Oxacyclohexadec-13-ene-2,6-dione, 4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-, (4S,7R,8S,9S,13Z,16S)-
| Title | Journal |
|---|---|
| Identification of glycan structure alterations on cell membrane proteins in desoxyepothilone B resistant leukemia cells. | Molecular & cellular proteomics : MCP 20111101 |
| The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. | Pharmacological research 20110401 |
| Synthesis of (Z)-trisubstituted olefins by decarboxylative grob-type fragmentations: epothilone D, discodermolide, and peloruside A. | Chemistry (Weinheim an der Bergstrasse, Germany) 20100111 |
| Simultaneous determination of epothilone D and its hydrolytic metabolite in human plasma by high performance liquid chromatography-tandem mass spectrometry for pharmacokinetic studies. | Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20091101 |
| Determination of a novel epothilone D analog (AV-EPO-106) in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry. | Biomedical chromatography : BMC 20090301 |
| Decarboxylative Grob-type fragmentations in the synthesis of trisubstituted Z olefins: application to peloruside A, discodermolide, and epothilone D. | Angewandte Chemie (International ed. in English) 20090101 |
| Total synthesis of epothilones B and D: stannane equivalents for beta-keto ester dianions. | The Journal of organic chemistry 20081219 |
| Epothilones and new analogues of the microtubule modulators in taxane-resistant disease. | Expert opinion on investigational drugs 20080401 |
| Preclinical investigations with epothilones in breast cancer models. | Seminars in oncology 20080401 |
| Clinical studies with epothilones for the treatment of metastatic breast cancer. | Seminars in oncology 20080401 |
| Phase II study of KOS-862 in patients with metastatic androgen independent prostate cancer previously treated with docetaxel. | Investigational new drugs 20071201 |
| Epothilone D, a microtubule-stabilizing compound, inhibits neointimal hyperplasia after rat carotid artery injury by cell cycle arrest via regulation of G1-checkpoint proteins. | Vascular pharmacology 20071001 |
| Epothilones induce human colon cancer SW620 cell apoptosis via the tubulin polymerization independent activation of the nuclear factor-kappaB/IkappaB kinase signal pathway. | Molecular cancer therapeutics 20071001 |
| Novel tubulin-targeting agents: anticancer activity and pharmacologic profile of epothilones and related analogues. | Annals of oncology : official journal of the European Society for Medical Oncology 20070701 |
| Alterations in gamma-actin and tubulin-targeted drug resistance in childhood leukemia. | Journal of the National Cancer Institute 20061004 |
| Determination of desoxyepothilone B in nude mice plasma by liquid-liquid extraction and reversed-phase high-performance liquid chromatography. | Journal of pharmaceutical and biomedical analysis 20060918 |
| Heterologous production of epothilone C and D in Escherichia coli. | Biochemistry 20060131 |
| Current state of the art of new tubulin inhibitors in the clinic. | Current clinical pharmacology 20060101 |
| Total synthesis of 12,13-desoxyepothilone B (Epothilone D). | Bioorganic chemistry 20050401 |
| Total syntheses of epothilones B and d. | The Journal of organic chemistry 20041224 |
| Kinetics and mechanism of degradation of epothilone-D: an experimental anticancer agent. | Journal of pharmaceutical sciences 20041201 |
| A comparison of signaling activities induced by Taxol and desoxyepothilone B. | Journal of chemotherapy (Florence, Italy) 20041201 |
| Crystal structures of epothilone D-bound, epothilone B-bound, and substrate-free forms of cytochrome P450epoK. | The Journal of biological chemistry 20031107 |
| Creating polyketide diversity through genetic engineering. | Frontiers in bioscience : a journal and virtual library 20030101 |
| Probing the SAR of dEpoB via chemical synthesis: a total synthesis evaluation of C26-(1,3-dioxolanyl)-12,13-desoxyepothilone B. | The Journal of organic chemistry 20021101 |
| A new cytotoxic epothilone from modified polyketide synthases heterologously expressed in Myxococcus xanthus. | Journal of natural products 20020701 |
| Optimizing the heterologous production of epothilone D in Myxococcus xanthus. | Biotechnology and bioengineering 20020505 |
| Large-scale isolation and crystallization of epothilone D from Myxococcus xanthus cultures. | Journal of natural products 20020401 |
| Total synthesis of epothilones B and D. | Organic letters 20010712 |
| New natural epothilones from Sorangium cellulosum, strains So ce90/B2 and So ce90/D13: isolation, structure elucidation, and SAR studies. | Journal of natural products 20010701 |
| Total synthesis of epothilone B, epothilone D, and cis- and trans-9,10-dehydroepothilone D. | Journal of the American Chemical Society 20010613 |
| Catalytic antibody route to the naturally occurring epothilones: total synthesis of epothilones A-F. | Chemistry (Weinheim an der Bergstrasse, Germany) 20010417 |