Home Other Building Blocks 6-Methyl-7h-purine

6-Methyl-7h-purine

CAS No.:
2004-03-7
Catalog Number:
AG002CR0
Molecular Formula:
C6H6N4
Molecular Weight:
134.1386
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
98%
1 week
United States
$107
- +
1g
98%
1 week
United States
$213
- +
Product Description
Catalog Number:
AG002CR0
Chemical Name:
6-Methyl-7h-purine
CAS Number:
2004-03-7
Molecular Formula:
C6H6N4
Molecular Weight:
134.1386
MDL Number:
MFCD00083663
IUPAC Name:
6-methyl-7H-purine
InChI:
InChI=1S/C6H6N4/c1-4-5-6(9-2-7-4)10-3-8-5/h2-3H,1H3,(H,7,8,9,10)
InChI Key:
SYMHUEFSSMBHJA-UHFFFAOYSA-N
SMILES:
Cc1ncnc2c1nc[nH]2
EC Number:
217-903-2
UNII:
SEO6WX0OZG
NSC Number:
407198
Properties
Complexity:
127  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
134.059g/mol
Formal Charge:
0
Heavy Atom Count:
10  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
134.142g/mol
Monoisotopic Mass:
134.059g/mol
Rotatable Bond Count:
0
Topological Polar Surface Area:
54.5A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.5  
Literature
Title Journal
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Effect of expression of adenine phosphoribosyltransferase on the in vivo anti-tumor activity of prodrugs activated by E. coli purine nucleoside phosphorylase. Cancer gene therapy 20110601
Molecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitors. Chemistry (Weinheim an der Bergstrasse, Germany) 20110527
Purine Nucleoside Phosphorylase mediated molecular chemotherapy and conventional chemotherapy: a tangible union against chemoresistant cancer. BMC cancer 20110101
Promoters with cancer cell-specific activity for melanoma gene therapy. Acta naturae 20110101
Enzymatic synthesis of 2'-deoxyadenosine and 6-methylpurine-2'-deoxyriboside by Escherichia coli DH5alpha overexpressing nucleoside phosphorylases from Escherichia coli BL21. Journal of bioscience and bioengineering 20100801
Regioselective metalation of 6-methylpurines: synthesis of fluoromethyl purines and related nucleosides for suicide gene therapy of cancer. Nucleosides, nucleotides & nucleic acids 20090501
Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy. PloS one 20090101
Characterization of an engineered human purine nucleoside phosphorylase fused to an anti-her2/neu single chain Fv for use in ADEPT. Journal of experimental & clinical cancer research : CR 20090101
A comparison of leaf and petal senescence in wallflower reveals common and distinct patterns of gene expression and physiology. Plant physiology 20080801
Synergistic antitumor efficacy of suicide/ePNP gene and 6-methylpurine 2'-deoxyriboside via Salmonella against murine tumors. Cancer gene therapy 20080701
Suicide gene/prodrug therapy using salmonella-mediated delivery of Escherichia coli purine nucleoside phosphorylase gene and 6-methoxypurine 2'-deoxyriboside in murine mammary carcinoma 4T1 model. Cancer science 20080601
Controlled aggregation of adenine by sugars: physicochemical studies, molecular modelling simulations of sugar-aromatic CH-pi stacking interactions, and biological significance. Physical chemistry chemical physics : PCCP 20080521
Prodrug converting enzyme gene delivery by L. monocytogenes. BMC cancer 20080101
hTERT-targeted E. coli purine nucleoside phosphorylase gene/6-methylpurine deoxyribose therapy for pancreatic cancer. Chinese medical journal 20070805
Induction of wall ingrowths of transfer cells occurs rapidly and depends upon gene expression in cotyledons of developing Vicia faba seeds. Protoplasma 20070101
[Killing effect of PNP/MeP-dR suicide gene system driven by an AFP promoter AF0.3 on AFP-positive hepatoma cells]. Ai zheng = Aizheng = Chinese journal of cancer 20061101
Improved synthesis of beta-D-6-methylpurine riboside and antitumor effects of the beta-D- and alpha-D-anomers. Molecules (Basel, Switzerland) 20050831
Transcriptional tumor-selective promoter targeting of E. coli purine nucleoside phosphorylase for pancreatic cancer suicide gene therapy. The journal of gene medicine 20050501
Antibiotic-mediated chemoprotection enhances adaptation of E. coli PNP for herpes simplex virus-based glioma therapy. Human gene therapy 20050301
Synthesis and biological activity of 2-fluoro adenine and 6-methyl purine nucleoside analogs as prodrugs for suicide gene therapy of cancer. Nucleosides, nucleotides & nucleic acids 20050101
PNP anticancer gene therapy. Current topics in medicinal chemistry 20050101
Suicide gene/prodrug therapy for pancreatic adenocarcinoma by E. coli purine nucleoside phosphorylase and 6-methylpurine 2'-deoxyriboside. Pancreas 20040301
An efficient synthesis of 2-substituted 6-methylpurine bases and nucleosides by Fe- or Pd-catalyzed cross-coupling reactions of 2,6-dichloropurines. The Journal of organic chemistry 20030711
A long-acting suicide gene toxin, 6-methylpurine, inhibits slow growing tumors after a single administration. The Journal of pharmacology and experimental therapeutics 20030301
Selective metalation of 6-methylpurines: synthesis of 6-fluoromethylpurines and related nucleosides. Nucleosides, nucleotides & nucleic acids 20030101
Current progress in suicide gene therapy for cancer. World journal of surgery 20020701
Structural basis for the binding affinity of xanthines with the DNA intercalator acridine orange. Journal of medicinal chemistry 20011220
Synthesis, antiproliferative and antiviral activity of imidazo[4,5-d]isothiazole nucleosides as 5:5 fused analogs of nebularine and 6-methylpurine ribonucleoside. Journal of medicinal chemistry 19970227
Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii. Biochemical pharmacology 19951109
A STUDY OF THE CROSS-REACTIVITY OF ANTIPURIN-6-OYL SERUM WITH DEOXYRIBONUCLEIC ACID (DNA). The Journal of experimental medicine 19650101
Properties