2,4-Diaminoquinazoline
| Title | Journal |
|---|---|
| Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. | PLoS genetics 20120601 |
| Discovery and optimization of 2,4-diaminoquinazoline derivatives as a new class of potent dengue virus inhibitors. | Journal of medicinal chemistry 20120412 |
| Synthesis of 2,4-diaminoquinazolines and tricyclic quinazolines by cascade reductive cyclization of methyl N-cyano-2-nitrobenzimidates. | The Journal of organic chemistry 20120316 |
| Design, synthesis, and biological evaluation of new diaminoquinazolines as β-catenin/Tcf4 pathway inhibitors. | Journal of medicinal chemistry 20120209 |
| Structure-based design of new DHFR-based antibacterial agents: 7-aryl-2,4-diaminoquinazolines. | Bioorganic & medicinal chemistry letters 20110915 |
| New insights into the structural requirements for pro-apoptotic agents based on 2,4-diaminoquinazoline, 2,4-diaminopyrido[2,3-d]pyrimidine and 2,4-diaminopyrimidine derivatives. | European journal of medicinal chemistry 20110901 |
| Importazole, a small molecule inhibitor of the transport receptor importin-β. | ACS chemical biology 20110715 |
| The contribution of mouse models to understanding the pathogenesis of spinal muscular atrophy. | Disease models & mechanisms 20110701 |
| Synthesis and biological evaluation of 2,4-diaminoquinazoline derivatives as novel heat shock protein 90 inhibitors. | Bioorganic & medicinal chemistry letters 20110315 |
| Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design. | Journal of tropical medicine 20110101 |
| Utility of survival motor neuron ELISA for spinal muscular atrophy clinical and preclinical analyses. | PloS one 20110101 |
| Spinal muscular atrophy. | Orphanet journal of rare diseases 20110101 |
| Synthesis of highly functionalized 2,4-diaminoquinazolines as anticancer and anti-HIV agents. | Bioorganic & medicinal chemistry letters 20100801 |
| Synthesis and characterization of potent inhibitors of Trypanosoma cruzi dihydrofolate reductase. | Bioorganic & medicinal chemistry 20100601 |
| Effects of 2,4-diaminoquinazoline derivatives on SMN expression and phenotype in a mouse model for spinal muscular atrophy. | Human molecular genetics 20100201 |
| Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase. | Analytical biochemistry 20100115 |
| Binding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies. | Indian journal of pharmaceutical sciences 20100101 |
| Mouse survival motor neuron alleles that mimic SMN2 splicing and are inducible rescue embryonic lethality early in development but not late. | PloS one 20100101 |
| N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a 'chemical knock-out equivalent' to assess the impact of efflux transporters on oral drug absorption in the rat. | Journal of pharmaceutical sciences 20091201 |
| 2,4-Diamino-quinazolines as inhibitors of beta-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer. | Bioorganic & medicinal chemistry letters 20090901 |
| N9-substituted 2,4-diaminoquinazolines: synthesis and biological evaluation of lipophilic inhibitors of pneumocystis carinii and toxoplasma gondii dihydrofolate reductase. | Journal of medicinal chemistry 20081009 |
| Potent CCR4 antagonists: synthesis, evaluation, and docking study of 2,4-diaminoquinazolines. | Bioorganic & medicinal chemistry 20080901 |
| Discovery of potent CCR4 antagonists: Synthesis and structure-activity relationship study of 2,4-diaminoquinazolines. | Bioorganic & medicinal chemistry 20080715 |
| Synthesis and biological evaluation of novel 2,4-diaminoquinazoline derivatives as SMN2 promoter activators for the potential treatment of spinal muscular atrophy. | Journal of medicinal chemistry 20080214 |
| Binding of an aminoacridine derivative to a GAAA RNA tetraloop. | Bioorganic & medicinal chemistry letters 20041206 |
| A novel method of synthesis of 2,4-diamino-6-arylmethylquinazolines using palladium(0)-catalyzed organozinc chemistry. | The Journal of organic chemistry 20011102 |
| Traceless solid-phase synthesis of 2,4-diaminoquinazolines. | Organic letters 20010222 |
| Solid-phase synthesis of 2,4-diaminoquinazoline libraries. | Journal of combinatorial chemistry 20010101 |
| Inhibitors of protein-RNA complexation that target the RNA: specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules. | Biochemistry 19981006 |
| Selective inhibitors of Candida albicans dihydrofolate reductase: activity and selectivity of 5-(arylthio)-2,4-diaminoquinazolines. | Journal of medicinal chemistry 19950901 |
| 2,4-Diamino-5-substituted-quinazolines as inhibitors of a human dihydrofolate reductase with a site-directed mutation at position 22 and of the dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii. | Journal of medicinal chemistry 19950303 |
| Assays to detect and characterize human immunodeficiency virus type 1 (HIV-1) receptor antagonists, compounds that inhibit binding of the HIV-1 surface glycoprotein, gp120, to the CD4 receptor on human T lymphocytes. | Antimicrobial agents and chemotherapy 19940901 |