel exhaust particle extracts and associated polycyclic aromatic hydrocarbons inhibit Cox-2-dependent prostaglandin synthesis in murine macrophages and fibroblasts.

The Journal of biological chemistry 20021018

Distinct roles for cyclooxygenases 1 and 2 in interleukin-1-induced behavioral changes.

The Journal of pharmacology and experimental therapeutics 20020901

COX and NOS isoforms involved in acid-induced duodenal bicarbonate secretion in rats.

Digestive diseases and sciences 20020901

Cyclooxygenase-1-selective inhibition prolongs gestation in mice without adverse effects on the ductus arteriosus.

The Journal of clinical investigation 20020815

The skin fungus-induced Th1- and Th2-related cytokine, chemokine and prostaglandin E2 production in peripheral blood mononuclear cells from patients with atopic dermatitis and psoriasis vulgaris.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20020801

COX-1 and 2, intestinal integrity, and pathogenesis of nonsteroidal anti-inflammatory drug enteropathy in mice.

Gastroenterology 20020601

Cyclooxygenase-1 and bicistronic cyclooxygenase-1/prostacyclin synthase gene transfer protect against ischemic cerebral infarction.

Circulation 20020423

Effects of cyclooxygenase-1/cyclooxygenase-2 inhibition on leukocyte/endothelial cell interactions in the rat mesentery.

European journal of pharmacology 20020405

The role of cyclooxygenase-1 and -2 in the rat formalin test.

Anesthesia and analgesia 20020401

COX-2 inhibition attenuates anorexia during systemic inflammation without impairing cytokine production.

American journal of physiology. Endocrinology and metabolism 20020301

Up-regulation of cyclooxygenase-2 by inhibition of cyclooxygenase-1: a key to nonsteroidal anti-inflammatory drug-induced intestinal damage.

The Journal of pharmacology and experimental therapeutics 20020301

Involvement of peripheral cyclooxygenase-1 and cyclooxygenase-2 in inflammatory pain.

The Journal of pharmacy and pharmacology 20020301

Cyclooxygenase-1 derived prostaglandins are involved in the maintenance of renal function in rats with cirrhosis and ascites.

British journal of pharmacology 20020201

Selective inhibition of COX-2 is beneficial to mice infected intranasally with VSV.

Prostaglandins & other lipid mediators 20020201

Mechanism of inhibition of novel COX-2 inhibitors.

Advances in experimental medicine and biology 20020101

LPS-induced synthesis and release of PGE2 in liver macrophages: regulation by CPLA2, COX-1, COX-2, and PGE2 synthase.

Advances in experimental medicine and biology 20020101

COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011201

Effects of selective COX-1 and -2 inhibition on formalin-evoked nociceptive behaviour and prostaglandin E(2) release in the spinal cord.

Journal of neurochemistry 20011101

The acute antihyperalgesic action of nonsteroidal, anti-inflammatory drugs and release of spinal prostaglandin E2 is mediated by the inhibition of constitutive spinal cyclooxygenase-2 (COX-2) but not COX-1.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815

Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo.

The Journal of clinical investigation 20010815

Key role for constitutive cyclooxygenase-2 of MDCK cells in basal signaling and response to released ATP.

American journal of physiology. Cell physiology 20010801

A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.

The Biochemical journal 20010801

Cholera toxin induces prostaglandin synthesis via post-transcriptional activation of cyclooxygenase-2 in the rat jejunum.

The Journal of pharmacology and experimental therapeutics 20010601

Effects of specific inhibition of cyclo-oxygenase-1 and cyclo-oxygenase-2 in the rat stomach with normal mucosa and after acid challenge.

British journal of pharmacology 20010401

Cyclooxygenase-1 participates in selected vasodilator responses of the cerebral circulation.

Circulation research 20010330

Disturbance of peristalsis in the guinea-pig isolated small intestine by indomethacin, but not cyclo-oxygenase isoform-selective inhibitors.

British journal of pharmacology 20010301

Effects of COX-1 and COX-2 inhibitors on eicosanoid biosynthesis and the release of substance P from the guinea-pig isolated perfused lung.

Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010101

Inhibition of both COX-1 and COX-2 is required for development of gastric damage in response to nonsteroidal antiinflammatory drugs.

Journal of physiology, Paris 20010101

Differential inhibition by nimesulide of the early and late phases of intravenous- and intracerebroventricular-LPS-induced fever in guinea pigs.

Neuroimmunomodulation 20010101