Home Aminos Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-

CAS No.:
192705-79-6
Catalog Number:
AG002G84
Molecular Formula:
C20H24N6O3
Molecular Weight:
396.4430
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
5mg
99%
1 week
United States
$154
- +
10mg
99%
1 week
United States
$210
- +
25mg
99%
1 week
United States
$390
- +
50mg
99%
1 week
United States
$640
- +
100mg
99%
1 week
United States
$1085
- +
Product Description
Catalog Number:
AG002G84
Chemical Name:
Urea, N-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)-
CAS Number:
192705-79-6
Molecular Formula:
C20H24N6O3
Molecular Weight:
396.4430
MDL Number:
MFCD12922514
IUPAC Name:
1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea
InChI:
InChI=1S/C20H24N6O3/c1-20(2,3)26-19(27)25-17-15(8-12-10-22-18(21)24-16(12)23-17)11-6-13(28-4)9-14(7-11)29-5/h6-10H,1-5H3,(H4,21,22,23,24,25,26,27)
InChI Key:
NHJSWORVNIOXIT-UHFFFAOYSA-N
SMILES:
COc1cc(OC)cc(c1)c1cc2cnc(nc2nc1NC(=O)NC(C)(C)C)N
UNII:
NA856793UT
Properties
Complexity:
545  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
396.191g/mol
Formal Charge:
0
Heavy Atom Count:
29  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
396.451g/mol
Monoisotopic Mass:
396.191g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
124A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.3  
Literature
Title Journal
The synthetic inhibitor of fibroblast growth factor receptor PD166866 controls negatively the growth of tumor cells in culture. Journal of experimental & clinical cancer research : CR 20090101
2D Autocorrelation, CoMFA, and CoMSIA modeling of protein tyrosine kinases' inhibition by substituted pyrido[2,3-d]pyrimidine derivatives. Bioorganic & medicinal chemistry 20080115
Reduction of cell proliferation induced by PD166866: an inhibitor of the basic fibroblast growth factor. Journal of experimental & clinical cancer research : CR 20070901
Metabolic alterations in cultured mouse fibroblasts induced by an inhibitor of the tyrosine kinase receptor Fibroblast Growth Factor Receptor 1. Analytical biochemistry 20070801
Increased glutathione biosynthesis by Nrf2 activation in astrocytes prevents p75NTR-dependent motor neuron apoptosis. Journal of neurochemistry 20060501
Astrocyte activation by fibroblast growth factor-1 and motor neuron apoptosis: implications for amyotrophic lateral sclerosis. Journal of neurochemistry 20050401
Structure-activity relationships for 2-anilino-6-phenylpyrido[2,3-d]pyrimidin-7(8H)-ones as inhibitors of the cellular checkpoint kinase Wee1. Bioorganic & medicinal chemistry letters 20050401
Disruption of fibroblast growth factor signal pathway inhibits the growth of synovial sarcomas: potential application of signal inhibitors to molecular target therapy. Clinical cancer research : an official journal of the American Association for Cancer Research 20050401
Essential role of fibroblast growth factor signaling in preadipoctye differentiation. The Journal of clinical endocrinology and metabolism 20050201
Hypoxia-responsive growth factors upregulate periostin and osteopontin expression via distinct signaling pathways in rat pulmonary arterial smooth muscle cells. Journal of applied physiology (Bethesda, Md. : 1985) 20041001
Thyroid hormone activates fibroblast growth factor receptor-1 in bone. Molecular endocrinology (Baltimore, Md.) 20030901
Soluble 2-substituted aminopyrido[2,3-d]pyrimidin-7-yl ureas. Structure-activity relationships against selected tyrosine kinases and exploration of in vitro and in vivo anticancer activity. Journal of medicinal chemistry 20010607
Development of a binding model to protein tyrosine kinases for substituted pyrido[2,3-d]pyrimidine inhibitors. Journal of medicinal chemistry 19980521
Properties