Home Other Building Blocks Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-

Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-

CAS No.:
188343-77-3
Catalog Number:
AG002GUE
Molecular Formula:
C21H22FN3
Molecular Weight:
335.4179
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
95%
In Stock USA
United States
$82
- +
Product Description
Catalog Number:
AG002GUE
Chemical Name:
Pyridine, 4-[2-(4-fluorophenyl)-5-(1-methyl-4-piperidinyl)-1H-pyrrol-3-yl]-
CAS Number:
188343-77-3
Molecular Formula:
C21H22FN3
Molecular Weight:
335.4179
MDL Number:
MFCD30474871
IUPAC Name:
4-[2-(4-fluorophenyl)-5-(1-methylpiperidin-4-yl)-1H-pyrrol-3-yl]pyridine
InChI:
InChI=1S/C21H22FN3/c1-25-12-8-16(9-13-25)20-14-19(15-6-10-23-11-7-15)21(24-20)17-2-4-18(22)5-3-17/h2-7,10-11,14,16,24H,8-9,12-13H2,1H3
InChI Key:
RBWNFHXBUDPAIO-UHFFFAOYSA-N
SMILES:
CN1CCC(CC1)c1[nH]c(c(c1)c1ccncc1)c1ccc(cc1)F
Properties
Complexity:
409  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
335.18g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
335.426g/mol
Monoisotopic Mass:
335.18g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
31.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.6  
Literature
Title Journal
A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (New York, N.Y.) 20100514
Anticoccidial kinase inhibitors: identification of protein kinase targets secondary to cGMP-dependent protein kinase. Molecular and biochemical parasitology 20060901
Highly substituted terphenyls as inhibitors of parasite cGMP-dependent protein kinase activity. Journal of natural products 20060401
Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor. Molecular and biochemical parasitology 20060301
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents. Bioorganic & medicinal chemistry letters 20050701
Tenellones A and B from a Diaporthe sp.: two highly substituted benzophenone inhibitors of parasite cGMP-dependent protein kinase activity. Journal of natural products 20050401
A role for coccidian cGMP-dependent protein kinase in motility and invasion. International journal for parasitology 20040309
Toxoplasma gondii cyclic GMP-dependent kinase: chemotherapeutic targeting of an essential parasite protein kinase. Eukaryotic cell 20020601
Purification and molecular characterization of cGMP-dependent protein kinase from Apicomplexan parasites. A novel chemotherapeutic target. The Journal of biological chemistry 20020503
Properties