Talarozole
| Title | Journal |
|---|---|
| Induction of CYP26A1 by metabolites of retinoic acid: evidence that CYP26A1 is an important enzyme in the elimination of active retinoids. | Molecular pharmacology 20150301 |
| Homology models of human all-trans retinoic acid metabolizing enzymes CYP26B1 and CYP26B1 spliced variant. | Journal of chemical information and modeling 20121022 |
| Cloning and functional studies of a splice variant of CYP26B1 expressed in vascular cells. | PloS one 20120101 |
| Synthesis and biological evaluation of 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-[4-(naphthalen-2-ylamino)phenyl]propyl derivatives as small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26). | Journal of medicinal chemistry 20111013 |
| Complete meiosis from human induced pluripotent stem cells. | Stem cells (Dayton, Ohio) 20110801 |
| Small molecule inhibitors of retinoic acid 4-hydroxylase (CYP26): synthesis and biological evaluation of imidazole methyl 3-(4-(aryl-2-ylamino)phenyl)propanoates. | Journal of medicinal chemistry 20110428 |
| CYP26B1 plays a major role in the regulation of all-trans-retinoic acid metabolism and signaling in human aortic smooth muscle cells. | Journal of vascular research 20110101 |
| Local skin pharmacokinetics of talarozole, a new retinoic acid metabolism-blocking agent. | Skin pharmacology and physiology 20110101 |
| CYP26A1-specific antagonist influence on embryonic implantation, gene expression and endogenous retinoid concentration in rats. | Reproductive toxicology (Elmsford, N.Y.) 20101101 |
| Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis. | Archives of dermatological research 20090801 |
| The CYP26 inhibitor R115866 potentiates the effects of all-trans retinoic acid on cultured human epidermal keratinocytes. | The British journal of dermatology 20090301 |
| The involvement of cytochrome p450 (CYP) 26 in the retinoic acid metabolism of human epidermal keratinocytes. | Biochimica et biophysica acta 20090301 |
| Topical treatment with CYP26 inhibitor talarozole (R115866) dose dependently alters the expression of retinoid-regulated genes in normal human epidermis. | The British journal of dermatology 20090101 |
| Talarozole, a selective inhibitor of P450-mediated all-trans retinoic acid for the treatment of psoriasis and acne. | Current opinion in investigational drugs (London, England : 2000) 20081101 |
| Gateways to clinical trials. | Methods and findings in experimental and clinical pharmacology 20080601 |
| Oral R115866 in the treatment of moderate to severe plaque-type psoriasis. | Journal of the European Academy of Dermatology and Venereology : JEADV 20070901 |
| Oral R115866 in the treatment of moderate to severe facial acne vulgaris: an exploratory study. | The British journal of dermatology 20070701 |
| CYP26 inhibitor R115866 increases retinoid signaling in intimal smooth muscle cells. | Arteriosclerosis, thrombosis, and vascular biology 20070701 |
| Oral retinoic acid metabolism blocking agent Rambazole for plaque psoriasis: an immunohistochemical study. | The British journal of dermatology 20070201 |
| Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development. | Development (Cambridge, England) 20070101 |
| Cyp26 genes a1, b1 and c1 are down-regulated in Tbx1 null mice and inhibition of Cyp26 enzyme function produces a phenocopy of DiGeorge Syndrome in the chick. | Human molecular genetics 20061201 |
| Homology model of human retinoic acid metabolising enzyme cytochrome P450 26A1 (CYP26A1): active site architecture and ligand binding. | Journal of enzyme inhibition and medicinal chemistry 20060801 |
| Retinoic acid regulates sex-specific timing of meiotic initiation in mice. | Proceedings of the National Academy of Sciences of the United States of America 20060221 |
| Pharmacology of an original and selective nonpeptide antagonist ligand for the human tachykinin NK2 receptor. | European journal of pharmacology 20050601 |
| Patterning of motor neurons by retinoic acid in the chick embryo hindbrain in vitro. | Molecular and cellular neurosciences 20030501 |
| R115866 inhibits all-trans-retinoic acid metabolism and exerts retinoidal effects in rodents. | The Journal of pharmacology and experimental therapeutics 20000401 |