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Firocoxib

CAS No.:
189954-96-9
Catalog Number:
AG002E6F
Molecular Formula:
C17H20O5S
Molecular Weight:
336.4027
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%(GCHPLC)
In Stock USA
United States
$82
- +
5mg
98%(GCHPLC)
In Stock USA
United States
$221
- +
10mg
98%(GCHPLC)
In Stock USA
United States
$289
- +
50mg
98%(GCHPLC)
In Stock USA
United States
$985
- +
Product Description
Catalog Number:
AG002E6F
Chemical Name:
Firocoxib
CAS Number:
189954-96-9
Molecular Formula:
C17H20O5S
Molecular Weight:
336.4027
MDL Number:
MFCD09837800
IUPAC Name:
3-(cyclopropylmethoxy)-5,5-dimethyl-4-(4-methylsulfonylphenyl)furan-2-one
InChI:
InChI=1S/C17H20O5S/c1-17(2)14(12-6-8-13(9-7-12)23(3,19)20)15(16(18)22-17)21-10-11-4-5-11/h6-9,11H,4-5,10H2,1-3H3
InChI Key:
FULAPETWGIGNMT-UHFFFAOYSA-N
SMILES:
O=C1OC(C(=C1OCC1CC1)c1ccc(cc1)S(=O)(=O)C)(C)C
UNII:
Y6V2W4S4WT
NSC Number:
758895
Properties
Complexity:
614  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
336.103g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
336.402g/mol
Monoisotopic Mass:
336.103g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
78A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.2  
Literature
Title Journal
Efficacy and safety of firocoxib for the treatment of pain associated with soft tissue surgery in dogs under field conditions in Japan. The Journal of veterinary medical science 20121001
Determination of non-steroidal anti-inflammatory drugs and their metabolites in milk by liquid chromatography-tandem mass spectrometry. Analytical and bioanalytical chemistry 20120701
Evaluation of oral administration of firocoxib for the management of musculoskeletal pain and lameness associated with osteoarthritis in horses. American journal of veterinary research 20120501
Vesiculobullous skin reaction temporally related to firocoxib treatment in a white rhinoceros (Ceratotherium simum). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20120301
Efficacy of ABT-116, an antagonist of transient receptor potential vanilloid type 1, in providing analgesia for dogs with chemically induced synovitis. American journal of veterinary research 20120101
Canine malignant mammary gland neoplasms with advanced clinical staging treated with carboplatin and cyclooxygenase inhibitors. In vivo (Athens, Greece) 20120101
Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis 20110910
Long-term efficacy and safety of firocoxib in the treatment of dogs with osteoarthritis. The Veterinary record 20110611
Post-operative analgesic effects of butorphanol or firocoxib administered to dogs undergoing elective ovariohysterectomy. Veterinary anaesthesia and analgesia 20110501
Tolerance of firocoxib in dogs with osteoarthritis during 90 days. Journal of veterinary pharmacology and therapeutics 20110401
Determination of firocoxib in equine plasma using high performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110115
Distribution of flunixin meglumine and firocoxib into aqueous humor of horses. Journal of veterinary internal medicine 20110101
[New drugs for horses and production animals in 2010]. Tierarztliche Praxis. Ausgabe G, Grosstiere/Nutztiere 20110101
Does administration of non-steroidal anti-inflammatory drug determine morphological changes in adrenal cortex: ultrastructural studies. Protoplasma 20101001
Effects of firocoxib, meloxicam, and tepoxalin administration on eicosanoid production in target tissues of healthy cats. American journal of veterinary research 20100901
Effect of nonsteroidal anti-inflammatory drugs with varied cyclooxygenase-2 selectivity on cyclooxygenase protein and prostanoid concentrations in pyloric and duodenal mucosa of dogs. American journal of veterinary research 20091001
The effect of doxycycline on canine hip osteoarthritis: design of a 6-months clinical trial. Journal of veterinary science 20090901
The effects of firocoxib (Previcox) in geriatric dogs over a period of 90 days. Journal of the South African Veterinary Association 20090901
Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. American journal of veterinary research 20090801
Systematic review of the management of canine osteoarthritis. The Veterinary record 20090404
The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses. Equine veterinary journal 20090301
Confirmatory analysis of firocoxib in bovine milk by rapid resolution liquid chromatography tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090215
Effects of firocoxib and tepoxalin on healing in a canine gastric mucosal injury model. Journal of veterinary internal medicine 20090101
Pharmacokinetics of firocoxib after administration of multiple consecutive daily doses to horses. American journal of veterinary research 20081101
Effects of firocoxib, meloxicam, and tepoxalin on prostanoid and leukotriene production by duodenal mucosa and other tissues of osteoarthritic dogs. American journal of veterinary research 20080901
Comparison of the effects of firocoxib, carprofen and vedaprofen in a sodium urate crystal induced synovitis model of arthritis in dogs. Research in veterinary science 20080201
Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. Journal of the American Veterinary Medical Association 20080101
Quantitative HPLC-UV method for the determination of firocoxib from horse and dog plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070701
Automated liquid chromatography-tandem mass spectrometry method for the analysis of firocoxib in urine and plasma from horse and dog. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20070615
Pharmacokinetics and metabolism of orally administered firocoxib, a novel second generation coxib, in horses. Journal of veterinary pharmacology and therapeutics 20070601
Evaluation of the adverse effects of oral firocoxib in healthy dogs. Journal of veterinary pharmacology and therapeutics 20070601
[European symposium about osteoarthritis in a dog]. Tijdschrift voor diergeneeskunde 20070101
Firocoxib efficacy preventing urate-induced synovitis, pain, and inflammation in dogs. Veterinary therapeutics : research in applied veterinary medicine 20070101
Switching NSAIDs in practice: insights from the Previcox (firocoxib) Experience Trial. Veterinary therapeutics : research in applied veterinary medicine 20070101
Clinical evaluation of firocoxib and carprofen for the treatment of dogs with osteoarthritis. The Veterinary record 20061021
The clinical pharmacology of cyclooxygenase-2-selective and dual inhibitors. The Veterinary clinics of North America. Small animal practice 20060901
Clinical effectiveness and safety of a new NSAID, firocoxib: a 1,000 dog study. Veterinary therapeutics : research in applied veterinary medicine 20060101
Efficacy and safety of firocoxib in the management of canine osteoarthritis under field conditions. Veterinary therapeutics : research in applied veterinary medicine 20060101
In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in cats with lipopolysaccharide-induced pyrexia. American journal of veterinary research 20050701
In vitro effects and in vivo efficacy of a novel cyclooxygenase-2 inhibitor in dogs with experimentally induced synovitis. American journal of veterinary research 20040401
Properties