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Bepotastine besilate

CAS No.:
190786-44-8
Catalog Number:
AG002ET1
Molecular Formula:
C27H31ClN2O6S
Molecular Weight:
547.0628
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
97%
In Stock USA
United States
$61
- +
25mg
97%
In Stock USA
United States
$158
- +
100mg
97%
In Stock USA
United States
$478
- +
Product Description
Catalog Number:
AG002ET1
Chemical Name:
Bepotastine besilate
CAS Number:
190786-44-8
Molecular Formula:
C27H31ClN2O6S
Molecular Weight:
547.0628
MDL Number:
MFCD01938491
IUPAC Name:
benzenesulfonic acid;4-[4-[(S)-(4-chlorophenyl)-pyridin-2-ylmethoxy]piperidin-1-yl]butanoic acid
InChI:
InChI=1S/C21H25ClN2O3.C6H6O3S/c22-17-8-6-16(7-9-17)21(19-4-1-2-12-23-19)27-18-10-14-24(15-11-18)13-3-5-20(25)26;7-10(8,9)6-4-2-1-3-5-6/h1-2,4,6-9,12,18,21H,3,5,10-11,13-15H2,(H,25,26);1-5H,(H,7,8,9)/t21-;/m0./s1
InChI Key:
UDGHXQPQKQPSBB-BOXHHOBZSA-N
SMILES:
OS(=O)(=O)c1ccccc1.OC(=O)CCCN1CCC(CC1)O[C@H](c1ccccn1)c1ccc(cc1)Cl
UNII:
6W18MO1QR3
Properties
Complexity:
632  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
546.159g/mol
Formal Charge:
0
Heavy Atom Count:
37  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
547.063g/mol
Monoisotopic Mass:
546.159g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
125A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Health-related quality of life assessed by the effect of bepotastine besilate in patients with pruritus: importance of emotions score in atopic dermatitis. The Journal of dermatology 20120601
Effects of bepotastine and fexofenadine on histamine-induced flare, wheal and itch. International archives of allergy and immunology 20120101
Next-day residual sedative effect after nighttime administration of an over-the-counter antihistamine sleep aid, diphenhydramine, measured by positron emission tomography. Journal of clinical psychopharmacology 20101201
Non-clinical pharmacology, pharmacokinetics, and safety findings for the antihistamine bepotastine besilate. Current medical research and opinion 20101001
Oral bepotastine: in allergic disorders. Drugs 20100820
Bepotastine besilate, a highly selective histamine H(1) receptor antagonist, suppresses vascular hyperpermeability and eosinophil recruitment in in vitro and in vivo experimental allergic conjunctivitis models. Experimental eye research 20100701
Bepotastine besilate ophthalmic solution for the relief of nonocular symptoms provoked by conjunctival allergen challenge. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20100701
Bepotastine (bepreve)--an ophthalmic H1-antihistamine. The Medical letter on drugs and therapeutics 20100208
New drugs: asenapine, iloperidone, and bepotastine besilate. Journal of the American Pharmacists Association : JAPhA 20100101
Multiple H1-antihistamine-induced urticaria. The Journal of dermatology 20090401
Bepotastine besilate OD tablets suppress nasal symptoms caused by Japanese cedar pollen exposure in an artificial exposure chamber (OHIO Chamber). Expert opinion on pharmacotherapy 20090301
Downmodulatory effects of the antihistaminic drug bepotastine on cytokine/chemokine production and CD54 expression in human keratinocytes. Skin pharmacology and physiology 20090101
Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin. British journal of clinical pharmacology 20080601
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale. Methods and findings in experimental and clinical pharmacology 20080401
Oral administration of bepotastine besilate suppressed scratching behavior of atopic dermatitis model NC/Nga mice. International archives of allergy and immunology 20080101
Involvement of histamine released from mast cells in acute radiation dermatitis in mice. Journal of pharmacological sciences 20070601
Suppression by bepotastine besilate of substance P-induced itch-associated responses through the inhibition of the leukotriene B4 action in mice. European journal of pharmacology 20061010
Effect of P-glycoprotein on intestinal absorption and brain penetration of antiallergic agent bepotastine besilate. Drug metabolism and disposition: the biological fate of chemicals 20060501
Properties